Terazosin (BioDeep_00000003181)
Secondary id: BioDeep_00000406034
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
化学式: C19H25N5O4 (387.190645)
中文名称: 特拉唑嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 27.27%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
InChI: InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
描述信息
Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
G - Genito urinary system and sex hormones > G04 - Urologicals > G04C - Drugs used in benign prostatic hypertrophy > G04CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
同义名列表
36 个代谢物同义名
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine; 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine; Terazosin, monohydrochloride, dihydrate; Hexal brand OF terazosin hydrochloride; Terazosin hydrochloride anhydrous; Terazosin hydrochloride; Terazosina qualix; Terazosina alter; Terazosina kern; Ratio-terazosin; Terazosin hexal; Novo-terazosin; Terazosin azu; PMS-Terazosin; Apo-terazosin; Nu-terazosin; Abbott 45975; Terazosinum; Terazosabb; Hytrin BPH; Terazosina; Terazosine; Terazoflo; terazosin; Magnurol; Hytrine; Dysalfa; Tazusin; Zayasel; Heitrin; Flotrin; Hytrin; Deflox; Adecur; Sutif; Terazosin
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:9445
- KEGG: C07127
- KEGGdrug: D08569
- PubChem: 5401
- HMDB: HMDB0015293
- Metlin: METLIN2721
- DrugBank: DB01162
- ChEMBL: CHEMBL611
- Wikipedia: Terazosin
- chemspider: 5208
- CAS: 141269-45-6
- CAS: 141269-44-5
- CAS: 63590-64-7
- PMhub: MS000008411
- PubChem: 9337
- NIKKAJI: J19.669J
- RefMet: Terazosin
- KNApSAcK: 9445
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Lian-Lian Fan, Mu-Peng Li, Tong Wu, Chun-Yan Gan, Pei-Wen Zhang, Gang Mai, Jian-Zhong Shen-Tu. Bioequivalence study of two formulations of terazosin hydrochloride capsule in healthy Chinese subjects under fasting and fed conditions.
International journal of clinical pharmacology and therapeutics.
2022 Jan; 60(1):57-66. doi:
10.5414/cp204018. [PMID: 34672254] - Sreenivasulu Kilari, Amit Sharma, Chenglei Zhao, Avishek Singh, Chuanqi Cai, Michael Simeon, Andre J van Wijnen, Sanjay Misra. Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI.
Translational research : the journal of laboratory and clinical medicine.
2021 09; 235(?):32-47. doi:
10.1016/j.trsl.2021.03.005. [PMID: 33711514] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia.
Urology journal.
2021 Apr; 18(3):337-342. doi:
10.22037/uj.v18i.5678. [PMID: 33840085] - Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 02; 77(2):178-189.e1. doi:
10.1053/j.ajkd.2020.07.018. [PMID: 32920153] - Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Loke Meng Ong, Ru Shing Ng, Hong Chin Wee, Kok Khiang Peh. Simple and fast LC-MS/MS method for quantification of terazosin in human plasma and application to bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jan; 1163(?):122517. doi:
10.1016/j.jchromb.2020.122517. [PMID: 33429127] - Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults.
The Cochrane database of systematic reviews.
2020 11; 11(?):CD013393. doi:
10.1002/14651858.cd013393.pub2. [PMID: 33179245] - Yaser Pashaei, Bahram Daraei, Maryam Shekarchi. Magnetic-Dispersive Solid Phase Extraction Based on Graphene Oxide-Fe3O4 Nanocomposites Followed by High Performance Liquid Chromatography-Fluorescence for the Preconcentration and Determination of Terazosin Hydrochloride in Human Plasma.
Journal of chromatographic science.
2020 Jan; 58(2):178-186. doi:
10.1093/chromsci/bmz085. [PMID: 31746326] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Mahmoud Roushani, Zeynab Jalilian, Azizollah Nezhadali. A novel electrochemical sensor based on electrode modified with gold nanoparticles and molecularly imprinted polymer for rapid determination of trazosin.
Colloids and surfaces. B, Biointerfaces.
2018 Dec; 172(?):594-600. doi:
10.1016/j.colsurfb.2018.09.015. [PMID: 30218985] - Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma.
Luminescence : the journal of biological and chemical luminescence.
2018 Nov; 33(7):1226-1234. doi:
10.1002/bio.3539. [PMID: 30094938] - Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Apr; 195(?):215-222. doi:
10.1016/j.saa.2018.01.077. [PMID: 29414581] - Jun-Jun Huang, Zhi-Han Zhang, Fei He, Xia-Wen Liu, Xing-Jie Xu, Li-Jun Dai, Qi-Meng Liu, Mu Yuan. Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α1D/1A-adrenoreceptor subtypes.
Bioorganic & medicinal chemistry letters.
2018 02; 28(4):547-551. doi:
10.1016/j.bmcl.2018.01.068. [PMID: 29422390] - Zhe-Xian Deng, Ling-Xiao Ji, Yi-Rong Zhang, Cheng-di Li, Jian Cai, Hai-Hong Jiang. [Ningmitai Capsules relieve lower urinary tract symptoms in patients with benign prostatic hyperplasia : A short-term clinical observation].
Zhonghua nan ke xue = National journal of andrology.
2018 Jan; 24(1):72-77. doi:
. [PMID: 30157365] - Tong-Xin Yang, Bang-Hua Liao, Yun-Tian Chen, Hong Li, Qing He, Qin-Yu Liu, Kun-Jie Wang. A network meta-analysis on the beneficial effect of medical expulsive therapy after extracorporeal shock wave lithotripsy.
Scientific reports.
2017 10; 7(1):14429. doi:
10.1038/s41598-017-14862-3. [PMID: 29089544] - Mohamed A Hammad, Mahmoud A Omar, Baher I Salman. Utility of Hantzsch reaction for development of highly sensitive spectrofluorimetric method for determination of alfuzosin and terazosin in bulk, dosage forms and human plasma.
Luminescence : the journal of biological and chemical luminescence.
2017 Sep; 32(6):1066-1071. doi:
10.1002/bio.3292. [PMID: 28303653] - Yasaman Sefid-Sefidehkhan, Khadijeh Nekoueian, Mandana Amiri, Mika Sillanpaa, Habibollah Eskandari. Palladium nanoparticles in electrochemical sensing of trace terazosin in human serum and pharmaceutical preparations.
Materials science & engineering. C, Materials for biological applications.
2017 Jun; 75(?):368-374. doi:
10.1016/j.msec.2017.02.061. [PMID: 28415474] - Hafiz Mohammad Rashid Nadeem, Ejaz Mohiuddin, Shahab UdDin, Muhammad Daniyal, Khan Usmanghani. Comparison of Anti BPH capsule (herbal) and Terazosin HCl in the treatment of benign prostate hyperplasia.
Pakistan journal of pharmaceutical sciences.
2017 Jan; 30(1 Suppl):289-293. doi:
". [PMID: 28625956] - Jian-Ming Sun, Peng Liu, Wen-Jun Han. [Efficacy and safety of Tonglin Powder in the treatment of benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2016 Oct; 22(10):897-901. doi:
. [PMID: 29278471] - Ai Ping Li, Huanjun Peng, Jing Dong Peng, Ming Qiong Zhou, Jing Zhang. Rayleigh light scattering detection of three α1-adrenoceptor antagonists coupled with high performance liquid chromatograph.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Aug; 147(?):178-84. doi:
10.1016/j.saa.2015.02.062. [PMID: 25840026] - Junjun Huang, Fei He, Minyi Huang, Xiawen Liu, Yan Xiong, Yajian Huang, Liu Zhu, Ya Yang, Xingjie Xu, Mu Yuan. Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.
European journal of medicinal chemistry.
2015; 96(?):83-91. doi:
10.1016/j.ejmech.2015.04.005. [PMID: 25874333] - D Mitropoulos, E Patris, G Deliconstantinos, A Kyroudi-Voulgari, I Anastasiou, D Perea. Terazosin-induced alterations in catalase expression and lipid peroxidation in the rat seminal vesicles.
Andrologia.
2013 Apr; 45(2):128-34. doi:
10.1111/j.1439-0272.2012.01324.x. [PMID: 22731390] - Minoru Miyazato, Takuma Oshiro, Michael B Chancellor, William C de Groat, Naoki Yoshimura, Seiichi Saito. An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats.
Life sciences.
2013 Feb; 92(2):125-30. doi:
10.1016/j.lfs.2012.11.006. [PMID: 23178151] - Man Liu, Dan Zhang, Man Yang, Ting Zhao, Xiaolin Wang, Yanan Zhang, Jing Han, Huichen Liu. Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects.
Chirality.
2012 Dec; 24(12):1047-50. doi:
10.1002/chir.22095. [PMID: 22887707] - Xinfeng Zhao, Qian Li, Liujiao Bian, Xiaohui Zheng, Jianbin Zheng, Youyi Zhang, Zijian Li. Using immobilized G-protein coupled receptors to screen bioactive traditional Chinese medicine compounds with multiple targets.
Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):549-52. doi:
10.1016/j.jpba.2012.05.004. [PMID: 22651959] - Britta J Veitenheimer, William C Engeland, Pilar A Guzman, Gregory D Fink, John W Osborn. Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats.
American journal of physiology. Heart and circulatory physiology.
2012 Oct; 303(8):H1022-34. doi:
10.1152/ajpheart.00413.2012. [PMID: 22904160] - Sanam Mustafa, Heng B See, Ruth M Seeber, Stephen P Armstrong, Carl W White, Sabatino Ventura, Mohammed Akli Ayoub, Kevin D G Pfleger. Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer.
The Journal of biological chemistry.
2012 Apr; 287(16):12952-65. doi:
10.1074/jbc.m111.322834. [PMID: 22371491] - E E Filyushina, M D Shmerling, V A Lazarev, I I Buzueva, A L Merkel, G S Yakobson. Structural characteristics of renal glomerular system in ISIAH rats under conditions of chronic stress and preventive hypotensive drug therapy.
Bulletin of experimental biology and medicine.
2011 Dec; 152(2):249-52. doi:
10.1007/s10517-011-1500-z. [PMID: 22808472] - Yang Wang, Zhishun Liu, Jinna Yu, Yulong Ding, Xuan Liu. Efficacy of electroacupuncture at Zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: study protocol for a randomized controlled trial.
Trials.
2011 Sep; 12(?):211. doi:
10.1186/1745-6215-12-211. [PMID: 21943105] - Timothy J Wilt, R William Howe, Indy Rutks, Roderick Macdonald. WITHDRAWN: Terazosin for benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2011 Sep; ?(9):CD003851. doi:
10.1002/14651858.cd003851.pub2. [PMID: 21901686] - Jae-Wook Chung, Seock Hwan Choi, Bum Soo Kim, Tae-Hwan Kim, Eun Sang Yoo, Chun Il Kim, Kyung Seop Lee, Tae Gyun Kwon. Efficacy and Tolerability of Tamsulosin 0.4 mg in Patients with Symptomatic Benign Prostatic Hyperplasia.
Korean journal of urology.
2011 Jul; 52(7):479-84. doi:
10.4111/kju.2011.52.7.479. [PMID: 21860769] - Joon Seok Kwon, Jung Woo Lee, Seung Wook Lee, Hong Yong Choi, Hong Sang Moon. Comparison of effectiveness of monopolar and bipolar transurethral resection of the prostate and open prostatectomy in large benign prostatic hyperplasia.
Korean journal of urology.
2011 Apr; 52(4):269-73. doi:
10.4111/kju.2011.52.4.269. [PMID: 21556214] - Daryl S Schiller, Ashish Parikh. Identification, pharmacologic considerations, and management of prostatitis.
The American journal of geriatric pharmacotherapy.
2011 Feb; 9(1):37-48. doi:
10.1016/j.amjopharm.2011.02.005. [PMID: 21459307] - James Tacklind, Howard A Fink, Roderick Macdonald, Indy Rutks, Timothy J Wilt. Finasteride for benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2010 Oct; ?(10):CD006015. doi:
10.1002/14651858.cd006015.pub3. [PMID: 20927745] - Yong Hyeuk Choi, Sung Yong Cho, In Rae Cho. The different reduction rate of prostate-specific antigen in dutasteride and finasteride.
Korean journal of urology.
2010 Oct; 51(10):704-8. doi:
10.4111/kju.2010.51.10.704. [PMID: 21031091] - Ji-ye Aa, Guang-ji Wang, Hai-ping Hao, Qing Huang, Yi-hong Lu, Bei Yan, Wei-bin Zha, Lin-sheng Liu, An Kang. Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats.
Acta pharmacologica Sinica.
2010 Aug; 31(8):930-7. doi:
10.1038/aps.2010.86. [PMID: 20686518] - Constantin Popa, Florian Popa, Valentin Titus Grigorean, Gelu Onose, Aurelia Mihaela Sandu, Mihai Popescu, Gheorghe Burnei, Victor Strambu, Crina Sinescu. Vascular dysfunctions following spinal cord injury.
Journal of medicine and life.
2010 Jul; 3(3):275-85. doi:
NULL. [PMID: 20945818] - Dean Sol Elterman, Nathan Lawrentschuk, Emma Guns, Karen Hersey, Hans Adomat, Catherine A Wood, Neil Fleshner. Investigating contamination of phytotherapy products for benign prostatic hyperplasia with alpha-blockers and 5alpha-reductase inhibitors.
The Journal of urology.
2010 May; 183(5):2085-9. doi:
10.1016/j.juro.2009.12.097. [PMID: 20303529] - Shao Li, Aiping Lu, Yongyan Wang. Symptomatic comparison in efficacy on patients with benign prostatic hyperplasia treated with two therapeutic approaches.
Complementary therapies in medicine.
2010 Feb; 18(1):21-7. doi:
10.1016/j.ctim.2009.10.002. [PMID: 20178875] - F Giuliano, G Jackson, F Montorsi, A Martin-Morales, P Raillard. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database.
International journal of clinical practice.
2010 Jan; 64(2):240-55. doi:
10.1111/j.1742-1241.2009.02254.x. [PMID: 19900167] - Mohan K Abraham, Abdul Rasheed A Nasir, Bindu Sudarsanan, Ramakrishnan Puzhankara, Prashant M Kedari, Gopidas R Unnithan, Kalyan Ravi Prasad Damisetti, Tutu Narayanan. Role of alpha adrenergic blocker in the management of posterior urethral valves.
Pediatric surgery international.
2009 Dec; 25(12):1113-5. doi:
10.1007/s00383-009-2469-9. [PMID: 19727771] - Jerry G Blaivas. A round table discussion: case studies of patients with lower urinary tract symptoms.
The Urologic clinics of North America.
2009 Nov; 36(4):537-69, vii. doi:
10.1016/j.ucl.2009.08.006. [PMID: 19942051] - Madhu S Agrawal, Abhishek Yadav, Himanshu Yadav, Amit K Singh, Prashant Lavania, Richa Jaiman. A prospective randomized study comparing alfuzosin and tamsulosin in the management of patients suffering from acute urinary retention caused by benign prostatic hyperplasia.
Indian journal of urology : IJU : journal of the Urological Society of India.
2009 Oct; 25(4):474-8. doi:
10.4103/0970-1591.57917. [PMID: 19955671] - Maria Katsogiannou, Charbel El Boustany, Florian Gackiere, Philippe Delcourt, Anne Athias, Pascal Mariot, Etienne Dewailly, Nathalie Jouy, Christophe Lamaze, Gabriel Bidaux, Brigitte Mauroy, Natalia Prevarskaya, Christian Slomianny. Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells.
PloS one.
2009 Sep; 4(9):e7068. doi:
10.1371/journal.pone.0007068. [PMID: 19763272] - Hong-Yan Zou, Hai-Long Wu, Li-Qun OuYang, Yan Zhang, Jin-Fang Nie, Hai-Yan Fu, Ru-Qin Yu. Fluorescent quantification of terazosin hydrochloride content in human plasma and tablets using second-order calibration based on both parallel factor analysis and alternating penalty trilinear decomposition.
Analytica chimica acta.
2009 Sep; 650(1):143-9. doi:
10.1016/j.aca.2009.07.022. [PMID: 19720185] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - O V Teodorovich, N B Zabrodina, A B Bochkarev. [Using setegis (terasosine) in early postoperative period after transurethral prostate resection].
Urologiia (Moscow, Russia : 1999).
2009 May; ?(3):62-4. doi:
. [PMID: 19673124] - Stefan Pilz, Andreas Tomaschitz, Vinzenz Stepan, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer, Natascha Schweighofer, Horst R Portugaller, Harald Sourij, Harald Dobnig, Andreas Meinitzer, Thomas R Pieber. Graz Endocrine Causes of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism.
BMC endocrine disorders.
2009 Apr; 9(?):11. doi:
10.1186/1472-6823-9-11. [PMID: 19351411] - Chung-Jing Wang, Shi-Wei Huang, Chien-Hsing Chang. Adjunctive medical therapy with an alpha-1A-specific blocker after shock wave lithotripsy of lower ureteral stones.
Urologia internationalis.
2009; 82(2):166-9. doi:
10.1159/000200793. [PMID: 19322003] - J Miller, T H Tarter. Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate.
Clinical interventions in aging.
2009; 4(?):251-8. doi:
10.2147/cia.s4102. [PMID: 19554096] - Kohji Takara, Toshiyuki Sakaeda, Mikio Kakumoto, Yusuke Tanigawara, Hironao Kobayashi, Katsuhiko Okumura, Noriaki Ohnishi, Teruyoshi Yokoyama. Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport.
Oncology research.
2009; 17(11-12):527-33. doi:
10.3727/096504009789745601. [PMID: 19806783] - Tao Yang, Xing-Qiao Zhang, Yong-Wei Feng. [Efficacy of electroacupuncture in treating 93 patients with benign prostatic hyperplasia].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Nov; 28(11):998-1000. doi:
". [PMID: 19213342] - Rahmi Onur, Cemal Tasdemir, Dilara Seckin, Necip Ilhan, Selim Kutlu, Nusret Akpolat. Combined use of melatonin and terazosin restores bladder contractility in rabbits with partial outlet obstruction.
Urology.
2008 Aug; 72(2):439-43. doi:
10.1016/j.urology.2008.02.053. [PMID: 18455780] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Jae-Seung Paick, Min Chul Cho, Sang Hoon Song, Soo Woong Kim, Ja Hyeon Ku. Impacts of the quinazoline-based alpha1-antagonist, terazosin, and of the sulfonamide derivative, tamsulosin, on serum prostate-specific antigen and prostate volume.
Journal of Korean medical science.
2008 Jun; 23(3):509-13. doi:
10.3346/jkms.2008.23.3.509. [PMID: 18583890] - Bee Yean Low, Men Long Liong, Kah Hay Yuen, Christopher Chee, Wing Seng Leong, Wooi Loong Chong, Nurzalina Abdul Karim Khan, Phaik Yeong Cheah, Ker Keong Liong. Terazosin therapy for patients with female lower urinary tract symptoms: a randomized, double-blind, placebo controlled trial.
The Journal of urology.
2008 Apr; 179(4):1461-9. doi:
10.1016/j.juro.2007.11.060. [PMID: 18295277] - J Curtis Nickel. Role of alpha1-blockers in chronic prostatitis syndromes.
BJU international.
2008 Mar; 101 Suppl 3(?):11-6. doi:
10.1111/j.1464-410x.2008.07496.x. [PMID: 18307680] - L E Randle, J G Sathish, N R Kitteringham, I Macdonald, D P Williams, B K Park. alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.
British journal of pharmacology.
2008 Feb; 153(4):820-30. doi:
10.1038/sj.bjp.0707620. [PMID: 18071297] - Miguel Angel Campanero, Belén Sádaba, Maria José Muñoz-Juarez, Emilio García Quetglas, Jose Ramón Azanza. Pharmacokinetic and pharmacodynamic modelling of arterial haemodynamic effects of terazosin in healthy volunteers.
Clinical drug investigation.
2008; 28(3):139-47. doi:
10.2165/00044011-200828030-00001. [PMID: 18266399] - Phillip P Smith, Eric Hurtado, Christopher P Smith, Timothy B Boone, George T Somogyi. Comparison of cystometric methods in female rats.
Neurourology and urodynamics.
2008; 27(4):324-9. doi:
10.1002/nau.20512. [PMID: 17849479] - Xiaoyi Wei, Junfa Yin, Gengliang Yang, Chunxia He, Yi Chen. On-line solid-phase extraction with a monolithic weak cation-exchange column and simultaneous screening of alpha1-adrenergic receptor antagonists in human plasma.
Journal of separation science.
2007 Nov; 30(17):2851-7. doi:
10.1002/jssc.200700342. [PMID: 17960849] - Jawad Kiani, Sardar Z Imam. Medicinal importance of grapefruit juice and its interaction with various drugs.
Nutrition journal.
2007 Oct; 6(?):33. doi:
10.1186/1475-2891-6-33. [PMID: 17971226] - Zhi-Ling Zhou, Min Yang, Xi-Yong Yu, Huai-Yan Peng, Zhi-Xin Shan, Shu-Zhen Chen, Qiu-Xiong Lin, Xiao-Ying Liu, Tie-Feng Chen, Shu-Feng Zhou, Shu-Guang Lin. A rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence studies.
Biomedical chromatography : BMC.
2007 Oct; 21(10):1045-51. doi:
10.1002/bmc.851. [PMID: 17549677] - Ning-chen Li, Shi-liang Wu, Jie Jin, Shao-peng Qiu, Chui-ze Kong, Yong-sheng Song, Zhang-qun Ye, Guang Sun, Ying-hao Sun, Yu-cheng Sun, Xiao-feng Wang, Yan-qun Na. [Comparison of different drugs on the treatment of benign prostate hyperplasia].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2007 Jul; 45(14):947-50. doi:
. [PMID: 17961376] - Shizuo Yamada, Yasuhiro Kato, Takashi Okura, Yoshiyuki Kagawa, Kazuki Kawabe. Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.
Biological & pharmaceutical bulletin.
2007 Jul; 30(7):1237-41. doi:
10.1248/bpb.30.1237. [PMID: 17603160] - He Xiao, Han-Zhong Li, Yong Yang, Zhong-Ming Huang, Yong-Qiang Li, Xiao-Feng Zhao. [Clinical effectiveness and safety study of combined therapy with an alpha-blocker and an anticholinergic for patients with LUT/BPH].
Zhonghua yi xue za zhi.
2007 Jun; 87(23):1590-3. doi:
NULL. [PMID: 17803845] - Nada F Atta, Soher A Darwish, Sayed E Khalil, A Galal. Effect of surfactants on the voltammetric response and determination of an antihypertensive drug.
Talanta.
2007 Jun; 72(4):1438-45. doi:
10.1016/j.talanta.2007.01.053. [PMID: 19071781] - E E Filyushina, M D Shmerling, V A Lazarev, I I Buzuyeva, A L Markel', G S Yakobson. Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats.
Bulletin of experimental biology and medicine.
2007 Jun; 143(6):749-52. doi:
10.1007/s10517-007-0232-6. [PMID: 18239819] - E Y Oh, S K Bae, J W Kwon, M You, D C Lee, M G Lee. Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats.
British journal of pharmacology.
2007 May; 151(1):24-34. doi:
10.1038/sj.bjp.0707192. [PMID: 17351661] - Takashi Fukagai, Kunitaka Maruyama, Masakazu Nagata, Masashi Morita, Michio Naoe, Hideki Yoshida. Practice patterns regarding prostate cancer and benign prostatic hyperplasia in Japanese primary care practitioners.
International journal of urology : official journal of the Japanese Urological Association.
2007 May; 14(5):412-5. doi:
10.1111/j.1442-2042.2007.01742.x. [PMID: 17511723] - Kaori Ito, Hisakazu Ohtani, Yasufumi Sawada. Assessment of alpha1-adrenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory.
British journal of clinical pharmacology.
2007 Apr; 63(4):394-403. doi:
10.1111/j.1365-2125.2006.02783.x. [PMID: 17052252] - Yong Yang, Xiao-feng Zhao, Han-zhong Li, Wei Wang, Yong Zhang, He Xiao, Xin Zhang. Efficacy and safety of combined therapy with terazosin and tolteradine for patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a prospective study.
Chinese medical journal.
2007 Mar; 120(5):370-4. doi:
. [PMID: 17376305] - Bo Li, Li-jun Jiang, Juan Chai. [Clinical observation on treatment of chronic prostatitis syndrome type III B by Tiaoshen Tonglin Decoction].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Mar; 27(3):251-4. doi:
. [PMID: 17432691] - Ning Ma, Wenying Liu, Huande Li, Benmei Chen, Yungui Zhu, Xiaolei Liu, Feng Wang, Daxiong Xiang, Bikui Zhang. LC-MS determination and relative bioavailability of doxazosin mesylate tablets in healthy Chinese male volunteers.
Journal of pharmaceutical and biomedical analysis.
2007 Feb; 43(3):1049-56. doi:
10.1016/j.jpba.2006.09.013. [PMID: 17055685] - Dionisios Mitropoulos, Eleni Papakonstantinou, Alexios J Aletras, Nikolaos Kalinderis, Anastasios Zervas, Dimitrios Hatzichristou, George Karakiulakis. Terazosin modifies the content of glycosaminoglycans and the activity of matrix metalloproteinase 2 in the rat ventral prostate.
European urology.
2007 Feb; 51(2):447-56; discussion 456. doi:
10.1016/j.eururo.2006.06.028. [PMID: 16899336] - Joe Miller, Thomas H Tarter. Update on the use of dutasteride in the management of benign prostatic hypertrophy.
Clinical interventions in aging.
2007; 2(1):99-104. doi:
10.2147/ciia.2007.2.1.99. [PMID: 18044081] - Rameshwar Jatwa, Anand Kar. Cardio-protective role of terazosin is possibly mediated through alteration in thyroid function.
European journal of pharmacology.
2006 Dec; 551(1-3):87-91. doi:
10.1016/j.ejphar.2006.08.074. [PMID: 17027746] - Dong Soo Park, Taek Woo Cho, Yong Kyu Lee, Young Tae Lee, Young Kwon Hong, Woong Ki Jang. Evaluation of short term clinical effects and presumptive mechanism of botulinum toxin type A as a treatment modality of benign prostatic hyperplasia.
Yonsei medical journal.
2006 Oct; 47(5):706-14. doi:
10.3349/ymj.2006.47.5.706. [PMID: 17066515] - Thomas M Kessler, Urs E Studer, Fiona C Burkhard. The effect of terazosin on functional bladder outlet obstruction in women: a pilot study.
The Journal of urology.
2006 Oct; 176(4 Pt 1):1487-92. doi:
10.1016/j.juro.2006.06.009. [PMID: 16952666] - V G Gomberg, Iu T Nad'. [Using terasosine (setegis) in the treatment of hyperactive urinary bladder in elderly women].
Urologiia (Moscow, Russia : 1999).
2006 Sep; ?(5):63-7, 71. doi:
NULL. [PMID: 17444155] - R Berges. [Drug therapy for benign prostatic syndrome (BPS)].
Aktuelle Urologie.
2006 Sep; 37(5):351-62. doi:
10.1055/s-2006-944297. [PMID: 17004180] - Francois Giuliano. Impact of medical treatments for benign prostatic hyperplasia on sexual function.
BJU international.
2006 Apr; 97 Suppl 2(?):34-8; discussion 44. doi:
10.1111/j.1464-410x.2006.06104.x. [PMID: 16507052] - T H Tarter, E D Vaughan. Inhibitors of 5alpha-reductase in the treatment of benign prostatic hyperplasia.
Current pharmaceutical design.
2006; 12(7):775-83. doi:
10.2174/138161206776056010. [PMID: 16515494] - A K M Anwarul Islam, M A Kashem, I A Shameem, S A M G Kibria. Efficacy of terazosin and finasteride in symptomatic benign prostatic hyperplasia: A comparative study.
Bangladesh Medical Research Council bulletin.
2005 Aug; 31(2):54-61. doi:
. [PMID: 16967810] - NULL. [Kornam in the treatment of imperative urine incontinence in females].
Urologiia (Moscow, Russia : 1999).
2005 May; ?(3):26-8. doi:
NULL. [PMID: 16097709] - M F Trapeznikova, M A Gurevich, K V Pozdniakov, S Ia Tazina, N V Bychkova. [Clinical efficacy and safety of terazosine (setegis) in patients with benign prostatic hyperplasia with concomitant cardiovascular diseases].
Urologiia (Moscow, Russia : 1999).
2005 Mar; ?(2):50-3. doi:
. [PMID: 15989029] - John M Fitzpatrick, François Desgrandchamps. The clinical efficacy and tolerability of doxazosin standard and gastrointestinal therapeutic system for benign prostatic hyperplasia.
BJU international.
2005 Mar; 95(4):575-9. doi:
10.1111/j.1464-410x.2005.05342.x. [PMID: 15705083] - A V Sivkov, V N Oshchepkov, A A Egorov. [Double-blind placebo-controlled trial of terazosine efficacy in patients with chronic abacterial prostatitis].
Urologiia (Moscow, Russia : 1999).
2005 Jan; ?(1):47-53. doi:
. [PMID: 15776832] - M M Ghoneim, M A El Ries, E Hammam, A M Beltagi. A validated stripping voltammetric procedure for quantification of the anti-hypertensive and benign prostatic hyperplasia drug terazosin in tablets and human serum.
Talanta.
2004 Oct; 64(3):703-10. doi:
10.1016/j.talanta.2004.03.043. [PMID: 18969662] - Z Ge, E Tessier, L Neirinck, Z Zhu. High performance liquid chromatographic method for the determination of sumatriptan with fluorescence detection in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jul; 806(2):299-303. doi:
10.1016/j.jchromb.2004.03.057. [PMID: 15171943] - Baihua Shen, Xiaodong Jin, Songliang Cai, Jun Chen, Geming Chen, Weiping Zhao, Xin Sun. [Effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics for chronic prostatitis].
Zhonghua nan ke xue = National journal of andrology.
2004 Jul; 10(7):518-20. doi:
NULL. [PMID: 15354524] - Wanhong Zhang, Zilong Liu, Hansheng Dong, Chao Sun. [Related pathogen examinations and therapeutic choices for chronic prostatitis following sexually transmitted diseases].
Zhonghua nan ke xue = National journal of andrology.
2004 Apr; 10(4):275-7, 281. doi:
". [PMID: 15148924] - V Srivatsan, A K Dasgupta, Prashant Kale, Ravi Verma, Paresh Joshi, Devangi Soni, Mahendra Patel, Gunjan Soni, Jignesh Patel, Harshad Modi. Determination of mycophenolic acid in human plasma by high-performance liquid chromatography.
Journal of chromatography. A.
2004 Mar; 1031(1-2):259-64. doi:
10.1016/j.chroma.2003.08.073. [PMID: 15058591] - David R P Guay. Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia.
The American journal of geriatric pharmacotherapy.
2004 Mar; 2(1):14-23. doi:
10.1016/s1543-5946(04)90003-7. [PMID: 15555475] - Albaha Barqawi, Eduard Gamito, Colin O'Donnell, E David Crawford. Herbal and vitamin supplement use in a prostate cancer screening population.
Urology.
2004 Feb; 63(2):288-92. doi:
10.1016/j.urology.2003.09.019. [PMID: 14972473] - Murat Bozlu, Ercüment Ulusoy, Selahittin Cayan, Esen Akbay, Sadik Görür, Erdem Akbay. A comparison of four different alpha1-blockers in benign prostatic hyperplasia patients with and without diabetes.
Scandinavian journal of urology and nephrology.
2004; 38(5):391-5. doi:
10.1080/00365590410015678. [PMID: 15764250] - Wei-ru Zhang, Ming Sun, Jie-kun Luo. [Serum nitric oxide and D-dimer before and after administering antihypertensive drugs in essential hypertension].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2003 Aug; 28(4):382-4. doi:
NULL. [PMID: 14653123] - Yasuko Hiraoka, Takanobu Taniguchi, Takashi Tanaka, Kenichiro Okada, Hiroshi Kanamaru, Ikunobu Muramatsu. Pharmacological characterization of unique prazosin-binding sites in human kidney.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Jul; 368(1):49-56. doi:
10.1007/s00210-003-0764-x. [PMID: 12827214] - Eric A Stone, Gary L Grunewald, Yan Lin, Rashedul Ahsan, Helen Rosengarten, H Kenneth Kramer, David Quartermain. Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice.
Synapse (New York, N.Y.).
2003 Jul; 49(1):67-76. doi:
10.1002/syn.10212. [PMID: 12710017]