Methacholine (BioDeep_00000002990)
Secondary id: BioDeep_00001868277
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds natural product
代谢物信息卡片
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride
化学式: C8H18NO2+ (160.1337468)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CC(=O)OC(C)C[N+](C)(C)C
InChI: InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
描述信息
Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test. Through this test, the drug causes bronchoconstriction and people with pre-existing airway hyperreactivity, such as asthmatics, will react to lower doses of drug.
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
D019141 - Respiratory System Agents > D016085 - Bronchoconstrictor Agents
V - Various > V04 - Diagnostic agents
同义名列表
23 个代谢物同义名
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride; Methapharma brand OF methacholine chloride; Lindopharm brand OF methacholine chloride; [2-(acetyloxy)propyl]trimethylazanium; Roche brand OF methacholine chloride; Acetyl beta methacholine chloride; Acetyl-beta-methacholine chloride; Acetyl 2 methylcholine chloride; Acetyl-2-methylcholine chloride; Acetyl beta methylcholine; Acetyl-beta-methylcholine; Acetyl-β-methylcholine; Chloride, methacholine; Acetyl-b-methylcholine; Methacholine chloride; Acetylmethylcholine; Provocholine; methacholine; Mecholine; Mecholyl; Provokit; MCh; Methacholine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:6804
- KEGG: C07471
- PubChem: 1993
- HMDB: HMDB0015654
- DrugBank: DB06709
- ChEMBL: CHEMBL978
- Wikipedia: Methacholine
- MeSH: Methacholine Chloride
- chemspider: 1916
- CAS: 55-92-5
- PMhub: MS000007639
- PubChem: 9674
- NIKKAJI: J11.055H
- RefMet: Methacholine
- KNApSAcK: 6804
- LOTUS: LTS0156587
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0156587
- 1236 - Gammaproteobacteria: LTS0156587
- 9606 - Homo sapiens: -
- 135621 - Pseudomonadaceae: LTS0156587
- 286 - Pseudomonas: LTS0156587
- 287 - Pseudomonas aeruginosa: LTS0156587
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan-Jiao Chen, Yu Yuan, Lu Peng, Xin-Yi Dong, Yu-Dong Xu, Yu Wang, Yong-Qing Yang. Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.
Immunity, inflammation and disease.
2024 Mar; 12(3):e1225. doi:
10.1002/iid3.1225. [PMID: 38533918] - . [Standard technical specifications for methacholine chloride (Methacholine) bronchial challenge test (2023)].
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2024 Feb; 47(2):101-119. doi:
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2022 05; 381(2):176-187. doi:
10.1124/jpet.121.001029. [PMID: 35153197] - Madeleine M Mank, Leah F Reed, Camille J Walton, Madison L T Barup, Jennifer L Ather, Matthew E Poynter. Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
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