Methacholine (BioDeep_00000002990)
Secondary id: BioDeep_00001868277
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride
化学式: C8H18NO2+ (160.1337468)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CC(=O)OC(C)C[N+](C)(C)C
InChI: InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
描述信息
Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test. Through this test, the drug causes bronchoconstriction and people with pre-existing airway hyperreactivity, such as asthmatics, will react to lower doses of drug.
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
D019141 - Respiratory System Agents > D016085 - Bronchoconstrictor Agents
V - Various > V04 - Diagnostic agents
同义名列表
22 个代谢物同义名
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride; Methapharma brand OF methacholine chloride; Lindopharm brand OF methacholine chloride; [2-(acetyloxy)propyl]trimethylazanium; Roche brand OF methacholine chloride; Acetyl beta methacholine chloride; Acetyl-beta-methacholine chloride; Acetyl 2 methylcholine chloride; Acetyl-2-methylcholine chloride; Acetyl beta methylcholine; Acetyl-beta-methylcholine; Acetyl-β-methylcholine; Chloride, methacholine; Acetyl-b-methylcholine; Methacholine chloride; Acetylmethylcholine; Provocholine; methacholine; Mecholine; Mecholyl; Provokit; MCh
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:6804
- KEGG: C07471
- PubChem: 1993
- HMDB: HMDB0015654
- DrugBank: DB06709
- ChEMBL: CHEMBL978
- Wikipedia: Methacholine
- MeSH: Methacholine Chloride
- chemspider: 1916
- CAS: 55-92-5
- PMhub: MS000007639
- PubChem: 9674
- NIKKAJI: J11.055H
- RefMet: Methacholine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan-Jiao Chen, Yu Yuan, Lu Peng, Xin-Yi Dong, Yu-Dong Xu, Yu Wang, Yong-Qing Yang. Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.
Immunity, inflammation and disease.
2024 Mar; 12(3):e1225. doi:
10.1002/iid3.1225. [PMID: 38533918] - . [Standard technical specifications for methacholine chloride (Methacholine) bronchial challenge test (2023)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2024 Feb; 47(2):101-119. doi:
10.3760/cma.j.cn112147-20231019-00247. [PMID: 38309959] - Alexander Tamalunas, Amin Wendt, Florian Springer, Victor Vigodski, Anna Ciotkowska, Beata Rutz, Ruixiao Wang, Ru Huang, Yuhan Liu, Heiko Schulz, Stephan Ledderose, Thomas Kolben, Giuseppe Magistro, Christian G Stief, Martin Hennenberg. Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells.
Life sciences.
2022 Nov; 308(?):120931. doi:
10.1016/j.lfs.2022.120931. [PMID: 36084760] - Ki-Shuk Shim, Hyun-Kyung Song, Youn-Hwan Hwang, Sungwook Chae, Ho Kyoung Kim, Seol Jang, Yun Hee Kim, Byung-Kil Choo, Won-Kyung Yang, Seung-Hyung Kim, Taesoo Kim, Ki Mo Kim. Ethanol extract of Veronica persica ameliorates house dust mite-induced asthmatic inflammation by inhibiting STAT-3 and STAT-6 activation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113264. doi:
10.1016/j.biopha.2022.113264. [PMID: 35696941] - Ru Huang, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G Stief, Martin Hennenberg. Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions.
The Journal of pharmacology and experimental therapeutics.
2022 05; 381(2):176-187. doi:
10.1124/jpet.121.001029. [PMID: 35153197] - Madeleine M Mank, Leah F Reed, Camille J Walton, Madison L T Barup, Jennifer L Ather, Matthew E Poynter. Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
American journal of physiology. Lung cellular and molecular physiology.
2022 02; 322(2):L243-L257. doi:
10.1152/ajplung.00309.2021. [PMID: 34936508] - Yosuf W Subat, Matthew E Hainy, Keith D Torgerud, Pavol Sajgalik, Siva Kamal Guntupalli, Bruce D Johnson, Kim Chul-Ho, Kaiser G Lim, Scott A Helgeson, Paul D Scanlon, Alexander S Niven. Aerosol Generation and Mitigation During Methacholine Bronchoprovocation Testing: Infection Control Implications in the Era of COVID-19.
Respiratory care.
2021 12; 66(12):1858-1865. doi:
10.4187/respcare.09236. [PMID: 34789516] - Norhan Badr ElDin, Mohamed K Abd El-Rahman, Hala E Zaazaa, Azza A Moustafa, Said A Hassan. Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic.
Biosensors & bioelectronics.
2021 Oct; 190(?):113439. doi:
10.1016/j.bios.2021.113439. [PMID: 34166943] - Purevsuren Losol, Lindert P Mercken, Helena L Fisk, Philip C Calder, John W Holloway, Christopher Torrens. Maternal high-fat diet in mice alters immune regulation and lung function in the offspring.
The British journal of nutrition.
2021 09; 126(6):844-852. doi:
10.1017/s0007114520004742. [PMID: 33243305] - Kevin Looi, Alexander N Larcombe, Kara L Perks, Luke J Berry, Graeme R Zosky, Paul Rigby, Darryl A Knight, Anthony Kicic, Stephen M Stick. Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168790. [PMID: 34445491] - Rongying Zheng, Fangmin Wang, Yue Huang, Qiangwei Xiang, Huan Dai, Weixi Zhang. Elevated Th17 cell frequencies and Th17/Treg ratio are associated with airway hyperresponsiveness in asthmatic children.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2021 06; 58(6):707-716. doi:
10.1080/02770903.2020.1737710. [PMID: 32114839] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Hung-Chang Tsui, Tatjana Decaesteker, Anne-Charlotte Jonckheere, Greetje Vande Velde, Jonathan Cremer, Erik Verbeken, Peter H M Hoet, Benoit Nemery, Jeroen A J Vanoirbeek. Cobalt exposure via skin alters lung immune cells and enhances pulmonary responses to cobalt in mice.
American journal of physiology. Lung cellular and molecular physiology.
2020 10; 319(4):L641-L651. doi:
10.1152/ajplung.00265.2020. [PMID: 32726143] - Jihang Chen, Wing Man Chan, Hoi Yan Leung, Pou Kuan Leong, Choly Tat Ming Yan, Kam Ming Ko. Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184051. [PMID: 32899766] - Kenta Yamamura, Johsuke Hara, Tamami Sakai, Noriyuki Ohkura, Miki Abo, Naohiko Ogawa, Akihito Okazaki, Takashi Sone, Hideharu Kimura, Masaki Fujimura, Shinji Nakao, Kazuo Kasahara. Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs.
Allergology international : official journal of the Japanese Society of Allergology.
2020 Apr; 69(2):223-231. doi:
10.1016/j.alit.2019.09.002. [PMID: 31601467] - Pia Kalm-Stephens, Andrei Malinovschi, Christer Janson, Per Venge, Lennart Nordvall, Kjell Alving. Concurrence of elevated FeNO and airway hyperresponsiveness in nonasthmatic adolescents.
Pediatric pulmonology.
2020 03; 55(3):571-579. doi:
10.1002/ppul.24578. [PMID: 31944632] - Jennifer Danielsson, Aisha S Kuforiji, Gene T Yocum, Yi Zhang, Dingbang Xu, George Gallos, Charles W Emala. Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone.
American journal of physiology. Lung cellular and molecular physiology.
2020 02; 318(2):L287-L295. doi:
10.1152/ajplung.00552.2018. [PMID: 31747299] - Farzaneh Shakeri, Nama Mohamadian Roshan, Mohammad Hossein Boskabady. Hydro-ethanolic extract of Curcuma longa affects tracheal responsiveness and lung pathology in ovalbumin-sensitized rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2020 Jan; 90(1-2):141-150. doi:
10.1024/0300-9831/a000524. [PMID: 30789805] - D Rosenkranz, J Bünger, F Hoffmeyer, C Monsé, V van Kampen, M Raulf, T Brüning, K Sucker. How Healthy Is Healthy? Comparison Between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects.
Advances in experimental medicine and biology.
2020; 1271(?):49-59. doi:
10.1007/5584_2019_472. [PMID: 31974924] - Zheng Zhu, Shu Xia, Xi Chen, Wei-Jie Guan, Zi-Jun Guo, Bao-Qing Sun. Factors associated with exhaled nitric oxide in children with asthma and allergic rhinitis.
The clinical respiratory journal.
2020 Jan; 14(1):9-15. doi:
10.1111/crj.13093. [PMID: 31602812] - Saeideh Saadat, Amin Mokhtari-Zaer, Mousa-Al-Reza Hadjzadeh, Mohammad Hossein Boskabady. Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats.
Iranian journal of allergy, asthma, and immunology.
2019 Oct; 18(6):624-638. doi:
10.18502/ijaai.v18i6.2175. [PMID: 32245306] - Xinfu Yang, Feida Wang. The effect of astragaloside IV on JAK2-STAT6 signalling pathway in mouse model of ovalbumin-induced asthma.
Journal of animal physiology and animal nutrition.
2019 Sep; 103(5):1578-1584. doi:
10.1111/jpn.13114. [PMID: 31148265] - Jack Yang, Ivan Ramirez Moral, Cornelis van 't Veer, Alex F de Vos, Regina de Beer, Joris J T H Roelofs, B Paul Morgan, Tom van der Poll. Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.
Respiratory research.
2019 Jul; 20(1):165. doi:
10.1186/s12931-019-1136-5. [PMID: 31340811] - Elizabeth R Vogel, Logan J Manlove, Ine Kuipers, Michael A Thompson, Yun-Hua Fang, Michelle R Freeman, Rodney D Britt, Arij Faksh, Binxia Yang, Y S Prakash, Christina M Pabelick. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model.
American journal of physiology. Lung cellular and molecular physiology.
2019 07; 317(1):L99-L108. doi:
10.1152/ajplung.00111.2018. [PMID: 31042080] - Anastasiya Birukova, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M Gowdy, Loretta G Que, Robert M Tighe. Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 06; 169(2):499-510. doi:
10.1093/toxsci/kfz056. [PMID: 30825310] - Naeima Eftekhar, Ali Moghimi, Mohammad Hossein Boskabady, Mahsa Kaveh, Farzaneh Shakeri. Ocimum basilicum affects tracheal responsiveness, lung inflammatory cells and oxidant-antioxidant biomarkers in sensitized rats.
Drug and chemical toxicology.
2019 May; 42(3):286-294. doi:
10.1080/01480545.2018.1459672. [PMID: 29683006] - Godrat Akhavanakbari, Behzad Babapour, Mohammad Reza Alipour, Rana Keyhanmanesh, Mahdi Ahmadi, Mohammad Reza Aslani. Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats.
BioFactors (Oxford, England).
2019 Jan; 45(1):75-84. doi:
10.1002/biof.1466. [PMID: 30521085] - Daniel Silveira Serra, Maria Diana Moreira Gomes, Francisco Sales Ávila Cavalcante, José Henrique Leal-Cardoso. Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2019 01; 56(1):1-10. doi:
10.1080/02770903.2018.1430828. [PMID: 29437496] - Aibibai Aierken, Peiru Xu. Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3.
Microbial pathogenesis.
2018 Dec; 125(?):313-317. doi:
10.1016/j.micpath.2018.09.043. [PMID: 30278208] - Shu-Jung Huang, Li-Lun Lin, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Kuo-Chien Tsao, Kuo-Wei Yeh, Jing-Long Huang. Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma.
Pediatrics and neonatology.
2018 12; 59(6):561-566. doi:
10.1016/j.pedneo.2018.01.005. [PMID: 29398555] - Gijs Ijpma, Chu Qiao Liang, Linda Kachmar, Alice Panariti, Andrea Benedetti, Jean-Pierre Lavoie, Anne-Marie Lauzon. Maintenance of contractile function of isolated airway smooth muscle after cryopreservation.
American journal of physiology. Lung cellular and molecular physiology.
2018 11; 315(5):L724-L733. doi:
10.1152/ajplung.00064.2018. [PMID: 30091377] - Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang. Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance.
The Korean journal of internal medicine.
2018 07; 33(4):807-814. doi:
10.3904/kjim.2017.043. [PMID: 29334723] - Farzaneh Naghdi, Zahra Gholamnezhad, Mohammad Hossein Boskabady, Morteza Bakhshesh. Muscarinic receptors, nitric oxide formation and cyclooxygenase pathway involved in tracheal smooth muscle relaxant effect of hydro-ethanolic extract of Lavandula angustifolia flowers.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):1221-1228. doi:
10.1016/j.biopha.2018.04.004. [PMID: 29710541] - Cynthia Kanagaratham, Victoria Chiwara, Bianca Ho, Sanny Moussette, Mina Youssef, David Venuto, Lucie Jeannotte, Guillaume Bourque, Juan Bautista de Sanctis, Danuta Radzioch, Anna K Naumova. Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Mammalian genome : official journal of the International Mammalian Genome Society.
2018 04; 29(3-4):281-298. doi:
10.1007/s00335-018-9743-x. [PMID: 29536159] - Akihito Okazaki, Johsuke Hara, Noriyuki Ohkura, Masaki Fujimura, Tamami Sakai, Miki Abo, Nobuyuki Katayama, Kazuo Kasahara, Shinji Nakao. Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs.
Pulmonary pharmacology & therapeutics.
2018 02; 48(?):62-70. doi:
10.1016/j.pupt.2017.09.003. [PMID: 28951192] - Abderrahim Nemmar, Suhail Al-Salam, Priya Yuvaraju, Sumaya Beegam, Badreldin H Ali. Exercise Training Mitigates Water Pipe Smoke Exposure-Induced Pulmonary Impairment via Inhibiting NF-κB and Activating Nrf2 Signalling Pathways.
Oxidative medicine and cellular longevity.
2018; 2018(?):7459612. doi:
10.1155/2018/7459612. [PMID: 29692875] - Lisette Haddad, Stéphanie Corriveau, Eric Rousseau, Simon Blouin, Jean-Charles Pasquier, Yves Ponsot, Marie-Ève Roy-Lacroix. Impact of tamsulosin and nifedipine on contractility of pregnant rat ureters in vitro.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2018 Jan; 31(2):191-196. doi:
10.1080/14767058.2017.1280017. [PMID: 28068846] - Bahman Emami, Farzaneh Shakeri, Vahideh Ghorani, Mohammad Hossein Boskabady. Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms.
Pharmaceutical biology.
2017 Dec; 55(1):2248-2258. doi:
10.1080/13880209.2017.1400079. [PMID: 29169285] - Young A Park, Hyun Bin Park, Yoon Hee Kim, In Sook Sul, Seo Hee Yoon, Hye Ran Kim, Kyung Won Kim, Kyu-Earn Kim, Myung Hyun Sohn. Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide in children with asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2017 Aug; 54(6):644-651. doi:
10.1080/02770903.2016.1255751. [PMID: 28055271] - S-Y Kang, D-E Park, W-J Song, B-R Bae, J-W Lee, K-H Sohn, H-S Lee, H-R Kang, H-W Park, Y-S Chang, S-J Choi, W-I Oh, K-U Min, S-H Cho. Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2017 Jul; 47(7):937-945. doi:
10.1111/cea.12920. [PMID: 28294434] - Katherine N Cahill, Howard R Katz, Jing Cui, Juying Lai, Shamsah Kazani, Allison Crosby-Thompson, Denise Garofalo, Mario Castro, Nizar Jarjour, Emily DiMango, Serpil Erzurum, Jennifer L Trevor, Kartik Shenoy, Vernon M Chinchilli, Michael E Wechsler, Tanya M Laidlaw, Joshua A Boyce, Elliot Israel. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.
The New England journal of medicine.
2017 05; 376(20):1911-1920. doi:
10.1056/nejmoa1613125. [PMID: 28514613] - Jun Chen, Michael J Sanderson. Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle.
The Journal of physiology.
2017 05; 595(10):3203-3218. doi:
10.1113/jp272694. [PMID: 27396568] - Joshua S Davis, Maoyun Sun, Alvin T Kho, Kip G Moore, Jody M Sylvia, Scott T Weiss, Quan Lu, Kelan G Tantisira. Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort.
PloS one.
2017; 12(7):e0180329. doi:
10.1371/journal.pone.0180329. [PMID: 28749975] - Anne-Lise Bjørke-Monsen, Maria Vollsæter, Per M Ueland, Trond Markestad, Knut Øymar, Thomas Halvorsen. Increased Bronchial Hyperresponsiveness and Higher Asymmetric Dimethylarginine Levels after Fetal Growth Restriction.
American journal of respiratory cell and molecular biology.
2017 01; 56(1):83-89. doi:
10.1165/rcmb.2016-0210oc. [PMID: 27574738] - Joshua A Beckman, Allison B Goldfine, Jane A Leopold, Mark A Creager. Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.
American journal of physiology. Heart and circulatory physiology.
2016 12; 311(6):H1431-H1436. doi:
10.1152/ajpheart.00504.2016. [PMID: 27765750] - Chia-Ta Wu, Peng-Jung Chen, Yu-Tzu Lee, Jiunn-Liang Ko, Ko-Haung Lue. Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2016 Oct; 49(5):625-635. doi:
10.1016/j.jmii.2014.08.001. [PMID: 25440975] - Natalie R Shilo, Aceel Alawadi, Alexandra Allard-Coutu, Nancy Robitaille, Yves Pastore, Denis Bérubé, Sheila V Jacob, Sharon Abish, Nurlan Dauletbaev, Larry C Lands. Airway hyperreactivity is frequent in non-asthmatic children with sickle cell disease.
Pediatric pulmonology.
2016 09; 51(9):950-7. doi:
10.1002/ppul.23374. [PMID: 26716600] - Hong Lin Li, Xiao Li He, Bing Miao Liang, Hong Ping Zhang, Yan Wang, Gang Wang. Anxiety but not depression symptoms are associated with greater perceived dyspnea in asthma during bronchoconstriction.
Allergy and asthma proceedings.
2015 Nov; 36(6):447-57. doi:
10.2500/aap.2015.36.3897. [PMID: 26534751] - Marta Rava, Nicole Le Moual, Xavier Dumont, Stefano Guerra, Valerie Siroux, Benedicte Jacquemin, Francine Kauffmann, Alfred Bernard, Rachel Nadif. Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma.
Respirology (Carlton, Vic.).
2015 Nov; 20(8):1198-205. doi:
10.1111/resp.12609. [PMID: 26439880] - Naoto Fujii, Lyra Halili, Maya Sarah Singh, Robert D Meade, Glen P Kenny. Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 Oct; 309(8):R912-9. doi:
10.1152/ajpregu.00261.2015. [PMID: 26290105] - Abderrahim Nemmar, Suhail Al-Salam, Priya Yuvaraju, Sumaya Beegam, Badreldin H Ali. Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice.
Respiratory physiology & neurobiology.
2015 Aug; 215(?):51-7. doi:
10.1016/j.resp.2015.05.006. [PMID: 26001677] - S D Keir, D Spina, C P Page. Bradykinin and capsaicin induced airways obstruction in the guinea pig are platelet dependent.
Pulmonary pharmacology & therapeutics.
2015 Aug; 33(?):25-31. doi:
10.1016/j.pupt.2015.05.004. [PMID: 26006082] - Husein Dabbah, Ronen Bar Yoseph, Galit Livnat, Fahed Hakim, Lea Bentur. Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma.
Respiratory care.
2015 Aug; 60(8):1157-63. doi:
10.4187/respcare.03763. [PMID: 25899478] - Hong Yong Peh, Wanxing Eugene Ho, Chang Cheng, Tze Khee Chan, Ann Ching Genevieve Seow, Albert Y H Lim, Chee Wai Fong, Kok Yong Seng, Choon Nam Ong, W S Fred Wong. Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma.
Journal of immunology (Baltimore, Md. : 1950).
2015 Jul; 195(2):437-44. doi:
10.4049/jimmunol.1500362. [PMID: 26041537] - J-S Song, J-S You, S-I Jeong, S Yang, I-T Hwang, Y-G Im, H-S Baek, H-Y Kim, D-I Suh, H-B Lee, K Izuhara. Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma.
Allergy.
2015 Jun; 70(6):674-81. doi:
10.1111/all.12599. [PMID: 25703927] - Jeremy A Scott, Michelle L North, Mahrouk Rafii, Hailu Huang, Paul Pencharz, Hartmut Grasemann. Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
Journal of applied physiology (Bethesda, Md. : 1985).
2015 May; 118(10):1229-33. doi:
10.1152/japplphysiol.00865.2014. [PMID: 25979935] - Louise L Toennesen, Celeste Porsbjerg, Lars Pedersen, Vibeke Backer. Predictors of airway hyperresponsiveness in elite athletes.
Medicine and science in sports and exercise.
2015 May; 47(5):914-20. doi:
10.1249/mss.0000000000000496. [PMID: 25202844] - L Gholami Mahtaj, M H Boskabady, N Mohamadian Roshan. The Effect of Zataria multiflora and its Constituent, Carvacrol, on Tracheal Responsiveness and Lung Pathology in Guinea Pig Model of COPD.
Phytotherapy research : PTR.
2015 May; 29(5):730-6. doi:
10.1002/ptr.5309. [PMID: 25682768] - Ludovic Waeckel, Florence Bertin, Nicolas Clavreul, Thibaut Damery, Ralf Köhler, Jérôme Paysant, Patricia Sansilvestri-Morel, Serge Simonet, Christine Vayssettes-Courchay, Heike Wulff, Tony J Verbeuren, Michel Félétou. Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.
Pflugers Archiv : European journal of physiology.
2015 Apr; 467(4):817-31. doi:
10.1007/s00424-014-1542-y. [PMID: 24903240] - Galit Livnat, Ronen Bar Yoseph, Vered Nir, Fahed Hakim, Mordechai Yigla, Lea Bentur. Evaluation of high-sensitivity serum CRP levels compared to markers of airway inflammation and allergy as predictors of methacholine bronchial hyper-responsiveness in children.
Lung.
2015 Feb; 193(1):39-45. doi:
10.1007/s00408-014-9658-6. [PMID: 25331535] - Matthew S Perzanowski, Young Yoo. Exhaled Nitric Oxide and Airway Hyperresponsiveness to Adenosine 5'-monophosphate and Methacholine in Children with Asthma.
International archives of allergy and immunology.
2015; 166(2):107-13. doi:
10.1159/000375237. [PMID: 25792296] - Methap Yurt, Jie Liu, Reiko Sakurai, Ming Gong, Sumair M Husain, Mohammed A Siddiqui, Maleha Husain, Patricia Villarreal, Fatih Akcay, John S Torday, Virender K Rehan. Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency.
American journal of physiology. Lung cellular and molecular physiology.
2014 Dec; 307(11):L859-67. doi:
10.1152/ajplung.00032.2014. [PMID: 25305247] - Bradly J Biagioni, Mandy M Pui, Elkie Fung, SzeWing Wong, Ali Hosseini, Anne Dybuncio, Neil E Alexis, Chris Carlsten. Sputum adiponectin as a marker for western red cedar asthma.
The Journal of allergy and clinical immunology.
2014 Dec; 134(6):1446-1448.e5. doi:
10.1016/j.jaci.2014.06.037. [PMID: 25129682] - Mohammad Hossein Boskabady, Sediqeh Jalali, Tahereh Farkhondeh, Goltaj Byrami. The extract of Zataria multiflora affect tracheal responsiveness, serum levels of NO, nitrite, PLA2, TP and histamine in sensitized Guinea pigs.
Journal of ethnopharmacology.
2014 Oct; 156(?):301-8. doi:
10.1016/j.jep.2014.08.024. [PMID: 25196823] - Kameran Daham, Anna James, David Balgoma, Maciej Kupczyk, Bo Billing, Agneta Lindeberg, Elisabeth Henriksson, Garret A FitzGerald, Craig E Wheelock, Sven-Erik Dahlén, Barbro Dahlén. Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma.
The Journal of allergy and clinical immunology.
2014 Aug; 134(2):306-13. doi:
10.1016/j.jaci.2013.12.002. [PMID: 24461582] - Robert Lim, Alexey V Fedulov, Lester Kobzik. Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
American journal of physiology. Lung cellular and molecular physiology.
2014 Jul; 307(2):L141-8. doi:
10.1152/ajplung.00250.2013. [PMID: 24838749] - Maria Matteis, Francesca Polverino, Giuseppe Spaziano, Fiorentina Roviezzo, Carlo Santoriello, Nikol Sullo, Maria Rosaria Bucci, Francesco Rossi, Mario Polverino, Caroline A Owen, Bruno D'Agostino. Effects of sex hormones on bronchial reactivity during the menstrual cycle.
BMC pulmonary medicine.
2014 Jul; 14(?):108. doi:
10.1186/1471-2466-14-108. [PMID: 24984749] - Mohammad Hossein Boskabady, Ali Neamati, Saleh Mohaghegh Hazrati, Mohammad Reza Khakzad, Shakeeb Hassan Moosavi, Zahra Gholamnezhad. The preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-γ (th1/th2 balance) in sensitized guinea pigs.
Clinics (Sao Paulo, Brazil).
2014 Jul; 69(7):491-6. doi:
10.6061/clinics/2014(07)09. [PMID: 25029582] - Andrea Adamcakova-Dodd, Larissa V Stebounova, Jong Sung Kim, Sabine U Vorrink, Andrew P Ault, Patrick T O'Shaughnessy, Vicki H Grassian, Peter S Thorne. Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models.
Particle and fibre toxicology.
2014 Apr; 11(?):15. doi:
10.1186/1743-8977-11-15. [PMID: 24684892] - T Farkhondeh, M H Boskabady, S Jalali, G Bayrami. The effect of lead exposure on tracheal responsiveness to methacholine and ovalbumin, total and differential white blood cells count, and serum levels of immunoglobulin E, histamine, and cytokines in guinea pigs.
Human & experimental toxicology.
2014 Mar; 33(3):325-33. doi:
10.1177/0960327113499040. [PMID: 23928832] - Mohammad Hossein Boskabady, Goltaj Byrami, Azadeh Feizpour. The effect of safranal, a constituent of Crocus sativus (saffron), on tracheal responsiveness, serum levels of cytokines, total NO and nitrite in sensitized guinea pigs.
Pharmacological reports : PR.
2014 Feb; 66(1):56-61. doi:
10.1016/j.pharep.2013.08.004. [PMID: 24905307] - Bethan E Phillips, Philip J Atherton, Krishna Varadhan, Daniel J Wilkinson, Marie Limb, Anna L Selby, Michael J Rennie, Kenneth Smith, John P Williams. Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions.
American journal of physiology. Endocrinology and metabolism.
2014 Jan; 306(2):E168-76. doi:
10.1152/ajpendo.00440.2013. [PMID: 24280127] - Jennifer A Phan, Anthony Kicic, Luke J Berry, Lynette B Fernandes, Graeme R Zosky, Peter D Sly, Alexander N Larcombe. Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice.
PloS one.
2014; 9(3):e92163. doi:
10.1371/journal.pone.0092163. [PMID: 24632596] - Natsuko Taniguchi, Satoshi Konno, Takeshi Hattori, Akira Isada, Kaoruko Shimizu, Kenichi Shimizu, Noriharu Shijubo, Shau-Ku Huang, Nobuyuki Hizawa, Masaharu Nishimura. The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2013 Nov; 111(5):376-381.e1. doi:
10.1016/j.anai.2013.08.005. [PMID: 24125144] - Jason T Alexander, Alexander M El-Ali, James L Newman, Sulaiman Karatela, Benjamin L Predmore, David J Lefer, Roy L Sutliff, John D Roback. Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.
Transfusion.
2013 Nov; 53(11):2619-2628. doi:
10.1111/trf.12111. [PMID: 23480490] - Asger Sverrild, Sophie van der Sluis, Kirsten O Kyvik, Lene H Garvey, Celeste Porsbjerg, Vibeke Backer, Simon F Thomsen. Genetic factors account for most of the variation in serum tryptase--a twin study.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2013 Oct; 111(4):286-9. doi:
10.1016/j.anai.2013.07.011. [PMID: 24054365] - Mohammad Hossein Boskabaddy, Tahere Farkhondeh. Inhaled lead exposure affects tracheal responsiveness and lung inflammation in guinea pigs during sensitization.
Biological trace element research.
2013 Sep; 154(3):363-71. doi:
10.1007/s12011-013-9742-4. [PMID: 23881795] - Alison S Williams, Lucas Chen, David I Kasahara, Huiqing Si, Allison P Wurmbrand, Stephanie A Shore. Obesity and airway responsiveness: role of TNFR2.
Pulmonary pharmacology & therapeutics.
2013 Aug; 26(4):444-54. doi:
10.1016/j.pupt.2012.05.001. [PMID: 22584291] - Finn Rasmussen, Robert J Hancox, Parameswaran Nair, Henrik Steen Hansen, Hans Christian Siersted, Mads Nybo. Associations between airway hyperresponsiveness, obesity and lipoproteins in a longitudinal cohort.
The clinical respiratory journal.
2013 Jul; 7(3):268-75. doi:
10.1111/crj.12000. [PMID: 22906044] - Goltaj Byrami, Mohammad Hossein Boskabady, Sedigheh Jalali, Tahereh Farkhondeh. The effect of the extract of Crocus sativus on tracheal responsiveness and plasma levels of IL-4, IFN-γ, total NO and nitrite in ovalbumin sensitized guinea-pigs.
Journal of ethnopharmacology.
2013 May; 147(2):530-5. doi:
10.1016/j.jep.2013.03.014. [PMID: 23506987] - Cheng-Jang Wu, Hou-Wen Chou, Chian-Jiun Liou, Jiann-Jong Shen, Lian-Chen Wang, Ming-Ling Kuo. Prophylactic vaccination with adjuvant monophosphoryl lipid a prevents Th2-mediated murine asthmatic responses.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2013 May; 50(4):327-33. doi:
10.3109/02770903.2013.769268. [PMID: 23343407] - Yong Ju Lee, Hyun Hee Lee, Bong Seok Choi, Hye Mi Jee, Kyung Won Kim, Myung Hyun Sohn, Kyu Earn Kim. Association between eosinophilic airway inflammation and persistent airflow limitation.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2013 May; 50(4):342-6. doi:
10.3109/02770903.2013.776074. [PMID: 23414249] - Christopher M Royer, Karin Rudolph, Edward G Barrett. The neonatal susceptibility window for inhalant allergen sensitization in the atopically predisposed canine asthma model.
Immunology.
2013 Apr; 138(4):361-9. doi:
10.1111/imm.12043. [PMID: 23181409] - Elizabeth A Townsend, Matthew E Siviski, Yi Zhang, Carrie Xu, Bhupinder Hoonjan, Charles W Emala. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation.
American journal of respiratory cell and molecular biology.
2013 Feb; 48(2):157-63. doi:
10.1165/rcmb.2012-0231oc. [PMID: 23065130] - Mohammad Hossein Boskabady, Sediqeh Jalali. Effect of carvacrol on tracheal responsiveness, inflammatory mediators, total and differential WBC count in blood of sensitized guinea pigs.
Experimental biology and medicine (Maywood, N.J.).
2013 Feb; 238(2):200-8. doi:
10.1177/1535370212474604. [PMID: 23576802] - Yu-Tzu Lee, Shiuan-Shinn Lee, Hai-Lun Sun, Ko-Hsiu Lu, Min-Sho Ku, Ji-Nan Sheu, Jiunn-Liang Ko, Ko-Haung Lue. Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
Cytokine.
2013 Jan; 61(1):237-44. doi:
10.1016/j.cyto.2012.09.024. [PMID: 23107824] - Thereza Cristina Lonzetti Bargut, Tatiana Paula Teixeira Ferreira, Julio Beltrame Daleprane, Marco Aurélio Martins, Patrícia Machado Rodrigues Silva, Marcia Barbosa Aguila. Fish oil has beneficial effects on allergen-induced airway inflammation and hyperreactivity in mice.
PloS one.
2013; 8(9):e75059. doi:
10.1371/journal.pone.0075059. [PMID: 24040386] - Katie Chun, Lisa A Miller, Edward S Schelegle, Dallas M Hyde, John P Capitanio. Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma.
PloS one.
2013; 8(8):e71575. doi:
10.1371/journal.pone.0071575. [PMID: 23951195] - Hualiang Jin, Qingli Luo, Yijie Zheng, Muhammat Nurahmat, Jinfeng Wu, Bei Li, Yubao Lv, Genfa Wang, Xiaohong Duan, Jingcheng Dong. CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma.
International immunopharmacology.
2013 Jan; 15(1):42-9. doi:
10.1016/j.intimp.2012.11.009. [PMID: 23186751] - Mohammad Hossein Boskabady, Gholam Reza Karimi, Saeed Samarghandian, Tahere Farkhondeh. Tracheal responsiveness to methacholine and ovalbumin; and lung inflammation in guinea pigs exposed to inhaled lead after sensitization.
Ecotoxicology and environmental safety.
2012 Dec; 86(?):233-8. doi:
10.1016/j.ecoenv.2012.09.025. [PMID: 23088908] - Bharathi Aravamudan, Sarah K VanOosten, Lucas W Meuchel, Pawan Vohra, Michael Thompson, Gary C Sieck, Y S Prakash, Christina M Pabelick. Caveolin-1 knockout mice exhibit airway hyperreactivity.
American journal of physiology. Lung cellular and molecular physiology.
2012 Oct; 303(8):L669-81. doi:
10.1152/ajplung.00018.2012. [PMID: 22923642] - Young Hyo Kim, Chang-Shin Park, Dae Hyun Lim, Sung-Hye Ahn, Byong Kwan Son, Jeong Hee Kim, Tae Young Jang. Beneficial effect of anti-interleukin-33 on the murine model of allergic inflammation of the lower airway.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2012 Sep; 49(7):738-43. doi:
10.3109/02770903.2012.702841. [PMID: 22799279] - Young Yoo, Sung Chul Seo, Young Il Kim, Bo Hyun Chung, Dae Jin Song, Ji Tae Choung. Bronchodilator responses after methacholine and adenosine 5'-monophosphate (AMP) challenges in children with asthma: their relationships with eosinophil markers.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2012 Sep; 49(7):717-23. doi:
10.3109/02770903.2012.692845. [PMID: 22747180] - Alexandre P Rogerio, Oliver Haworth, Roxanne Croze, Sungwhan F Oh, Mohib Uddin, Troy Carlo, Michael A Pfeffer, Rebekah Priluck, Charles N Serhan, Bruce D Levy. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.
Journal of immunology (Baltimore, Md. : 1950).
2012 Aug; 189(4):1983-91. doi:
10.4049/jimmunol.1101665. [PMID: 22802419] - Xiao Chu, Miaomiao Wei, Xiaofeng Yang, Qingjun Cao, Xianxing Xie, Mingfeng Guan, Dacheng Wang, Xuming Deng. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Jul; 50(7):2368-75. doi:
10.1016/j.fct.2012.03.076. [PMID: 22484343] - Claudio R Bezerra-Santos, Adriana Vieira-de-Abreu, Giciane Carvalho Vieira, Jaime R Filho, José Maria Barbosa-Filho, Ana Lucia Pires, Marco Aurelio Martins, Heitor S Souza, Christianne Bandeira-Melo, Patrícia T Bozza, Marcia R Piuvezam. Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma.
International immunopharmacology.
2012 Jun; 13(2):148-55. doi:
10.1016/j.intimp.2012.03.014. [PMID: 22480776] - Sung-Ho Kim, Gil-Soon Choi, Young-Hee Nam, Joo-Hee Kim, Gyu-Young Hur, Seung-Hyun Kim, Sang Myun Park, Hae-Sim Park. Role of vitamin D-binding protein in isocyanate-induced occupational asthma.
Experimental & molecular medicine.
2012 May; 44(5):319-29. doi:
10.3858/emm.2012.44.5.036. [PMID: 22314196] - Michelle V Fanucchi, Andreas Bracher, Stephen F Doran, Giuseppe L Squadrito, Solana Fernandez, Edward M Postlethwait, Larry Bowen, Sadis Matalon. Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation.
American journal of respiratory cell and molecular biology.
2012 May; 46(5):599-606. doi:
10.1165/rcmb.2011-0196oc. [PMID: 22162906] - Aimee Hoskins, Jackson L Roberts, Ginger Milne, Leena Choi, Ryszard Dworski. Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo.
Allergy.
2012 May; 67(5):676-82. doi:
10.1111/j.1398-9995.2012.02810.x. [PMID: 22435735]