L-Name (BioDeep_00000002947)
代谢物信息卡片
N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester
化学式: C7H15N5O4 (233.1124)
中文名称:
谱图信息:
最多检出来源 Anoectochilus roxburghii(viridiplantae) 33.33%
分子结构信息
SMILES: COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N
InChI: InChI=1S/C7H15N5O4/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15/h5H,2-4,8H2,1H3,(H3,9,10,11)/t5-/m0/s1
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:7549
- KEGG: C04337
- PubChem: 39836
- Metlin: METLIN64861
- DrugBank: DB12750
- ChEMBL: CHEMBL7890
- MeSH: NG-Nitroarginine Methyl Ester
- CAS: 50903-99-6
- PMhub: MS000007273
- PubChem: 6988
- NIKKAJI: J264.830J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiacheng Wu, Zhijie Wu, Wenlong Kuang, Dingyang Shi, Yulu Yang, Xin Li, Jianwu Huang, Xuehan Li, Yuhua Liao, Zihua Zhou, Zhihua Qiu. Combined vaccines against angiotensin II receptor type 1 and alpha 1D-adrenergic receptor for hypertension.
Journal of hypertension.
2024 Jul; 42(7):1184-1196. doi:
10.1097/hjh.0000000000003710. [PMID: 38690916] - Kaori Katiuska Yamaguchi Isla, Mirtes Midori Tanae, Maria Teresa Riggio de Lima-Landman, Pedro Melillo de Magalhães, Antônio José Lapa, Caden Souccar. Vasorelaxant effects of ellagitannins isolated from Cuphea carthagenensis.
Planta medica.
2024 Apr; 90(4):276-285. doi:
10.1055/a-2240-7372. [PMID: 38272038] - Yi Sun, Jialin Yao, Changyuan Wang, Yue Jin, Xinyu Wan, Qiang Meng, Jingjing Wu, Qi Liu, Huijun Sun. Epigenetic modification of TWIST1 in macrophages promotes hypertension-induced atherosclerotic plaque instability.
International immunopharmacology.
2024 Jan; 127(?):111313. doi:
10.1016/j.intimp.2023.111313. [PMID: 38134595] - F Rafique, M N Mushtaq, H Ahmed, W Younis. Evaluation and estimation of diuretic activity of the linalyl acetate in the rats.
Brazilian journal of biology = Revista brasleira de biologia.
2024; 83(?):e277354. doi:
10.1590/1519-6984.277354. [PMID: 38452187] - Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He. Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy.
Journal of diabetes research.
2024; 2024(?):6942156. doi:
10.1155/2024/6942156. [PMID: 38282657] - Albina Uka, Donjeta Krasniqi, Giangiacomo Beretta, Armond Daci. Assessment of In Vitro Airway Smooth Muscle Relaxant Activity of Rhus coriaria L. Fruit Ethanolic Extract and Its Possible Mechanisms.
Journal of medicinal food.
2023 Nov; 26(11):820-830. doi:
10.1089/jmf.2022.0126. [PMID: 37902984] - Xiao-Qi Wei, Xin-Yi Fan, Hai-Yin Pu, Shuai Li, Jia-Yang Tang, Kuo Gao, Fang-He Li, Xue Yu, Shu-Zhen Guo. [Mechanism of Jiming Powder in ameliorating heart failure with preserved ejection fraction based on metabolomics].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Sep; 48(17):4747-4760. doi:
10.19540/j.cnki.cjcmm.20230510.702. [PMID: 37802814] - Pattaneeya Prangthip, Watanalai Panbangred, Onrapak Reamtong. Potential antihypertensive activity of novel peptides from green basil leaves.
BMC complementary medicine and therapies.
2023 Aug; 23(1):282. doi:
10.1186/s12906-023-04098-2. [PMID: 37553559] - Ayokunle Ademosun, Opeyemi Ojueromi, Olukorede Peace, Ganiyu Oboh. Cardiomodulatory and Antioxidative Potentials of Almond-Citrus Peel Fortified Shortbread in High Fat Diet/L-NAME-Induced Hyperlipidemic-Hypertensive Rats.
Journal of medicinal food.
2023 Aug; 26(8):586-594. doi:
10.1089/jmf.2023.0050. [PMID: 37594561] - Danilo Galvão Rocha, Thais Muratori Holanda, Helyson Lucas Bezerra Braz, João Alison Silveira de Moraes, Aline Diogo Marinho, Pedro Henrique Freitas Maia, Maria Elisabete Amaral de Moraes, Francisco Vagnaldo Fechine-Jamacaru, Manoel Odorico de Moraes Filho. Vasorelaxant effect of Alpinia zerumbet's essential oil on rat resistance artery involves blocking of calcium mobilization.
Fitoterapia.
2023 Jul; 169(?):105623. doi:
10.1016/j.fitote.2023.105623. [PMID: 37500018] - Farzana Sadaf, Rubeena Saleem, Rashid A Khan, Usman Ahmad, Lubna, Samina Bano, Shaheen Faizi. Antihypertensive effect of patulitrin and other constituents from Tagetes patula L. (French marigold) in acute L-NAME induced hypertensive rats.
Natural product research.
2023 Jul; ?(?):1-7. doi:
10.1080/14786419.2023.2233673. [PMID: 37458205] - Asser F Bedair, Ahmed Wahid, Nesrine S El-Mezayen, Amira F El-Yazbi, Hadeel A Khalil, Nayera W Hassan, Elham A Afify. Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 165(?):115068. doi:
10.1016/j.biopha.2023.115068. [PMID: 37392650] - Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol.
Alcohol (Fayetteville, N.Y.).
2023 Jun; ?(?):. doi:
10.1016/j.alcohol.2023.05.008. [PMID: 37295565] - Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoru Tamura, Minoru Ueda, Satoshi Hirohata, Shogo Watanabe. Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model.
Canadian journal of physiology and pharmacology.
2023 May; ?(?):. doi:
10.1139/cjpp-2022-0532. [PMID: 37224568] - Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Soonghee Chung, Ju-Tae Sohn. Lipid Emulsion Inhibits Amlodipine-Induced Nitric Oxide-Mediated Vasodilation in Isolated Rat Aorta.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108741. [PMID: 37240087] - Ademola Adetokunbo Oyagbemi, Adedeji Kolawole Adebayo, Olamide Elizabeth Adebiyi, Kabirat Oluwaseun Adigun, Oluwabusayo Racheal Folarin, Oluwaseun Olanrewaju Esan, Temitayo Olabisi Ajibade, Blessing Seun Ogunpolu, Olufunke Olubunmi Falayi, Iyanuoluwa Omolola Ogunmiluyi, Temidayo Olutayo Omobowale, Olufunke Eunice Ola-Davies, James Olukayode Olopade, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy McGaw, Momoh Audu Yakubu, Evaristus Nwulia, Oluwafemi Omoniyi Oguntibeju. Leaf extract of Anacardium occidentale ameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester (L-NAME) treated rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2023 May; 28(3):263-272. doi:
10.1080/1354750x.2022.2164354. [PMID: 36632742] - Xiaopei Yang, Chen Na, Yan Wang. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel.
Journal of ethnopharmacology.
2023 Apr; 313(?):116527. doi:
10.1016/j.jep.2023.116527. [PMID: 37088236] - Linli Hu, Xueqin Gao, Yutong Li, Jian Lyu, Xuemei Xiao, Guobin Zhang, Jihua Yu. Nitric Oxide Induced by Ammonium/Nitrate Ratio Ameliorates Low-Light Stress in Brassica pekinesis: Regulation of Photosynthesis and Root Architecture.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24087271. [PMID: 37108434] - Li-Jun Yang, Jia-Bei He, Yu Jiang, Jianzhong Li, Zhen-Wei Zhou, Chuan Zhang, Xia Tao, Alex F Chen, Cheng Peng, He-Hui Xie. Berberine hydrochloride inhibits migration ability via increasing inducible NO synthase and peroxynitrite in HTR-8/SVneo cells.
Journal of ethnopharmacology.
2023 Apr; 305(?):116087. doi:
10.1016/j.jep.2022.116087. [PMID: 36584918] - Adeniyi Adebayo, Ayokunle Ademosun, Bukola Adedayo, Ganiyu Oboh. Antioxidant-rich Terminalia catappa fruit exerts antihypertensive effect via modulation of angiotensin-1-converting enzyme activity and H2S/NO/cGMP signaling pathway in Wistar rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2023 Apr; ?(?):1-18. doi:
10.1080/1354750x.2023.2198680. [PMID: 37002876] - Milad Rahemi, Shokooh Mohtadi, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. The role of L-arginine/NO/cGMP/KATP channel pathway in the local antinociceptive effect of berberine in the rat formalin test.
Behavioural pharmacology.
2023 Mar; ?(?):. doi:
10.1097/fbp.0000000000000721. [PMID: 36939560] - Mikayel Ginovyan, Hayarpi Javrushyan, Gayane Petrosyan, Barbara Kusznierewicz, Izabela Koss-Mikołajczyk, Zuzanna Koziara, Monika Kuczyńska, Patrycja Jakubek, Anna Karapetyan, Naira Sahakyan, Alina Maloyan, Agnieszka Bartoszek, Nikolay Avtandilyan. Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and polyamine synthesis.
The international journal of biochemistry & cell biology.
2023 Mar; 158(?):106396. doi:
10.1016/j.biocel.2023.106396. [PMID: 36918141] - Milos Krivokapic, Israpil Alisultanovich Omarov, Vladimir Zivkovic, Tamara Nikolic Turnic, Vladimir Jakovljevic. Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion.
Medicina (Kaunas, Lithuania).
2023 Feb; 59(3):. doi:
10.3390/medicina59030458. [PMID: 36984459] - Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Lucila Herrera-Ruiz, Jaqueline Molina-Cabrera, María Cruz Juárez-Aragón, Francisco Javier Flores-Murrieta. Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception.
Journal of ethnopharmacology.
2023 Jan; 300(?):115756. doi:
10.1016/j.jep.2022.115756. [PMID: 36170958] - Smail Amtaghri, Adil Qabouche, Miloudia Slaoui, Mohamed Eddouks. Potential Antihypertensive Activity of the Aqueous Extract of Ammi visnaga and its Effect on ACE-2 in Rats.
Cardiovascular & hematological disorders drug targets.
2023; 23(4):277-284. doi:
10.2174/011871529x255465231120055555. [PMID: 38115615] - Mariane Meurer, Fabiula Felisbino, Fabiana B Müller, Lincon B Somensi, Benhur J Cury, Daniele T Jerônimo, Larissa Venzon, Tauani C S França, Marihá Mariott, Ana C Santos, Ruan Kaio S Nunes, Thaise Boeing, Alexandre Bella-Cruz, Priscila DE Souza, Walter A Roman-Junior, Karuppusamy Arunachalam, Ruberlei G Oliveira, Luisa M Silva. Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.).
Anais da Academia Brasileira de Ciencias.
2023; 95(suppl 1):e20220427. doi:
10.1590/0001-3765202320220427. [PMID: 37556712] - Ayoub Amssayef, Ismail Bouadid, Mohamed Eddouks. L-Tartaric Acid Exhibits Antihypertensive and Vasorelaxant Effects: The Possible Role of eNOS/NO/cGMP Pathways.
Cardiovascular & hematological agents in medicinal chemistry.
2023; 21(3):202-212. doi:
10.2174/1871525721666230111150501. [PMID: 36635922] - Smail Amthaghri, Ayoub Amssayef, Miloudia Slaoui, Mohamed Eddouks. Antihypertensive Effect of Euphorbia cheiradenia in Rats.
Cardiovascular & hematological agents in medicinal chemistry.
2023; 21(3):213-222. doi:
10.2174/1871525721666230118154023. [PMID: 36654473] - Ismail Bouadid, Mourad Akdad, Mohamed Eddouks. Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats.
Cardiovascular & hematological agents in medicinal chemistry.
2023; 21(1):20-30. doi:
10.2174/1871525720666220613164559. [PMID: 35702770] - Muryam Abdul Razzaq, Waqas Younis, Muhammad Nasir Hayat Malik, Tariq G Alsahli, Alamgeer, Shah Jahan, Roma Ehsan, Arquimedes Gasparotto Junior, Asifa Bashir. Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats.
Cardiovascular therapeutics.
2023; 2023(?):8166840. doi:
10.1155/2023/8166840. [PMID: 37214130] - Smail Amtaghri, Miloudia Slaoui, Mohamed Eddouks. Ammodaucus leucotrichus acts as an antihypertensive and vasorelaxant agent through sGC and prostaglandin synthesis pathways.
Cardiovascular & hematological agents in medicinal chemistry.
2022 Dec; ?(?):. doi:
10.2174/1871525721666221209161605. [PMID: 36503395] - Jamila El-Akhal, Andreia P Oliveira, Rachid Bencheikh, Patrícia Valentão, Paula B Andrade, Manuela Morato. Vasorelaxant Mechanism of Herbal Extracts from Mentha suaveolens, Conyza canadensis, Teucrium polium and Salvia verbenaca in the Aorta of Wistar Rats.
Molecules (Basel, Switzerland).
2022 Dec; 27(24):. doi:
10.3390/molecules27248752. [PMID: 36557886] - Elif Alan, Gokay Albayrak, Gulnur Sevin, Gunay Yetik-Anacak, Sura Baykan. Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum.
Andrologia.
2022 Dec; 54(11):e14604. doi:
10.1111/and.14604. [PMID: 36163644] - Yaraset López-Lorenzo, María Elena Sánchez-Mendoza, Daniel Arrieta-Baez, Adriana Guadalupe Perez-Ruiz, Jesús Arrieta. Gastroprotective activity of (E)-ethyl-12-cyclohexyl-4,5-dihydroxydodec-2-enoate, a compound isolated from Heliotropium indicum: role of nitric oxide, prostaglandins, and sulfhydryls in its mechanism of action.
Pharmaceutical biology.
2022 Dec; 60(1):1207-1213. doi:
10.1080/13880209.2022.2087690. [PMID: 35764528] - D A Ibarrola, W Arrua, J E Gonzalez, M S Soverina Escobar, J Centurión, A M Campuzano Benitez, F M Ovando Soria, E I Rodas González, K G Arrúa, M B Acevedo Barrios, O Y Heinichen, Y Montalbetti, M A Campuzano-Bublitz, M L Kennedy, S J Figueredo Thiel, N L Alvarenga, M C Hellión-Ibarrola. The antihypertensive and diuretic effect of crude root extract and saponins from Solanum sisymbriifolium Lam., in L-NAME-induced hypertension in rats.
Journal of ethnopharmacology.
2022 Nov; 298(?):115605. doi:
10.1016/j.jep.2022.115605. [PMID: 35973627] - Cheng Ma, Zi-Qi Pei, Xue Bai, Ju-Yan Feng, Lu Zhang, Jie-Ru Fan, Juan Wang, Teng-Guo Zhang, Sheng Zheng. Involvement of NO and Ca2+ in the enhancement of cold tolerance induced by melatonin in winter turnip rape (Brassica rapa L.).
Plant physiology and biochemistry : PPB.
2022 Nov; 190(?):262-276. doi:
10.1016/j.plaphy.2022.09.011. [PMID: 36152511] - Ademola Adetokunbo Oyagbemi, Fasilat Oluwakemi Hassan, Temitayo Olabisi Ajibade, Olufunke Eunice Ola-Davies, Temidayo Olutayo Omobowale, Olumide Samuel Ajani, Theophilus Aghogho Jarikre, Kehinde Olugboyega Soetan, Adebowale Benard Saba, Adeolu Alex Adedapo, Abimbola Obemisola Aro, Matthew Olugbenga Oyeyemi, Benjamin Obukowho Emikpe, Sanah Malomile Nkadimeng, Lyndy Joy McGaw, Prudence Ngalula Kayoka-Kabongo, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju. Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action.
Pakistan journal of pharmaceutical sciences.
2022 Nov; 35(6):1581-1694. doi:
". [PMID: 36789818] - Sadettin Demirel. Rosa damascena Miller essential oil relaxes rat thoracic aorta through the NO-cGMP-dependent pathway.
Prostaglandins & other lipid mediators.
2022 10; 162(?):106661. doi:
10.1016/j.prostaglandins.2022.106661. [PMID: 35750298] - Sonia Spinelli, Lucrezia Guida, Tiziana Vigliarolo, Mario Passalacqua, Giulia Begani, Mirko Magnone, Laura Sturla, Andrea Benzi, Pietro Ameri, Edoardo Lazzarini, Claudia Bearzi, Roberto Rizzi, Elena Zocchi. The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism.
Cells.
2022 09; 11(18):. doi:
10.3390/cells11182888. [PMID: 36139463] - Hina Iqbal, Pankaj Yadav, Amit Kumar Verma, Divya Mishra, Beena Vamadevan, Dhirendra Singh, Suaib Luqman, Arvind Singh Negi, Debabrata Chanda. Anti-inflammatory, anti-oxidant and cardio-protective properties of novel fluorophenyl benzimidazole in L-NAME-induced hypertensive rats.
European journal of pharmacology.
2022 Aug; 929(?):175132. doi:
10.1016/j.ejphar.2022.175132. [PMID: 35792173] - Jin-Feng Chen, Fei Liu, Ming-Ming Qiao, Hong-Zhen Shu, Xiao-Cui Li, Cheng Peng, Liang Xiong. Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway.
Journal of ethnopharmacology.
2022 Aug; 294(?):115332. doi:
10.1016/j.jep.2022.115332. [PMID: 35525529] - Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Shinichi Usui, Ryoko Shinohata, Kazuya Kitamori, Satoshi Hirohata, Shogo Watanabe. Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism.
Pharmacological reports : PR.
2022 Aug; 74(4):669-683. doi:
10.1007/s43440-022-00380-1. [PMID: 35819592] - Patchareewan Pannangpetch, Panot Tangsucharit, Ratthipha Thanaruksa, Tunvaraporn Proongkhong, Supawadee Srisuwan, Direk Aekthammarat. Antihypertensive effect of Mali-Nil surin rice bran hydrolysate and its mechanisms related to the EDHF-mediated vasorelaxation and L-type Ca2+ channel-mediated vasoconstriction in L-NAME hypertensive rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):113003. doi:
10.1016/j.biopha.2022.113003. [PMID: 35462340] - Daniel Stehle, Min Ze Xu, Tibor Schomber, Michael G Hahn, Frank Schweda, Susanne Feil, Jan R Kraehling, Frank Eitner, Andreas Patzak, Peter Sandner, Robert Feil, Agnès Bénardeau. Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney.
British journal of pharmacology.
2022 06; 179(11):2476-2489. doi:
10.1111/bph.15586. [PMID: 34096053] - Javier Palacios, Adrián Paredes, Marcelo A Catalán, Chukwuemeka R Nwokocha, Fredi Cifuentes. Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103333. [PMID: 35630811] - Zhenkun Li, Fengrong Zhang, Shicong Wang, Honghe Xiao, Jingyi Wang, Xianyu Li, Hongjun Yang. Endothelium-dependent vasorelaxant effects of praeruptorin a in isolated rat thoracic aorta.
Bioengineered.
2022 04; 13(4):10038-10046. doi:
10.1080/21655979.2022.2062979. [PMID: 35416124] - Luckika Panthiya, Jiraporn Tocharus, Amnart Onsa-Ard, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus. Hexahydrocurcumin ameliorates hypertensive and vascular remodeling in L-NAME-induced rats.
Biochimica et biophysica acta. Molecular basis of disease.
2022 03; 1868(3):166317. doi:
10.1016/j.bbadis.2021.166317. [PMID: 34883248] - Gabrielle A Dillon, S Tony Wolf, Lacy M Alexander. Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection.
American journal of physiology. Heart and circulatory physiology.
2022 02; 322(2):H319-H327. doi:
10.1152/ajpheart.00602.2021. [PMID: 34995164] - H Dubey, A Dubey, K Gulati, A Ray. Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's disease in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Feb; 73(1):. doi:
10.26402/jpp.2022.1.01. [PMID: 35639033] - Jingjing Wu, Dongmei Zhang, Linlin Hu, Xiaowei Zheng, Caihong Chen. Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage.
Bioengineered.
2022 02; 13(2):2248-2258. doi:
10.1080/21655979.2021.2024325. [PMID: 35030965] - Paul-Mihai Boarescu, Ioana Boarescu, Raluca Maria Pop, Ştefan Horia Roşian, Ioana Corina Bocșan, Vasile Rus, Răzvan Olimpiu Mada, Iulia Diana Popa, Nicholas Neagu, Adriana Elena Bulboacă, Anca Dana Buzoianu, Sorana D Bolboacă. Evaluation of Oxidative Stress Biomarkers, Pro-Inflammatory Cytokines, and Histological Changes in Experimental Hypertension, Dyslipidemia, and Type 1 Diabetes Mellitus.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031438. [PMID: 35163364] - Ayesha Rahman Ahmed, Senty Vun-Sang, Mohammad Iqbal. Therapeutic role of nitroglycerin against copper-nitrilotriacetate induced hepatic and renal damage.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221131312. doi:
10.1177/09603271221131312. [PMID: 36305384] - Anam Saeed, Kashif Bashir, Abdul Jabbar Shah, Rahila Qayyum, Taous Khan. Antihypertensive Activity in High Salt-Induced Hypertensive Rats and LC-MS/MS-Based Phytochemical Profiling of Melia azedarach L. (Meliaceae) Leaves.
BioMed research international.
2022; 2022(?):2791874. doi:
10.1155/2022/2791874. [PMID: 35928913] - Victoria Anthony Uyanga, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Okanlawon M Onagbesan, Hai Lin. Dietary L-citrulline influences body temperature and inflammatory responses during nitric oxide synthase inhibition and endotoxin challenge in chickens.
Stress (Amsterdam, Netherlands).
2022 01; 25(1):74-86. doi:
10.1080/10253890.2021.2023495. [PMID: 34962227] - Qiuyue Wang, Caihui Zhang, Chen Yang, Yue Sun, Keyang Chen, Yao Lu. Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats.
Oxidative medicine and cellular longevity.
2022; 2022(?):6482363. doi:
10.1155/2022/6482363. [PMID: 35602097] - Amine Azzane, Bouchra Azzaoui, Mourad Akdad, Ismail Bouadid, Mohamed Eddouks. Effect of Calamintha officinalis on Vascular Contractility and Angiotensinconverting Enzyme-2.
Cardiovascular & hematological agents in medicinal chemistry.
2022; 20(3):219-236. doi:
10.2174/1871525720666220302125242. [PMID: 35236273] - Zhongxiao Zhou, Haimeng Zhou, Xin Zou, Xiaowei Wang, Mengjun Yan. Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats.
International journal of immunopathology and pharmacology.
2022 Jan; 36(?):3946320221111117. doi:
10.1177/03946320221111117. [PMID: 35731855] - Mayara Alves Amorim, Janiana Raíza Jentsch Matias de Oliveira, Vitor Hélio Souza Oliveira, Daniela Almeida Cabrini, Michel Fleith Otuki, Eunice André. Role of nitric oxide, bradykinin B2 receptor, and TRPV1 in the airway alterations caused by simvastatin in rats.
European journal of pharmacology.
2021 Dec; 912(?):174591. doi:
10.1016/j.ejphar.2021.174591. [PMID: 34710369] - Juhi Nema, Karuna Randhir, Nisha Wadhwani, Deepali Sundrani, Sadhana Joshi. Maternal vitamin D deficiency reduces docosahexaenoic acid, placental growth factor and peroxisome proliferator activated receptor gamma levels in the pup brain in a rat model of preeclampsia.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 12; 175(?):102364. doi:
10.1016/j.plefa.2021.102364. [PMID: 34768025] - Raphaëlle Corremans, Patrick C D'Haese, Benjamin A Vervaet, Anja Verhulst. L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312767. [PMID: 34884571] - Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote. Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats.
Life sciences.
2021 Nov; 285(?):119965. doi:
10.1016/j.lfs.2021.119965. [PMID: 34543638] - Nan Li, Yefeng Chen, Yanmin Pei, Liangjuan Han, Jun Ren, Wei Zhou, Ru Zhou. Vasorelaxation effect of oxysophoridine on isolated thoracicc aorta rings of rats.
The Chinese journal of physiology.
2021 Nov; 64(6):274-280. doi:
10.4103/cjp.cjp_60_21. [PMID: 34975120] - P Haramipour, A Asghari, Sh Hassanpour, A Jahandideh. Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice.
Archives of Razi Institute.
2021 11; 76(5):1404-1417. doi:
10.22092/ari.2020.352221.1553. [PMID: 35355756] - Yasser H Habib, Mennatallah A Gowayed, Sherien A Abdelhady, Nevine M El-Deeb, Inas E Darwish, Mahmoud M El-Mas. Modulation by antenatal therapies of cardiovascular and renal programming in male and female offspring of preeclamptic rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2273-2287. doi:
10.1007/s00210-021-02146-7. [PMID: 34468816] - Benchaporn Saengnak, Pipatpong Kanla, Rarinthorn Samrid, Thewarid Berkban, Wilaiwan Mothong, Poungrat Pakdeechote, Parichat Prachaney. Clitoria ternatea L. extract prevents kidney damage by suppressing the Ang II/Nox4/oxidative stress cascade in l-NAME-induced hypertension model of rats.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
2021 Nov; 238(?):151783. doi:
10.1016/j.aanat.2021.151783. [PMID: 34144158] - Jie Xiao, Ben Zhang, Zhengchen Su, Yakun Liu, Thomas R Shelite, Qing Chang, Yuan Qiu, Jiani Bei, Pingyuan Wang, Alexander Bukreyev, Lynn Soong, Yang Jin, Thomas Ksiazek, Angelo Gaitas, Shannan L Rossi, Jia Zhou, Michael Laposata, Tais B Saito, Bin Gong. Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation.
The Journal of biological chemistry.
2021 11; 297(5):101315. doi:
10.1016/j.jbc.2021.101315. [PMID: 34678311] - Ingrid Beatriz de Melo Morais, Denise Brentan Silva, Carlos Alexandre Carollo, Marcos Luiz Ferreira-Neto, Patrícia Fidelis-de-Oliveira, Luiz Borges Bispo-da-Silva. Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage.
Natural product research.
2021 Nov; 35(22):4798-4802. doi:
10.1080/14786419.2020.1727467. [PMID: 32081043] - Lijun Tao, Lina Chen, Yanmin Pei, Ping Ma, Qingbin Xu, Jialing Wang, Yang Yu, Jiang Cheng, Ru Zhou. Vasodilatory effects of betaine on isolated rat pulmonary artery rings.
Die Pharmazie.
2021 10; 76(10):499-502. doi:
10.1691/ph.2021.1392. [PMID: 34620278] - Yu Liu, HaoRan Shi, Di Wu, GuiXiang Xu, RuiLin Ma, XiaoXia Liu, Yan Mao, Yang Zhang, Li Zou, Yin Zhao. The Protective Benefit of Heme Oxygenase-1 Gene-Modified Human Placenta-Derived Mesenchymal Stem Cells in a N-Nitro-L-Arginine Methyl Ester-Induced Preeclampsia-Like Rat Model: Possible Implications for Placental Angiogenesis.
Stem cells and development.
2021 10; 30(19):991-1002. doi:
10.1089/scd.2021.0174. [PMID: 34470469] - Tamer I M Ragab, Naglaa A Ali, Abdel Nasser G El Gendy, Safaa H Mohamed, Aziza B Shalby, Abdel-Razik H Farrag, Al Shimaa Gamal Shalaby. Renoprotective and therapeutic effects of newly water, ethanol, and butanol ginseng fractions in hypertensive and chronic kidney disease with L-NAME.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111978. doi:
10.1016/j.biopha.2021.111978. [PMID: 34411920] - Jing Yu, Shuqin Wang, Wei Shi, Wei Zhou, Yujia Niu, Songming Huang, Yue Zhang, Aihua Zhang, Zhanjun Jia. Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS.
JCI insight.
2021 09; 6(18):. doi:
10.1172/jci.insight.133690. [PMID: 34403364] - Fuqiang Zhao, Xiaoyan Zhou, Eric Messina, Lufei Hu, Marie A Holahan, Gayathri Swaminath, Catherine D G Hines. Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys.
NMR in biomedicine.
2021 09; 34(9):e4566. doi:
10.1002/nbm.4566. [PMID: 34096123] - Yasser H Habib, Sherien A Abdelhady, Mennatallah A Gowayed, Nevine M El-Deeb, Inas E Darwish, Mahmoud M El-Mas. Prenatal endothelin or thromboxane receptor antagonism surpasses sympathoinhibition in improving cardiorenal malfunctions in preeclamptic rats.
Toxicology and applied pharmacology.
2021 09; 426(?):115615. doi:
10.1016/j.taap.2021.115615. [PMID: 34102242] - Nilanjan Chakraborty. Salicylic acid and nitric oxide cross-talks to improve innate immunity and plant vigor in tomato against Fusarium oxysporum stress.
Plant cell reports.
2021 Aug; 40(8):1415-1427. doi:
10.1007/s00299-021-02729-x. [PMID: 34109470] - Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jul; 43(5):462-473. doi:
10.1080/10641963.2021.1901110. [PMID: 33775188] - Jeong Eun Lee, Hoon Jung, Jin Duck Cho, Eun Kyung Choi, Hyun Ah Kim, Younghoon Jeon, Sung-Sik Park, Sioh Kim, Dong Gun Lim, Kyung-Hwa Kwak. The Role of Dexmedetomidine in Hepatic Ischemia-Reperfusion Injury Via a Nitric Oxide-Dependent Mechanism in Rats.
Transplantation proceedings.
2021 Jul; 53(6):2060-2069. doi:
10.1016/j.transproceed.2021.05.008. [PMID: 34238590] - Zuneera Akram, Rehana Perveen, Hasan Salman Siddiqi, Muzammil Hussain, Shahlla Imam, Hina Abrar, Syed Mohammad Mahmood. Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract.
Pakistan journal of pharmaceutical sciences.
2021 Jul; 34(4):1429-1436. doi:
". [PMID: 34799318] - Yukio Suga, Yoko Takahashi, Tsutomu Shimada, Shinya Yamada, Eriko Morishita, Hidesaku Asakura. Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model.
In vivo (Athens, Greece).
2021 Jul; 35(4):1999-2004. doi:
10.21873/invivo.12468. [PMID: 34182474] - Jian Shuai, Yufang Gao, Ling Chen, Zhongli Wang. Role of serotonin in regulation of pancreatic and mesenteric arterial function in diabetic mice.
European journal of pharmacology.
2021 Jun; 901(?):174070. doi:
10.1016/j.ejphar.2021.174070. [PMID: 33798598] - Luis Arias-Durán, Samuel Estrada-Soto, Monserrat Hernández-Morales, César Millán-Pacheco, Gabriel Navarrete-Vázquez, Rafael Villalobos-Molina, Maximiliano Ibarra-Barajas, Julio C Almanza-Pérez. Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies.
Journal of ethnopharmacology.
2021 Jun; 273(?):113948. doi:
10.1016/j.jep.2021.113948. [PMID: 33610712] - Jelica Grujić-Milanović, Vesna Jaćević, Zoran Miloradović, Djurdjica Jovović, Ivica Milosavljević, Sladjan D Milanović, Nevena Mihailović-Stanojević. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties.
International journal of molecular sciences.
2021 May; 22(9):. doi:
10.3390/ijms22095006. [PMID: 34066865] - Abubakar Alhaji Liman, Aliyu Salihu, Elewechi Onyike. Effect of Methanol Extract of Baobab (Adansonia digitata L.) Fruit Pulp on NG-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Hypertension in Rats.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2021 May; 28(3):291-300. doi:
10.1007/s40292-021-00448-8. [PMID: 33826116] - Soo Hee Lee, Seong-Ho Ok, Dawon Kang, Hyun-Jin Kim, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Eun-Jin Kim, Sunmin Kim, Yeran Hwag, Ju-Tae Sohn. Nitric oxide-dependent vasodilation induced by minoxidil in isolated rat aorta.
General physiology and biophysics.
2021 May; 40(3):197-206. doi:
10.4149/gpb_2021012. [PMID: 34100376] - Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn. Lipid Emulsion Enhances Vasoconstriction Induced by Dexmedetomidine in the Isolated Endothelium-Intact Aorta.
International journal of molecular sciences.
2021 Mar; 22(7):. doi:
10.3390/ijms22073309. [PMID: 33804982] - T Y Chia, V Murugaiyah, N Ak Khan, M A Sattar, M H Abdulla, E J Johns, A Ahmad, Z Hassan, G Kaur, H Y Mei, F U Ahmad, S Akhtar. Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression.
Physiological research.
2021 03; 70(1):13-26. doi:
10.33549/physiolres.934497. [PMID: 33728924] - Ana Ilic, Dusan Todorovic, Slavica Mutavdzin, Novica Boricic, Biljana Bozic Nedeljkovic, Sanja Stankovic, Tatjana Simic, Predrag Stevanovic, Vera Celic, Dragan Djuric. Translocator Protein Modulation by 4'-Chlorodiazepam and NO Synthase Inhibition Affect Cardiac Oxidative Stress, Cardiometabolic and Inflammatory Markers in Isoprenaline-Induced Rat Myocardial Infarction.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062867. [PMID: 33799869] - Anuson Poasakate, Putcharawipa Maneesai, Petcharat Chiangsaen, Sarawoot Bunbupha, Wannapa Settheetham-Ishida, Poungrat Pakdeechote. Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats.
Andrologia.
2021 Mar; 53(2):e13917. doi:
10.1111/and.13917. [PMID: 33244785] - Sarawoot Bunbupha, Kwanjit Apaijit, Prapassorn Potue, Putcharawipa Maneesai, Poungrat Pakdeechote. Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-β1, and oxidative stress.
Clinical and experimental pharmacology & physiology.
2021 03; 48(3):412-421. doi:
10.1111/1440-1681.13438. [PMID: 33185907] - Mohammed Ajebli, Mohamed Eddouks. Eucalyptus globulus possesses antihypertensive activity in L-NAME-induced hypertensive rats and relaxes isolated rat thoracic aorta through nitric oxide pathway.
Natural product research.
2021 Mar; 35(5):819-821. doi:
10.1080/14786419.2019.1598992. [PMID: 30966776] - Heesu Kim, Dong Gun Lee. Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner.
The Biochemical journal.
2021 02; 478(4):855-869. doi:
10.1042/bcj20200925. [PMID: 33522568] - Ece Koc Yildirim, Zahide Dedeoglu, Mehmet Kaya, Aykut G Uner. The effect of swimming training on adrenomedullin levels, oxidative stress variables, and gastrocnemius muscle contractile properties in hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Feb; 43(2):131-137. doi:
10.1080/10641963.2020.1825726. [PMID: 32985250] - Corinne Vanucci-Bacqué, Florence Bedos-Belval. Anti-inflammatory activity of naturally occuring diarylheptanoids - A review.
Bioorganic & medicinal chemistry.
2021 02; 31(?):115971. doi:
10.1016/j.bmc.2020.115971. [PMID: 33422907] - I C Wennysia, L Zhao, T Schomber, D Braun, S Golz, H Summer, A Benardeau, E Y Lai, F-B Lichtenberger, R Schubert, P B Persson, M Z Xu, A Patzak. Role of soluble guanylyl cyclase in renal afferent and efferent arterioles.
American journal of physiology. Renal physiology.
2021 02; 320(2):F193-F202. doi:
10.1152/ajprenal.00272.2020. [PMID: 33356952] - Yasaman Husseini, Alireza Mohammadi, Gila Pirzad Jahromi, Gholamhossein Meftahi, Hedayat Sahraei, Boshra Hatef. The controlling role of nitric oxide within the shell of nucleus accumbens in the stress-induced metabolic disturbance.
Archives of physiology and biochemistry.
2021 Feb; 127(1):73-81. doi:
10.1080/13813455.2019.1611865. [PMID: 31094227] - Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak, Guldal Gulec Suyen. Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation.
Chemico-biological interactions.
2021 Jan; 334(?):109351. doi:
10.1016/j.cbi.2020.109351. [PMID: 33301711] - Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jan; 43(1):49-55. doi:
10.1080/10641963.2020.1797087. [PMID: 32706597] - Prosper A Dabiré, Youssoufou Ouédraogo, Abel A Somé, Stanislas Sawadogo, Issaka Ouédraogo, Edith M Ilboudo, Raymond G Belemtougri. Relaxant Effects of the Aqueous Extract of Excoecaria grahamii (Euphorbiaceae) Leaves on Uterine Horn Contractility in Wistar Rats.
BioMed research international.
2021; 2021(?):6618565. doi:
10.1155/2021/6618565. [PMID: 33928151] - A Kapucu, K Akgun-Dar. Leptin ameliorates testicular injury by altering expression of nitric oxide synthases in diabetic rats.
Bratislavske lekarske listy.
2021; 122(2):111-115. doi:
10.4149/bll_2021_016. [PMID: 33502878] - Reza Mohebbati, Yasamin Kamkar-Del, Mohammad N Shafei. The Possible Regulatory Mechanisms of Aqueous, Ethyl Acetate and NHexane Fractions of the Ribes khorassanicum Extract on Acute Hypertension in Rats.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(9):1620-1626. doi:
10.2174/1871530320666201104114609. [PMID: 33148161]
