(-)-Thebaine (BioDeep_00000002703)

 

Secondary id: BioDeep_00000397987

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


10,14-dimethoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,14,16-pentaene

化学式: C19H21NO3 (311.1521)
中文名称: 蒂巴因
谱图信息: 最多检出来源 Homo sapiens(plant) 7.95%

分子结构信息

SMILES: CN1CCC23C4C(=CC=C2C1CC5=C3C(=C(C=C5)OC)O4)OC
InChI: InChI=1S/C19H21NO3/c1-20-9-8-19-12-5-7-15(22-3)18(19)23-17-14(21-2)6-4-11(16(17)19)10-13(12)20/h4-7,13,18H,8-10H2,1-3H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist > C1657 - Opiate
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
(-)-Thebaine is a minor constituent of opiu

同义名列表

4 个代谢物同义名

10,14-dimethoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,14,16-pentaene; (-)-Thebaine; thebaine; Thebaine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ACE2, CAT, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, FTO, MATK, RPL32, RPS16
Peripheral membrane protein 2 CYP2B6, CYP2E1
Endoplasmic reticulum membrane 8 CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Nucleus 2 FTO, TOP1
cytosol 5 CAT, FTO, MATK, RPL32, RPS16
dendrite 2 DRD2, OPRM1
nucleoplasm 3 FTO, RPS16, TOP1
Cell membrane 5 ACE2, DRD2, OPRD1, OPRM1, SLC38A5
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 4 DRD2, OPRD1, OPRM1, SLC38A5
Golgi apparatus membrane 1 DRD2
Synapse 3 DRD2, OPRM1, RPS16
cell surface 1 ACE2
glutamatergic synapse 1 DRD2
Golgi apparatus 1 OPRM1
Golgi membrane 1 DRD2
mitochondrial inner membrane 1 CYP2E1
presynaptic membrane 2 DRD2, OPRD1
acrosomal vesicle 1 DRD2
endosome 1 OPRM1
plasma membrane 9 ACE2, CYP2C19, CYP2C9, DRD2, FTO, MATK, OPRD1, OPRM1, SLC38A5
synaptic vesicle membrane 2 DRD2, OPRD1
Membrane 11 ACE2, CAT, CYP2A6, CYP2D6, CYP3A4, MATK, OPRD1, OPRM1, RPL32, RPS16, SLC38A5
apical plasma membrane 1 ACE2
axon 2 DRD2, OPRM1
extracellular exosome 4 ACE2, CAT, CPVL, RPS16
endoplasmic reticulum 2 CYP2D6, OPRM1
extracellular space 1 ACE2
mitochondrion 2 CAT, CYP2D6
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 10 CAT, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, FTO
Microsome membrane 6 CYP1A2, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Single-pass type I membrane protein 1 ACE2
Secreted 1 ACE2
extracellular region 2 ACE2, CAT
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 1 CAT
Cell projection, cilium 1 ACE2
ciliary membrane 1 DRD2
dendritic spine 1 DRD2
perikaryon 3 DRD2, OPRM1, TOP1
nucleolus 2 RPS16, TOP1
P-body 1 TOP1
postsynaptic membrane 1 DRD2
Apical cell membrane 1 ACE2
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 ACE2
focal adhesion 2 CAT, RPS16
GABA-ergic synapse 1 DRD2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 DRD2
nuclear speck 1 FTO
neuron projection 2 OPRD1, OPRM1
cilium 2 ACE2, DRD2
Chromosome 1 TOP1
brush border membrane 1 ACE2
Nucleus, nucleolus 2 RPS16, TOP1
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
fibrillar center 1 TOP1
Nucleus, nucleoplasm 1 TOP1
Cell projection, dendrite 1 OPRM1
Nucleus speckle 1 FTO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 ACE2
male germ cell nucleus 1 TOP1
axon terminus 2 DRD2, OPRD1
endocytic vesicle membrane 1 ACE2
endocytic vesicle 1 DRD2
small-subunit processome 1 RPS16
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
ribonucleoprotein complex 2 RPL32, RPS16
cytoplasmic microtubule 1 CYP2A6
protein-DNA complex 1 TOP1
dopaminergic synapse 1 DRD2
dendrite membrane 1 OPRD1
cytosolic ribosome 2 RPL32, RPS16
ribosome 2 RPL32, RPS16
catalase complex 1 CAT
cytosolic large ribosomal subunit 1 RPL32
cytosolic small ribosomal subunit 1 RPS16
G protein-coupled receptor complex 1 DRD2
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
small ribosomal subunit 1 RPS16
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

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