Verapamil (BioDeep_00000229723)
Main id: BioDeep_00000001523
human metabolite Volatile Flavor Compounds
代谢物信息卡片
Verapamil
化学式: C27H38N2O4 (454.2831428)
中文名称: 维拉帕米
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08D - Selective calcium channel blockers with direct cardiac effects > C08DA - Phenylalkylamine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 674
EAWAG_UCHEM_ID 674; CONFIDENCE standard compound
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:77733
- ChEBI: CHEBI:9948
- KEGG: C07188
- PubChem: 2520
- HMDB: HMDB01850
- DrugBank: DB00661
- ChEMBL: CHEMBL6966
- MeSH: Verapamil
- CAS: 56949-77-0
- CAS: 52-53-9
- MoNA: EA067403
- MoNA: EA067412
- MoNA: EA067402
- MoNA: EA067414
- MoNA: EA067404
- MoNA: EA067407
- MoNA: EA067401
- MoNA: EA067410
- MoNA: EA067408
- MoNA: EA067405
- MoNA: EA067413
- MoNA: EA067406
- MoNA: EA067411
- MoNA: EA067409
- PubChem: 9397
- NIKKAJI: J4.132G
- RefMet: Verapamil
- KNApSAcK: 77733
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emrah Gün, Mahmut Çiçek, Mustafa Kafalı, Hüsnü Demir, İlknur Arslan, Tanıl Kendirli. Use of Intravenous Lipid Emulsion Therapy and Insulin in a Case of Tarka Intoxication.
WMJ : official publication of the State Medical Society of Wisconsin.
2024 May; 123(2):144-146. doi:
". [PMID: 38718248] - Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Abuzer Ali. Calcium Channel Inhibitory Effect of Marjoram (Origanum majorana L.): Its Medicinal Use in Diarrhea and Gut Hyperactivity.
Frontiers in bioscience (Landmark edition).
2024 Feb; 29(2):47. doi:
10.31083/j.fbl2902047. [PMID: 38420828] - Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad. Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies.
Frontiers in bioscience (Landmark edition).
2024 Jan; 29(1):43. doi:
10.31083/j.fbl2901043. [PMID: 38287835] - Rana Abutaima, Yousef Al-Ebini, Ahmad Alkofahi, Anas Alshishani, Samar Thiab, Kumarappan C Alagammai, Mohammad Khalid. In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics.
The Journal of pharmacy and pharmacology.
2024 Jan; 76(1):57-63. doi:
10.1093/jpp/rgad110. [PMID: 37978932] - Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis.
Drugs in R&D.
2023 Aug; ?(?):. doi:
10.1007/s40268-023-00435-5. [PMID: 37556093] - Anam Ali, Fatima Saqib. Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques.
Journal of ethnopharmacology.
2023 Jun; 317(?):116696. doi:
10.1016/j.jep.2023.116696. [PMID: 37315649] - Jing Wen, Jian-Wu Zhang, Yuan-Xia Lyu, Hui Zhang, Kai-Xi Deng, Hong-Xue Chen, Ying Wei. Ethanol Extract of Glycyrrhiza uralensis Fisch: Antidiarrheal Activity in Mice and Contraction Effect in Isolated Rabbit Jejunum.
Chinese journal of integrative medicine.
2023 Apr; 29(4):325-332. doi:
10.1007/s11655-022-3536-5. [PMID: 35997860] - Deeba Bashir, Taous Khan, Taseer Ahmad, Abdul Jabbar Shah. Antidiarrheal, antisecretory and intestinal smooth muscle relaxant effects of Platanus orientalis in mice.
Pakistan journal of pharmaceutical sciences.
2023 Jan; 36(1):17-22. doi:
. [PMID: 36967492] - Ayitila Maimaitijiang, Bianlin Wang, Hequn Yang, Dan Tang, Yongqiang Liu, Haji Akber Aisa. Discovery of a novel highly potent and low-toxic jatrophane derivative enhancing the P-glycoprotein-mediated doxorubicin sensitivity of MCF-7/ADR cells.
European journal of medicinal chemistry.
2022 Dec; 244(?):114822. doi:
10.1016/j.ejmech.2022.114822. [PMID: 36242992] - Bin Bao, Yonglin Zhao, Huan Gong, Songshan Shi, Huijun Wang, Shunchun Wang. Quantification of Paeoniflorin by Fully Validated LC-MS/MS Method: Its Application to Pharmacokinetic Interaction between Paeoniflorin and Verapamil.
Molecules (Basel, Switzerland).
2022 Nov; 27(23):. doi:
10.3390/molecules27238337. [PMID: 36500431] - Abdul Waheed Khan, Zain Ul Abidin, Muhammad Umar Khayam Sahibzada, Muhammad Faheem, Neelam Gul Qazi, Mahboob Alam, Irfan Ullah, Jalal Uddin, Ajmal Khan, Ahmed Al-Harrasi. Potential biomedical applications of Araucaria araucana as an antispasmodic, bronchodilator, vasodilator, and antiemetic: Involvement of calcium channels.
Journal of ethnopharmacology.
2022 Nov; 298(?):115651. doi:
10.1016/j.jep.2022.115651. [PMID: 35998784] - Yuntong Lv, Jianyi Li, Kunpeng Yan, Yaping Ding, Xiwu Gao, Rui Bi, Hang Zhang, Yiou Pan, Qingli Shang. Functional characterization of ABC transporters mediates multiple neonicotinoid resistance in a field population of Aphis gossypii Glover.
Pesticide biochemistry and physiology.
2022 Nov; 188(?):105264. doi:
10.1016/j.pestbp.2022.105264. [PMID: 36464369] - Cristina Duarte Silva, Cátia Ramalhete, Gabriella Spengler, Silva Mulhovo, Joseph Molnar, Maria-José U Ferreira. Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells.
Phytochemistry.
2022 Nov; 203(?):113354. doi:
10.1016/j.phytochem.2022.113354. [PMID: 35940427] - Lei Liu, Bo Hong, Jiang-Wen Wei, Yi-Ting Wu, Li-Wen Song, Sen-Shan Wang. Transcriptional response and functional analysis of ATP-binding cassette transporters to tannic acid in pea aphid, Acyrthosiphon pisum (Harris).
International journal of biological macromolecules.
2022 Nov; 220(?):250-257. doi:
10.1016/j.ijbiomac.2022.08.091. [PMID: 35981673] - Yuntong Lv, Kunpeng Yan, Xiwu Gao, Xuewei Chen, Jianyi Li, Yaping Ding, Hang Zhang, Yiou Pan, Qingli Shang. Functional Inquiry into ATP-Binding Cassette Transporter Genes Contributing to Spirotetramat Resistance in Aphis gossypii Glover.
Journal of agricultural and food chemistry.
2022 Oct; 70(41):13132-13142. doi:
10.1021/acs.jafc.2c04263. [PMID: 36194468] - Yogeeta O Agrawal, Muzammil Husain, Kiran D Patil, Vishal Sodgir, Tulshidas S Patil, Vinit V Agnihotri, Hitendra S Mahajan, Charu Sharma, Shreesh Ojha, Sameer N Goyal. Verapamil hydrochloride loaded solid lipid nanoparticles: Preparation, optimization, characterisation, and assessment of cardioprotective effect in experimental model of myocardial infarcted rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113429. doi:
10.1016/j.biopha.2022.113429. [PMID: 36007280] - Yoshiharu Mimata, Shintaro Munemasa, Fahmida Akter, Israt Jahan, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshiyuki Murata. Malate induces stomatal closure via a receptor-like kinase GHR1- and reactive oxygen species-dependent pathway in Arabidopsis thaliana.
Bioscience, biotechnology, and biochemistry.
2022 Sep; 86(10):1362-1367. doi:
10.1093/bbb/zbac122. [PMID: 35867880] - Neelum Gul Qazi, Arif-Ullah Khan, Sumra Wajid Abbasi, Fawad Ali Shah, Faisal Rasheed, Fawad Ali, Syed Shams Ul Hassan, Simona Bungau. Pharmacological Basis of Rumex hastatus D. Don in Gastrointestinal Diseases with Focusing Effects on H+/K+-ATPase, Calcium Channels Inhibition and PDE Mediated Signaling: Toxicological Evaluation on Vital Organs.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185919. [PMID: 36144661] - Esmaeil Behmard, Ebrahim Barzegari, Sohrab Najafipour, Amin Kouhpayeh, Younes Ghasemi, Ali A Asadi-Pooya. Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations.
Scientific reports.
2022 08; 12(1):13674. doi:
10.1038/s41598-022-17994-3. [PMID: 35953704] - Naveed Muhammad, Shafiq Ur Rahman, Hilal Uddin, Omer Shehzad, Muhammad Ismail, Niaz Ali, Aslam Khan, Muhammad Shahid, Abid Ullah, Shujaat Ahmad, Haya Hussain, Ikram Ul Haq, Sara Vitalini, Marcello Iriti. Antidiarrheal and antispasmodic activities of Trillium govanianum rhizomes extract: involvement of calcium channel blockade.
Natural product research.
2022 Aug; 36(16):4238-4242. doi:
10.1080/14786419.2021.1973463. [PMID: 34652246] - Emma R Rengasamy, Sarah A Long, Sophie C Rees, Sioned Davies, Torsten Hildebrandt, Emily Payne. Impact of COVID-19 lockdown: Domestic and child abuse in Bridgend.
Child abuse & neglect.
2022 Aug; 130(Pt 1):105386. doi:
10.1016/j.chiabu.2021.105386. [PMID: 34789382] - Mouqadus-Un -Nisa, Imran Imran, M Khalid Khan, Amna Shabih, Hassan Ali, Ali M Alqahtani, Taha Alqahtani, Barkat Ali Khan. Pharmacological effects (gastrointestinal, respiratory and vascular) of Calligonum polygonoides: Animal model based studies.
Pakistan journal of pharmaceutical sciences.
2022 Jul; 35(4(Special)):1201-1208. doi:
. [PMID: 36218098] - Waleed Albalat, Sara Nabil, Fathia Khattab. Assessment of various intralesional injections in keloid: comparative analysis.
The Journal of dermatological treatment.
2022 Jun; 33(4):2051-2056. doi:
10.1080/09546634.2021.1914307. [PMID: 33849382] - Mikael Wallman, Jens Markus Borghardt, Eric Martel, Nicolas Pairet, Michael Markert, Mats Jirstrand. An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds.
Journal of pharmacological and toxicological methods.
2022 May; 115(?):107171. doi:
10.1016/j.vascn.2022.107171. [PMID: 35398273] - Xiaodan Wu, He Gong, Xiaorong Hu, Peipei Shi, Haipeng Cen, Chenchen Li. Effect of verapamil on bone mass, microstructure and mechanical properties in type 2 diabetes mellitus rats.
BMC musculoskeletal disorders.
2022 Apr; 23(1):363. doi:
10.1186/s12891-022-05294-w. [PMID: 35436905] - Guanlan Xu, Tiffany D Grimes, Truman B Grayson, Junqin Chen, Lance A Thielen, Hubert M Tse, Peng Li, Matt Kanke, Tai-Tu Lin, Athena A Schepmoes, Adam C Swensen, Vladislav A Petyuk, Fernando Ovalle, Praveen Sethupathy, Wei-Jun Qian, Anath Shalev. Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes.
Nature communications.
2022 03; 13(1):1159. doi:
10.1038/s41467-022-28826-3. [PMID: 35241690] - S R Vaibavi, Manoj Sivasubramaniapandian, Rahul Vaippully, Privita Edwina, Basudev Roy, Saumendra Kumar Bajpai. Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells.
Cell biochemistry and biophysics.
2022 Mar; 80(1):171-190. doi:
10.1007/s12013-021-01035-3. [PMID: 34643835] - P Lido, D Romanello, M Tesauro, A Bei, M A Perrone, D Palazzetti, A Noce, L Di Lullo, L Calò, G Cice. Verapamil: prevention and treatment of cardio-renal syndromes in diabetic hypertensive patients?.
European review for medical and pharmacological sciences.
2022 Mar; 26(5):1524-1534. doi:
10.26355/eurrev_202203_28217. [PMID: 35302215] - Taizong Wu, Angela A Salim, Hui Cui, Zeinab G Khalil, Paul V Bernhardt, Robert J Capon. Glenthenamines A-F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived Streptomyces sp. CMB-PB042.
Journal of natural products.
2022 02; 85(2):337-344. doi:
10.1021/acs.jnatprod.1c00821. [PMID: 35073486] - Jordan Williams, Vishal Siramshetty, Ðắc-Trung Nguyễn, Elias Carvalho Padilha, Md Kabir, Kyeong-Ri Yu, Amy Q Wang, Tongan Zhao, Misha Itkin, Paul Shinn, Ewy A Mathé, Xin Xu, Pranav Shah. Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.
Bioorganic & medicinal chemistry.
2022 02; 56(?):116588. doi:
10.1016/j.bmc.2021.116588. [PMID: 35030421] - Li Che, Guangshu Chen, Xingdong Cai, Zhefan Xie, Tingting Xia, Wei Zhang, Shengming Liu. Bioinformatics Approach Predicts Candidate Targets for SARS-CoV-2 Infections to COPD Patients.
BioMed research international.
2022; 2022(?):1806427. doi:
10.1155/2022/1806427. [PMID: 35747501] - Rabia Bibi, Umme Salma, Kashif Bashir, Taous Khan, Abdul Jabbar Shah. Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.
Arquivos brasileiros de cardiologia.
2021 12; 117(6):1093-1103. doi:
10.36660/abc.20200055. [PMID: 35613166] - Allison Jo Boyer, Rachael Erin Ketcham, Clint Allen Hostetler, Jeffrey Paul Orlowski, Ronald A Squires. Performance of Renal Allografts Perfused With Verapamil-Treated Perfusion Solution.
Progress in transplantation (Aliso Viejo, Calif.).
2021 12; 31(4):373-380. doi:
10.1177/15269248211045999. [PMID: 34713753] - Lara García-Varela, David Vállez García, Pablo Aguiar, Takeharu Kakiuchi, Hiroyuki Ohba, Norihiro Harada, Shingo Nishiyama, Tetsuro Tago, Philip H Elsinga, Hideo Tsukada, Nicola A Colabufo, Rudi A J O Dierckx, Aren van Waarde, Jun Toyohara, Ronald Boellaard, Gert Luurtsema. Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function.
European journal of nuclear medicine and molecular imaging.
2021 12; 48(13):4307-4317. doi:
10.1007/s00259-021-05411-2. [PMID: 34117508] - Haihua Shang, Ze Wang, Hong Ma, Yinghui Sun, Xiaoyan Ci, Yuan Gu, Changxiao Liu, Duanyun Si. Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism.
Pharmaceutical biology.
2021 Dec; 59(1):200-208. doi:
10.1080/13880209.2021.1871634. [PMID: 33595422] - Jian-Lin Lai, Yuan-E Lian, Jun-Yi Wu, Yao-Dong Wang, Yan-Nan Bai. Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice.
Adipocyte.
2021 12; 10(1):532-545. doi:
10.1080/21623945.2021.1983241. [PMID: 34699301] - Yi Song, Feng Guo, Yanyan Zhao, Lin Zhao, Xunjie Fan, Yuanyuan Zhang, Yanling Liu, Guijun Qin. Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney.
European journal of pharmacology.
2021 Nov; 911(?):174552. doi:
10.1016/j.ejphar.2021.174552. [PMID: 34627808] - Laura Burattini, Agnese Sbrollini, Laura Scinocca, Chiara Peroni, Ilaria Marcantoni, Micaela Morettini. Electrocardiogram-based index for the assessment of drug-induced hERG potassium channel block.
Journal of electrocardiology.
2021 Nov; 69S(?):55-60. doi:
10.1016/j.jelectrocard.2021.10.005. [PMID: 34736759] - Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats.
Toxicology letters.
2021 Nov; 352(?):46-53. doi:
10.1016/j.toxlet.2021.09.010. [PMID: 34600097] - Shuo Yuan, Bo Wang, Qing-Qing Dai, Xiao-Nan Zhang, Jing-Ya Zhang, Jia-Hui Zuo, Hui Liu, Zhe-Sheng Chen, Guo-Bo Li, Shaomeng Wang, Hong-Min Liu, Bin Yu. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.
Journal of medicinal chemistry.
2021 10; 64(19):14895-14911. doi:
10.1021/acs.jmedchem.1c01452. [PMID: 34546748] - Poulami Gupta, Bratati De. Influence of calcium channel modulators on the production of serotonin, gentisic acid, and a few other biosynthetically related phenolic metabolites in seedling leaves of salt tolerant rice variety Nonabokra.
Plant signaling & behavior.
2021 10; 16(10):1929732. doi:
10.1080/15592324.2021.1929732. [PMID: 34024248] - Ana Ferreira, Márcio Rodrigues, Sara Meirinho, Ana Fortuna, Amílcar Falcão, Gilberto Alves. Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.
Drug and chemical toxicology.
2021 Sep; 44(5):458-469. doi:
10.1080/01480545.2019.1601736. [PMID: 31020859] - Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Gang Cai, Fengyu She, Lulu Wei, Shaohui Wang, Jie Yu, Dingyan Wang, Laurent Calcul, Xingmin Sun, Xiaomin Luo, Feng Cheng, Qi Li, Yan Wang, Jianfeng Cai. Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR.
Journal of medicinal chemistry.
2021 08; 64(15):11219-11228. doi:
10.1021/acs.jmedchem.1c00607. [PMID: 34297567] - Xingxing Liu, Xueyun Duan, Heng Fan, Hongfei Wang, Xionggang Jiang, Ying Fang, Qing Tang, Jun Xiao, Qian Li. 8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker.
Journal of ethnopharmacology.
2021 Aug; 276(?):114168. doi:
10.1016/j.jep.2021.114168. [PMID: 33932511] - Ying-Chao Duan, Lin-Feng Jin, Hong-Mei Ren, Shao-Jie Zhang, Yue-Jiao Liu, Yong-Tao Xu, Zi-Hao He, Yu Song, Hang Yuan, Shu-Hui Chen, Yuan-Yuan Guan. Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.
European journal of medicinal chemistry.
2021 Aug; 220(?):113453. doi:
10.1016/j.ejmech.2021.113453. [PMID: 33957387] - Flavia Storelli, Olena Anoshchenko, Jashvant D Unadkat. Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach.
Clinical pharmacology and therapeutics.
2021 08; 110(2):432-442. doi:
10.1002/cpt.2227. [PMID: 33675056] - Anna Palko-Łabuz, Maria Błaszczyk, Kamila Środa-Pomianek, Olga Wesołowska. Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter.
Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
10.3390/molecules26154637. [PMID: 34361789] - Mohamed Hefnawy, Abdulrhman Al-Majed, Haitham Alrabiah, Nasser Algrain, Mostafa Mohammed, Yousef Bin Jardan. Rapid and sensitive LC-MS/MS method for the enantioanalysis of verapamil in rat plasma using superficially porous silica isopropyl-cyclofructan 6 chiral stationary phase after SPE: Application to a stereoselective pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2021 Jul; 201(?):114108. doi:
10.1016/j.jpba.2021.114108. [PMID: 33962179] - Sanja Mutić, Danka Radanović, Milan Vraneš, Slobodan GadŽurić, Jasmina Anojčić. Electroanalytical performance of a β-cyclodextrin and ionic liquid modified carbon paste electrode for the determination of verapamil in urine and pharmaceutical formulation.
Analytical methods : advancing methods and applications.
2021 07; 13(26):2963-2973. doi:
10.1039/d1ay00358e. [PMID: 34110333] - Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Chu. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111552. doi:
10.1016/j.biopha.2021.111552. [PMID: 33839495] - Mohamed Salem, Al-Aliaa M Sallam, Eman Abdel-Aleem, Hala O El-Mesallamy. Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin in Hypertensive Diabetic Patients with Nephropathy: A Randomized Trial.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2021 Jul; 53(7):470-477. doi:
10.1055/a-1517-6643. [PMID: 34282598] - Shayan Taheri, Farshid Davoodi, Abbas Raisi, Amir Zakian, Asghar Rajabzadeh, Mohammad Hassan Hablolvarid, Abdolrahman Khezri, Hassan Ahmadvand. Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats.
Andrologia.
2021 Jul; 53(6):e14049. doi:
10.1111/and.14049. [PMID: 33733509] - Annelies Noorlander, Sebastiaan Wesseling, Ivonne M C M Rietjens, Bennard van Ravenzwaay. Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat.
Toxicology letters.
2021 Jun; 343(?):34-43. doi:
10.1016/j.toxlet.2021.02.013. [PMID: 33639197] - E Huyghe, J P Graziana, C Methorst, N Morel Journel, J E Terrier, F Marcelli, F X Madec, R Yiou, W Akakpo, V Hupertan, D Carnicelli, S Beley, L Ferretti, A Faix. [Recommendations of the Committee of Andrology and Sexual Medicine of the AFU concerning the management of andrological and sexual medicine pathologies during the COVID-19 crisis].
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.
2021 Jun; 31(8-9):495-502. doi:
10.1016/j.purol.2020.08.001. [PMID: 33941462] - Qianqian Qiu, Feng Zou, Huilan Li, Wei Shi, Daoguang Zhou, Ping Zhang, Teng Li, Ziyu Yin, Zilong Cai, Yuxuan Jiang, Wenlong Huang, Hai Qian. Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.
Journal of medicinal chemistry.
2021 05; 64(9):6179-6197. doi:
10.1021/acs.jmedchem.1c00246. [PMID: 33938746] - Sara T Elazab, Walter H Hsu. Effects of verapamil on the pharmacokinetics of ivermectin in rabbits.
Journal of veterinary pharmacology and therapeutics.
2021 May; 44(3):397-405. doi:
10.1111/jvp.12919. [PMID: 33070345] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Takahiro Konuma, Kotaro Ogawa, Yukinori Okada. Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates.
Human molecular genetics.
2021 04; 30(3-4):294-304. doi:
10.1093/hmg/ddab049. [PMID: 33577681] - Bridget L Morse, John K Fallon, Anil Kolur, Andrew T Hogan, Philip C Smith, Kathleen M Hillgren. Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity.
The AAPS journal.
2021 04; 23(3):58. doi:
10.1208/s12248-021-00583-z. [PMID: 33903987] - Hana Sklenářová, Michaela Rosecká, Burkhard Horstkotte, Petr Pávek, Manuel Miró, Petr Solich. 3D printed permeation module to monitor interaction of cell membrane transporters with exogenic compounds in real-time.
Analytica chimica acta.
2021 Apr; 1153(?):338296. doi:
10.1016/j.aca.2021.338296. [PMID: 33714442] - Mostafa S Mohammed, Mohamed M Hefnawy, Abdulrhman A Al-Majed, Haitham K Alrabiah, Nasser A Algrain, Ahmad J Obaidullah, Abdulmalik S Altamimi, Yousef A Bin Jardan, Abdullah M Al-Hossaini. Development and Validation of a Chiral Liquid Chromatographic Assay for Enantiomeric Separation and Quantification of Verapamil in Rat Plasma: Stereoselective Pharmacokinetic Application.
Molecules (Basel, Switzerland).
2021 Apr; 26(7):. doi:
10.3390/molecules26072091. [PMID: 33917412] - Jing Zhao, Dongdong Li, Jun Ma, Huiquan Yang, Wenbin Chen, Yuyu Cao, Peidang Liu. Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma.
Nanotechnology.
2021 Apr; 32(14):145102. doi:
10.1088/1361-6528/abd20a. [PMID: 33296880] - Shuangjiao Sun, Yanfen Wei, Hao Wang, Lifu Tang, Biyang Deng. Determination of Verapamil Hydrochloride and Norverapamil Hydrochloride in Rat Plasma by Capillary Electrophoresis With End-Column Electrochemiluminescence Detection and Their Pharmacokinetics Study.
Journal of chromatographic science.
2021 Feb; 59(3):289-296. doi:
10.1093/chromsci/bmaa098. [PMID: 33333557] - Hai-Jun Gao, Xu-Dong Sun, Yan-Ping Luo, Hua-Sheng Pang, Xing-Ming Ma, Ting Zhang, Tao Jing, Wei Hu, Yu-Juan Shen, Jian-Ping Cao. Anti-echinococcal effect of verapamil involving the regulation of the calcium/calmodulin-dependent protein kinase II response in vitro and in a murine infection model.
Parasites & vectors.
2021 Feb; 14(1):108. doi:
10.1186/s13071-021-04618-4. [PMID: 33588933] - Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li. The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Feb; 51(2):239-248. doi:
10.1080/00498254.2017.1359433. [PMID: 28745128] - Lara García-Varela, David Vállez García, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Tetsuro Tago, Philip H Elsinga, Hideo Tsukada, Nicola A Colabufo, Rudi A J O Dierckx, Aren van Waarde, Jun Toyohara, Ronald Boellaard, Gert Luurtsema. Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates.
Molecular pharmaceutics.
2021 01; 18(1):416-428. doi:
10.1021/acs.molpharmaceut.0c01014. [PMID: 33315404] - Jerónimo Laiolo, Cecilia L Barbieri, Mariana B Joray, Priscila A Lanza, Sara M Palacios, D Mariano A Vera, María C Carpinella. Plant extracts and betulin from Ligaria cuneifolia inhibit P-glycoprotein function in leukemia cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jan; 147(?):111922. doi:
10.1016/j.fct.2020.111922. [PMID: 33321149] - Riku Arai, Daisuke Fukamachi, Masaki Monden, Naotaka Akutsu, Nobuhiro Murata, Yasuo Okumura. Bradycardia Shock Caused by the Combined Use of Carteolol Eye Drops and Verapamil in an Elderly Patient with Atrial Fibrillation and Chronic Kidney Disease.
Internal medicine (Tokyo, Japan).
2021 Jan; 60(1):79-83. doi:
10.2169/internalmedicine.5598-20. [PMID: 32830185] - Noemi Esteras, Franziska Kundel, Giuseppe F Amodeo, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase.
The FEBS journal.
2021 01; 288(1):127-141. doi:
10.1111/febs.15340. [PMID: 32338825] - Bruna A C Rattis, Ana C Freitas, Jordana F Oliveira, João L A Calandrini-Lima, Maria J Figueiredo, Danilo F Soave, Simone G Ramos, Mara R N Celes. Effect of Verapamil, an L-Type Calcium Channel Inhibitor, on Caveolin-3 Expression in Septic Mouse Hearts.
Oxidative medicine and cellular longevity.
2021; 2021(?):6667074. doi:
10.1155/2021/6667074. [PMID: 33927797] - Thomas L Hunt, Evan Tzanis, Stephen Bai, Amy Manley, Surya Chitra, Paul C McGovern. The Effect of Verapamil, a P-gp Inhibitor, on the Pharmacokinetics, Safety, and Tolerability of Omadacycline in Healthy Adults: A Phase I, Open-Label, Single-Sequence Study.
European journal of drug metabolism and pharmacokinetics.
2021 Jan; 46(1):85-92. doi:
10.1007/s13318-020-00651-3. [PMID: 33180250] - Ana P Costa, Michael H Court, Nicolas F Villarino, Neal S Burke, Katrina L Mealey. Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding.
Journal of veterinary pharmacology and therapeutics.
2021 Jan; 44(1):116-125. doi:
10.1111/jvp.12899. [PMID: 32744755] - Hua Xing, Xiao Luo, Yang Li, Chunni Fan, Ning Liu, Chunguo Cui, Wenjia Li. Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism.
Pharmaceutical biology.
2020 Dec; 58(1):152-156. doi:
10.1080/13880209.2020.1717550. [PMID: 31990625] - Sabrina T Wiebe, Thomas Giessmann, Kathrin Hohl, Sven Schmidt-Gerets, Edith Hauel, Alen Jambrecina, Kerstin Bader, Naoki Ishiguro, Mitchell E Taub, Ashish Sharma, Thomas Ebner, Gerd Mikus, Martin F Fromm, Fabian Müller, Peter Stopfer. Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Clinical pharmacokinetics.
2020 12; 59(12):1627-1639. doi:
10.1007/s40262-020-00907-w. [PMID: 32504272] - Nicholas Gau, Brenda J Grossman. Therapeutic plasma exchange for iatrogenic hypertrigylceridemia.
Transfusion.
2020 12; 60(12):2785-2786. doi:
10.1111/trf.16016. [PMID: 32870503] - Linfeng Sun, Xiaoding Lin, Sakorn Pornprasert, Xiaomei Lü, Bing Ran, Yan Lin. L-type calcium channel blockers decrease the iron overload-mediated oxidative stress in renal epithelial cells by reducing iron accumulation.
European journal of pharmacology.
2020 Nov; 886(?):173513. doi:
10.1016/j.ejphar.2020.173513. [PMID: 32898550] - H E Abo Mansour, M M El-Batsh, N S Badawy, E T Mehanna, N M Mesbah, D M Abo-Elmatty. Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
Human & experimental toxicology.
2020 Nov; 39(11):1528-1544. doi:
10.1177/0960327120930266. [PMID: 32519553] - Ahmet Tektemur, Ebru Etem Önalan, Nalan Kaya Tektemur, İbrahim Halil Güngör, Gaffari Türk, Tuncay Kuloğlu. Verapamil-induced ion channel and miRNA expression changes in rat testis and/or spermatozoa may be associated with male infertility.
Andrologia.
2020 Nov; 52(10):e13778. doi:
10.1111/and.13778. [PMID: 32725937] - Denis B Tikhonov, Lianyun Lin, Daniel S C Yang, Zhiguang Yuchi, Boris S Zhorov. Phenylalkylamines in calcium channels: computational analysis of experimental structures.
Journal of computer-aided molecular design.
2020 11; 34(11):1157-1169. doi:
10.1007/s10822-020-00330-0. [PMID: 32648151] - Geoffrey Strobbe, Diane Pannier, Ilyes Sakji, Alexandre Villain, Frédéric Feutry, Guillaume Marliot. Advantages of everolimus therapeutic drug monitoring in oncology when drug-drug interaction is suspected: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2020 Oct; 26(7):1743-1749. doi:
10.1177/1078155220904761. [PMID: 32070198] - Ratih Ratih, Hermann Wätzig, Matthias Stein, Sami El Deeb. Investigation of the enantioselective interaction between selected drug enantiomers and human serum albumin by mobility shift-affinity capillary electrophoresis.
Journal of separation science.
2020 Oct; 43(20):3960-3968. doi:
10.1002/jssc.202000372. [PMID: 32823373] - Kuan-Fu Chen, Lingtak-Neander Chan, Yvonne S Lin. PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Journal of pharmacokinetics and pharmacodynamics.
2020 10; 47(5):493-512. doi:
10.1007/s10928-020-09701-4. [PMID: 32710209] - Yuzhou Gui, Youli Lu, Shuijun Li, Mengqi Zhang, Xiaokun Duan, Charles C Liu, Jingying Jia, Gangyi Liu. Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring.
Scientific reports.
2020 09; 10(1):15550. doi:
10.1038/s41598-020-72490-w. [PMID: 32968164] - Saskia Floerl, Annett Kuehne, Yohannes Hagos. Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186871. [PMID: 32961667] - Dmitry Sychev, Karin Mirzaev, Marina Cherniaeva, Maria Kulikova, Pavel Bochkov, Roman Shevchenko, Svetlana Gorbatenkova, Olga Golovina, Olga Ostroumova, Damirya Bahteeva, Eric Rytkin. Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.
Drug metabolism and personalized therapy.
2020 09; 35(3):. doi:
10.1515/dmpt-2020-0127. [PMID: 32975202] - Sara Gómez-Enjuto, Virgilio Hernando-Requejo, José Lapeña-Motilva, Gonzalo Ogando-Durán, Daniel Fouz-Ruiz, Julio Domingo-García, Elena Rodríguez-García, Carlos Alberto Cemillán-Fernández. Verapamil as treatment for refractory status epilepticus secondary to PRES syndrome on a SARS-Cov-2 infected patient.
Seizure.
2020 08; 80(?):157-158. doi:
10.1016/j.seizure.2020.06.008. [PMID: 32574838] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004. [PMID: 32690433] - Maria Ilyas-Feldmann, Marie-Claude Asselin, Shaonan Wang, Adam McMahon, José Anton-Rodriguez, Gavin Brown, Rainer Hinz, John S Duncan, Sanjay M Sisodiya, Matthias Koepp. P-glycoprotein overactivity in epileptogenic developmental lesions measured in vivo using (R)-[11 C]verapamil PET.
Epilepsia.
2020 07; 61(7):1472-1480. doi:
10.1111/epi.16581. [PMID: 32627849] - Maria M Posada, Bridget L Morse, P Kellie Turner, Palaniappan Kulanthaivel, Stephen D Hall, Gemma L Dickinson. Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Journal of clinical pharmacology.
2020 07; 60(7):915-930. doi:
10.1002/jcph.1584. [PMID: 32080863] - Mailys De Sousa Mendes, Oliver Hatley, Katherine Linda Gill, Karen Rowland Yeo, Alice Ban Ke. A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Jul; 150(?):105355. doi:
10.1016/j.ejps.2020.105355. [PMID: 32438273] - Y F Tan, H X Ma, B Zhao, H R Zhang. [Therapeutic effects of target artery infusion of verapamil and chemotherapy drugs on advanced non-small cell lung cancer].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2020 Jun; 42(6):486-490. doi:
10.3760/cma.j.cn112152-20190724-00461. [PMID: 32575945] - Xiaoyang Li, Richard A Himes, Lyndsey C Prosser, Charleston F Christie, Emma Watt, Sharon F Edwards, Cameron S Metcalf, Peter J West, Karen S Wilcox, Sherine S L Chan, C James Chou. Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.
Journal of medicinal chemistry.
2020 06; 63(11):5865-5878. doi:
10.1021/acs.jmedchem.0c00168. [PMID: 32390424] - Hongping Yao, Changhe Wang, Wen Lu, Wen Li, Wanghui Jing, Jiye Zhang, Guangde Yang, Aiguo Zeng. Comparative pharmacokinetics of verapamil and norverapamil in normal and ulcerative colitis rats after oral administration of low and high dose verapamil by UPLC-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Jun; 50(6):713-721. doi:
10.1080/00498254.2019.1682715. [PMID: 31633443] - Luke B Allen, Thiago C Genaro-Mattos, Allison Anderson, Ned A Porter, Károly Mirnics, Zeljka Korade. Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24.
ACS chemical neuroscience.
2020 05; 11(10):1413-1423. doi:
10.1021/acschemneuro.0c00042. [PMID: 32286791] - Phuong Pham, Stephan Schmidt, Lawrence Lesko, Gregory Y H Lip, Joshua D Brown. Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.
JAMA network open.
2020 04; 3(4):e203593. doi:
10.1001/jamanetworkopen.2020.3593. [PMID: 32329770] - Im-Sook Song, Hyeon-Uk Jeong, Min-Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim, Hye-Suk Lee. Interactions between cyazofamid and human drug transporters.
Journal of biochemical and molecular toxicology.
2020 Apr; 34(4):e22459. doi:
10.1002/jbt.22459. [PMID: 32003934] - Neha Agrawal, Jennifer Rowe, Jie Lan, Qigui Yu, Christine A Hrycyna, Jean Chmielewski. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity.
Journal of medicinal chemistry.
2020 03; 63(5):2131-2138. doi:
10.1021/acs.jmedchem.9b00779. [PMID: 31505928] - Fahad Aftab Khan Lodhi, Sophie L Shogren, Jayanth G Vedre, Najiya Haque, Martin Reriani, Rashid Ali. Calcium Channel Blocker Toxicity Causing Acute Respiratory Distress Syndrome: A Commonly Used Drug Triggering a Life-Threatening Condition.
WMJ : official publication of the State Medical Society of Wisconsin.
2020 Mar; 119(1):66-68. doi:
NULL. [PMID: 32348076] - - Mouqadus-Un-Nisa, Imran Imran. Pharmacological studies pertaining to spasmolytic, bronchodilator and vasodilating effect of Typha domingensis: An evidence-based approach.
Pakistan journal of pharmaceutical sciences.
2020 Mar; 33(2(Supplementary)):827-834. doi:
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