BRODIFACOUM (BioDeep_00000002120)
代谢物信息卡片
BRODIFACOUM
化学式: C31H23BrO3 (522.0830468)
中文名称: 溴鼠灵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(CC2=CC=CC=C2C1C3=C(C4=CC=CC=C4OC3=O)O)C5=CC=C(C=C5)C6=CC=C(C=C6)Br
InChI: InChI=1S/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2
描述信息
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
D010575 - Pesticides > D012378 - Rodenticides
D016573 - Agrochemicals
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:81892
- KEGG: C18694
- PubChem: 54680676
- Metlin: METLIN72472
- ChEMBL: CHEMBL233451
- CAS: 56073-10-0
- CAS: 80449-88-3
- PMhub: MS000001876
- PubChem: 124489368
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bernd Walther, Anke Geduhn, Detlef Schenke, Jens Jacob. Exposure of passerine birds to brodifacoum during management of Norway rats on farms.
The Science of the total environment.
2021 Mar; 762(?):144160. doi:
10.1016/j.scitotenv.2020.144160. [PMID: 33373750] - Federica Foti, Simona Sica, Eleonora Alma, Raimondo De Cristofaro, Nadia Mores, Giuseppe Vetrugno. Sudden nasal bleeding and brodifacoum: A case of accidental exposure or attempted homicide?.
Legal medicine (Tokyo, Japan).
2020 Nov; 47(?):101772. doi:
10.1016/j.legalmed.2020.101772. [PMID: 32771937] - Douglas L Feinstein, Daniel G Nosal, Swetha Ramanathan, Jifang Zhou, Luying Chen, Ronald C Hershow, Richard B van Breemen, Erik Wright, John W Hafner, Israel Rubinstein. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids.
Clinical toxicology (Philadelphia, Pa.).
2020 07; 58(7):716-724. doi:
10.1080/15563650.2019.1687903. [PMID: 31736367] - Kristin Opdal Seljetun, Vigdis Vindenes, Elisabeth Leere Øiestad, Gerd-Wenche Brochmann, Elin Eliassen, Lars Moe. Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population.
Acta veterinaria Scandinavica.
2020 Jun; 62(1):30. doi:
10.1186/s13028-020-00531-5. [PMID: 32546243] - Daniel G Nosal, Douglas L Feinstein, Luying Chen, Richard B van Breemen. Separation and Quantification of Superwarfarin Rodenticide Diastereomers-Bromadiolone, Difenacoum, Flocoumafen, Brodifacoum, and Difethialone-in Human Plasma.
Journal of AOAC International.
2020 Jun; 103(3):770-778. doi:
10.1093/jaoacint/qsaa007. [PMID: 33241367] - Barnett A Rattner, Steven F Volker, Julia S Lankton, Thomas G Bean, Rebecca S Lazarus, Katherine E Horak. Brodifacoum Toxicity in American Kestrels (Falco sparverius) with Evidence of Increased Hazard on Subsequent Anticoagulant Rodenticide Exposure.
Environmental toxicology and chemistry.
2020 02; 39(2):468-481. doi:
10.1002/etc.4629. [PMID: 31707739] - Christopher H Ross, Parvinder Singh, Erin L Simon. Hemorrhagic Soft Tissue Upper Airway Obstruction From Brodifacoum-Contaminated Synthetic Cannabinoid.
The Journal of emergency medicine.
2019 Jul; 57(1):47-50. doi:
10.1016/j.jemermed.2019.03.007. [PMID: 31078349] - Weronika Micula-Gondek, Vanessa Ruales, Colleen Zorn, Andrew Angelino. Synthetic Cannabinoid-Associated Coagulopathy: Case Report.
Psychosomatics.
2019 Mar; 60(2):211-215. doi:
10.1016/j.psym.2018.05.010. [PMID: 30104022] - Israel Rubinstein, Richard van Breemen, Daniel G Nosal, Guy Weinberg, Ronald C Hershow, Douglas L Feinstein. Should Cytochrome P450 Inducers be Used to Accelerate Clearance of Brodifacoum from Poisoned Patients?.
Drugs in R&D.
2019 Mar; 19(1):67-71. doi:
10.1007/s40268-019-0261-4. [PMID: 30689138] - Amar H Kelkar, Nichole A Smith, Annia Martial, Harsha Moole, Michael D Tarantino, Jonathan C Roberts. An Outbreak of Synthetic Cannabinoid-Associated Coagulopathy in Illinois.
The New England journal of medicine.
2018 09; 379(13):1216-1223. doi:
10.1056/nejmoa1807652. [PMID: 30280655] - Alan B Franklin, Peter C Carlson, Angela Rex, Jeremy T Rockweit, David Garza, Emily Culhane, Steven F Volker, Robert J Dusek, Valerie I Shearn-Bochsler, Mourad W Gabriel, Katherine E Horak. Grass is not always greener: rodenticide exposure of a threatened species near marijuana growing operations.
BMC research notes.
2018 Feb; 11(1):94. doi:
10.1186/s13104-018-3206-z. [PMID: 29391058] - H Yan, X Y Zhuo, B H Shen, P Xiang, M Shen. [Evaluation of Brodifacoum-induced Toxicity by Metabonomics Approach Based on HPLC-TOF-MS].
Fa yi xue za zhi.
2017 Jun; 33(3):247-251. doi:
10.3969/j.issn.1004-5619.2017.03.007. [PMID: 29230988] - Hui Yan, Zheng Qiao, Baohua Shen, Ping Xiang, Min Shen. Plasma metabolic profiling analysis of toxicity induced by brodifacoum using metabonomics coupled with multivariate data analysis.
Forensic science international.
2016 Oct; 267(?):129-135. doi:
10.1016/j.forsciint.2016.08.027. [PMID: 27598867] - Nursel Gül, Nuri Yiğit, Fulya Saygılı, Ebru Demirel, Ceren Geniş. Comparison of the effects of difenacoum and brodifacoum on the ultrastructure of rat liver cells.
Arhiv za higijenu rada i toksikologiju.
2016 Sep; 67(3):204-209. doi:
10.1515/aiht-2016-67-2783. [PMID: 27749259] - Zane Z Hauck, Douglas L Feinstein, Richard B van Breemen. LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue.
Journal of analytical toxicology.
2016 May; 40(4):304-9. doi:
10.1093/jat/bkw008. [PMID: 26912564] - Garrett S Booth, Perceus Z Mody. Brodifacoum Inhalation and its Clinical Manifestations in a 21-Year-Old Caucasian Man.
Laboratory medicine.
2016 Feb; 47(1):63-6. doi:
10.1093/labmed/lmv008. [PMID: 26715613] - Yuchen Wang, Viktoriya Kotik, Germin Fahim, Sayee Alagusundaramoorthy, Sherif Ali Eltawansy, Scott Mathis, Julie Saleh. Treatment of brodifacoum overdose with prothrombin complex concentrate.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2016 Jan; 73(1):e14-7. doi:
10.2146/ajhp150233. [PMID: 26683673] - Leonel A Londoño, Andrew J Specht, Dan J VanderHart, Carsten Bandt. What Is Your Diagnosis? Gastric wall hemorrhage secondary to anticoagulant rodenticide intoxication.
Journal of the American Veterinary Medical Association.
2015 Aug; 247(3):243-5. doi:
10.2460/javma.247.3.243. [PMID: 26176721] - Kyle M Ware, Douglas L Feinstein, Israel Rubinstein, Guy Weinberg, Brad H Rovin, Lee Hebert, Navin Muni, Rachel E Cianciolo, Anjali A Satoskar, Tibor Nadasdy, Sergey V Brodsky. Brodifacoum induces early hemoglobinuria and late hematuria in rats: novel rapid biomarkers of poisoning.
American journal of nephrology.
2015; 41(4-5):392-9. doi:
10.1159/000433568. [PMID: 26111556] - Anke Geduhn, Jens Jacob, Detlef Schenke, Barbara Keller, Sven Kleinschmidt, Alexandra Esther. Relation between Intensity of Biocide Practice and Residues of Anticoagulant Rodenticides in Red Foxes (Vulpes vulpes).
PloS one.
2015; 10(9):e0139191. doi:
10.1371/journal.pone.0139191. [PMID: 26418154] - Anke Geduhn, Alexandra Esther, Detlef Schenke, Hermann Mattes, Jens Jacob. Spatial and temporal exposure patterns in non-target small mammals during brodifacoum rat control.
The Science of the total environment.
2014 Oct; 496(?):328-338. doi:
10.1016/j.scitotenv.2014.07.049. [PMID: 25087064] - Hee-Jeong Lee, Mi-Ra You, Woo-Ram Moon, Hyoung Sul, Choon-Hae Chung, Chi-Young Park, Sang-Gon Park. Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum.
The Korean journal of internal medicine.
2014 Jul; 29(4):498-508. doi:
10.3904/kjim.2014.29.4.498. [PMID: 25045298] - Elizabeth L Underwood, JoLeigh Sutton, Ira Keith Ellis, Brian Qualls, Jon Zamber, Brian N Walker. Prolonged coagulopathy after brodifacoum exposure.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2014 Apr; 71(8):639-42. doi:
10.2146/ajhp130537. [PMID: 24688037] - David Franco, George Everett, Manoucher Manoucheri. I smell a rat: a case report and literature review of paradoxical thrombosis and hemorrhage in a patient with brodifacoum toxicity.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2013 Mar; 24(2):202-4. doi:
10.1097/mbc.0b013e328358e959. [PMID: 23358203] - Servet Altay, Huseyin Altug Cakmak, Gulsah Cemiloglu Boz, Sinan Koca, Yalcin Velibey. Prolonged coagulopathy related to coumarin rodenticide in a young patient: superwarfarin poisoning.
Cardiovascular journal of Africa.
2012 Oct; 23(9):e9-e11. doi:
10.5830/cvja-2012-051. [PMID: 23108575] - Jason Reese, Timothy Tausch, Megan Barnwell, Andrew C Peterson, Maryanne McDonald. Spontaneous bilateral renal pelvis thrombus formation presenting as anuric acute renal failure.
Clinical nephrology.
2012 Oct; 78(4):312-5. doi:
10.5414/cn107127. [PMID: 22981032] - Vernon M Pais. In a well presented report of bilateral renal pelvic thrombus formation with subsequent bilateral ureteral obstruction. Introduction.
Clinical nephrology.
2012 Oct; 78(4):253. doi:
NULL. [PMID: 23115797] - Zhao-hui Fu, Quan-kai Wang, Wen-lan Yu, Jian Wang, An-na Wang, Jian-ning Xu. [Determination of brodifacoum in rat plasma by HPLC].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2012 Feb; 30(2):135-6. doi:
NULL. [PMID: 22808549] - Robert A Middleberg, Joseph Homan. Qualitative identification of rodenticide anticoagulants by LC-MS/MS.
Methods in molecular biology (Clifton, N.J.).
2012; 902(?):139-48. doi:
10.1007/978-1-61779-934-1_12. [PMID: 22767114] - A Ozcan, K Ware, E Calomeni, T Nadasdy, R Forbes, A A Satoskar, G Nadasdy, B H Rovin, L A Hebert, S V Brodsky. 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy.
American journal of nephrology.
2012; 35(4):356-64. doi:
10.1159/000337918. [PMID: 22473220] - Kyle Ware, Polina Brodsky, Anjali A Satoskar, Tibor Nadasdy, Gyongyi Nadasdy, Haifeng Wu, Brad H Rovin, Udayan Bhatt, Jon Von Visger, Lee A Hebert, Sergey V Brodsky. Warfarin-related nephropathy modeled by nephron reduction and excessive anticoagulation.
Journal of the American Society of Nephrology : JASN.
2011 Oct; 22(10):1856-62. doi:
10.1681/asn.2010101110. [PMID: 21885669] - Jae-chul Jung, Hyung-in Moon. Larvicidal activity of 4-hydroxycoumarin derivatives against Aedes aegypti.
Pharmaceutical biology.
2011 Feb; 49(2):190-3. doi:
10.3109/13880209.2010.507769. [PMID: 21043993] - Hu Nie, Wei Wei, Yu Cao, Xiao-Dong Du. Superwarfarin poisoning as a cause of intestinal obstruction.
Clinical toxicology (Philadelphia, Pa.).
2010 Mar; 48(3):238-9. doi:
10.3109/15563650903555302. [PMID: 20141426] - Isabelle Fourel, Christophe Hugnet, Isabelle Goy-Thollot, Philippe Berny. Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products.
Journal of analytical toxicology.
2010 Mar; 34(2):95-102. doi:
10.1093/jat/34.2.95. [PMID: 20223102] - So Young Kim, Sun Young Cho, Hee Joo Lee, Jin-Tae Suh, Seung Hwan Oh, Woo-In Lee, Tae Sung Park, Hwi-Joong Yoon. Superwarfarin intoxication of unknown etiology accompanying hemoperitoneum in a patient on fluconazole therapy.
Annals of clinical and laboratory science.
2010; 40(3):300-3. doi:
. [PMID: 20689146] - Yun-Qing Duan, Huan-Gui Lei, Shun-Geng Min, Zhi-Qing Duan. [Spectroscopic study on interaction of rodenticide brodifacoum with bovine serum albumin].
Guang pu xue yu guang pu fen xi = Guang pu.
2009 Nov; 29(11):2998-3002. doi:
. [PMID: 20101972] - Yi-Feng Wu, Cheng-Shyong Chang, Chih-Yuan Chung, Hsuan-Yu Lin, Chuan-Cheng Wang, Ming-Ching Shen. Superwarfarin intoxication: hematuria is a major clinical manifestation.
International journal of hematology.
2009 Sep; 90(2):170-173. doi:
10.1007/s12185-009-0374-6. [PMID: 19588218] - Mohammad Tahir, Muhammad F Khan, Kamal Tourbaf. Impending compartment syndrome and hemothorax after brodifacoum ingestion.
Southern medical journal.
2008 Dec; 101(12):1277. doi:
10.1097/smj.0b013e3181887566. [PMID: 19005444] - V Vandenbroucke, A Bousquet-Melou, P De Backer, S Croubels. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration.
Journal of veterinary pharmacology and therapeutics.
2008 Oct; 31(5):437-45. doi:
10.1111/j.1365-2885.2008.00979.x. [PMID: 19000263] - Virginie Vandenbroucke, Noël Desmet, Patrick De Backer, Siska Croubels. Multi-residue analysis of eight anticoagulant rodenticides in animal plasma and liver using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jun; 869(1-2):101-10. doi:
10.1016/j.jchromb.2008.05.011. [PMID: 18502701] - Pragna Kapadia, Robert Bona. Acquired deficiency of vitamin K-dependent clotting factors due to brodifacoum ingestion.
Connecticut medicine.
2008 Apr; 72(4):207-9. doi:
. [PMID: 18478986] - Panagiotis Kotsaftis, Fotios Girtovitis, Afroditi Boutou, George Ntaios, Pantelis E Makris. Haemarthrosis after superwarfarin poisoning.
European journal of haematology.
2007 Sep; 79(3):255-7. doi:
10.1111/j.1600-0609.2007.00904.x. [PMID: 17655702] - Kurt M Bohren, Kenneth H Gabbay, David Owerbach. Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.
Protein expression and purification.
2007 Aug; 54(2):289-94. doi:
10.1016/j.pep.2007.03.013. [PMID: 17459725] - Joseph E Spahr, J Scott Maul, George M Rodgers. Superwarfarin poisoning: a report of two cases and review of the literature.
American journal of hematology.
2007 Jul; 82(7):656-60. doi:
10.1002/ajh.20784. [PMID: 17022046] - Hossam Ebaid, Mohamed A Dkhil, Mohamed A Danfour, Amany Tohamy, Mohamed S Gabry. Piroxicam-induced hepatic and renal histopathological changes in mice.
The Libyan journal of medicine.
2007 Jun; 2(2):82-9. doi:
10.4176/070130. [PMID: 21503258] - Valentina Olmos, Clara Magdalena López. Brodifacoum poisoning with toxicokinetic data.
Clinical toxicology (Philadelphia, Pa.).
2007 Jun; 45(5):487-9. doi:
10.1080/15563650701354093. [PMID: 17503253] - Awad A F El-Bahrawy, Martina G Vijver, Geert R De Snoo. Threats and control of the brown necked ravens (Corvus ruficollis) in Egypt.
Communications in agricultural and applied biological sciences.
2007; 72(2):221-32. doi:
". [PMID: 18399444] - Elizabeth K Dolin, Damon L Baker, Steven C Buck. A 44-year-old woman with hematemesis and cutaneous hemorrhages as a result of superwarfarin poisoning.
The Journal of the American Osteopathic Association.
2006 May; 106(5):280-4. doi:
. [PMID: 16717370] - Zaher A Radi, Larry J Thompson. Renal subcapsular hematoma associated with brodifacoum toxicosis in a dog.
Veterinary and human toxicology.
2004 Apr; 46(2):83-4. doi:
. [PMID: 15080210] - Ben T Tsutaoka, Michael Miller, Stacey M Fung, Manish M Patel, Kent R Olson. Superwarfarin and glass ingestion with prolonged coagulopathy requiring high-dose vitamin K1 therapy.
Pharmacotherapy.
2003 Sep; 23(9):1186-9. doi:
10.1592/phco.23.10.1186.32755. [PMID: 14524650] - David Michael Wood, Paul Ivor Dargan, Alison Linda Jones. Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units.
Critical care (London, England).
2003 Apr; 7(2):147-54. doi:
10.1186/cc1880. [PMID: 12720561] - Mirjana Huić, Igor Francetić, Ivan Bakran, Viola Macolić-Sarinić, Marinko Bilusić. Acquired coagulopathy due to anticoagulant rodenticide poisoning.
Croatian medical journal.
2002 Oct; 43(5):615-7. doi:
NULL. [PMID: 12402407] - J Walker, F X M Beach. Deliberate self-poisoning with rodenticide: a diagnostic dilemma.
International journal of clinical practice.
2002 Apr; 56(3):223-4. doi:
NULL. [PMID: 12018832] - Charles T Eason, Elaine C Murphy, Geoffrey R G Wright, Eric B Spurr. Assessment of risks of brodifacoum to non-target birds and mammals in New Zealand.
Ecotoxicology (London, England).
2002 Feb; 11(1):35-48. doi:
10.1023/a:1013793029831. [PMID: 11898799] - G R Bruno, M A Howland, A McMeeking, R S Hoffman. Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing.
Annals of emergency medicine.
2000 Sep; 36(3):262-7. doi:
10.1067/mem.2000.108317. [PMID: 10969235] - S Emre, K Kitabayashi, C M Miller. Successful liver transplantation from a donor with brodifacoum intoxication.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
1999 Nov; 5(6):509-11. doi:
10.1002/lt.500050610. [PMID: 10545539] - D L Ornstein, K E Lord, N N Yanofsky, C J Cornell, L R Zacharski. Successful donation and transplantation of multiple organs after fatal poisoning with brodifacoum, a long-acting anticoagulant rodenticide: case report.
Transplantation.
1999 Feb; 67(3):475-8. doi:
10.1097/00007890-199902150-00022. [PMID: 10030297] - S L Padgett, J E Stokes, R L Tucker, L G Wheaton. Hematometra secondary to anticoagulant rodenticide toxicity.
Journal of the American Animal Hospital Association.
1998 Sep; 34(5):437-9. doi:
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Journal of the American Veterinary Medical Association.
1997 Oct; 211(7):882-6. doi:
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Southern medical journal.
1997 Oct; 90(10):1053-5. doi:
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Biochimica et biophysica acta.
1997 Feb; 1334(1):44-50. doi:
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The American journal of emergency medicine.
1996 Nov; 14(7):656-9. doi:
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Forensic science international.
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Journal of analytical toxicology.
1995 Nov; 19(7):557-62. doi:
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Journal of analytical toxicology.
1995 Nov; 19(7):576-80. doi:
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Archives of internal medicine.
1993 Aug; 153(16):1925-8. doi:
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The American journal of pediatric hematology/oncology.
1993 Feb; 15(1):126-30. doi:
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Annals of emergency medicine.
1992 Mar; 21(3):331-6. doi:
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Archives of internal medicine.
1992 Feb; 152(2):410-2. doi:
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Journal of veterinary internal medicine.
1992 Jan; 6(1):23-8. doi:
10.1111/j.1939-1676.1992.tb00981.x. [PMID: 1548622] - S M O'Bryan, D J Constable. Quantification of brodifacoum in plasma and liver tissue by HPLC.
Journal of analytical toxicology.
1991 May; 15(3):144-7. doi:
10.1093/jat/15.3.144. [PMID: 1943058] - H J Boermans, I Johnstone, W D Black, M Murphy. Clinical signs, laboratory changes and toxicokinetics of brodifacoum in the horse.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
1991 Jan; 55(1):21-7. doi:
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American journal of hematology.
1991 Jan; 36(1):50-4. doi:
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Blood.
1990 Dec; 76(12):2555-9. doi:
NULL. [PMID: 2265249] - R G Watts, R P Castleberry, J A Sadowski. Accidental poisoning with a superwarfarin compound (brodifacoum) in a child.
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