Flupentixol (BioDeep_00000001984)
代谢物信息卡片
cis-(Z)-Flupenthixol
化学式: C23H25F3N2OS (434.164)
中文名称: 三氟噻吨, 氟哌噻吨
谱图信息:
最多检出来源 Mentha canadensis(plant) 50%
分子结构信息
SMILES: C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO
InChI: InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5+
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AF - Thioxanthene derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
同义名列表
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:93235
- ChEBI: CHEBI:10454
- KEGG: C11191
- KEGGdrug: D01044
- PubChem: 5281878
- PubChem: 5281881
- PubChem: 17012
- Metlin: METLIN68905
- DrugBank: DB00875
- ChEMBL: CHEMBL42055
- ChEMBL: CHEMBL54661
- MeSH: Flupenthixol
- CAS: 53772-85-3
- CAS: 2709-56-0
- CAS: 53772-82-0
- MoNA: WA002117
- MoNA: WA002116
- MoNA: WA002115
- MoNA: WA002114
- PMhub: MS000001596
- PubChem: 13372
- NIKKAJI: J10.870G
- KNApSAcK: 10454
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ragnhild Birkeland Waade, Vigdis Solhaug, Gudrun Høiseth. Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol.
British journal of clinical pharmacology.
2021 05; 87(5):2228-2235. doi:
10.1111/bcp.14626. [PMID: 33118660] - D Yu Sanzhieva, I P Remezova. [Analysis of the flupenthixol distribution in the internal organs of laboratory animals for the diagnosis of acute poisoning].
Sudebno-meditsinskaia ekspertiza.
2021; 64(4):60-63. doi:
10.17116/sudmed20216404160. [PMID: 34264583] - Loren Bailey, David Taylor. Estimating the optimal dose of flupentixol decanoate in the maintenance treatment of schizophrenia-a systematic review of the literature.
Psychopharmacology.
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10.1007/s00213-019-05311-2. [PMID: 31300829] - Tanja Veselinović, Martin Scharpenberg, Martin Heinze, Joachim Cordes, Bernd Mühlbauer, Georg Juckel, Eckart Rüther, Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Jürgen Timm, Gerhard Gründer. Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
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10.1097/jcp.0000000000001131. [PMID: 31688449] - Xenija Wagner, Michael Kluge. Abrupt Decrease of Clozapine Plasma Concentration After Discontinuation of Flupentixol Comedication.
Journal of clinical psychopharmacology.
2019 Mar; 39(2):168-169. doi:
10.1097/jcp.0000000000001013. [PMID: 30811373] - Dilek Yonar, M Maral Sunnetcioglu. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol.
Chemistry and physics of lipids.
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