Ticlopidine (BioDeep_00000001972)

 

Secondary id: BioDeep_00000406041

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine

化学式: C14H14ClNS (263.0535434)
中文名称: 噻氯匹啶
谱图信息: 最多检出来源 Ailuropoda melanoleuca(urine) 8.33%

分子结构信息

SMILES: c1ccc(c(c1)CN1CCc2c(ccs2)C1)Cl
InChI: InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2

描述信息

Ticlopidine is an effective inhibitor of platelet aggregation. The drug has been found to significantly reduce infarction size in acute myocardial infarcts and is an effective antithrombotic agent in arteriovenous fistulas, aorto-coronary bypass grafts, ischemic heart disease, venous thrombosis, and arteriosclerosis. [PubChem]
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065689 - Cytochrome P-450 CYP2C19 Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent > C190801 - P2Y12 Inhibitor
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3029
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents

同义名列表

13 个代谢物同义名

5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine; Almirall brand OF ticlopidine hydrochloride; Vitoria brand OF ticlopidine hydrochloride; Roche brand OF ticlopidine hydrochloride; Hydrochloride, ticlopidine; Ticlopidine Hydrochloride; Ticlopidin-puren; Ticlopidinum; ticlopidine; Ticlopidina; Ticlodone; Ticlodix; Ticlid



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yongkang Zhang, Qingzhi Ran, Kangli Yin, Yinkai Wang, Jiarui Liu, Yuan Zong, Yuzhen Wang, Yemin Cao. The effects of CYP2C19 genotype polymorphism and clopidogrel resistance on ischemic event occurrence in patients with peripheral arterial disease undergoing revascularization: A prospective cohort study. Thrombosis research. 2024 Apr; 236(?):37-50. doi: 10.1016/j.thromres.2024.02.010. [PMID: 38387302]
  • Hongwei Li, Yizhen Fang, Yongquan Chen, Yuning Lin, Zanxi Fang, Zhiyuan Lin, Huabin Xie, Zhongying Zhang. A novel AllGlo probe-quantitative PCR method for detecting single nucleotide polymorphism in CYP2C19 to evaluate the antiplatelet activity of clopidogrel. Scientific reports. 2024 01; 14(1):2358. doi: 10.1038/s41598-024-52540-3. [PMID: 38286794]
  • Yongkang Zhang, Yuan Zong, Jiarui Liu, Kangli Yin, Yuzhen Wang, Yuefeng Bian, Yichen Huang, Wei Liu, Yemin Cao. Clopidogrel-Related High Residual Platelet Reactivity Associated with Estimated Glomerular Filtration Rate in Patients with Acute Ischemic Stroke. Cerebrovascular diseases extra. 2023; 13(1):83-89. doi: 10.1159/000534466. [PMID: 37812922]
  • Jiyi Li, Jin Yang, Qinglin Yu, Lian Chen, Xiliang Shi, Jia Su, Keqi Zhu. The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance. Journal of clinical laboratory analysis. 2022 Oct; 36(10):e24690. doi: 10.1002/jcla.24690. [PMID: 36087301]
  • Yuichi Saito, Takeshi Nishi, Shinichi Wakabayashi, Yuji Ohno, Hideki Kitahara, Noritaka Ariyoshi, Yoshio Kobayashi. Differential Impact of Clinical and Genetic Factors on High Platelet Reactivity in Patients with Coronary Artery Disease Treated with Clopidogrel and Prasugrel. Journal of atherosclerosis and thrombosis. 2022 Jul; 29(7):1031-1039. doi: 10.5551/jat.63035. [PMID: 34234079]
  • D-L Wang, X Li, R-N Wang, Y Sun, X-S Xia, W-J Tian, L Wang. A study of microRNA-223 in evaluating platelet reactivity in patients with acute ischemic stroke. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2022 Feb; 73(1):. doi: 10.26402/jpp.2022.1.11. [PMID: 35793763]
  • Yan-Ling Liu, Xiao-Lei Hu, Pei-Yuan Song, He Li, Mu-Peng Li, Yin-Xiao Du, Mo-Yun Li, Qi-Lin Ma, Li-Ming Peng, Ming-Yu Song, Xiao-Ping Chen. Influence of GAS5/MicroRNA-223-3p/P2Y12 Axis on Clopidogrel Response in Coronary Artery Disease. Journal of the American Heart Association. 2021 11; 10(21):e021129. doi: 10.1161/jaha.121.021129. [PMID: 34713722]
  • Levent Altınay, Erdem Çetin. The comparison between the effects of aspirin and clopidogrel monotherapy on postoperative bleeding in diabetic patients after off-pump coronary artery bypass surgery. Reviews in cardiovascular medicine. 2021 Sep; 22(3):975-981. doi: 10.31083/j.rcm2203106. [PMID: 34565098]
  • Ying-Chao Duan, Lin-Feng Jin, Hong-Mei Ren, Shao-Jie Zhang, Yue-Jiao Liu, Yong-Tao Xu, Zi-Hao He, Yu Song, Hang Yuan, Shu-Hui Chen, Yuan-Yuan Guan. Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer. European journal of medicinal chemistry. 2021 Aug; 220(?):113453. doi: 10.1016/j.ejmech.2021.113453. [PMID: 33957387]
  • Imran Mohamed, Mohamad Fathul Aizat Kamarizan, Antonio Da Silva. Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts. The Cochrane database of systematic reviews. 2021 07; 7(?):CD002786. doi: 10.1002/14651858.cd002786.pub4. [PMID: 34298589]
  • Yicong Ye, Xiliang Zhao, Yong Zeng. Serum Free Triiodothyronine and the Responsiveness to Clopidogrel in Patients Undergoing Elective Percutaneous Coronary Intervention. Advances in therapy. 2021 06; 38(6):3077-3088. doi: 10.1007/s12325-021-01749-z. [PMID: 33913121]
  • Qing Li, Yinong Chen, Ying Liu, Luyao Yu, Jingang Zheng, Yihong Sun. Impact of renal function on residual platelet reactivity and clinical outcomes in patients with acute coronary syndrome treated with clopidogrel. Clinical cardiology. 2021 Jun; 44(6):789-796. doi: 10.1002/clc.23588. [PMID: 33978269]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Urszula Adamiak-Giera, Anna Czerkawska, Szymon Olędzki, Mateusz Kurzawski, Krzysztof Safranow, Maria Jastrzębska, Barbara Gawrońska-Szklarz. Impact of selected genetic factors on clopidogrel inactive metabolite level and antiplatelet response in patients after percutaneous coronary intervention. Pharmacological reports : PR. 2021 Apr; 73(2):583-593. doi: 10.1007/s43440-020-00197-w. [PMID: 33270185]
  • L Song, D Y Xu, P Zhou, C Liu, Z X Sheng, J N Li, J Y Zhou, R Z Chen, Y Chen, H J Zhao, H B Yan. [The variation of serum uric acid levels among patients with myocardial infarction treated with ticagrelor and the association between serum uric acid and platelet reactivity]. Zhonghua xin xue guan bing za zhi. 2021 Feb; 49(2):170-175. doi: 10.3760/cma.j.cn112148-20200509-00383. [PMID: 33611904]
  • Monica Verdoia, Patrizia Pergolini, Matteo Nardin, Roberta Rolla, Federica Negro, Rocco Gioscia, Nicolai Fierro, Arraa Maddalena Saghir Afifeh, Filippo Viglione, Harry Suryapranata, Giuseppe De Luca. Gender Differences in Platelet Reactivity in Diabetic Patients Receiving Dual Antiplatelet Therapy. Cardiovascular revascularization medicine : including molecular interventions. 2020 09; 21(9):1144-1149. doi: 10.1016/j.carrev.2020.02.007. [PMID: 32085942]
  • S Casey Laizure, Zhe-Yi Hu, Philip M Potter, Robert B Parker. Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Mar; 50(3):245-251. doi: 10.1080/00498254.2019.1612535. [PMID: 31039046]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • N V Lomakin, L I Buryachkovskaya, A B Sumarokov, Z A Gabbasov, A N Gerasimov. [Relation of Functional Activity of Platelets to Prognosis of Unfavorable Cardiovascular Events in Patients with Acute Coronary Syndrome. Results of a Registry Study]. Kardiologiia. 2019 Oct; 59(10):5-13. doi: 10.18087/cardio.2019.10.n678. [PMID: 31615383]
  • Zheng-Wei Chen, Cho-Kai Wu, Yao-Hsu Yang, Jenq-Wen Huang, Vin-Cent Wu, Jen-Kuang Lee, Pau-Chung Chen, Yen-Hung Lin, Lian-Yu Lin. Efficacy of Antiplatelet Agent Usage for Primary and Secondary Prevention in Dialysis Patients: a Nationwide Data Survey and Propensity Analysis. Cardiovascular drugs and therapy. 2019 08; 33(4):471-479. doi: 10.1007/s10557-019-06882-0. [PMID: 31069576]
  • Yun Wang, Michael B Nichol, Bryan Py Yan, Joanne Wu, Brian Tomlinson, Vivian Wy Lee. Descriptive analysis of real-world medication use pattern of statins and antiplatelet agents among patients with acute coronary syndrome in Hong Kong and the USA. BMJ open. 2019 07; 9(7):e024937. doi: 10.1136/bmjopen-2018-024937. [PMID: 31315855]
  • Gianni Belcaro, Mark Dugall, Hugh D Bradford, Maria R Cesarone, Beatrice Feragalli, Corrado Gizzi, Roberto Cotellese, Shu Hu, Patrizia Rodriguez, Morio Hosoi. Recurrent retinal vein thrombosis: prevention with Aspirin, Pycnogenol®, ticlopidine, or sulodexide. Minerva cardioangiologica. 2019 Apr; 67(2):109-114. doi: 10.23736/s0026-4725.19.04891-6. [PMID: 30964246]
  • Shumaila Afrin, Yusra Rahman, Mohammad Tabish. Elucidating the interaction of ticlopidine with serum albumin and its role in bilirubin displacement in vitro. Journal of biomolecular structure & dynamics. 2019 Mar; 37(4):863-876. doi: 10.1080/07391102.2018.1449667. [PMID: 29513159]
  • Z Wang, L M Xia, K Song, X Y Li, Q Z Lyu, J Q Shen. [Impact of discontinuation of aspirin and clopidogrel before off-pump coronary artery bypass grafting on postoperative bleeding and transfusion requirement]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2019 Mar; 57(3):187-193. doi: 10.3760/cma.j.issn.0529-5815.2019.03.006. [PMID: 30861647]
  • Milan Pavlovic, Svetlana Apostolovic, Dragana Stokanovic, Jelena Lilic, Sandra S Konstantinovic, Jelena B Zvezdanovic, Valentina N Nikolic. The association between clopidogrel and 2-oxo-clopidogrel plasma levels and the long-term clinical outcome after acute myocardial infarction
. International journal of clinical pharmacology and therapeutics. 2019 Feb; 57(2):82-93. doi: 10.5414/cp203190. [PMID: 30431425]
  • Han-Gil Jeong, Jae Sun Yoon, Juneyoung Lee, Hee-Joon Bae. Incidence of neutropenia in patients with ticlopidine/Ginkgo biloba extract combination drug for vascular events: A post-marketing cohort study. PloS one. 2019; 14(6):e0217723. doi: 10.1371/journal.pone.0217723. [PMID: 31166961]
  • Milan Pavlovic, Svetlana Apostolovic, Dragana Stokanovic, Jelena Lilic, Sandra S Konstantinovic, Jelena B Zvezdanovic, Valentina Marinkovic, Valentina N Nikolic. The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40 months clinical outcome after primary PCI. International journal of clinical pharmacy. 2018 Dec; 40(6):1482-1489. doi: 10.1007/s11096-018-0730-9. [PMID: 30367373]
  • Takanari Kitazono, Yasuo Ikeda, Masakatsu Nishikawa, Satoshi Yoshiba, Kenji Abe, Akira Ogawa. Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel. Journal of thrombosis and thrombolysis. 2018 Nov; 46(4):488-495. doi: 10.1007/s11239-018-1714-2. [PMID: 30074128]
  • Hai-Rong Yu, Yue-Yue Wei, Jian-Guo Ma, Xiao-Yong Geng. Beneficial effects of combined administration of Clopidogrel and Aspirin on the levels of proinflammatory cytokines, cardiac function, and prognosis in ST-segment elevation myocardial infarction: A comparative study. Medicine. 2018 Nov; 97(45):e13010. doi: 10.1097/md.0000000000013010. [PMID: 30407292]
  • J J Li, H Q Gu, Y J Peng, X Q Zhao, Y L Wang, X Meng, L P Liu, Y J Wang. [The association of lipid profile and bleeding in patients with minor stroke or transient ischemic attack on antiplatelet therapy: subgroup analysis of CHANCE]. Zhonghua nei ke za zhi. 2018 Oct; 57(10):723-730. doi: 10.3760/cma.j.issn.0578-1426.2018.10.006. [PMID: 30293332]
  • Richard Myles Turner, Vanessa Fontana, Mark Bayliss, Sarah Whalley, Anahi Santoyo Castelazo, Munir Pirmohamed. Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):272-281. doi: 10.1016/j.jpba.2018.06.062. [PMID: 30005242]
  • Chenyu Qian, Xi Luo, Mengbi Yang, Jing Jin, Zhong Zuo. Impaired liver cytochrome P450 2C11 activity after dual antiplatelet therapy with aspirin and clopidogrel in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Sep; 48(9):911-919. doi: 10.1080/00498254.2017.1380242. [PMID: 29052493]
  • Hyeon Ho Lim, Shuhua Li, Gyu Dae An, Kwang Sook Woo, Kyeong Hee Kim, Jeong Man Kim, Moo Hyun Kim, Jin Yeong Han. Platelet Function Analyzer-200 P2Y Results Are Predictive of the Risk of Major Adverse Cardiac Events in Korean Patients Receiving Clopidogrel Therapy Following Acute Coronary Syndrome. Annals of laboratory medicine. 2018 Sep; 38(5):413-419. doi: 10.3343/alm.2018.38.5.413. [PMID: 29797810]
  • Gianni Belcaro, Mark Dugall, Shu Hu, Beatrice Feragalli, Roberto Cotellese, Andrea Ledda, Marcello Corsi, Andrea Ricci, Edmondo Ippolito, Bruno M Errichi, Umberto Cornelli, M Rosaria Cesarone, Morio Hosoi. Prevention of recurrent venous thrombosis and post-thrombotic syndrome. Minerva cardioangiologica. 2018 Jun; 66(3):238-245. doi: 10.23736/s0026-4725.18.04618-2. [PMID: 29795059]
  • Arwa M Amin, Lim Sheau Chin, Chin-Hoe Teh, Hamza Mostafa, Dzul Azri Mohamed Noor, Muhamad Ali S K Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim. Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 May; 117(?):351-361. doi: 10.1016/j.ejps.2018.03.011. [PMID: 29526765]
  • Yan Wu, Hua Yu, Hai-Qin Tang, Yong Su, Tian-Lu Shi, Sheng Liu, Quan Xia, Du-Juan Xu. PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention. Gene. 2018 May; 653(?):22-28. doi: 10.1016/j.gene.2018.02.022. [PMID: 29432831]
  • Gabriele Crimi, Alberto Somaschini, Marco Cattaneo, Dominick J Angiolillo, Federico Piscione, Tullio Palmerini, Stefano De Servi. Cigarette smoking reduces platelet reactivity independently of clopidogrel treatment in patients with non-ST elevation acute coronary syndromes. Platelets. 2018 May; 29(3):309-311. doi: 10.1080/09537104.2017.1394452. [PMID: 29206072]
  • Lining Ju, James D McFadyen, Saheb Al-Daher, Imala Alwis, Yunfeng Chen, Lotte L Tønnesen, Sophie Maiocchi, Brianna Coulter, Anna C Calkin, Eric I Felner, Neale Cohen, Yuping Yuan, Simone M Schoenwaelder, Mark E Cooper, Cheng Zhu, Shaun P Jackson. Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets. Nature communications. 2018 03; 9(1):1087. doi: 10.1038/s41467-018-03430-6. [PMID: 29540687]
  • Lei Zhang, Yi Li, Bai-Song Yang, Lu Li, Xiao-Zeng Wang, Mei-Ling Ge, Quan-Min Jing, Ying-Yan Ma, Geng Wang, Hai-Wei Liu, Xin Zhao, Bin Wang, Kai Xu, Ya-Ling Han. A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study of the Effects of Tongxinluo Capsules in Acute Coronary Syndrome Patients with High On-Treatment Platelet Reactivity. Chinese medical journal. 2018 Mar; 131(5):508-515. doi: 10.4103/0366-6999.226064. [PMID: 29483383]
  • Eun Chae Gong, Satya Chea, Anand Balupuri, Nam Sook Kang, Young-Won Chin, Young Hee Choi. Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030555. [PMID: 29498658]
  • Cai Liu, Youming Lu, Hongbin Sun, Jin Yang, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yongguo Li, Yifan Zhang, Xiaoyan Chen, Dafang Zhong. Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma. Journal of pharmaceutical and biomedical analysis. 2018 Feb; 149(?):394-402. doi: 10.1016/j.jpba.2017.11.019. [PMID: 29154109]
  • Slavenka Straus, Ilirijana Haxhibeqiri-Karabdic, Sanja Granov Grabovica, Nermir Granov. A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting. Medical archives (Sarajevo, Bosnia and Herzegovina). 2018 Feb; 72(1):31-35. doi: 10.5455/medarh.2018.72.31-35. [PMID: 29416215]
  • Helinä Kahma, Anne M Filppula, Mikko Neuvonen, E Katriina Tarkiainen, Aleksi Tornio, Mikko T Holmberg, Matti K Itkonen, Moshe Finel, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions . Drug metabolism and disposition: the biological fate of chemicals. 2018 02; 46(2):141-150. doi: 10.1124/dmd.117.078162. [PMID: 29138287]
  • Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li. Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry. 2018 01; 61(1):224-250. doi: 10.1021/acs.jmedchem.7b01300. [PMID: 29243920]
  • Heyang Wang, Jing Qi, Yi Li, Yunbiao Tang, Chao Li, Jing Li, Yaling Han. Pharmacodynamics and pharmacokinetics of ticagrelor vs. clopidogrel in patients with acute coronary syndromes and chronic kidney disease. British journal of clinical pharmacology. 2018 Jan; 84(1):88-96. doi: 10.1111/bcp.13436. [PMID: 28921624]
  • María Asunción Esteve-Pastor, Juan Miguel Ruíz-Nodar, Esteban Orenes-Piñero, José Miguel Rivera-Caravaca, Miriam Quintana-Giner, Andrea Véliz-Martínez, Antonio Tello-Montoliu, Vicente PerniasEscrig, Miriam Sandín Rollán, Nuria Vicente-Ibarra, Manuel Jesús MacíasVillanego, Elena Candela Sánchez, Luna Carrillo Alemán, Teresa Lozano, Mariano Valdés, Francisco Marín. Temporal Trends in the Use of Antiplatelet Therapy in Patients With Acute Coronary Syndromes. Journal of cardiovascular pharmacology and therapeutics. 2018 Jan; 23(1):57-65. doi: 10.1177/1074248417724869. [PMID: 28789568]
  • Petros Tzimas, Maria Tsoumani, Dimitrios Giannakis, Kallirroi Kalantzi, Anastasios Petrou, Vasileios Chantzichristos, Nikolaos Sofikitis, Georgios Papadopoulos, Haralampos Milionis, Alexandros Tselepis. Clopidogrel Therapy in Patients with Cardiovascular Disease Undergoing Transurethral Resection of the Prostate: A Step Towards Individualization. Drugs & aging. 2017 12; 34(12):917-923. doi: 10.1007/s40266-017-0504-4. [PMID: 29177885]
  • Tanja K Rudolph, Alexander Fuchs, Anna Klinke, Andrea Schlichting, Kai Friedrichs, Martin Hellmich, Martin Mollenhauer, Edzard Schwedhelm, Stephan Baldus, Volker Rudolph. Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial. International journal of cardiology. 2017 Dec; 248(?):7-13. doi: 10.1016/j.ijcard.2017.06.099. [PMID: 28709700]
  • Kenzo Uzu, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Tsuyoshi Osue, Masamichi Iwasaki, Hiroto Kinutani, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-Ichi Hirata, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka. Morphological and pharmacological determinants of peri-procedural myocardial infarction following elective stent implantation: Optical coherence tomography sub-analysis of the PRASFIT-Elective study. Journal of cardiology. 2017 Dec; 70(6):545-552. doi: 10.1016/j.jjcc.2017.05.002. [PMID: 28619235]
  • Vacis Tatarunas, Nora Kupstyte, Agne Giedraitiene, Vilius Skipskis, Valdas Jakstas, Vaidotas Zvikas, Vaiva Lesauskaite. The impact of CYP2C19*2, CYP4F2*3, and clinical factors on platelet aggregation, CYP4F2 enzyme activity, and 20-hydroxyeicosatetraenoic acid concentration in patients treated with dual antiplatelet therapy. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2017 Dec; 28(8):658-664. doi: 10.1097/mbc.0000000000000658. [PMID: 28806186]
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