Felbamate (BioDeep_00000001967)
Secondary id: BioDeep_00000398873
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester
化学式: C11H14N2O4 (238.0953524)
中文名称: 非氨酯
谱图信息:
最多检出来源 Homo sapiens(blood) 0.22%
分子结构信息
SMILES: C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N
InChI: InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)
描述信息
Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites.
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
同义名列表
20 个代谢物同义名
Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester; Carbamate 3-carbamoyloxy-2-phenyl-propyl ester; (3-Carbamoyloxy-2-phenyl-propyl) carbamate; 3-(carbamoyloxy)-2-phenylpropyl carbamate; 2-Phenyl-1,3-propanediol dicarbamic acid; Carbamic acid 2-phenyltrimethylene ester; 2-Phenyl-1,3-propanediol dicarbamate; Carbamate 2-phenyltrimethylene ester; 2 Phenyl 1,3 propanediol dicarbamate; Wallace brand 2 OF felbamate; Wallace brand 1 OF felbamate; Felbamic acid; Felbamatum; felbamate; Felbamato; Felbatol; Felbamyl; Taloxa; W-554; ADD-03055
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:4995
- KEGG: C07501
- KEGGdrug: D00536
- PubChem: 3331
- HMDB: HMDB0015084
- Metlin: METLIN2654
- DrugBank: DB00949
- ChEMBL: CHEMBL1094
- Wikipedia: Felbamate
- MeSH: Felbamate
- chemspider: 3214
- CAS: 25451-15-4
- PMhub: MS000001564
- PubChem: 9704
- NIKKAJI: J50.906J
- RefMet: Felbamate
- medchemexpress: HY-B0184
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(2)
- Felbamate metabolism:
Felbamate ⟶ 3-Hydroxy-2-phenylpropyl carbamate - Felbamate metabolism:
Felbamate ⟶ 3-Hydroxy-2-phenylpropyl carbamate
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Felbamate Metabolism Pathway:
Felbamate + Hydrogen Ion + NADPH + Oxygen ⟶ NADP + Water + p-Hydroxyfelbamate
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Koya Sato, Seigo Sanoh, Yuji Ishida, Chise Tateno, Shigeru Ohta, Yaichiro Kotake. Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays.
The Journal of toxicological sciences.
2022; 47(7):277-288. doi:
10.2131/jts.47.277. [PMID: 35786679] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
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2020 06; 63(11):5865-5878. doi:
10.1021/acs.jmedchem.0c00168. [PMID: 32390424] - Xiuqin Li, Hongze Wang, Qingnian Chen, Zhiqin Li, Chao Liu, Shengnan Yin, Zhengchen You. Felbamate produces antidepressant-like actions in the chronic unpredictable mild stress and chronic social defeat stress models of depression.
Fundamental & clinical pharmacology.
2019 Dec; 33(6):621-633. doi:
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