Aristospan (BioDeep_00000001959)
Secondary id: BioDeep_00001868450
代谢物信息卡片
Triamcinolone hexacetonide
化学式: C30H41FO7 (532.2836)
中文名称: 曲安奈德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)CC(=O)OCC(=O)C12OC(C)(C)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C
InChI: InChI=1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:9670
- KEGG: C08185
- KEGGdrug: D00985
- PubChem: 633091
- PubChem: 21826
- Metlin: METLIN2904
- ChEMBL: CHEMBL1200878
- CAS: 5611-51-8
- PMhub: MS000001548
- PubChem: 10385
- NIKKAJI: J8.026H
- KNApSAcK: 9670
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- José Carlos Nunes-Tamashiro, Jamil Natour, Fernando Maier Ramuth, Sandra Regina Toffolo, Jamile Godoy Mendes, André Rosenfeld, Rita Nely Vilar Furtado. Intra-articular injection with platelet-rich plasma compared to triamcinolone hexacetonide or saline solution in knee osteoarthritis: A double blinded randomized controlled trial with one year follow-up.
Clinical rehabilitation.
2022 Jul; 36(7):900-915. doi:
10.1177/02692155221090407. [PMID: 35379019] - Sergi Coll, Xavier Matabosch, Jone Llorente-Onaindia, Marcel Li Carbó, Clara Pérez-Mañá, Nuria Monfort, Jordi Monfort, Rosa Ventura. Elimination profile of triamcinolone hexacetonide and its metabolites in human urine and plasma after a single intra-articular administration.
Drug testing and analysis.
2019 Nov; 11(11-12):1589-1600. doi:
10.1002/dta.2614. [PMID: 31087549] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Wei Sun, Stacy Ho, Xiaojun Rick Fang, Thomas O'Shea, Hanlan Liu. Simultaneous determination of triamcinolone hexacetonide and triamcinolone acetonide in rabbit plasma using a highly sensitive and selective UPLC-MS/MS method.
Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):267-273. doi:
10.1016/j.jpba.2018.02.052. [PMID: 29550043] - Tomas Weitoft, Johan Rönnelid, Ann Knight, Jörgen Lysholm, Tore Saxne, Anders Larsson. Outcome predictors of intra-articular glucocorticoid treatment for knee synovitis in patients with rheumatoid arthritis - a prospective cohort study.
Arthritis research & therapy.
2014 Jun; 16(3):R129. doi:
10.1186/ar4586. [PMID: 24950951] - H Rintamäki, K Tamm, O Vaarala, M Sidoroff, V Honkanen, T Raivio, Oa Jänne, K-L Kolho. Intra-articular corticoid injection induces circulating glucocorticoid bioactivity and systemic immune activation in juvenile idiopathic arthritis.
Scandinavian journal of rheumatology.
2011; 40(5):347-53. doi:
10.3109/03009742.2011.560893. [PMID: 21619491] - Boris Hugle, Ronald M Laxer. Lipoatrophy resulting from steroid injection into the temporomandibular joint.
Arthritis and rheumatism.
2009 Nov; 60(11):3512. doi:
10.1002/art.24987. [PMID: 19877081] - Kasper Dahl Kristensen, Peter Stoustrup, Annelise Küseler, Thomas Klit Pedersen, Jens Randel Nyengaard, Ellen-Margrethe Hauge, Troels Herlin. Quantitative histological changes of repeated antigen-induced arthritis in the temporomandibular joints of rabbits treated with intra-articular corticosteroid.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2008 Aug; 37(7):437-44. doi:
10.1111/j.1600-0714.2007.00630.x. [PMID: 18266658] - T Weitoft, A Larsson, L Rönnblom. Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis.
Annals of the rheumatic diseases.
2008 Mar; 67(3):422-4. doi:
10.1136/ard.2007.081315. [PMID: 17878211] - Helmut Wittkowski, Dirk Foell, Erik af Klint, Leen De Rycke, Filip De Keyser, Michael Frosch, Ann-Kristin Ulfgren, Johannes Roth. Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis.
Annals of the rheumatic diseases.
2007 Aug; 66(8):1020-5. doi:
10.1136/ard.2006.061507. [PMID: 17223658] - T Weitoft, L Rönnblom. Glucocorticoid resorption and influence on the hypothalamic-pituitary-adrenal axis after intra-articular treatment of the knee in resting and mobile patients.
Annals of the rheumatic diseases.
2006 Jul; 65(7):955-7. doi:
10.1136/ard.2005.041525. [PMID: 16769782] - L Lepore, M Del Santo, C Malorgio, G Presani, S Perticarari, M Prodan, G Di Leo, V Leone, A Tommasini. Treatment of juvenile idiopathic arthritis with intra-articular triamcinolone hexacetonide: evaluation of clinical effectiveness correlated with circulating ANA and T gamma/delta + and B CD5+ lymphocyte populations of synovial fluid.
Clinical and experimental rheumatology.
2002 Sep; 20(5):719-22. doi:
. [PMID: 12412208] - Cristina Meazza, Paola Travaglino, Patrizia Pignatti, Silvia Magni-Manzoni, Angelo Ravelli, Alberto Martini, Fabrizio De Benedetti. Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis.
Arthritis and rheumatism.
2002 Jan; 46(1):232-7. doi:
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Journal of craniofacial genetics and developmental biology.
1995 Apr; 15(2):57-65. doi:
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Annals of the rheumatic diseases.
1992 Jul; 51(7):874-6. doi:
10.1136/ard.51.7.874. [PMID: 1632661] - D J McCarty, G McCarthy, G Carrera. Intraarticular corticosteroids possibly leading to local osteonecrosis and marrow fat induced synovitis.
The Journal of rheumatology.
1991 Jul; 18(7):1091-4. doi:
". [PMID: 1920314] - L A Joosten, M M Helsen, W B van den Berg. Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide.
Agents and actions.
1990 Aug; 31(1-2):135-42. doi:
10.1007/bf02003233. [PMID: 2285019] - A Weiss, E Raz, M Silbermann. Effects of systemic glucocorticoids on the degradation of glycosaminoglycans in the mandibular condylar cartilage of newborn mice.
Bone and mineral.
1986 Sep; 1(4):335-46. doi:
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Archives of internal medicine.
1986 Jun; 146(6):1113-5. doi:
. [PMID: 3718097] - B Kristal, S M Shasha, H Mahmoud, B Stamler. Management of uremic pericarditis.
Israel journal of medical sciences.
1986 Jun; 22(6):442-4. doi:
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The Journal of biological chemistry.
1986 Apr; 261(11):5094-103. doi:
10.1016/s0021-9258(19)89219-0. [PMID: 3957917] - H Derendorf, H Möllmann, A Grüner, D Haack, G Gyselby. Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration.
Clinical pharmacology and therapeutics.
1986 Mar; 39(3):313-7. doi:
10.1038/clpt.1986.45. [PMID: 3948470] - R I Grove, W D Willis, R M Pratt. Inhibition of arachidonic acid metabolism is not involved in dexamethasone-induced growth inhibition in embryonic palatal development.
Prostaglandins, leukotrienes, and medicine.
1985 Jan; 17(1):85-95. doi:
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