Triamcinolone hexacetonide (BioDeep_00001868450)

Main id: BioDeep_00000001959

 


代谢物信息卡片


Triamcinolone hexacetonide

化学式: C30H41FO7 (532.2836)
中文名称: 曲安奈德
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)CC(=O)OCC(=O)[C@@]12[C@@H](C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@]4([C@H](C[C@]13C)O)F)OC(C)(C)O2
InChI: InChI=1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

2 个代谢物同义名

Triamcinolone hexacetonide; Triamcinolone hexacetonide



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, BGLAP, CALCA, MIF, MYC, POMC, VEGFA
Nucleus 5 ACR, ALB, FOS, MYC, VEGFA
cytosol 4 ALB, FOS, IL1B, MIF
dendrite 1 BGLAP
centrosome 1 ALB
nucleoplasm 3 FOS, MIF, MYC
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 3 CD5, TNF, TRB
Multi-pass membrane protein 1 NNT
cell surface 4 MIF, TNF, TRB, VEGFA
Golgi apparatus 2 ALB, VEGFA
mitochondrial inner membrane 1 NNT
neuronal cell body 2 CALCA, TNF
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
plasma membrane 5 CD5, IFNLR1, MIF, TNF, TRB
terminal bouton 1 CALCA
Membrane 6 CD5, IFNLR1, MYC, NNT, TRB, VEGFA
extracellular exosome 3 ALB, COMP, MIF
endoplasmic reticulum 3 ALB, FOS, VEGFA
extracellular space 13 ALB, BGLAP, CALCA, COMP, CRP, CXCL8, IL17A, IL1B, IL6, MIF, POMC, TNF, VEGFA
adherens junction 1 VEGFA
mitochondrion 1 NNT
protein-containing complex 4 ACR, ALB, COMP, MYC
Single-pass type I membrane protein 2 CD5, IFNLR1
Secreted 11 ALB, BGLAP, CALCA, CRP, CXCL8, IL17A, IL1B, IL6, MIF, POMC, VEGFA
extracellular region 14 ACR, ALB, BGLAP, CALCA, COMP, CRP, CXCL8, IL17A, IL1B, IL6, MIF, POMC, TNF, VEGFA
hippocampal mossy fiber to CA3 synapse 1 CALCA
anchoring junction 1 ALB
external side of plasma membrane 3 CD5, IL17A, TNF
Secreted, extracellular space, extracellular matrix 2 COMP, VEGFA
perikaryon 1 BGLAP
nucleolus 1 MYC
Golgi-associated vesicle 1 ACR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 BGLAP, MIF
Mitochondrion inner membrane 1 NNT
Matrix side 1 NNT
Membrane raft 1 TNF
extracellular matrix 2 COMP, VEGFA
collagen-containing extracellular matrix 1 COMP
secretory granule 3 IL1B, POMC, VEGFA
ciliary basal body 1 ALB
chromatin 2 FOS, MYC
phagocytic cup 1 TNF
centriole 1 ALB
Nucleus, nucleolus 1 MYC
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MYC
Nucleus, nucleoplasm 1 MYC
respiratory chain complex 1 NNT
ficolin-1-rich granule lumen 1 MIF
secretory granule lumen 2 MIF, POMC
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 3 ALB, BGLAP, IL6
nuclear matrix 1 FOS
platelet alpha granule lumen 2 ALB, VEGFA
RNA polymerase II transcription repressor complex 1 MYC
Secreted, extracellular exosome 1 IL1B
neuronal dense core vesicle 1 CALCA
protein-DNA complex 1 FOS
Rough endoplasmic reticulum 1 MYC
transcription factor AP-1 complex 1 FOS
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 TRB
alpha-beta T cell receptor complex 1 TRB
interleukin-6 receptor complex 1 IL6
acrosomal matrix 1 ACR
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • José Carlos Nunes-Tamashiro, Jamil Natour, Fernando Maier Ramuth, Sandra Regina Toffolo, Jamile Godoy Mendes, André Rosenfeld, Rita Nely Vilar Furtado. Intra-articular injection with platelet-rich plasma compared to triamcinolone hexacetonide or saline solution in knee osteoarthritis: A double blinded randomized controlled trial with one year follow-up. Clinical rehabilitation. 2022 Jul; 36(7):900-915. doi: 10.1177/02692155221090407. [PMID: 35379019]
  • Sergi Coll, Xavier Matabosch, Jone Llorente-Onaindia, Marcel Li Carbó, Clara Pérez-Mañá, Nuria Monfort, Jordi Monfort, Rosa Ventura. Elimination profile of triamcinolone hexacetonide and its metabolites in human urine and plasma after a single intra-articular administration. Drug testing and analysis. 2019 Nov; 11(11-12):1589-1600. doi: 10.1002/dta.2614. [PMID: 31087549]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wei Sun, Stacy Ho, Xiaojun Rick Fang, Thomas O'Shea, Hanlan Liu. Simultaneous determination of triamcinolone hexacetonide and triamcinolone acetonide in rabbit plasma using a highly sensitive and selective UPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):267-273. doi: 10.1016/j.jpba.2018.02.052. [PMID: 29550043]
  • Tomas Weitoft, Johan Rönnelid, Ann Knight, Jörgen Lysholm, Tore Saxne, Anders Larsson. Outcome predictors of intra-articular glucocorticoid treatment for knee synovitis in patients with rheumatoid arthritis - a prospective cohort study. Arthritis research & therapy. 2014 Jun; 16(3):R129. doi: 10.1186/ar4586. [PMID: 24950951]
  • H Rintamäki, K Tamm, O Vaarala, M Sidoroff, V Honkanen, T Raivio, Oa Jänne, K-L Kolho. Intra-articular corticoid injection induces circulating glucocorticoid bioactivity and systemic immune activation in juvenile idiopathic arthritis. Scandinavian journal of rheumatology. 2011; 40(5):347-53. doi: 10.3109/03009742.2011.560893. [PMID: 21619491]
  • Boris Hugle, Ronald M Laxer. Lipoatrophy resulting from steroid injection into the temporomandibular joint. Arthritis and rheumatism. 2009 Nov; 60(11):3512. doi: 10.1002/art.24987. [PMID: 19877081]
  • Kasper Dahl Kristensen, Peter Stoustrup, Annelise Küseler, Thomas Klit Pedersen, Jens Randel Nyengaard, Ellen-Margrethe Hauge, Troels Herlin. Quantitative histological changes of repeated antigen-induced arthritis in the temporomandibular joints of rabbits treated with intra-articular corticosteroid. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2008 Aug; 37(7):437-44. doi: 10.1111/j.1600-0714.2007.00630.x. [PMID: 18266658]
  • T Weitoft, A Larsson, L Rönnblom. Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis. Annals of the rheumatic diseases. 2008 Mar; 67(3):422-4. doi: 10.1136/ard.2007.081315. [PMID: 17878211]
  • Helmut Wittkowski, Dirk Foell, Erik af Klint, Leen De Rycke, Filip De Keyser, Michael Frosch, Ann-Kristin Ulfgren, Johannes Roth. Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis. Annals of the rheumatic diseases. 2007 Aug; 66(8):1020-5. doi: 10.1136/ard.2006.061507. [PMID: 17223658]
  • T Weitoft, L Rönnblom. Glucocorticoid resorption and influence on the hypothalamic-pituitary-adrenal axis after intra-articular treatment of the knee in resting and mobile patients. Annals of the rheumatic diseases. 2006 Jul; 65(7):955-7. doi: 10.1136/ard.2005.041525. [PMID: 16769782]
  • L Lepore, M Del Santo, C Malorgio, G Presani, S Perticarari, M Prodan, G Di Leo, V Leone, A Tommasini. Treatment of juvenile idiopathic arthritis with intra-articular triamcinolone hexacetonide: evaluation of clinical effectiveness correlated with circulating ANA and T gamma/delta + and B CD5+ lymphocyte populations of synovial fluid. Clinical and experimental rheumatology. 2002 Sep; 20(5):719-22. doi: . [PMID: 12412208]
  • Cristina Meazza, Paola Travaglino, Patrizia Pignatti, Silvia Magni-Manzoni, Angelo Ravelli, Alberto Martini, Fabrizio De Benedetti. Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis. Arthritis and rheumatism. 2002 Jan; 46(1):232-7. doi: 10.1002/1529-0131(200201)46:1<232::aid-art10059>3.0.co;2-b. [PMID: 11817596]
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