(S)-2-Propylpiperidine (BioDeep_00000001937)

Main id: BioDeep_00000395546

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


coniine hydrochloride, (+-)-isomer

化学式: C8H17N (127.1361)
中文名称: 2-丙基哌啶, （S） -2-丙基哌啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC1CCCCN1
InChI: InChI=1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3

描述信息

(S)-2-Propylpiperidine is found in black elderberry. (S)-2-Propylpiperidine is an alkaloid of Amorphophalus rivieri (devils tongue
Alkaloid of Amorphophalus rivieri (devils tongue). (S)-2-Propylpiperidine is found in pomegranate and black elderberry.

同义名列表

25 个代谢物同义名

coniine hydrochloride, (+-)-isomer; coniine hydrochloride, (S)-isomer; coniine hydrobromide, (S)-isomer; (S)-beta-Propylpiperidine; (2S)-2-Propylpiperidine; (S)-2-Propylpiperidine; coniine, (+-)-isomer; 2-Propyl-piperidine; coniine, (S)-isomer; 2-Propylpiperidine; (S)-(+)-ConIIne; alpha-Conine; (±)-Coniine; (+)-Coniine; d-Conicine; cicutine; conicine; Cicutin; Coniine; Conine; koniin; Coniin; Coniine; (S)-2-Propylpiperidine; Coniine



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gopal Peddinti, Hannu Hotti, Teemu H Teeri, Heiko Rischer. De novo transcriptome assembly of Conium maculatum L. to identify candidate genes for coniine biosynthesis. Scientific reports. 2022 10; 12(1):17562. doi: 10.1038/s41598-022-21728-w. [PMID: 36266299]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Carlo Basile. [Rhabdomyolysis: have you considered food poisoning from quails?]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2020 Apr; 37(2):. doi: . [PMID: 32281758]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M V Karakasi, S Tologkos, V Papadatou, N Raikos, M Lambropoulou, P Pavlidis. Conium maculatum intoxication: Literature review and case report on hemlock poisoning. Forensic science review. 2019 Jan; 31(1):23-36. doi: ". [PMID: 30594904]
  • Hannu Hotti, Heiko Rischer. The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom. Molecules (Basel, Switzerland). 2017 Nov; 22(11):. doi: 10.3390/molecules22111962. [PMID: 29135964]
  • Hannu Hotti, Peddinti Gopalacharyulu, Tuulikki Seppänen-Laakso, Heiko Rischer. Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia. PloS one. 2017; 12(2):e0171078. doi: 10.1371/journal.pone.0171078. [PMID: 28222171]
  • Hannu Hotti, Tuulikki Seppänen-Laakso, Mikko Arvas, Teemu H Teeri, Heiko Rischer. Polyketide synthases from poison hemlock (Conium maculatum L.). The FEBS journal. 2015 Nov; 282(21):4141-56. doi: 10.1111/febs.13410. [PMID: 26260860]
  • Benedict T Green, Stephen T Lee, Kevin D Welch, James A Pfister, Kip E Panter. Fetal muscle-type nicotinic acetylcholine receptor activation in TE-671 cells and inhibition of fetal movement in a day 40 pregnant goat model by optical isomers of the piperidine alkaloid coniine. The Journal of pharmacology and experimental therapeutics. 2013 Jan; 344(1):295-307. doi: 10.1124/jpet.112.199588. [PMID: 23086230]
  • Okan Arihan, Mustafa Boz, Alper B Iskit, Mustafa Ilhan. Antinociceptive activity of coniine in mice. Journal of ethnopharmacology. 2009 Sep; 125(2):274-8. doi: 10.1016/j.jep.2009.06.032. [PMID: 19580858]
  • Stephen T Lee, Benedict T Green, Kevin D Welch, James A Pfister, Kip E Panter. Stereoselective potencies and relative toxicities of coniine enantiomers. Chemical research in toxicology. 2008 Oct; 21(10):2061-4. doi: 10.1021/tx800229w. [PMID: 18763813]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • K Suvardhan, K Suresh Kumar, L Krishnaiah, S Prabakhara Rao, P Chiranjeevi. The determination of nickel(II) after on-line sorbent preconcentration by inductively coupled plasma atomic emission spectrometry using Borassus Flabellifer inflorescence loaded with coniine dithiocarbamate. Journal of hazardous materials. 2004 Aug; 112(3):233-8. doi: 10.1016/j.jhazmat.2004.05.003. [PMID: 15302444]
  • T Blitzke, A Porzel, M Masaoud, J Schmidt. A chlorinated amide and piperidine alkaloids from Aloe sabaea. Phytochemistry. 2000 Dec; 55(8):979-82. doi: 10.1016/s0031-9422(00)00269-7. [PMID: 11140536]
  • B S Frank, W B Michelson, K E Panter, D R Gardner. Ingestion of poison hemlock (Conium maculatum). The Western journal of medicine. 1995 Dec; 163(6):573-4. doi: ". [PMID: 8553650]
  • A Scatizzi, A Di Maggio, D Rizzi, A M Sebastio, C Basile. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Renal failure. 1993; 15(1):93-6. doi: 10.3109/08860229309065580. [PMID: 8441844]
  • F D Galey, D M Holstege, E G Fisher. Toxicosis in dairy cattle exposed to poison hemlock (Conium maculatum) in hay: isolation of Conium alkaloids in plants, hay, and urine. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 1992 Jan; 4(1):60-4. doi: 10.1177/104063879200400113. [PMID: 1554771]
  • D Rizzi, C Basile, A Di Maggio, A Sebastio, F Introna, R Rizzi, A Scatizzi, S De Marco, J E Smialek. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1991; 6(12):939-43. doi: 10.1093/ndt/6.12.939. [PMID: 1798593]
  • K E Panter, R F Keeler, T D Bunch, R J Callan. Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon : official journal of the International Society on Toxinology. 1990; 28(12):1377-85. doi: 10.1016/0041-0101(90)90154-y. [PMID: 2089736]
  • D Rizzi, C Basile, A Di Maggio, A Sebastio, F Introna, R Rizzi, S Bruno, A Scatizzi, S De Marco. Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning. Lancet (London, England). 1989 Dec; 2(8677):1461-2. doi: 10.1016/s0140-6736(89)92075-8. [PMID: 2574394]
  • S B Short, W C Edwards. Accidental Conium maculata poisoning in the rabbit. Veterinary and human toxicology. 1989 Feb; 31(1):54-7. doi: ". [PMID: 2711610]
  • K E Panter, R F Keeler, W B Buck. Induction of cleft palate in newborn pigs by maternal ingestion of poison hemlock (Conium maculatum). American journal of veterinary research. 1985 Jun; 46(6):1368-71. doi: . [PMID: 4026015]
  • D A Hannam. Hemlock (Conium maculatum) poisoning in the pig. The Veterinary record. 1985 Mar; 116(12):322. doi: 10.1136/vr.116.12.322. [PMID: 3992847]
  • R F Keeler, L D Balls. Teratogenic effects in cattle of Conium maculatum and conium alkaloids and analogs. Clinical toxicology. 1978; 12(1):49-64. doi: 10.3109/15563657809149583. [PMID: 630821]