Diethylpropion (BioDeep_00000001887)

 

Secondary id: BioDeep_00001867957

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Investigacion farmaceutica brand OF amfepramone hydrochloride

化学式: C13H19NO (205.1467)
中文名称: 二乙基丙酮, 安非拉酮
谱图信息: 最多检出来源 Homo sapiens(blood) 14.44%

分子结构信息

SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1
InChI: InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3

描述信息

Diethylpropion is only found in individuals that have used or taken this drug. It is a appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Diethylpropion (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that diethylpropion can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

60 个代谢物同义名

Investigacion farmaceutica brand OF amfepramone hydrochloride; Marion merrell dow brand OF amfepramone hydrochloride; Marion merrell brand OF amfepramone hydrochloride; Artegodan brand OF amfepramone hydrochloride; Théranol brand OF amfepramone hydrochloride; Temmler brand OF amfepramone hydrochloride; Pro DOC brand OF amfepramone hydrochloride; Vortech brand OF amfepramone hydrochloride; Hoechst brand OF amfepramone hydrochloride; Crinex brand OF amfepramone hydrochloride; Uriach brand OF amfepramone hydrochloride; Nadeau brand OF amfepramone hydrochloride; Medix brand OF amfepramone hydrochloride; Medic brand OF amfepramone hydrochloride; Dexo brand OF amfepramone hydrochloride; 3m Brand OF amfepramone hydrochloride; 2-(diethylamino)-1-phenylpropan-1-one; 2-(Diethylamino)-1-phenyl-1-propanone; 1-Phenyl-2-diethylamino-1-propanone; alpha-Diethylaminopropiophenone; Hydrochloride, diethylpropion; 2-(Diethylamino)propiophenone; Diethylpropion Hydrochloride; 2-Diethylaminopropiophenone; Α-diethylaminopropiophenone; a-Diethylaminopropiophenone; alpha-Benzoyltriethylamine; Α-benzoyltriethylamine; a-Benzoyltriethylamine; (+-)-Diethylpropion; (S)-diethylpropion; Diethylcathinone; Diethylpropione; Diethylpropion; Dietil-retard; Dietil retard; Amfepramonum; DEA no. 1610; Dietilretard; Anfepramona; Amfepramone; Amfepramon; Norex, ifa; Préfamone; Ifa norex; Phepranon; Modératan; Nobesine; Delgamer; Regibon; Maruate; Tenuate; Tepanil; Propion; Regenon; Lipomin; Anorex; Neobes; Diethylpropion; Diethylpropion



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, BDNF, CYP3A4, NOS3, PKM, SLC6A3, TH
Endoplasmic reticulum membrane 2 CYP3A4, DRD1
Nucleus 4 DRD1, NOS3, PKM, TH
cytosol 6 LEP, LIPE, NOS3, PKM, TH, TPM3
dendrite 4 BDNF, BMPR2, DRD2, TH
nucleoplasm 2 BMPR2, NOS3
Cell membrane 8 ABCB1, BMPR2, DRD1, DRD2, LIPE, OPRD1, SLC6A2, SLC6A3
Cell projection, axon 2 SLC6A3, TH
Multi-pass membrane protein 7 ABCB1, DRD1, DRD2, OPRD1, SLC6A2, SLC6A3, UCP1
Golgi apparatus membrane 1 DRD2
Synapse 1 DRD2
cell surface 4 ABCB1, BMPR2, SLC6A2, SLC6A3
glutamatergic synapse 2 DRD1, DRD2
Golgi apparatus 1 NOS3
Golgi membrane 3 DRD2, INS, NOS3
mitochondrial inner membrane 1 UCP1
neuronal cell body 2 BMPR2, SLC6A3
presynaptic membrane 5 DRD1, DRD2, OPRD1, SLC6A2, SLC6A3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 BDNF, TH
Cytoplasm, cytosol 1 LIPE
acrosomal vesicle 1 DRD2
plasma membrane 8 ABCB1, BMPR2, DRD1, DRD2, NOS3, OPRD1, SLC6A2, SLC6A3
synaptic vesicle membrane 3 DRD2, OPRD1, SLC6A2
terminal bouton 1 TH
Membrane 7 ABCB1, BDNF, CYP3A4, LIPE, OPRD1, SLC6A2, SLC6A3
apical plasma membrane 2 ABCB1, BMPR2
axon 6 BDNF, BMPR2, DRD2, SLC6A2, SLC6A3, TH
caveola 3 BMPR2, LIPE, NOS3
extracellular exosome 3 ABCB1, PKM, TPM3
extracellular space 6 ARTN, BDNF, BMPR2, INS, LEP, PNLIP
perinuclear region of cytoplasm 3 BDNF, NOS3, TH
adherens junction 1 BMPR2
mitochondrion 4 PKM, TH, TPM3, UCP1
intracellular membrane-bounded organelle 1 CYP3A4
Microsome membrane 1 CYP3A4
postsynaptic density 1 BMPR2
Secreted 6 ARTN, BDNF, INS, LEP, PNLIP, PRB1
extracellular region 7 ARTN, BDNF, INS, LEP, PKM, PNLIP, PRB1
cytoplasmic side of plasma membrane 1 TH
neuronal cell body membrane 2 SLC6A2, SLC6A3
ciliary membrane 2 DRD1, DRD2
Extracellular vesicle 1 PKM
actin cytoskeleton 1 TPM3
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, TH
cytoplasmic vesicle 1 TH
Melanosome membrane 1 TH
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
clathrin-coated pit 1 BMPR2
vesicle 1 PKM
postsynaptic membrane 3 DRD1, DRD2, SLC6A3
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 1 UCP1
Membrane raft 1 SLC6A3
Cytoplasm, cytoskeleton 1 TPM3
GABA-ergic synapse 2 DRD1, DRD2
flotillin complex 1 SLC6A3
Cell projection, dendritic spine 1 DRD1
collagen-containing extracellular matrix 1 PKM
lateral plasma membrane 1 DRD2
receptor complex 1 BMPR2
Cell projection, neuron projection 1 SLC6A3
neuron projection 3 OPRD1, SLC6A3, TH
cilium 3 DRD1, DRD2, PKM
cytoskeleton 2 NOS3, TPM3
actin filament 1 TPM3
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 DRD1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
stress fiber 1 TPM3
basal plasma membrane 1 BMPR2
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 2 INS, PKM
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BDNF, INS
axon terminus 3 DRD2, OPRD1, SLC6A3
endocytic vesicle membrane 1 NOS3
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 2 DRD2, SLC6A3
dendrite membrane 1 OPRD1
Rough endoplasmic reticulum 1 PKM
Cell projection, cilium membrane 1 DRD1
muscle thin filament tropomyosin 1 TPM3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
spine apparatus 1 OPRD1


文献列表

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