DL-Leucic Acid (BioDeep_00001873781)

Main id: BioDeep_00000003198

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-hydroxy-4-methylvaleric acid

化学式: C6H12O3 (132.0786)
中文名称: DL-白氨酸, DL-闪白酸, 2-羟基-4-甲基戊酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)O
InChI: InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)

描述信息

A valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position; an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome.

同义名列表

3 个代谢物同义名

2-hydroxy-4-methylvaleric acid; DL-Leucic Acid; 2-Hydroxy-4-methylvaleric acid



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BGLAP, EIF4EBP1, PRKAA2, RBMS3, RELB, RPS6KB1, RUNX2, TP53BP1
Nucleus 8 CA9, EIF4EBP1, PRKAA2, RBMS3, RELB, RPS6KB1, RUNX2, TP53BP1
cytosol 8 ACP5, EIF4EBP1, PRKAA2, RBMS3, RELB, RPS6KB1, RUNX2, TDO2
dendrite 2 BGLAP, PRKAA2
nuclear body 1 TP53BP1
centrosome 1 RELB
nucleoplasm 5 PRKAA2, RELB, RPS6KB1, RUNX2, TP53BP1
Cell membrane 4 CA9, CASR, PSCA, SLC20A1
Multi-pass membrane protein 3 ABCA4, CASR, SLC20A1
Synapse 1 RELB
cell surface 3 ADIPOQ, CASR, RPS6KB1
glutamatergic synapse 2 CASR, RPS6KB1
Golgi apparatus 1 PRKAA2
neuronal cell body 2 CASR, PRKAA2
postsynapse 1 RPS6KB1
presynaptic membrane 1 CASR
Lysosome 1 ACP5
plasma membrane 5 ABCA4, CA9, CASR, PSCA, SLC20A1
Membrane 6 ABCA4, ACP5, CA9, CASR, PRKAA2, SLC20A1
apical plasma membrane 1 CASR
axon 1 PRKAA2
basolateral plasma membrane 2 CA9, CASR
extracellular exosome 2 BMP3, PSCA
endoplasmic reticulum 2 ABCA4, ADIPOQ
extracellular space 6 ADIPOQ, BGLAP, BMP3, CRP, IGF1, IL6
perinuclear region of cytoplasm 1 RPS6KB1
mitochondrion 1 RPS6KB1
protein-containing complex 1 RELB
intracellular membrane-bounded organelle 1 ABCA4
Single-pass type I membrane protein 1 CA9
Secreted 6 ADIPOQ, BGLAP, BMP3, CRP, IGF1, IL6
extracellular region 7 ADIPOQ, BGLAP, BMP3, CRP, IGF1, IL6, PSCA
mitochondrial outer membrane 1 RPS6KB1
transcription regulator complex 1 RUNX2
photoreceptor outer segment 1 ABCA4
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 RELB
perikaryon 1 BGLAP
cytoplasmic vesicle 1 ABCA4
nucleolus 1 CA9
vesicle 1 BGLAP
collagen trimer 1 ADIPOQ
collagen-containing extracellular matrix 1 ADIPOQ
nuclear speck 1 PRKAA2
neuron projection 1 RPS6KB1
chromatin 2 RELB, RUNX2
Chromosome 1 TP53BP1
Cell projection, cilium, photoreceptor outer segment 1 ABCA4
Nucleus, nucleolus 1 CA9
chromosome, telomeric region 1 TP53BP1
Lipid-anchor, GPI-anchor 1 PSCA
Cell projection, microvillus membrane 1 CA9
microvillus membrane 1 CA9
site of double-strand break 1 TP53BP1
Chromosome, centromere, kinetochore 1 TP53BP1
cytoplasmic stress granule 1 PRKAA2
side of membrane 1 PSCA
replication fork 1 TP53BP1
exocytic vesicle 1 IGF1
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 BGLAP, IL6
transcription repressor complex 1 RELB
platelet alpha granule lumen 1 IGF1
axon terminus 1 CASR
kinetochore 1 TP53BP1
ribonucleoprotein complex 1 RBMS3
Synapse, synaptosome 1 RPS6KB1
nucleotide-activated protein kinase complex 1 PRKAA2
DNA repair complex 1 TP53BP1
photoreceptor disc membrane 1 ABCA4
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
interleukin-6 receptor complex 1 IL6
NF-kappaB complex 1 RELB
rod photoreceptor disc membrane 1 ABCA4


文献列表

  • Cristina Piras, Stella Conte, Monica Pibiri, Giacomo Rao, Sandro Muntoni, Vera Piera Leoni, Gabriele Finco, Luigi Atzori. Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity. Scientific reports. 2020 11; 10(1):20418. doi: 10.1038/s41598-020-76876-8. [PMID: 33235303]
  • M Sakko, L Tjäderhane, T Sorsa, P Hietala, R Rautemaa. Antimicrobial 2-hydroxyisocaproic acid and chlorhexidine resist inactivation by dentine. International endodontic journal. 2016 Apr; 49(4):352-60. doi: 10.1111/iej.12465. [PMID: 25944560]
  • M Sakko, C Moore, L Novak-Frazer, V Rautemaa, T Sorsa, P Hietala, A Järvinen, P Bowyer, L Tjäderhane, R Rautemaa. 2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species. Mycoses. 2014 Apr; 57(4):214-21. doi: 10.1111/myc.12145. [PMID: 24125484]
  • Dora Ndagano, Thibaut Lamoureux, Carine Dortu, Sophie Vandermoten, Philippe Thonart. Antifungal activity of 2 lactic acid bacteria of the Weissella genus isolated from food. Journal of food science. 2011 Aug; 76(6):M305-11. doi: 10.1111/j.1750-3841.2011.02257.x. [PMID: 21729073]
  • Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Molecular bioSystems. 2010 May; 6(5):909-21. doi: 10.1039/b914182k. [PMID: 20567778]
  • Michael H T Li, Peter M U Ung, James Zajkowski, Sylvie Garneau-Tsodikova, David H Sherman. Automated genome mining for natural products. BMC bioinformatics. 2009 Jun; 10(?):185. doi: 10.1186/1471-2105-10-185. [PMID: 19531248]
  • Vilson de Castro Vasques, Fabrício Brinco, Moacir Wajner. Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks. Journal of the neurological sciences. 2005 May; 232(1-2):11-21. doi: 10.1016/j.jns.2004.12.015. [PMID: 15850577]
  • Alexandra Muth, Jochen Jung, Steffi Bilke, Annette Scharrer, Armin Mosandl, Adrian C Sewell, Hans Böhles. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 792(2):269-77. doi: 10.1016/s1570-0232(03)00285-x. [PMID: 12860034]
  • K D Webster, M W Anders. Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid. Archives of biochemistry and biophysics. 1989 Sep; 273(2):562-71. doi: 10.1016/0003-9861(89)90516-x. [PMID: 2774567]
  • L J Spaapen, D Ketting, S K Wadman, L Bruinvis, M Duran. Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin. Journal of inherited metabolic disease. 1987; 10(4):383-90. doi: 10.1007/bf01799981. [PMID: 3126358]
  • E Haan, G Brown, A Bankier, D Mitchell, S Hunt, J Blakey, G Barnes. Severe illness caused by the products of bacterial metabolism in a child with a short gut. European journal of pediatrics. 1985 May; 144(1):63-5. doi: 10.1007/bf00491929. [PMID: 4018104]
  • C Jakobs, L Sweetman, W L Nyhan. Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Clinica chimica acta; international journal of clinical chemistry. 1984 Jul; 140(2):157-66. doi: 10.1016/0009-8981(84)90340-1. [PMID: 6467607]
  • T Kuhara, T Shinka, Y Inoue, M Matsumoto, M Yoshino, Y Sakaguchi, I Matsumoto. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Clinica chimica acta; international journal of clinical chemistry. 1983 Sep; 133(2):133-40. doi: 10.1016/0009-8981(83)90398-4. [PMID: 6688766]