Isovaleryl-CoA (BioDeep_00001868628)

Main id: BioDeep_00000630309

 

PANOMIX_OTCML-2023


代谢物信息卡片


Isovaleryl-CoA

  化学式: C26H44N7O17P3S (851.1727)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C26H44N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h12-15,19-21,25,36-37H,5-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/t15-,19-,20-,21+,25-/m1/s1

描述信息

A methylbutanoyl-CoA is the S-isovaleryl derivative of coenzyme A.

同义名列表

2 个代谢物同义名

Isovaleryl-CoA; 3-Methylbutanoyl-CoA



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACADL, ACADM, GLI3, MMUT
Peripheral membrane protein 2 CRAT, HSD17B6
Nucleus 3 ACADM, GLI3, PDHB
cytosol 6 ACOX1, ACOX2, CRAT, GLI3, HMGCL, PHYH
mitochondrial membrane 4 ACADL, ACADM, ETFDH, IVD
nucleoplasm 3 GLI3, IVD, PDHB
Early endosome membrane 1 HSD17B6
Golgi membrane 1 INS
mitochondrial inner membrane 3 CRAT, ETFDH, L2HGDH
Membrane 3 ACOX1, ETFDH, L2HGDH
axon 1 ACADM
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 CRAT, HSD17B6
extracellular space 1 INS
mitochondrion 14 ACAD8, ACADL, ACADM, ACADSB, CRAT, ETFB, ETFDH, GCDH, GLYATL1, HMGCL, IVD, L2HGDH, MMUT, PDHB
protein-containing complex 1 HMGCL
intracellular membrane-bounded organelle 3 ACOX2, GLI3, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 1 INS
extracellular region 1 INS
Mitochondrion matrix 8 ACADL, ACADM, ACADSB, ETFB, GCDH, HMGCL, IVD, MMUT
mitochondrial matrix 10 ACAD8, ACADL, ACADM, ACADSB, ETFB, GCDH, HMGCL, IVD, MMUT, PDHB
nucleolus 1 GLI3
Mitochondrion inner membrane 1 CRAT
Matrix side 1 CRAT
Peroxisome 5 ACOX1, ACOX2, CRAT, HMGCL, PHYH
peroxisomal matrix 5 ACOX1, ACOX2, CRAT, HMGCL, PHYH
peroxisomal membrane 1 ACOX1
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
ciliary base 1 GLI3
cilium 1 GLI3
[Isoform 1]: Mitochondrion 1 CRAT
endosome lumen 1 INS
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transcription repressor complex 1 GLI3
pyruvate dehydrogenase complex 1 PDHB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
9+0 non-motile cilium 1 PHYH
GLI-SUFU complex 1 GLI3
electron transfer flavoprotein complex 1 ETFB
[Isoform 2]: Peroxisome 1 CRAT


文献列表

  • Christopher B Eiben, Tian Tian, Mitchell G Thompson, Daniel Mendez-Perez, Nurgul Kaplan, Garima Goyal, Jennifer Chiniquy, Nathan J Hillson, Taek Soon Lee, Jay D Keasling. Adenosine Triphosphate and Carbon Efficient Route to Second Generation Biofuel Isopentanol. ACS synthetic biology. 2020 03; 9(3):468-474. doi: 10.1021/acssynbio.9b00402. [PMID: 32149502]
  • Randy W Purves, Stephen J Ambrose, Shawn M Clark, Jake M Stout, Jonathan E Page. Separation of isomeric short-chain acyl-CoAs in plant matrices using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Feb; 980(?):1-7. doi: 10.1016/j.jchromb.2014.12.007. [PMID: 25553535]
  • Geng Ding, Ping Che, Hilal Ilarslan, Eve S Wurtele, Basil J Nikolau. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. The Plant journal : for cell and molecular biology. 2012 May; 70(4):562-77. doi: 10.1111/j.1365-313x.2011.04893.x. [PMID: 22211474]
  • Kimitsune Ishizaki, Tony R Larson, Nicolas Schauer, Alisdair R Fernie, Ian A Graham, Christopher J Leaver. The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. The Plant cell. 2005 Sep; 17(9):2587-600. doi: 10.1105/tpc.105.035162. [PMID: 16055629]
  • S E Faivre-Nitschke, I Couée, M Vermel, J M Grienenberger, J M Gualberto. Purification, characterization and cloning of isovaleryl-CoA dehydrogenase from higher plant mitochondria. European journal of biochemistry. 2001 Mar; 268(5):1332-9. doi: 10.1046/j.1432-1327.2001.01999.x. [PMID: 11231285]
  • A Sener, B Reusens, C Remacle, J J Hoet, W J Malaisse. Nutrient metabolism in pancreatic islets from protein malnourished rats. Biochemical and molecular medicine. 1996 Oct; 59(1):62-7. doi: 10.1006/bmme.1996.0066. [PMID: 8902196]
  • D G Hine, K Tanaka. The identification and the excretion pattern of isovaleryl glucuronide in the urine of patients with isovaleric acidemia. Pediatric research. 1984 Jun; 18(6):508-12. doi: 10.1203/00006450-198406000-00004. [PMID: 6547525]
  • N Gregersen. The specific inhibition of the pyruvate dehydrogenase complex from pig kidney by propionyl-CoA and isovaleryl-Co-A. Biochemical medicine. 1981 Aug; 26(1):20-7. doi: 10.1016/0006-2944(81)90026-0. [PMID: 7295301]