methacholine (BioDeep_00001868277)
Main id: BioDeep_00000002990
Chemicals and Drugs natural product
代谢物信息卡片
methacholine
化学式: C8H18NO2+ (160.1337)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC(C)C[N+](C)(C)C
InChI: InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
描述信息
A quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis.
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
D019141 - Respiratory System Agents > D016085 - Bronchoconstrictor Agents
V - Various > V04 - Diagnostic agents
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:6804
- KEGG: C07471
- PubChem: 1993
- DrugBank: DB06709
- ChEMBL: CHEMBL978
- MeSH: Methacholine Chloride
- CAS: 55-92-5
- MetaboLights: MTBLC6804
- PubChem: 9674
- NIKKAJI: J11.055H
- RefMet: Methacholine
- KNApSAcK: 6804
- LOTUS: LTS0156587
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 2 - Bacteria: LTS0156587
- 1236 - Gammaproteobacteria: LTS0156587
- 135621 - Pseudomonadaceae: LTS0156587
- 286 - Pseudomonas: LTS0156587
- 287 - Pseudomonas aeruginosa: LTS0156587
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan-Jiao Chen, Yu Yuan, Lu Peng, Xin-Yi Dong, Yu-Dong Xu, Yu Wang, Yong-Qing Yang. Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.
Immunity, inflammation and disease.
2024 Mar; 12(3):e1225. doi:
10.1002/iid3.1225. [PMID: 38533918] - . [Standard technical specifications for methacholine chloride (Methacholine) bronchial challenge test (2023)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2024 Feb; 47(2):101-119. doi:
10.3760/cma.j.cn112147-20231019-00247. [PMID: 38309959] - Alexander Tamalunas, Amin Wendt, Florian Springer, Victor Vigodski, Anna Ciotkowska, Beata Rutz, Ruixiao Wang, Ru Huang, Yuhan Liu, Heiko Schulz, Stephan Ledderose, Thomas Kolben, Giuseppe Magistro, Christian G Stief, Martin Hennenberg. Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells.
Life sciences.
2022 Nov; 308(?):120931. doi:
10.1016/j.lfs.2022.120931. [PMID: 36084760] - Ki-Shuk Shim, Hyun-Kyung Song, Youn-Hwan Hwang, Sungwook Chae, Ho Kyoung Kim, Seol Jang, Yun Hee Kim, Byung-Kil Choo, Won-Kyung Yang, Seung-Hyung Kim, Taesoo Kim, Ki Mo Kim. Ethanol extract of Veronica persica ameliorates house dust mite-induced asthmatic inflammation by inhibiting STAT-3 and STAT-6 activation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113264. doi:
10.1016/j.biopha.2022.113264. [PMID: 35696941] - Ru Huang, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G Stief, Martin Hennenberg. Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions.
The Journal of pharmacology and experimental therapeutics.
2022 05; 381(2):176-187. doi:
10.1124/jpet.121.001029. [PMID: 35153197] - Madeleine M Mank, Leah F Reed, Camille J Walton, Madison L T Barup, Jennifer L Ather, Matthew E Poynter. Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
American journal of physiology. Lung cellular and molecular physiology.
2022 02; 322(2):L243-L257. doi:
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Respiratory care.
2021 12; 66(12):1858-1865. doi:
10.4187/respcare.09236. [PMID: 34789516] - Norhan Badr ElDin, Mohamed K Abd El-Rahman, Hala E Zaazaa, Azza A Moustafa, Said A Hassan. Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic.
Biosensors & bioelectronics.
2021 Oct; 190(?):113439. doi:
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The British journal of nutrition.
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International journal of molecular sciences.
2021 Aug; 22(16):. doi:
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The Journal of asthma : official journal of the Association for the Care of Asthma.
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2019 Oct; 18(6):624-638. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2019 06; 169(2):499-510. doi:
10.1093/toxsci/kfz056. [PMID: 30825310] - Naeima Eftekhar, Ali Moghimi, Mohammad Hossein Boskabady, Mahsa Kaveh, Farzaneh Shakeri. Ocimum basilicum affects tracheal responsiveness, lung inflammatory cells and oxidant-antioxidant biomarkers in sensitized rats.
Drug and chemical toxicology.
2019 May; 42(3):286-294. doi:
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BioFactors (Oxford, England).
2019 Jan; 45(1):75-84. doi:
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Microbial pathogenesis.
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Pediatrics and neonatology.
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American journal of physiology. Lung cellular and molecular physiology.
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The Korean journal of internal medicine.
2018 07; 33(4):807-814. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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Mammalian genome : official journal of the International Mammalian Genome Society.
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Pulmonary pharmacology & therapeutics.
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Oxidative medicine and cellular longevity.
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
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PloS one.
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