FLUNISOLIDE (BioDeep_00001868025)
Main id: BioDeep_00000002722
代谢物信息卡片
FLUNISOLIDE
化学式: C24H31FO6 (434.2104558)
中文名称: 氟尼缩松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@@H](C5=CC(=O)C=C[C@]5(C)[C@H]4[C@H](C[C@]3(C)[C@]2(C(=O)CO)O1)O)F
InChI: InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D000893 - Anti-Inflammatory Agents
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:5106
- KEGG: C07005
- KEGGdrug: D78324
- PubChem: 82153
- DrugBank: DB00180
- ChEMBL: CHEMBL1512
- CAS: 3385-03-3
- PubChem: 9218
- NIKKAJI: J3.402I
- RefMet: Flunisolide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Keivan Gohari Moghaddam, Negin Rashidi, Hamidreza Aghaei Meybodi, Nader Rezaie, Mahdi Montazeri, Ramin Heshmat, Zohreh Annabestani. The effect of inhaled corticosteroids on hypothalamic-pituitary-adrenal axis.
Indian journal of pharmacology.
2012 May; 44(3):314-8. doi:
10.4103/0253-7613.96300. [PMID: 22701238] - Ilona G Bebenek, Parrisa Solaimani, Peter Bui, Oliver Hankinson. CYP2S1 is negatively regulated by corticosteroids in human cell lines.
Toxicology letters.
2012 Feb; 209(1):30-4. doi:
10.1016/j.toxlet.2011.11.020. [PMID: 22155357] - Joaquim Mullol, Francisco de Borja Callejas, Maria Asunción Martínez-Antón, Eva Méndez-Arancibia, Isam Alobid, Laura Pujols, Antonio Valero, Cesar Picado, Jordi Roca-Ferrer. Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells.
Respiratory research.
2011 Feb; 12(?):23. doi:
10.1186/1465-9921-12-23. [PMID: 21352574] - I Madhusudhana Reddy, Alka Beotra, S Jain, S Ahi. A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples.
Indian journal of pharmacology.
2009 Apr; 41(2):80-6. doi:
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Journal of asthma and allergy.
2008 Nov; 1(?):49-54. doi:
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Journal of chromatography. A.
2008 May; 1189(1-2):426-34. doi:
10.1016/j.chroma.2007.11.022. [PMID: 18054785] - Ahmad Kantar, Salman Mroueh, Alessandro Fiocchi. A reappraisal of the clinical efficacy of nebulized flunisolide in pediatric asthma: the Italian experience.
Allergy and asthma proceedings.
2007 Nov; 28(6):671-87. doi:
10.2500/aap.2007.28.2979. [PMID: 17883883] - Denis Caillaud, Charles Le Merre, Yan Martinat, Bernard Aguilaniu, Demetri Pavia. A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.
International journal of chronic obstructive pulmonary disease.
2007; 2(4):559-65. doi:
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BMC cancer.
2006 Mar; 6(?):72. doi:
10.1186/1471-2407-6-72. [PMID: 16545134] - Martha White, Tera Crisalida, Henry Li, Athena Economides, Michael Kaliner. Effects of long-term inhaled corticosteroids on adrenal function in patients with asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2006 Mar; 96(3):437-44. doi:
10.1016/s1081-1206(10)60911-8. [PMID: 16597078] - Carol R Reinero, Lisa Brownlee, Kendra C Decile, Bernard Seguin, Roy D Berghaus, Richard W Nelson, Laurel J Gershwin. Inhaled flunisolide suppresses the hypothalamic-pituitary-adrenocortical axis, but has minimal systemic immune effects in healthy cats.
Journal of veterinary internal medicine.
2006 Jan; 20(1):57-64. doi:
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American journal of veterinary research.
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Analytical and bioanalytical chemistry.
2005 Jan; 381(1):244-54. doi:
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Clinical chemistry.
2004 Dec; 50(12):2345-52. doi:
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Respiratory research.
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2004; 27(12):883-98. doi:
10.2165/00002018-200427120-00005. [PMID: 15366976] - Arno Nolting, Wattanaporn Abramowitz. Multiple-dose proportionality study of flunisolide hydrofluoroalkane.
Allergy and asthma proceedings.
2002 Sep; 23(5):311-8. doi:
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American journal of respiratory and critical care medicine.
2002 May; 165(10):1377-83. doi:
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Journal of clinical pharmacology.
2002 Mar; 42(3):319-26. doi:
10.1177/00912700222011355. [PMID: 11865969] - Arno Nolting, Suryanarayana Sista, Wattanaporn Abramowitz. Single-dose study to compare the pharmacokinetics of HFA flunisolide and CFC flunisolide.
Journal of pharmaceutical sciences.
2002 Feb; 91(2):424-32. doi:
10.1002/jps.10030. [PMID: 11835202] - A Nolting, S Sista, W Abramowitz. Flunisolide HFA vs flunisolide CFC: pharmacokinetic comparison in healthy volunteers.
Biopharmaceutics & drug disposition.
2001 Dec; 22(9):373-82. doi:
10.1002/bdd.274. [PMID: 11870676] - B I Florea, I C van der Sandt, S M Schrier, K Kooiman, K Deryckere, A G de Boer, H E Junginger, G Borchard. Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).
British journal of pharmacology.
2001 Dec; 134(7):1555-63. doi:
10.1038/sj.bjp.0704390. [PMID: 11724763] - T B Casale, H S Nelson, W E Stricker, H Raff, K B Newman. Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2001 Nov; 87(5):379-85. doi:
10.1016/s1081-1206(10)62918-3. [PMID: 11730179] - J Richards, P Hirst, G Pitcairn, S Mahashabde, W Abramowitz, A Nolting, S P Newman. Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.
2001; 14(2):197-208. doi:
10.1089/08942680152484126. [PMID: 11681651] - T B Kaye. Effect of an inhaled glucocorticoid, flunisolide, on bone mineral density: a 2-year prospective, controlled trial.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2000 Jul; 6(4):311-7. doi:
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International archives of allergy and immunology.
2000 Jun; 122(2):151-4. doi:
10.1159/000024371. [PMID: 10878494] - G R Dickens, D P Wermeling, C J Matheny, W John, W Abramowitz, S M Sista, T Foster, S Choudhury. Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2000 May; 84(5):528-32. doi:
10.1016/s1081-1206(10)62517-3. [PMID: 10831007] - R Brus. Effects of high-dose inhaled corticosteroids on plasma cortisol concentrations in healthy adults.
Archives of internal medicine.
1999 Sep; 159(16):1903-8. doi:
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Clinical endocrinology.
1999 Jul; 51(1):35-9. doi:
10.1046/j.1365-2265.1999.00658.x. [PMID: 10468963] - C A Sorkness, C LaForce, W Storms, W R Lincourt, L Edwards, P R Rogenes. Effects of the inhaled corticosteroids fluticasone propionate, triamcinolone acetonide, and flunisolide and oral prednisone on the hypothalamic-pituitary-adrenal axis in adult patients with asthma.
Clinical therapeutics.
1999 Feb; 21(2):353-67. doi:
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British journal of pharmacology.
1999 Feb; 126(3):794-800. doi:
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The Journal of clinical endocrinology and metabolism.
1998 Mar; 83(3):922-5. doi:
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Journal of clinical pharmacology.
1997 Oct; 37(10):893-903. doi:
10.1002/j.1552-4604.1997.tb04263.x. [PMID: 9505980] - S Rauli, M Del Puppo, L De Angelis, M Galli Kienle. [Determination of flunisolide and its principal hydrolytic metabolite in urine and plasma by LC-NICI-MS with a particle beam interface].
Bollettino chimico farmaceutico.
1997 Apr; 136(4):308-15. doi:
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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1997 Mar; 27(3):270-6. doi:
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The Journal of allergy and clinical immunology.
1997 Mar; 99(3):278-85. doi:
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Lancet (London, England).
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Pneumonologia i alergologia polska.
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Allergologia et immunopathologia.
1992 May; 20(3):124-6. doi:
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Allergologia et immunopathologia.
1991 Sep; 19(5):194-6. doi:
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Allergy.
1990 Nov; 45(8):612-6. doi:
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Allergy.
1982 Jul; 37(5):303-11. doi:
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Journal of steroid biochemistry.
1982 Jan; 16(1):75-80. doi:
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Clinical allergy.
1982 Jan; 12(1):95-105. doi:
10.1111/j.1365-2222.1982.tb03131.x. [PMID: 7067071] - S L Rusnak. Concurrent administration of flunisolide nasal solution with beclomethasone dipropionate bronchial aerosol in patients with both rhinitis and asthma.
Annals of allergy.
1981 Nov; 47(5 Pt 1):320-4. doi:
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Journal of pharmaceutical sciences.
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The Journal of pharmacology and experimental therapeutics.
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The Journal of allergy and clinical immunology.
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Clinical pharmacology and therapeutics.
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Drug metabolism and disposition: the biological fate of chemicals.
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Annals of allergy.
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Canadian Medical Association journal.
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