propofol (BioDeep_00001867993)
Main id: BioDeep_00000006524
代谢物信息卡片
propofol
化学式: C12H18O (178.1357578)
中文名称: 丙泊酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)O
InChI: InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:44915
- KEGG: C07523
- KEGGdrug: D00549
- PubChem: 4943
- DrugBank: DB00818
- ChEMBL: CHEMBL526
- MeSH: Propofol
- CAS: 113981-41-2
- CAS: 2078-54-8
- PubChem: 9726
- PDB-CCD: PFL
- NIKKAJI: J102.606B
- RefMet: Propofol
- medchemexpress: HY-B0649
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Li, Yanwei Li, Yiwei Zeng, Xin Zhou, Su Zhang, Yulan Ren. Construction of preclinical evidence for propofol in the treatment of reperfusion injury after acute myocardial infarction: A systematic review and meta-analysis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 May; 174(?):116629. doi:
10.1016/j.biopha.2024.116629. [PMID: 38640712] - Wen Sun, Pengyue Zhao, Shidong Hu, Zhenting Zhao, Boyan Liu, Xingpeng Yang, Jiaqi Yang, Ze Fu, Songyan Li, Wenli Yu. NUFIP1-engineered exosomes derived from hUMSCs regulate apoptosis and neurological injury induced by propofol in newborn rats.
Neurotoxicology.
2024 May; 102(?):81-95. doi:
10.1016/j.neuro.2024.04.002. [PMID: 38599287] - Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, Song Tao. Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis.
Advances in therapy.
2024 May; 41(5):1896-1910. doi:
10.1007/s12325-024-02820-1. [PMID: 38480661] - Hui Liu, Mingshuo Hao, Wen Liu, Haiyan Chen, Changlong Han, Yun Shao, Liyuan Wang. Medium- and long-chain triglyceride propofol activates PI3K/AKT pathway and inhibits non-alcoholic fatty liver disease by inhibiting lipid accumulation.
Journal of bioenergetics and biomembranes.
2024 Feb; 56(1):45-53. doi:
10.1007/s10863-023-09997-0. [PMID: 38032443] - Changyin Lu, Yin Kang, Quehua Luo, Fei Zhong, Yujing Cai, Guangyan Zhang, Zhimin Guo, Shaoting Zhang, Jue Ma, HaiHua Shu. Effectiveness of general anaesthesia with remimazolam tosilate on intraoperative haemodynamics and postoperative recovery: study protocol for a randomised, positive-controlled, pragmatic clinical trial (GARTH trial).
BMJ open.
2024 01; 14(1):e073024. doi:
10.1136/bmjopen-2023-073024. [PMID: 38176870] - Mei-Ji Zhao, Hai-Feng Hu, Xin-Lei Li, Xiao-Ming Li, Da-Chuan Wang, Ming-Jie Kuang. The safety and efficacy between remimazolam and propofol in intravenous anesthesia of endoscopy operation: a systematic review and meta-analysis.
International journal of surgery (London, England).
2023 Nov; 109(11):3566-3577. doi:
10.1097/js9.0000000000000638. [PMID: 37534687] - Xiaofei Wu, Jinhe Deng, Xiaona Li, Li Yang, Gaofeng Zhao, Qing Yin, Yongyong Shi, Zhilan Tong. Effects of Propofol on Perioperative Sleep Quality in Patients Undergoing Gastrointestinal Endoscopy: A Prospective Cohort Study.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 10; 38(5):787-791. doi:
10.1016/j.jopan.2023.02.001. [PMID: 37269278] - Amitabh Dutta, Nitin Sethi, Goverdhan D Puri, Jayashree Sood, Prabhat Kumar Choudhary, Anil Kumar Jain, Bhuwan Chand Panday, Manish Gupta. Automated Closed-Loop Propofol Anesthesia Versus Desflurane Inhalation Anesthesia in Obese Patients Undergoing Bariatric Surgery: A Comparative Randomized Analysis of Recovery Profile.
Asian journal of anesthesiology.
2023 Jun; ?(?):. doi:
10.6859/aja.202306/pp.0001. [PMID: 37386923] - T Rooimans, M Damen, C M A Markesteijn, C C L Schuurmans, N H C de Zoete, P M van Hasselt, W E Hennink, C F van Nostrum, M Hermes, R Besseling, H Vromans. Development of a compounded propofol nanoemulsion using multiple non-invasive process analytical technologies.
International journal of pharmaceutics.
2023 Jun; 640(?):122960. doi:
10.1016/j.ijpharm.2023.122960. [PMID: 37061210] - Michiko Higashi, Saori Taharabaru, Yushi U Adachi, Maiko Satomoto, Takahiro Tamura, Naoyuki Matsuda, Aiji Sato-Boku, Masahiro Okuda. Administration of lipid emulsion reduced the hypnotic potency of propofol more than that of thiamylal in mice.
Experimental animals.
2023 Jun; ?(?):. doi:
10.1538/expanim.23-0010. [PMID: 37271538] - Xiaoyu Qin, Xiaoting Lu, Lu Tang, Chunai Wang, Jianjun Xue. Ciprofol versus propofol for sedation in gastrointestinal endoscopy: protocol for a systematic review and meta-analysis.
BMJ open.
2023 05; 13(5):e071438. doi:
10.1136/bmjopen-2022-071438. [PMID: 37258073] - Yong Yang, Lin Feng, Chengcheng Ji, Kaizhi Lu, Yang Chen, Bing Chen. Inhalational Versus Propofol-based Intravenous Maintenance of Anesthesia for Emergence Delirium in Adults: A Meta-analysis and Trial Sequential Analysis.
Journal of neurosurgical anesthesiology.
2023 Apr; 35(2):177-186. doi:
10.1097/ana.0000000000000830. [PMID: 35026799] - Yue Sui, Yanhua Zheng, Qing Wang, Jieping Lv, Hongjin Wang, Qing Wen, Zhenzhen Wang, Guanfeng Wang, Hui Jia, Fengzhen Cao, Naping Wang, Junlian Hao, Yiping Zhang, Xiaopeng Wu, Haihua Chen, Junhui Lu, Xing Chen. Comparison of missed adenomas in deep-sedated and unsedated colonoscopy: A multicenter retrospective study.
European journal of internal medicine.
2023 04; 110(?):48-53. doi:
10.1016/j.ejim.2023.01.019. [PMID: 36710136] - Briana J Negaard, Ryan Hobbs, Jared R Frye, Anna E Merrill. Propofol-induced interference with activated partial thromboplastin time-based monitoring of therapeutic heparin anticoagulation.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2023 03; 80(7):445-451. doi:
10.1093/ajhp/zxac337. [PMID: 36370416] - Bin Han, Yanyan Liu, Qiongqiong Zhang, Liqun Liang. Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Journal of proteomics.
2023 03; 274(?):104777. doi:
10.1016/j.jprot.2022.104777. [PMID: 36427803] - Gui-Bo Fan, Yan Li, Gao-Shuo Xu, A-Yang Zhao, Hong-Jiang Jin, Si-Qi Sun, Si-Hua Qi. Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Neurochemical research.
2023 Mar; 48(3):956-966. doi:
10.1007/s11064-022-03822-7. [PMID: 36402927] - Nan Jiang, Xianxu Li, Qian Wang, Baikerouzi Baihetiyaer, Xiaoteng Fan, Mingsheng Li, Huimin Sun, Xianqiang Yin, Jun Wang. Ecological risk assessment of environmentally relevant concentrations of propofol on zebrafish (Danio rerio) at early life stage: Insight into physiological, biochemical, and molecular aspects.
Chemosphere.
2023 Mar; 316(?):137846. doi:
10.1016/j.chemosphere.2023.137846. [PMID: 36646180] - Nianping Chen, Jiang Qian, Dan Wu, Wei Chen, Jiayan Mao, Ying Cai, Mengting Gu. Propofol mediates bone metastasis by regulating PC-derived exosomal miR-142-3p.
Bulletin du cancer.
2023 Feb; ?(?):. doi:
10.1016/j.bulcan.2023.01.008. [PMID: 36781343] - Mohsin Kazi, Athba Alqahtani, Majed Alharbi, Ajaz Ahmad, Muhammad Delwar Hussain, Hani Alothaid, Mohammed S Aldughaim. The Development and Optimization of Lipid-Based Self-Nanoemulsifying Drug Delivery Systems for the Intravenous Delivery of Propofol.
Molecules (Basel, Switzerland).
2023 Feb; 28(3):. doi:
10.3390/molecules28031492. [PMID: 36771156] - Bo Zhang, Qi Hou, Xiaoli Zhang, Yiming Ma, Junhu Yuan, Shuai Li, Xinhua Zhao, Li Sun, Hongying Wang, Hui Zheng. Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
Free radical biology & medicine.
2023 02; 195(?):298-308. doi:
10.1016/j.freeradbiomed.2022.12.092. [PMID: 36586453] - Nan Jiang, Jun Wang, Qian Wang, Baikerouzi Baihetiyaer, Xianxu Li, Zhongkang Yang, Mingsheng Li, Huimin Sun, Xianqiang Yin. Evaluation of the biological response of propofol in zebrafish (Danio rerio): Focusing on biochemical, transcriptional, and molecular level.
Environmental pollution (Barking, Essex : 1987).
2023 Jan; 317(?):120764. doi:
10.1016/j.envpol.2022.120764. [PMID: 36455772] - Edip Gonullu, Gozde Dagistan, Yuksel Erkin, Mumin Alper Erdogan, Oytun Erbas. Demonstration of the protective effect of propofol in rat model of cisplatin-induced neuropathy.
Bratislavske lekarske listy.
2023; 124(1):64-69. doi:
10.4149/bll_2023_010. [PMID: 36519610] - JianE Wu, Fucheng Zhou, Shangshu Lai, Wenhua Wang, Ting Wu, Ying Liu, Li Yang. Propofol Inhibits Biological Function of Hepatocellular Carcinoma Cells through LINC00475-Mediated Sonic Hedgehog Pathway.
Pharmacology.
2023; 108(2):127-137. doi:
10.1159/000527200. [PMID: 36516819] - Tian-Yuan Luo, Long-Yu Li, Jia Li, Shuang Cai, Yuan Wang, Lin Zhang, Shou-Yang Yu, Tian Yu. Claustrum modulates behavioral sensitivity and EEG activity of propofol anesthesia.
CNS neuroscience & therapeutics.
2023 01; 29(1):378-389. doi:
10.1111/cns.14012. [PMID: 36353753] - Ai Wei, Shijin Ma, Yuzhe Dou, Xiaojun Wang, Jianxiong Wu, Shuzhi Zhou, Yanfang Deng, Xinquan Liu, Dongming Li, Mengchang Yang. The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.
PloS one.
2023; 18(8):e0282930. doi:
10.1371/journal.pone.0282930. [PMID: 37535618] - Hui Yang, YuJun Zhang, ChuiLiang Liu, YangWen Ou, YuHang Zhu, Yun Xue, GaoFeng Zhao, YuShuang Lin, Chun Chen, GuoHai Xu, KaiMing Yuan, Qiang Wang, Min Zhang, LiE Li, Jin Liu, WenSheng Zhang. A Multicenter, Randomized, Double-Blind, Positive-Controlled, Non-Inferiority, Phase III Clinical Trial Evaluating the Efficacy and Safety of Emulsified Isoflurane for Anesthesia Induction in Patients.
CNS drugs.
2022 12; 36(12):1301-1311. doi:
10.1007/s40263-022-00970-w. [PMID: 36385453] - Milad Karamlou, Iman Asaria, Jaime Barron, Petra Boutros, Vincent Fisher, Rachel Grandinetti, Julian Johnson, Emily Richard, David Susko, Cristobal Urrutia, Bryce Woolsey, Ronald Baumann, James Cottle, Richard Sweaney, Mark Wenzel, John Nusstein, David Hall. Complications After Dental Sedation: A Myotonic Mystery Case Report.
Anesthesia progress.
2022 12; 69(4):26-31. doi:
10.2344/anpr-69-02-09. [PMID: 36534775] - Yusheng Yao, Jinsheng Guan, Linwei Liu, Bingbing Fu, Lei Chen, Xiaochun Zheng. Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
European journal of anaesthesiology.
2022 12; 39(12):911-917. doi:
10.1097/eja.0000000000001715. [PMID: 35796575] - Xiao Liu, Bo Yang, Ya-Fang Tan, Jian-Guo Feng, Jing Jia, Cheng-Jie Yang, Ye Chen, Mao-Hua Wang, Jun Zhou. The role of AMPK-Sirt1-autophagy pathway in the intestinal protection process by propofol against regional ischemia/reperfusion injury in rats.
International immunopharmacology.
2022 Oct; 111(?):109114. doi:
10.1016/j.intimp.2022.109114. [PMID: 35933747] - Ruyu Yan, Tieying Song, Wenli Wang, Jun Tian, Xiaojing Ma. Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer.
Immunopharmacology and immunotoxicology.
2022 Sep; ?(?):1-7. doi:
10.1080/08923973.2022.2122501. [PMID: 36073191] - Yue Sui, Qing Wang, Hai-Hua Chen, Jun-Hui Lu, Qing Wen, Zhen-Zhen Wang, Guan-Feng Wang, Hui Jia, Tao Xiao, Na-Ping Wang, Jun-Lian Hao, Yi-Ping Zhang, Feng-Zhen Cao, Xiao-Peng Wu, Xing Chen. Comparison of adenoma detection in different colorectal segments between deep-sedated and unsedated colonoscopy.
Scientific reports.
2022 09; 12(1):15356. doi:
10.1038/s41598-022-19468-y. [PMID: 36097050] - Eugene Kim, Shivali Mukerji, Deen Debryn, Ryan Price, Carl Streed, Ala Nozari. Oxygen desaturation in a transgender man: initial concerns and recommendations regarding the practice of chest binding: a case report.
Journal of medical case reports.
2022 Sep; 16(1):333. doi:
10.1186/s13256-022-03527-z. [PMID: 36057618] - Wenting Xuan, Xinyi Lu, Zeyong Yang, Jun Li, Weilin Jin, Yuanhai Li. Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells.
Journal of molecular neuroscience : MN.
2022 Sep; 72(9):1797-1808. doi:
10.1007/s12031-022-02017-7. [PMID: 35727524] - Yue Sui, Xing Chen, Ting Ma, Junhui Lu, Tao Xiao, Zhenzhen Wang, Qing Wen, Guanfeng Wang, Hui Jia, Fengzhen Cao, Xiaopeng Wu, Yiping Zhang, Junlian Hao, Naping Wang. Comparison of three sedation models for same-day painless bidirectional endoscopy: A multicenter randomized controlled trial.
Journal of gastroenterology and hepatology.
2022 Aug; 37(8):1603-1609. doi:
10.1111/jgh.15901. [PMID: 35618650] - Yajing Dong, Zhi Liang, Zhe Xu, Wei Hao, Dandan Wang, Jing Yang, Jun Yuan. Effect of Wrist-Ankle Acupuncture on Propofol Dosage in Painless Gastroscopy of Elderly Patients: A Randomized Controlled Trial.
American journal of therapeutics.
2022 07; 29(4):467-470. doi:
10.1097/mjt.0000000000001272. [PMID: 33021547] - Marina V Viana, Olivier Pantet, Mélanie Charrière, Doris Favre, Lise Piquilloud, Antoine G Schneider, Claire-Anne Hurni, Mette M Berger. Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19.
JPEN. Journal of parenteral and enteral nutrition.
2022 07; 46(5):1149-1159. doi:
10.1002/jpen.2334. [PMID: 35048374] - Ming-Shan Chen, Kung-Ssu Yang, Wen-Chun Lin, Chien-Liang Fang, Hsin-Fu Chen, Shew-Meei Sheu. Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps.
Molecular biology reports.
2022 Jul; 49(7):6517-6529. doi:
10.1007/s11033-022-07482-2. [PMID: 35637315] - Lingling Ding, Jiaqi Ning, Yuhong Guo, Qi Wang, Shishun Kou, Hai Ke, Ruiling Zhou, Bo Yu. The Preventive Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients with Time Factors: A Randomized Trial.
Journal of integrative and complementary medicine.
2022 Jun; ?(?):. doi:
10.1089/jicm.2021.0141. [PMID: 35714357] - Nicole Wylie, Lee Beale, Ian Westley. Consistency of remifentanil concentrations in propofol-Remifentanil infusions. A laboratory-based study.
Paediatric anaesthesia.
2022 06; 32(6):727-731. doi:
10.1111/pan.14427. [PMID: 35234322] - Matthias Preusse, Georgia Paraschaki, Soeren Lutz. A Case of ECHS1 Deficiency with Severe Encephalopathy and Status Epilepticus after a Propofol Sedation: Case Report.
Neuropediatrics.
2022 06; 53(3):213-216. doi:
10.1055/s-0042-1742305. [PMID: 35098523] - Wasim S El Nekidy, Abdullah Shatnawei, Manal M Abdelsalam, Mariam Hassan, Ruba Z Dajani, Nouran Salem, Terrence J Lee St John, Nadeem Rahman, Fadi Hamed, Jihad Mallat. Hypertriglyceridemia in Critically Ill Patients With SARS-CoV-2 Infection.
The Annals of pharmacotherapy.
2022 06; 56(6):637-644. doi:
10.1177/10600280211038302. [PMID: 34470517] - Aleksi J Nummela, Lauri T Laaksonen, Timo T Laitio, Roosa E Kallionpää, Jaakko W Långsjö, Joonas M Scheinin, Tero J Vahlberg, Harri T Koskela, Viljami Aittomäki, Katja J Valli, Antti Revonsuo, Mikko Niemi, Markus Perola, Harry Scheinin. Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy.
European journal of anaesthesiology.
2022 06; 39(6):521-532. doi:
10.1097/eja.0000000000001591. [PMID: 34534172] - Pedro David Wendel-Garcia, Rolf Erlebach, Daniel Andrea Hofmaenner, Giovanni Camen, Reto Andreas Schuepbach, Christoph Jüngst, Beat Müllhaupt, Jan Bartussek, Philipp Karl Buehler, Rea Andermatt, Sascha David. Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome.
Critical care (London, England).
2022 05; 26(1):148. doi:
10.1186/s13054-022-04019-8. [PMID: 35606831] - Daniel Kiefer, Lukas M Müller-Wirtz, Felix Maurer, Tobias Hüppe, Alexander M Mathes, Thomas Volk, Sascha Kreuer, Tobias Fink. Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats.
Experimental animals.
2022 May; 71(2):231-239. doi:
10.1538/expanim.21-0147. [PMID: 34880161] - Yongjun Liu, Xiangyou Yu, Duming Zhu, Jun Zeng, Qinhan Lin, Bin Zang, Chuanxi Chen, Ning Liu, Xiao Liu, Wei Gao, Xiangdong Guan. Safety and efficacy of ciprofol vs. propofol for sedation in intensive care unit patients with mechanical ventilation: a multi-center, open label, randomized, phase 2 trial.
Chinese medical journal.
2022 05; 135(9):1043-1051. doi:
10.1097/cm9.0000000000001912. [PMID: 34924506] - Ju-Tae Sohn. Comment: The Safety of Continuous Infusion Propofol in Mechanically Ventilated Adults With Coronavirus Disease 2019.
The Annals of pharmacotherapy.
2022 05; 56(5):626-627. doi:
10.1177/10600280211043505. [PMID: 34496671] - Jiajia Ma, Wei Xiong, Dongze Guo, Anxin Wang, Hui Qiao, Ruquan Han. Effects of Sevoflurane-Propofol-Balanced Anesthesia on Flash Visual Evoked Potential Monitoring in Spine Surgery: A Randomized Noninferiority Trial.
Anesthesia and analgesia.
2022 05; 134(5):1054-1061. doi:
10.1213/ane.0000000000005742. [PMID: 34543246] - Stephanie Franzén, Egidijus Semenas, Micael Taavo, Johan Mårtensson, Anders Larsson, Robert Frithiof. Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised controlled study.
British journal of anaesthesia.
2022 05; 128(5):838-848. doi:
10.1016/j.bja.2022.02.030. [PMID: 35279277] - Omid Azimaraghi, Karuna Wongtangman, Luca J Wachtendorf, Peter Santer, Sandra Rumyantsev, Curie Ahn, Michael E Kiyatkin, Bijan Teja, Todd Sarge, Balachundhar Subramaniam, Matthias Eikermann. Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network.
Critical care medicine.
2022 05; 50(5):e434-e444. doi:
10.1097/ccm.0000000000005425. [PMID: 34982739] - Martin R Braathen, Ivan Rimstad, Terje Dybvik, Ståle Nygård, Johan Raeder. Online exhaled propofol monitoring in normal-weight and obese surgical patients.
Acta anaesthesiologica Scandinavica.
2022 05; 66(5):598-605. doi:
10.1111/aas.14043. [PMID: 35138633] - Corey J Witenko, Audrey J Littlefield, Sajjad Abedian, Anjile An, Philip S Barie, Karen Berger. Reply: The Safety of Continuous Infusion Propofol in Mechanically Ventilated Adults With Coronavirus Disease 2019.
The Annals of pharmacotherapy.
2022 05; 56(5):628-629. doi:
10.1177/10600280211043188. [PMID: 34486409] - Junbao Zhang, Xin Wang, Qing Zhang, Zicheng Wang, Shoufeng Zhu. Application effects of remimazolam and propofol on elderly patients undergoing hip replacement.
BMC anesthesiology.
2022 04; 22(1):118. doi:
10.1186/s12871-022-01641-5. [PMID: 35461223] - Colleen Elizabeth Howing, Farzad Razi, Wael Hakmeh. Resolution of status epilepticus after ketamine administration.
The American journal of emergency medicine.
2022 Apr; 54(?):328.e1-328.e2. doi:
10.1016/j.ajem.2021.10.052. [PMID: 34763960] - Seunghee Ki, Yongwon Cho, Youngkyung Choi, Sehun Lim, Myounghun Kim, Jeonghan Lee. Effect of chemotherapy on effect-site concentration of propofol for loss of consciousness in patients with colorectal cancer.
Korean journal of anesthesiology.
2022 04; 75(2):160-167. doi:
10.4097/kja.21327. [PMID: 34551470] - Jia Guo, Ke Xu, Jiang-Wen Yin, Han Zhang, Jie-Ting Yin, Yan Li. Dopamine transporter in the ventral tegmental area modulates recovery from propofol anesthesia in rats.
Journal of chemical neuroanatomy.
2022 04; 121(?):102083. doi:
10.1016/j.jchemneu.2022.102083. [PMID: 35181484] - Youn Joung Cho, Dhong-Eun Jung, Karam Nam, Jinyoung Bae, Seohee Lee, Yunseok Jeon. Effects of transcutaneous electrical nerve stimulation on myocardial protection in patients undergoing aortic valve replacement: a randomized clinical trial.
BMC anesthesiology.
2022 03; 22(1):68. doi:
10.1186/s12871-022-01611-x. [PMID: 35264104] - Akira Kuriyama. Green urine due to propofol.
Postgraduate medical journal.
2022 Mar; 98(1157):230. doi:
10.1136/postgradmedj-2020-139486. [PMID: 33380442] - James D Morse, Luis Ignacio Cortinez, Stephen Meneely, Brian J Anderson. Propofol context-sensitive decrement times in children.
Paediatric anaesthesia.
2022 Mar; 32(3):396-403. doi:
10.1111/pan.14391. [PMID: 34971456] - Hua Yang, Qian Zhao, Hai-Yan Chen, Wen Liu, Tong Ding, Bin Yang, Jin-Chao Song. The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: A randomized controlled trial.
British journal of clinical pharmacology.
2022 03; 88(3):1279-1287. doi:
10.1111/bcp.15072. [PMID: 34496448] - LongYuan Zhou, RuiLan Wu, Chang Cai, Yong Qi, XingHua Bi, Qi Hang. The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy: A randomized controlled trial (CONSORT compliant).
Medicine.
2022 Feb; 101(6):e27642. doi:
10.1097/md.0000000000027642. [PMID: 35147085] - Ashraf A Dahaba, Zhaoyang Xiao, Xiaoling Zhu, Karl Oettl, Hailong Dong, Lize Xiong, Sieglinde Zelzer, Shuiyu Zhao, Gilbert Reibnegger. Location matters: Overlooked ethnic-geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in men, women, and one transgender subject.
Fundamental & clinical pharmacology.
2022 Feb; 36(1):182-198. doi:
10.1111/fcp.12704. [PMID: 34050969] - Chinatsu Umaba, Yohei Mineharu, Nan Liang, Toshiyuki Mizota, Rie Yamawaki, Masaya Ueda, Yukihiro Yamao, Manabu Nankaku, Susumu Miyamoto, Shuichi Matsuda, Hiroyuki Inadomi, Yoshiki Arakawa. Intraoperative hand strength as an indicator of consciousness during awake craniotomy: a prospective, observational study.
Scientific reports.
2022 01; 12(1):216. doi:
10.1038/s41598-021-04026-9. [PMID: 34997054] - W W Zhang, R Xue, T Y Mi, X M Shen, J C Li, S Li, Y Zhang, Y Li, L X Wang, X L Yin, H L Wang, Y Z Zhang. Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids beta-oxidation.
Biochemical and biophysical research communications.
2022 01; 586(?):121-128. doi:
10.1016/j.bbrc.2021.11.073. [PMID: 34839190] - Farhad Gorjipour, Tahereh Saeedzadeh, Yaser Toloueitabar, Naser Kachoueian, Sepideh Bahlouli Ghashghaei, Meysam Mortazian, Mehdi Dehghani Firoozabadi, Amirnaser Jadbabaie, Koroush Tirgarfakheri, Amir Motamednejad, Ziae Totonchi. Remote ischemic preconditioning effects on inflammatory markers and myocardial protection in coronary artery bypass graft surgery.
Perfusion.
2022 Jan; 37(1):56-61. doi:
10.1177/0267659120979293. [PMID: 33280529] - Yuanyuan Gao, Fei Yan. Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
Current drug metabolism.
2022; 23(1):45-56. doi:
10.2174/1389200222666211103121832. [PMID: 34732114] - Thomas A Neff, Julia Braun, Dhanu Rana, Milo Puhan, Miodrag Filipovic, Manfred Seeberger, Frank Stüber, Simona B Neff, Beatrice Beck-Schimmer, Martin Schläpfer. Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial.
Anesthesia and analgesia.
2022 01; 134(1):123-132. doi:
10.1213/ane.0000000000005639. [PMID: 34132704] - Bailong Hu, Ke Jiang, Wenyan Shi, Shixiang Xiao, Shili Zhang, Yongguo Zhang, Yuancheng Zhou, Chengwei Tan, Songjiang Tan, Xiaohua Zou. Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study.
Drug design, development and therapy.
2022; 16(?):4151-4159. doi:
10.2147/dddt.s391147. [PMID: 36506792] - Minhye Chang, Sung-Ae Cho, Seok-Jin Lee, Tae-Yun Sung, Choon-Kyu Cho, Young Seok Jee. Comparison of the effects of dexmedetomidine and propofol on hypothermia in patients under spinal anesthesia: a prospective, randomized, and controlled trial.
International journal of medical sciences.
2022; 19(5):909-915. doi:
10.7150/ijms.72754. [PMID: 35693746] - Corey J Witenko, Audrey J Littlefield, Sajjad Abedian, Anjile An, Philip S Barie, Karen Berger. The Safety of Continuous Infusion Propofol in Mechanically Ventilated Adults With Coronavirus Disease 2019.
The Annals of pharmacotherapy.
2022 01; 56(1):5-15. doi:
10.1177/10600280211017315. [PMID: 33985368] - Hennadiy P Pasichnyk, Jan Bilawicz, Yaroslav M Pidhirnyj, Romana O Merza. SAFETY OF PROPOFOL ANESTHESIA DURING NEUROSURGICAL OPERATIONS.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2022; 75(11 pt 1):2631-2634. doi:
10.36740/wlek202211114. [PMID: 36591745] - Jin-Chao Song, Xiao-Yan Meng, Hua Yang, Hao Gao, Mei-Hua Cai, Ma-Zhong Zhang, Wei-Feng Yu. Obstructive Jaundice does not Change the Population Pharmacokinetics of Etomidate in Patients who Underwent Bile Duct Surgery.
Current drug delivery.
2022; 19(5):635-641. doi:
10.2174/1567201818666210617101630. [PMID: 34139982] - Dandan Xing, QiuChang Li, Guanwen Lin, Hui Lin, Wenyue Kang, Min Zhang, Rong Ding, Na Li. The protective effects of propofol against renal ischemia-reperfusion injury are potentiated by norisoboldine treatment via inhibition of oxidative stress pathways.
Journal of biochemical and molecular toxicology.
2022 Jan; 36(1):e22937. doi:
10.1002/jbt.22937. [PMID: 34719823] - Hsin-Yu Huang, Kai-Yueh Liao, Wei-Yau Shia, Chao-Chin Chang, Hsien-Chi Wang. Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs.
The Journal of veterinary medical science.
2021 Dec; 83(12):1869-1876. doi:
10.1292/jvms.20-0657. [PMID: 34629333] - Tae Kyun Kim. Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil.
Korean journal of anesthesiology.
2021 12; 74(6):478-487. doi:
10.4097/kja.21345. [PMID: 34407372] - Qingduo Guo, Meina Ma, Qiuying Yang, Hong Yu, Xupeng Wang, Chunling Wu, Rui Li. Effects of different sedatives/analgesics on stress responses in patients undergoing craniotomy and bone flap decompression.
The Journal of international medical research.
2021 Dec; 49(12):3000605211062789. doi:
10.1177/03000605211062789. [PMID: 34898308] - Wenshui Yao, Longxin Zhang, Guolin Lu, Jing Wang, Li Zhang, Yuping Wang, Peihan Xiao, Xiaofen Chen, Chanjuan Chen, Min Zhou. Use of intravenous lidocaine for dose reduction of propofol in paediatric colonoscopy patients: a randomised placebo-controlled study.
BMC anesthesiology.
2021 12; 21(1):299. doi:
10.1186/s12871-021-01525-0. [PMID: 34852767] - Logan J Voss, John C Voss, Jamie W Sleigh. Application of a benchtop colorimetric method for quantification of blood propofol levels.
Journal of clinical monitoring and computing.
2021 12; 35(6):1485-1489. doi:
10.1007/s10877-020-00616-6. [PMID: 33180248] - M A Chagas, L P Custodio, B S Gusmão, I M Costa, G H Julião, Sls Bordolini, L R Costa, Mrm Bosculo, T F Moreira, Bfm Almeida, N P Reis Filho, F G Romão, Cjx Abimussi, B P Floriano. Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy.
Topics in companion animal medicine.
2021 Nov; 45(?):100560. doi:
10.1016/j.tcam.2021.100560. [PMID: 34260989] - Orlando Garner, Jonathan Patterson, Julieta Muñoz Mejia, Vijay Anand, Juan Deleija, Christopher Nemeh, Meghna Vallabh, Kristen A Staggers, Christopher M Howard, Sergio Enrique Treviño, Muhammad Asim Siddique, Christopher K Morgan. Impact of ketamine as an adjunct sedative in acute respiratory distress syndrome due to COVID-19 Pneumonia.
Respiratory medicine.
2021 Nov; 189(?):106667. doi:
10.1016/j.rmed.2021.106667. [PMID: 34757277] - Torin W Waters, David S Dickens. Reducing sedated lumbar punctures in pediatric patients with acute lymphoblastic leukemia.
Pediatric blood & cancer.
2021 11; 68(11):e29272. doi:
10.1002/pbc.29272. [PMID: 34331510] - Mauro Manno, Paolo Biancheri, Alessandro Pignatti, Enrica Becchi, Matteo Gazzi, Paola Soriani. Non-anesthesiologist sedation (NAS): The Italian retrotopia needs to be overcome.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2021 11; 53(11):1513-1514. doi:
10.1016/j.dld.2021.05.036. [PMID: 34162510] - Rattaphol Seangrung, Koravee Pasutharnchat, Subundit Injampa, Sirima Kumdang, Rojnarin Komonhirun. Comparison of the hemodynamic response of dexmedetomidine versus additional intravenous lidocaine with propofol during tracheal intubation: a randomized controlled study.
BMC anesthesiology.
2021 10; 21(1):265. doi:
10.1186/s12871-021-01484-6. [PMID: 34717532] - Tianyuan Li, Qing-Shi Zeng, Shou-Zhang She. Limb Remote Ischemic Preconditioning Applied During Sevoflurane Anesthesia Does Not Protect the Lungs in Patients Undergoing Adult Heart Valve Surgery.
The heart surgery forum.
2021 Oct; 24(5):E916-E924. doi:
10.1532/hsf.4139. [PMID: 34730488] - Ignazio Condello, Giuseppe Santarpino, Flavio Fiore, Nicola Di Bari, Giuseppe Speziale, Marco Moscarelli, Giuseppe Nasso. Propofol pharmacokinetics and pharmacodynamics-a perspective in minimally invasive extracorporeal circulation.
Interactive cardiovascular and thoracic surgery.
2021 10; 33(4):625-627. doi:
10.1093/icvts/ivab143. [PMID: 33969407] - Luciana Boavista Barros Heil, Fernanda Ferreira Cruz, Mariana Alves Antunes, Cassia Lisboa Braga, Lais Costa Agra, Rebecca Madureira Bose Leão, Soraia Carvalho Abreu, Paolo Pelosi, Pedro Leme Silva, Patricia Rieken Macedo Rocco. Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals.
Pharmacology research & perspectives.
2021 10; 9(5):e00873. doi:
10.1002/prp2.873. [PMID: 34632734] - Tianxiao Liu, Ting Lai, Jing Chen, Yizhi Lu, Fang He, Yanhua Chen, Yubo Xie. Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial.
Pharmacology research & perspectives.
2021 10; 9(5):e00851. doi:
10.1002/prp2.851. [PMID: 34390228] - Alexandra Baumgarten, Mark Newton. Propofol-induced uric acid crystals: A case of cloudy urine.
Paediatric anaesthesia.
2021 Oct; 31(10):1132-1133. doi:
10.1111/pan.14260. [PMID: 34309948] - Marius Bogdan Novac, Lidia Boldeanu, Luciana Teodora Rotaru, Anda Lorena Dijmărescu, Mircea Sebastian Şerbănescu, Lucreţiu Radu, Simona Daniela Neamţu, Alina Maria Vîlcea, Mihaela Niculescu, Cecil Sorin Mirea, Mihail Virgil Boldeanu, Maria Magdalena Manolea. The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.
2021 Oct; 62(4):961-969. doi:
10.47162/rjme.62.4.08. [PMID: 35673815] - Azzeddine Kermad, Jacques Speltz, Guy Danziger, Thilo Mertke, Robert Bals, Thomas Volk, Philipp M Lepper, Andreas Meiser. Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients-a retrospective chart review.
Journal of anesthesia.
2021 10; 35(5):625-632. doi:
10.1007/s00540-021-02960-6. [PMID: 34169362] - Ruiyun Li, Lu Yang, Su Guan, Ming Lin, Hanjin Lai, Kun Liu, Zimeng Liu, Xuyu Zhang. UPLC-MS-Based Serum Metabolic Profiling Reveals Potential Biomarkers for Predicting Propofol Responsiveness in Females.
Journal of proteome research.
2021 09; 20(9):4578-4588. doi:
10.1021/acs.jproteome.1c00554. [PMID: 34384217] - M M Granados, C Mengual, R Navarrete-Calvo, J A Fernández-Sarmiento, J Morgaz, S Quirós-Carmona, J M Domínguez, A Lora, Juan Manuel Serrano-Rodríguez. Influence of general anaesthesia on the intravenous acetaminophen pharmacokinetics in Beagle dogs.
Veterinary anaesthesia and analgesia.
2021 Sep; 48(5):637-644. doi:
10.1016/j.vaa.2021.02.007. [PMID: 34281773] - Yi Liu, Yuxia Ma, Yunfeng Liu, Wenhao Wang, Feifei Liu. Propofol shows less negative effects on cognitive performances than dexmedetomidine in elderly intensive care unit patients.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2021 Sep; 42(9):3767-3774. doi:
10.1007/s10072-020-04994-2. [PMID: 33449243] - Ashraf A Dahaba, Han Lin, Xue Fei Ye, Nu Zhang, Kun Wang, Gilbert Reibnegger, Qing Quan Lian. Propofol-Bispectral Index (BIS) Electroencephalography (EEG) Pharmacokinetic-Pharmacodynamic Model in Patients With Post-Cerebral Hemorrhage Hydrocephalus.
Clinical EEG and neuroscience.
2021 Sep; 52(5):351-359. doi:
10.1177/1550059420932042. [PMID: 32527157] - Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu. Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours.
Journal of Korean medical science.
2021 Aug; 36(34):e221. doi:
10.3346/jkms.2021.36.e221. [PMID: 34463064] - Kang Mi Lee, Sang Moon Han, Seunghwa Lee, Tae Young Jeong, Ho Jun Kim, Hophil Min, Ki Hun Kim, Sangwon Cha, Won Keun Oh, Jaeick Lee. Fluoride-assisted liquid chromatography-tandem mass spectrometry method for simultaneous analysis of propofol and its metabolites without derivatization in urine.
Journal of chromatography. A.
2021 Aug; 1652(?):462360. doi:
10.1016/j.chroma.2021.462360. [PMID: 34246057] - Kaiwei Wang, Hongqi Lin, Guosong Zhu, Haoran Zhang, Erju Jia. Effect of anesthesia on the expression of clock gene Clock and Bmal1 in New Zealand rabbits.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2021 Aug; 46(8):809-813. doi:
10.11817/j.issn.1672-7347.2021.200755. [PMID: 34565723] - Xuyang Li, Zhan Zhang, Aipeng Li, Yubo Hu. Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR-126-5p axis.
The journal of gene medicine.
2021 08; 23(8):e3349. doi:
10.1002/jgm.3349. [PMID: 33899983] - Elske Sitsen, Erik Olofsen, Albert Dahan, Jaap Vuyk. Effect of lumbar epidural blockade and propofol on mean arterial pressure, cardiac output and bispectral index: A randomised controlled and pharmacodynamic modelling study.
European journal of anaesthesiology.
2021 08; 38(Suppl 2):S121-S129. doi:
10.1097/eja.0000000000001516. [PMID: 33876784] - Valeria Ottaviano, Alessandro Mauro Tavone, Claudia Scipione, Saverio Potenza, Giulia Petroni, Gian Luca Marella. Drug detection in decomposed cadavers confirms testimonial evidence in a case of serial homicides.
Forensic science international.
2021 Aug; 325(?):110893. doi:
10.1016/j.forsciint.2021.110893. [PMID: 34273605]