isosorbide dinitrate (BioDeep_00001867721)
Main id: BioDeep_00000006502
代谢物信息卡片
isosorbide dinitrate
化学式: C6H8N2O8 (236.0281)
中文名称: 硝酸异山梨酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
InChI: InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1
描述信息
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AE - Muscle relaxants
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases > C01DA - Organic nitrates
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:6061
- KEGG: C07456
- KEGGdrug: D00516
- PubChem: 6883
- DrugBank: DB00883
- ChEMBL: CHEMBL6622
- MeSH: Isosorbide Dinitrate
- CAS: 1246815-45-1
- CAS: 54650-95-2
- CAS: 87-33-2
- PubChem: 9659
- NIKKAJI: J3.899G
- KNApSAcK: 6061
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed Amar, Simon W Lam, Kathleen Faulkenberg, Antonio Perez, W H Wilson Tang, J Bradley Williams. Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside.
Journal of cardiac failure.
2021 10; 27(10):1053-1060. doi:
10.1016/j.cardfail.2021.05.007. [PMID: 34051349] - Wael Talaat, Sohila ElOnsy, Reda Mohammed Keshk. Fluorescent sensing for some nitric oxide donors in dosage forms and biological matrices.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Aug; 257(?):119788. doi:
10.1016/j.saa.2021.119788. [PMID: 33894636] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - David M Charytan, Jesse Y Hsu, Finnian R Mc Causland, Sushrut S Waikar, T Alp Ikizler, Dominic S Raj, J Richard Landis, Rajnish Mehrotra, Mark Williams, Marcelo DiCarli, Hicham Skali, Paul L Kimmel, Alan S Kliger, Laura M Dember. Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial.
Kidney360.
2020 12; 1(12):1380-1389. doi:
10.34067/kid.0004342020. [PMID: 35372900] - Yubo Peng, Yanfang Li, Mengmeng Chen, Junying Song, Zhili Jiang, Shutian Shi. High-dose nitrate therapy recovers the expression of subtypes α1 and β-adrenoceptors and Ang II receptors of the renal cortex in rats with myocardial infarction-induced heart failures.
BMC cardiovascular disorders.
2020 02; 20(1):99. doi:
10.1186/s12872-020-01353-z. [PMID: 32106816] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Rasoul Sotoudehmanesh, Ali Ali-Asgari, Morteza Khatibian, Mehdi Mohamadnejad, Shahin Merat, Anahita Sadeghi, Abbas Keshtkar, Mohammad Bagheri, Alireza Delavari, Mohammad Amani, Homayoon Vahedi, Siavosh Nasseri-Moghaddam, Alireza Sima, Mohamad A Eloubeidi, Reza Malekzadeh. Pharmacological prophylaxis versus pancreatic duct stenting plus pharmacological prophylaxis for prevention of post-ERCP pancreatitis in high risk patients: a randomized trial.
Endoscopy.
2019 10; 51(10):915-921. doi:
10.1055/a-0977-3119. [PMID: 31454851] - Bhavesh D Patel, Nageswararao Pulakundam, Ajit R Gadekar, Amol A Raje, Vikram Ramanathan, Rakshit Ameta. Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):396-405. doi:
10.1016/j.jpba.2019.06.007. [PMID: 31212140] - Mohamed Khalaf, Sejal Chowdhary, Puja Sukhwani Elias, Donald Castell. Distal Esophageal Spasm: A Review.
The American journal of medicine.
2018 09; 131(9):1034-1040. doi:
10.1016/j.amjmed.2018.02.031. [PMID: 29605413] - Alanna Strong, Samina Muneeruddin, Richard Parrish, Daniel Lui, Susan B Conley. Isosorbide dinitrate in nephronophthisis treatment.
American journal of medical genetics. Part A.
2018 04; 176(4):1023-1026. doi:
10.1002/ajmg.a.38650. [PMID: 29575630] - Judy E Anderson, Antonia Zhu, Tooru M Mizuno. Nitric oxide treatment attenuates muscle atrophy during hind limb suspension in mice.
Free radical biology & medicine.
2018 02; 115(?):458-470. doi:
10.1016/j.freeradbiomed.2017.12.021. [PMID: 29277394] - Jin Wu, Dongchao Yuan, Mingqian Yang, Wei Xia, Zhe Zhang, Huiyong Zhang, Yutong Fei, Guanlin Yang. Sini decoction as an adjuvant therapy for angina pectoris: a systematic review of randomized controlled trials.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2017 02; 37(1):12-22. doi:
10.1016/s0254-6272(17)30021-3. [PMID: 29956897] - Matthew J Snyder, Lawrence M Gibbs, Tammy J Lindsay. Treating Painful Diabetic Peripheral Neuropathy: An Update.
American family physician.
2016 Aug; 94(3):227-34. doi:
". [PMID: 27479625] - Jerry Yee. PGX: Pharmacogenomics During Generation X.
Advances in chronic kidney disease.
2016 Mar; 23(2):57-60. doi:
10.1053/j.ackd.2016.01.012. [PMID: 26979142] - Zuoliang Liu, Bikui Zhang, Xin Guo, Lei Chen, Dongyang Yi, Junzi Cong, Ren Guo. CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway.
International journal of clinical pharmacology and therapeutics.
2015 Apr; 53(4):325-34. doi:
10.5414/cp202178. [PMID: 25740261] - Changyun Jin, Ji-Young Jeon, Yong-Jin Im, Jin-A Jeong, Yunjeong Kim, Soo-Wan Chae, Jürgen Bentz, Thomas Kumke, Min-Gul Kim. Pharmacokinetic properties of isosorbide-5-mononitrate under fasting and fed conditions in healthy male subjects.
International journal of clinical pharmacology and therapeutics.
2015 Jan; 53(1):97-106. doi:
10.5414/cp202169. [PMID: 25492848] - Ning Li, Chun-lan Li, Ning-wei Lu, Yu-ming Dong. A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):90-7. doi:
10.1016/j.jchromb.2014.07.019. [PMID: 25086418] - Gui-hua Li, Hong-yan Jiang, Yan-ming Xie, Jun-jie Jiang, Wei Yang, Wei Zhao, Yan Zhuang, Yong-yan Wang. [Analysis of traditional Chinese medicine syndrome, traditional Chinese medicine and western medicine in 84 697 patients with coronary heart disease based on big data].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Sep; 39(18):3462-8. doi:
. [PMID: 25532378] - Alok Sharma, Monica Colvin-Adams, Clyde W Yancy. Heart failure in African Americans: disparities can be overcome.
Cleveland Clinic journal of medicine.
2014 May; 81(5):301-11. doi:
10.3949/ccjm.81a.13045. [PMID: 24789589] - Z Jiang, C Wei, Z Sun, J Guo, R Li, R Zhang, G Yuan, R Guo. A simple and sensitive gas chromatography method for determination of isosorbide dinitrate and its metabolites in human plasma: application to pharmacokinetics study on oral spray.
Drug research.
2014 Feb; 64(2):73-8. doi:
10.1055/s-0033-1351286. [PMID: 23904215] - Camille Jardeleza, Shasha Rao, Benjamin Thierry, Pratik Gajjar, Sarah Vreugde, Clive A Prestidge, Peter-John Wormald. Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms.
PloS one.
2014; 9(3):e92117. doi:
10.1371/journal.pone.0092117. [PMID: 24658315] - Qian Fan, Lifen Chen, Shujuan Cheng, Fang Li, Wayne Bond Lau, Le Feng Wang, Jing Hua Liu. Aging aggravates nitrate-mediated ROS/RNS changes.
Oxidative medicine and cellular longevity.
2014; 2014(?):376515. doi:
10.1155/2014/376515. [PMID: 24790702] - Fatih Tarhan, Osman Çelik, Çağatay Tosun, Gökhan Faydacı, Bilal Eryıldırım. Comparison of the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract symptoms and benign prostatic hyperplasia: a randomized clinical trial.
Urologia internationalis.
2014; 93(1):17-21. doi:
10.1159/000357034. [PMID: 24643055] - Jiangtao Lai, Bifeng Wu, Jian Sun, Yunpeng Shang, Jianhua Zhu. Long-term isosorbide mononitrate treatment impairs endothelial function in patients with coronary artery disease.
Coronary artery disease.
2013 Nov; 24(7):566-71. doi:
10.1097/mca.0000000000000029. [PMID: 23994882] - Yan-Peng Chang, Hui Zhang, Yan-Ming Xie, Xian-Bin Zeng, Jian Hu, Yan Zhuang. [Analysis of salvianolate injection combined with usual drugs in treatment of coronary heart disease in real world].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Sep; 38(18):3186-9. doi:
NULL. [PMID: 24471349] - Abel Wakai, Aileen McCabe, Rachel Kidney, Steven C Brooks, Rawle A Seupaul, Deborah B Diercks, Nigel Salter, Gregory J Fermann, Caroline Pospisil. Nitrates for acute heart failure syndromes.
The Cochrane database of systematic reviews.
2013 Aug; ?(8):CD005151. doi:
10.1002/14651858.cd005151.pub2. [PMID: 23922186] - Ke-Qing Shi, Wen-Yue Liu, Zhen-Zhen Pan, Xiang-Feng Ling, Shao-Long Chen, Yong-Ping Chen, Yu-Chen Fan, Ming-Hua Zheng. Secondary prophylaxis of variceal bleeding for cirrhotic patients: a multiple-treatments meta-analysis.
European journal of clinical investigation.
2013 Aug; 43(8):844-54. doi:
10.1111/eci.12115. [PMID: 23725530] - L Wang, J Shi, Y Zhang. Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure.
European review for medical and pharmacological sciences.
2013 Jun; 17(12):1590-3. doi:
NULL. [PMID: 23832723] - Evin Bozcali, Erhan Babalik, Solen Himmetoglu, Ismail Mihmanli, Sadik Toprak. ω-3 fatty acid treatment in cardiac syndrome X: a double-blind, randomized, placebo-controlled clinical study.
Coronary artery disease.
2013 Jun; 24(4):328-33. doi:
10.1097/mca.0b013e32835f3005. [PMID: 23425772] - Han Li, Shixiang Wang. Organic nitrates favor regression of left ventricular hypertrophy in hypertensive patients on chronic peritoneal dialysis.
International journal of molecular sciences.
2013 Jan; 14(1):1069-79. doi:
10.3390/ijms14011069. [PMID: 23296279] - Takaharu Ishibashi, Mihoko Nomura-Nakamoto, Fusae Abe, Takayoshi Masuoka, Noriko Imaizumi, Junko Yoshida, Tomie Kawada, Matomo Nishio. Effects of cyanamide, an aldehyde dehydrogenase type 2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal.
Biological & pharmaceutical bulletin.
2013; 36(4):556-63. doi:
10.1248/bpb.b12-00855. [PMID: 23546291] - Y-H Kim, K-S Choi, S-H Kam, K-H Lee, J-S Park. In vitro dissolution and in vivo bioequivalence evaluation of two brands of isosorbide 5-mononitrate sustained release tablets.
Arzneimittel-Forschung.
2012 Dec; 62(12):576-82. doi:
10.1055/s-0032-1327614. [PMID: 23093481] - Lynn M Johnson, Robert L Strawderman. A smoothing expectation and substitution algorithm for the semiparametric accelerated failure time frailty model.
Statistics in medicine.
2012 Sep; 31(21):2335-58. doi:
10.1002/sim.5349. [PMID: 22437629] - Anne L Taylor, Michael L Sabolinski, S William Tam, Susan Ziesche, Jalal K Ghali, W Tad Archambault, Manuel Worcel, Jay N Cohn. Effect of fixed-dose combined isosorbide dinitrate/hydralazine in elderly patients in the African-American heart failure trial.
Journal of cardiac failure.
2012 Aug; 18(8):600-6. doi:
10.1016/j.cardfail.2012.06.526. [PMID: 22858074] - Farhad Tadayyon, Mohammadhossein Izadpanahi, Saeed Aali, Hamid Mazdak, Mohammad-Hatef Khorrami. The effect of sublingual isosorbide dinitrate on acute urinary retention due to benign prostatic hyperplasia.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2012 Jul; 23(4):782-5. doi:
10.4103/1319-2442.98160. [PMID: 22805391] - Jun Zhang, Guangdan Zhao, Xiaoling Yu, Xiaoming Pan. Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute exacerbation of chronic obstructive pulmonary disease.
Respirology (Carlton, Vic.).
2012 May; 17(4):715-20. doi:
10.1111/j.1440-1843.2012.02162.x. [PMID: 22394412] - Yong-Liang Jia, Fang-Yi Huang, Shi-Kai Zhang. [Assessment of the quality of randomized controlled trials in treating coronary heart disease by Chinese patent medicine].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Apr; 32(4):560-8. doi:
. [PMID: 22803444] - Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura, Hiroshi Ito. Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris.
Cardiovascular diabetology.
2012 Mar; 11(?):26. doi:
10.1186/1475-2840-11-26. [PMID: 22433902] - Yu Qiu, Hao Xu, Dazhuo Shi. Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):417387. doi:
10.1155/2012/417387. [PMID: 22536282] - Song Wen-Ting, Cheng Fa-Feng, Xu Li, Lin Cheng-Ren, Liu Jian-Xun. Chinese medicine shenfu injection for heart failure: a systematic review and meta-analysis.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):713149. doi:
10.1155/2012/713149. [PMID: 22611430] - Qinghua Shang, Zhaolan Liu, Keji Chen, Hao Xu, Jianping Liu. A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):636547. doi:
10.1155/2012/636547. [PMID: 22567033] - Gábor Eros, Petra Hartmann, Szilvia Berkó, Eszter Csizmazia, Erzsébet Csányi, Anita Sztojkov-Ivanov, István Németh, Piroska Szabó-Révész, István Zupkó, Lajos Kemény. A novel murine model for the in vivo study of transdermal drug penetration.
TheScientificWorldJournal.
2012; 2012(?):543536. doi:
10.1100/2012/543536. [PMID: 22272176] - Lucky Lebgosi Nwidu, Grace Emannuel Essien, Paul Alozie Nwafor, Wagner Vilegas. Antidiarrheal mechanism of Carpolobia lutea leaf fractions in rats.
Pharmaceutical biology.
2011 Dec; 49(12):1249-56. doi:
10.3109/13880209.2011.589854. [PMID: 21846171] - Swenja Schuhmacher, Matthias Oelze, Franziska Bollmann, Hartmut Kleinert, Christian Otto, Tjebo Heeren, Sebastian Steven, Michael Hausding, Maike Knorr, Andrea Pautz, Kurt Reifenberg, Eberhard Schulz, Tommaso Gori, Philip Wenzel, Thomas Münzel, Andreas Daiber. Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.
Diabetes.
2011 Oct; 60(10):2608-16. doi:
10.2337/db10-1395. [PMID: 21844097] - Zi-qiang Li, Xin He, Xiumei Gao, Yan-yan Xu, Yue-fei Wang, Hui Gu, Rui-feng Ji, Shu-jun Sun. Study on dissolution and absorption of four dosage forms of isosorbide mononitrate: level A in vitro-in vivo correlation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Oct; 79(2):364-71. doi:
10.1016/j.ejpb.2011.04.015. [PMID: 21569844] - Clara Sciorati, Daniela Miglietta, Roberta Buono, Viviana Pisa, Dario Cattaneo, Emanuele Azzoni, Silvia Brunelli, Emilio Clementi. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.
Pharmacological research.
2011 Sep; 64(3):210-7. doi:
10.1016/j.phrs.2011.05.003. [PMID: 21609764] - Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano, Hiroshi Ito. Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men.
Cardiovascular diabetology.
2011 May; 10(?):44. doi:
10.1186/1475-2840-10-44. [PMID: 21600061] - N I Vinnik, L A Kutsenko, N L Kutsenko, I L Solokhina, M V Mikitiuk, T V Mamontova, I P Kaĭdashev. [The effectiveness of pioglitazone in the treatment of patients with coronary heart disease on the background of metabolic syndrome].
Likars'ka sprava.
2011 Apr; ?(3-4):71-8. doi:
". [PMID: 22416367] - Yongping Chai, Dai-Min Zhang, Yu-Fung Lin. Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.
PloS one.
2011 Mar; 6(3):e18191. doi:
10.1371/journal.pone.0018191. [PMID: 21479273] - Han Li, Shi-xiang Wang. Improvement of hypertension and LVH in maintenance hemodialysis patients treated with sustained-release isosorbide mononitrate.
Journal of nephrology.
2011 Mar; 24(2):236-45. doi:
10.5301/jn.2011.6252. [PMID: 21240870] - Ren Guo, Lei Chen, Ling Li, Xin Guo, Ji Sun, Xiao-Ming Xiong, Ze-Neng Cheng, Yuan-Jian Li, Xiao-Ping Chen. Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers.
Pharmacogenetics and genomics.
2011 Mar; 21(3):142-51. doi:
10.1097/fpc.0b013e328343ea0a. [PMID: 21278620] - Paula Martínez-Santos, Isidre Vilacosta. Cardiorenal syndrome: an unsolved clinical problem.
International journal of nephrology.
2011; 2011(?):913029. doi:
10.4061/2011/913029. [PMID: 21660257] - N I Vinnik, I P Kaĭdashev. [Clinical description of effectiveness of pioglitazone in a complex therapy of patients with ischemic heart disease on background of metabolic syndrome].
Likars'ka sprava.
2011 Jan; ?(1-2):82-9. doi:
NULL. [PMID: 21954640] - Carlo R Bartoli, Kenneth R Brittian, Guruprasad A Giridharan, Steven C Koenig, Tariq Hamid, Sumanth D Prabhu. Bovine model of doxorubicin-induced cardiomyopathy.
Journal of biomedicine & biotechnology.
2011; 2011(?):758736. doi:
10.1155/2011/758736. [PMID: 21253525] - Takaharu Ishibashi, Tomoko Miwa, Naoki Nishizawa, Ikumi Shinkawa, Junko Yoshida, Tomie Kawada, Matomo Nishio. Role of plasma S-nitrosothiols in regulation of blood pressure in anesthetized rabbits with special references to hypotensive effects of acetylcholine and nitrovasodilators.
Biological & pharmaceutical bulletin.
2011; 34(8):1307-13. doi:
10.1248/bpb.34.1307. [PMID: 21804223] - Tomohiro Mizutani, Takayuki Inomata, Ichiro Watanabe, Emi Maekawa, Tomoyoshi Yanagisawa, Hisahito Shinagawa, Toshimi Koitabashi, Ichiro Takeuchi, Tohru Izumi. Comparison of nitrite compounds and carperitide for initial treatment of acute decompensated heart failure.
International heart journal.
2011; 52(2):114-8. doi:
10.1536/ihj.52.114. [PMID: 21483172] - Tetsuro Miyazaki, Kazunori Shimada, Katsumi Miyauchi, Atsumi Kume, Kosei Tanimoto, Takashi Kiyanagi, Katsuhiko Sumiyoshi, Makoto Hiki, Hiroshi Mokuno, Shinya Okazaki, Hitoshi Sato, Takeshi Kurata, Hiroyuki Daida. Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting.
Lipids in health and disease.
2010 Oct; 9(?):122. doi:
10.1186/1476-511x-9-122. [PMID: 20973966] - Jun-ichi Oyama, Shinji Satoh, Nobuhiro Suematsu, Toshiaki Kadokami, Toyoki Maeda, Masahiro Sugano, Naoki Makino. Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.
Heart and vessels.
2010 Sep; 25(5):379-85. doi:
10.1007/s00380-009-1221-7. [PMID: 20676959] - Dae Won Jun, Jin Hee Park, Yoo Sin Park, Ju-Seop Kang, Eun Kyung Kim, Kyung Tae Kim, Byoung Kwan Son, Seong Hwan Kim, Yun Ju Jo, Young Sook Park. The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?.
Digestive diseases and sciences.
2010 May; 55(5):1296-304. doi:
10.1007/s10620-009-0852-y. [PMID: 19517235] - Yonghai Lv, Xinru Liu, Shikai Yan, Xu Liang, Yun Yang, Weixing Dai, Weidong Zhang. Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2010 May; 52(1):129-35. doi:
10.1016/j.jpba.2009.12.016. [PMID: 20079594] - Omar Mohamed E Abdel Salam, Amany A Sleem, Nermeen Shafee. Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats.
Inflammopharmacology.
2010 Apr; 18(2):87-94. doi:
10.1007/s10787-009-0027-7. [PMID: 20069380] - Na-Young Kim, So Yeon Kim, Na Hyung Lee, Young Lan Kwak. Impact of the interval between coronary angiography and off-pump coronary bypass surgery on postoperative renal function.
Korean journal of anesthesiology.
2010 Feb; 58(2):142-7. doi:
10.4097/kjae.2010.58.2.142. [PMID: 20498792] - Young Song, Young Lan Kwak, Yong Seon Choi, Jong Chan Kim, Sang Baek Heo, Jae Kwang Shim. Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level.
Korean journal of anesthesiology.
2010 Feb; 58(2):136-41. doi:
10.4097/kjae.2010.58.2.136. [PMID: 20498791] - Ali Roshani, Iraj Khosropanah, Mohammad Salehi, Alireza Noshad Kamran. Effects of isosorbide dinitrate on the urinary flow rate in patients with benign prostatic hyperplasia.
Urology journal.
2010; 7(3):183-7. doi:
NULL. [PMID: 20845295] - En-Zhi Jia, Fu-Jun Zhao, Bo Hao, Tie-Bing Zhu, Lian-Sheng Wang, Bo Chen, Ke-Jiang Cao, Jun Huang, Wen-Zhu Ma, Zhi-Jian Yang, Guoxin Zhang. Helicobacter pylori infection is associated with decreased serum levels of high density lipoprotein, but not with the severity of coronary atherosclerosis.
Lipids in health and disease.
2009 Dec; 8(?):59. doi:
10.1186/1476-511x-8-59. [PMID: 20030806] - Darren C Henstridge, Stephen J Duffy, Melissa F Formosa, Anna A Ahimastos, Bruce R Thompson, Bronwyn A Kingwell. Oral nitrate therapy does not affect glucose metabolism in healthy men.
Clinical and experimental pharmacology & physiology.
2009 Nov; 36(11):1086-92. doi:
10.1111/j.1440-1681.2009.05195.x. [PMID: 19413595] - Ashish Kumar, Sanjeev Kumar Jha, Praveen Sharma, Saroj Dubey, Pankaj Tyagi, Barjesh Chander Sharma, Shiv Kumar Sarin. Addition of propranolol and isosorbide mononitrate to endoscopic variceal ligation does not reduce variceal rebleeding incidence.
Gastroenterology.
2009 Sep; 137(3):892-901, 901.e1. doi:
10.1053/j.gastro.2009.05.049. [PMID: 19481079] - Richard M Wilson, Deepa S De Silva, Kaori Sato, Yasuhiro Izumiya, Flora Sam. Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure.
Hypertension (Dallas, Tex. : 1979).
2009 Sep; 54(3):583-90. doi:
10.1161/hypertensionaha.109.134932. [PMID: 19620510] - O O Adeyemi, A J Akindele, E A Ogunleye. Evaluation of the antidiarrhoeal effect of Sanseviera liberica Gerome & Labroy (Agavaceae) root extract.
Journal of ethnopharmacology.
2009 Jun; 123(3):459-63. doi:
10.1016/j.jep.2009.03.023. [PMID: 19481383] - Ana C M Andrade, Fernando H Y Cesena, Fernanda M Consolim-Colombo, Silmara R Coimbra, Alexandre M Benjó, Eduardo M Krieger, Protasio Lemos da Luz. Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects.
Clinics (Sao Paulo, Brazil).
2009 May; 64(5):435-42. doi:
10.1590/s1807-59322009000500011. [PMID: 19488610] - Ricardo Carnicer, Natalia Guillén, José M Arbonés-Mainar, María A Navarro, Mario A Guzmán, Cristina Barranquero, Carmen Arnal, Sonia Gascón, Sergio Acín, Marisabel Mourelle, Jesús Osada. Nitric oxide-releasing agent, LA419, reduces atherogenesis in apolipoprotein E-deficient mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2009 May; 379(5):489-500. doi:
10.1007/s00210-008-0377-5. [PMID: 19050853] - Xueyan Duan, Qingfei Liu, Yu Zhang, Kaishun Bi, Xi Chen, Yiming Wang, Guoan Luo. Development of monolithic osmotic pump tablet system for isosorbide-5-mononitrate delivery and evaluation of it in vitro and in vivo.
Drug development and industrial pharmacy.
2009 Apr; 35(4):499-507. doi:
10.1080/03639040802459437. [PMID: 18979308] - Wen-chong Liu, Xiao-li Sun, Le-le Ji, Hai-bo Wang, Hai-feng Zhang, Jia Li, Lei Shi, Lin-lin Jing, Feng Gao. [Synthesis and cardioprotective effect of a novel anti-ischemic/reperfused injury compound].
Yao xue xue bao = Acta pharmaceutica Sinica.
2009 Mar; 44(3):321-6. doi:
. [PMID: 19449531] - Tsung-Ming Lee, Nen-Chung Chang. Effect of nicorandil on proteinuria in well controlled hypertensive patients.
Journal of hypertension.
2009 Mar; 27(3):618-25. doi:
10.1097/hjh.0b013e32831cbd73. [PMID: 19262229] - Alexander A Timoshin, Diana Yu Drobotova, Vladimir L Lakomkin, Enno K Ruuge, Anatoly F Vanin. Estimation of nitric oxide level in vivo by microdialysis with water-soluble iron-N-methyl-D-dithiocarbamate complexes as NO traps: a novel approach to nitric oxide spin trapping in animal tissues.
Nitric oxide : biology and chemistry.
2008 Dec; 19(4):338-44. doi:
10.1016/j.niox.2008.07.001. [PMID: 18664386] - Hirokazu Sudo, Kenji Yogo, Nobuhiko Ishizuka, Hideaki Otsuka, Shigeo Horie, Keiji Saito. Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction.
Biological & pharmaceutical bulletin.
2008 Nov; 31(11):2079-82. doi:
10.1248/bpb.31.2079. [PMID: 18981577] - M Oppermann, V T-V Dao, T Suvorava, M Bas, G Kojda. Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase.
British journal of pharmacology.
2008 Oct; 155(3):335-42. doi:
10.1038/bjp.2008.269. [PMID: 18587420] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Matteo Beretta, Karl Gruber, Alexander Kollau, Michael Russwurm, Doris Koesling, Walter Goessler, Wing Ming Keung, Kurt Schmidt, Bernd Mayer. Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases.
The Journal of biological chemistry.
2008 Jun; 283(26):17873-80. doi:
10.1074/jbc.m801182200. [PMID: 18450747] - José Mario Barichello, Noriko Yamakawa, Masatoshi Kisyuku, Hiroshi Handa, Taiki Shibata, Tatsuhiro Ishida, Hiroshi Kiwada. Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.
International journal of pharmaceutics.
2008 Jun; 357(1-2):199-205. doi:
10.1016/j.ijpharm.2008.01.052. [PMID: 18343610] - William E Chavey, Barry E Bleske, R Van Harrison, Robert V Hogikyan, Sean K Kesterson, John M Nicklas. Pharmacologic management of heart failure caused by systolic dysfunction.
American family physician.
2008 Apr; 77(7):957-64. doi:
NULL. [PMID: 18441861] - O O Adeyemi, A J Akindele. Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae).
Journal of ethnopharmacology.
2008 Mar; 116(3):407-12. doi:
10.1016/j.jep.2007.12.004. [PMID: 18276093] - Kavita Gulati, Ayanabha Chakraborti, Arunabha Ray. Modulation of stress-induced neurobehavioral changes and brain oxidative injury by nitric oxide (NO) mimetics in rats.
Behavioural brain research.
2007 Nov; 183(2):226-30. doi:
10.1016/j.bbr.2007.06.018. [PMID: 17675257] - F Reis, P Rocha-Pereira, E Teixeira de Lemos, B Parada, S Baptista, A Figueiredo, A Santos-Silva, C Costa-Almeida, A Mota, F Teixeira. Oxidative stress in cyclosporine-induced hypertension: evidence of beneficial effects or tolerance development with nitrate therapy.
Transplantation proceedings.
2007 Oct; 39(8):2494-500. doi:
10.1016/j.transproceed.2007.07.030. [PMID: 17954157] - Ji-Hui Zhao, Ji-Hua Fu, Shu-Ming Wang, Chang-Hai Su, Ying Shan, Shu-Jia Kong, Yuan Wang, Wan-Liang Lu, Hua Zhang, Shuang Zhang, Lin Li, En-Hong Zhang, Li Wang, Qiu-Ling Pei, Jian-Cheng Wang, Xuan Zhang, Qiang Zhang. A novel transdermal patch incorporating isosorbide dinitrate with bisoprolol: in vitro and in vivo characterization.
International journal of pharmaceutics.
2007 Jun; 337(1-2):88-101. doi:
10.1016/j.ijpharm.2006.12.030. [PMID: 17267147] - Jay N Cohn, S William Tam, Inder S Anand, Anne L Taylor, Michael L Sabolinski, Manuel Worcel. Isosorbide dinitrate and hydralazine in a fixed-dose combination produces further regression of left ventricular remodeling in a well-treated black population with heart failure: results from A-HeFT.
Journal of cardiac failure.
2007 Jun; 13(5):331-9. doi:
10.1016/j.cardfail.2007.03.001. [PMID: 17602978] - L Y Dirix, H Maes, C Sweldens. Treatment of arterial hypertension (AHT) associated with angiogenesis inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology.
2007 Jun; 18(6):1121-2. doi:
10.1093/annonc/mdm205. [PMID: 17586755] - Lisa J Frederiksen, Richard Sullivan, Lori R Maxwell, Shannyn K Macdonald-Goodfellow, Michael A Adams, Brian M Bennett, D Robert Siemens, Charles H Graham. Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Apr; 13(7):2199-206. doi:
10.1158/1078-0432.ccr-06-1807. [PMID: 17404104] - Carlos A Marra, Julio Nella, Damián Manti, María J T de Alaniz. Lipid metabolism in rats is modified by nitric oxide availability through a Ca++-dependent mechanism.
Lipids.
2007 Apr; 42(3):211-28. doi:
10.1007/s11745-006-3004-6. [PMID: 17393227] - Xiaohong Sun, Xiaoqin Li, Shuang Cai, Feng Qin, Xiumei Lu, Famei Li. High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Feb; 846(1-2):323-8. doi:
10.1016/j.jchromb.2006.08.022. [PMID: 16962389] - S William Tam, Michael L Sabolinski, Manuel Worcel, Milton Packer, Jay N Cohn. Lack of bioequivalence between different formulations of isosorbide dinitrate and hydralazine and the fixed-dose combination of isosorbide dinitrate/hydralazine: the V-HeFT paradox.
Clinical pharmacokinetics.
2007; 46(10):885-95. doi:
10.2165/00003088-200746100-00006. [PMID: 17854237] - Jeff C Huffman, Theodore A Stern. Neuropsychiatric consequences of cardiovascular medications.
Dialogues in clinical neuroscience.
2007; 9(1):29-45. doi:
. [PMID: 17506224] - Hajime Takano, Yasushi Kodama, Yoshinobu Kitta, Takamitsu Nakamura, Jyun-ei Obata, Akira Mende, Ken-ichi Kawabata, Yukio Saitoh, Daisuke Fujioka, Tsuyoshi Kobayashi, Hideyuki Hasebe, Kiyotaka Kugiyama. Transcardiac adiponectin gradient is independently related to endothelial vasomotor function in large and resistance coronary arteries in humans.
American journal of physiology. Heart and circulatory physiology.
2006 Dec; 291(6):H2641-6. doi:
10.1152/ajpheart.00702.2006. [PMID: 16877558] - R Preston Mason, John R Cockcroft. Targeting nitric oxide with drug therapy.
Journal of clinical hypertension (Greenwich, Conn.).
2006 Dec; 8(12 Suppl 4):40-52. doi:
10.1111/j.1524-6175.2006.06041.x. [PMID: 17170605] - A J Akindele, O O Adeyemi. Evaluation of the antidiarrhoeal activity of Byrsocarpus coccineus.
Journal of ethnopharmacology.
2006 Nov; 108(1):20-5. doi:
10.1016/j.jep.2006.03.038. [PMID: 16750338] - Dong Soo Park, Taek Woo Cho, Yong Kyu Lee, Young Tae Lee, Young Kwon Hong, Woong Ki Jang. Evaluation of short term clinical effects and presumptive mechanism of botulinum toxin type A as a treatment modality of benign prostatic hyperplasia.
Yonsei medical journal.
2006 Oct; 47(5):706-14. doi:
10.3349/ymj.2006.47.5.706. [PMID: 17066515] - Erik Tingberg, Ann-Kristin Ohlin, Anders Gottsäter, Hans Ohlin. Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy.
International journal of cardiology.
2006 Oct; 112(3):275-81. doi:
10.1016/j.ijcard.2005.09.004. [PMID: 16310262] - Erik Tingberg, Anders Roijer, Ulf Thilen, Hans Ohlin. Neurohumoral changes in patients with left ventricular dysfunction following acute myocardial infarction and the effect of nitrate therapy: a randomized, double-blind, placebo-controlled long-term study.
Journal of cardiovascular pharmacology.
2006 Oct; 48(4):166-72. doi:
10.1097/01.fjc.0000246149.92535.59. [PMID: 17086095] - Kazunori Shimada, Satoshi Sunayama, Kaoru Nakazato, Hiroyuki Satoh, Yoshiki Kusama, Kiyoshi Kawakubo, Hiroyuki Daida. Efficacy and safety of controlled-release isosorbide-5-mononitrate in Japanese patients with stable effort angina pectoris.
International heart journal.
2006 Sep; 47(5):695-705. doi:
10.1536/ihj.47.695. [PMID: 17106140]
