L,L-Cyclo(leucylprolyl) (BioDeep_00000018279)

 

Secondary id: BioDeep_00000402965, BioDeep_00000407629, BioDeep_00000618946

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


(3S,8aS)-1-hydroxy-3-(2-methylpropyl)-3H,4H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-4-one

化学式: C11H18N2O2 (210.1368208)
中文名称: 环(L-脯氨酰-L-亮氨酰)
谱图信息: 最多检出来源 Homo sapiens(blood) 0.08%

Reviewed

Last reviewed on 2024-07-10.

Cite this Page

L,L-Cyclo(leucylprolyl). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-leucyl-l-proline_lactam (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000018279). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)CC1C(=O)N2CCCC2C(=O)N1
InChI: InChI=1S/C11H18N2O2/c1-7(2)6-8-11(15)13-5-3-4-9(13)10(14)12-8/h7-9H,3-6H2,1-2H3,(H,12,14)/t8-,9-/m0/s1

描述信息

L,L-Cyclo(leucylprolyl) is found in alcoholic beverages. L,L-Cyclo(leucylprolyl) is produced by microorganisms and is a bitter component of sake and contributes to the flavour of beer.

L,L-Cyclo(leucylprolyl), also known as cyclo(leu-pro) or cyclo(L-prolyl-L-leucyl), belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. L,L-Cyclo(leucylprolyl) is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. Based on a literature review a significant number of articles have been published on L,L-Cyclo(leucylprolyl).

L-Leucyl-L-proline lactam. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2873-36-1 (retrieved 2024-07-10) (CAS RN: 2873-36-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1].

同义名列表

23 个代谢物同义名

(3S,8aS)-1-hydroxy-3-(2-methylpropyl)-3H,4H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-4-one; (3S,8aS)-1-hydroxy-3-(2-methylpropyl)-3H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-4-one; (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione; L-Leucyl-L-proline lactam; L-Leucyl-L-prolyl lactam; Cyclo-L-prolyl-L-leucine; Cyclo(S-leucyl-S-prolyl); Cyclo(L-prolyl-L-leucyl); Cyclo(L-leucyl-L-prolyl); L,L-Cyclo(leucylprolyl); Cyclo(proline-leucine); L-Cyclo(leucyloprolyl); cis-Cyclo(L-leu-L-pro); Cyclo(leucyl-prolyl); Cyclo(L-leu-L-pro); Cyclo(L-pro-L-leu); Cyclo-L-leu-L-pro; L-Cyclo(leu-pro); Cyclo(-leu-pro); Cyclo(leu-pro); Cyclo(pro-leu); Maculosin 6; Gancidin W



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

41 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jose Ramon Troche, Susan T Mayne, Neal D Freedman, Fatma M Shebl, Kristin A Guertin, Amanda J Cross, Christian C Abnet. Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. PloS one. 2016; 11(3):e0150962. doi: 10.1371/journal.pone.0150962. [PMID: 26967509]
  • Lei Jiang, Huaixiu Wen, Yun Shao, Ruitao Yu, Zenggen Liu, Shuo Wang, Qilan Wang, Xiaohui Zhao, Peng Zhang, Yanduo Tao, Lijuan Mei. Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi. Chemical biology & drug design. 2015 Oct; 86(4):626-36. doi: 10.1111/cbdd.12530. [PMID: 25626527]
  • S Nishanth Kumar, C Mohandas, J V Siji, K N Rajasekharan, Bala Nambisan. Identification of antimicrobial compound, diketopiperazines, from a Bacillus sp. N strain associated with a rhabditid entomopathogenic nematode against major plant pathogenic fungi. Journal of applied microbiology. 2012 Oct; 113(4):914-24. doi: 10.1111/j.1365-2672.2012.05385.x. [PMID: 22747978]