Furaltadone (BioDeep_00000001792)

 

Secondary id: BioDeep_00001869975


代谢物信息卡片


5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2- oxazolidinone

化学式: C13H16N4O6 (324.107)
中文名称: 左呋喃他酮, 呋喃他酮, 呋喃酮
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: C1COCCN1CC2CN(C(=O)O2)N=CC3=CC=C(O3)[N+](=O)[O-]
InChI: InChI=1S/C13H16N4O6/c18-13-16(14-7-10-1-2-12(22-10)17(19)20)9-11(23-13)8-15-3-5-21-6-4-15/h1-2,7,11H,3-6,8-9H2

描述信息

D000890 - Anti-Infective Agents > D023303 - Oxazolidinones
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent

同义名列表

7 个代谢物同义名

NF-902 (as hydrochloride); Levofuraltadone; Furaltadone; 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2- oxazolidinone; Levofuraltadona; Levofuraltadone; Furaltadone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CAT, FZD2, POMC, RARA, SYK, XDH
Endoplasmic reticulum membrane 1 ATP13A1
Nucleus 3 HMGA2, RARA, SYK
autophagosome 1 ATP13A2
cytosol 4 CAT, RARA, SYK, XDH
dendrite 1 RARA
nucleoplasm 2 HMGA2, RARA
RNA polymerase II transcription regulator complex 1 RARA
Cell membrane 4 FZD2, JAG1, SYK, TNF
Multi-pass membrane protein 4 ATP13A1, ATP13A2, FZD2, SPG7
cell surface 1 TNF
Golgi apparatus 1 ATRN
lysosomal membrane 1 ATP13A2
mitochondrial inner membrane 1 SPG7
neuronal cell body 2 ATP13A2, TNF
Cytoplasm, cytosol 1 SYK
Lysosome 2 ATP13A2, CTSV
plasma membrane 7 ATRN, FZD2, IGHE, JAG1, RARA, SYK, TNF
Membrane 5 ATP13A1, ATP13A2, CAT, JAG1, SPG7
apical plasma membrane 1 JAG1
extracellular exosome 2 ATRN, CAT
Lysosome membrane 1 ATP13A2
extracellular space 6 ATRN, CTSV, IGHE, POMC, TNF, XDH
lysosomal lumen 2 ATP13A2, CTSV
perinuclear region of cytoplasm 1 RARA
adherens junction 1 JAG1
mitochondrion 2 CAT, SPG7
protein-containing complex 3 CAT, RARA, SYK
intracellular membrane-bounded organelle 1 CAT
Single-pass type I membrane protein 3 ATRN, IGHE, JAG1
Secreted 1 POMC
extracellular region 6 CAT, CTSV, IGHE, JAG1, POMC, TNF
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
transcription regulator complex 1 RARA
external side of plasma membrane 1 TNF
multivesicular body 1 ATP13A2
actin cytoskeleton 1 RARA
nucleolus 1 RARA
axon cytoplasm 1 SPG7
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 ATP13A2
Mitochondrion inner membrane 1 SPG7
Membrane raft 1 TNF
focal adhesion 2 CAT, FZD2
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 POMC
Late endosome 1 ATP13A2
neuron projection 1 ATP13A2
chromatin 2 HMGA2, RARA
IgE immunoglobulin complex 1 IGHE
Cytoplasmic vesicle, autophagosome membrane 1 ATP13A2
Late endosome membrane 1 ATP13A2
autophagosome membrane 1 ATP13A2
phagocytic cup 1 TNF
nuclear chromosome 1 HMGA2
[Isoform 2]: Cell membrane 1 IGHE
[Isoform 3]: Secreted 1 ATRN
multivesicular body membrane 1 ATP13A2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, POMC
transport vesicle 1 ATP13A2
clathrin-coated endocytic vesicle membrane 1 FZD2
Endosome, multivesicular body membrane 1 ATP13A2
SMAD protein complex 1 HMGA2
protein-DNA complex 1 HMGA2
[Isoform 1]: Cell membrane 1 ATRN
early phagosome 1 SYK
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 SYK
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
mitochondrial permeability transition pore complex 1 SPG7
B cell receptor complex 1 SYK
senescence-associated heterochromatin focus 1 HMGA2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
m-AAA complex 1 SPG7


文献列表

  • Amanda Pacholak, Joanna Żur-Pińska, Artur Piński, Quynh Anh Nguyen, Marta Ligaj, Magdalena Luczak, Long D Nghiem, Ewa Kaczorek. Potential negative effect of long-term exposure to nitrofurans on bacteria isolated from wastewater. The Science of the total environment. 2023 Feb; 872(?):162199. doi: 10.1016/j.scitotenv.2023.162199. [PMID: 36791847]
  • Ying-Chun Liu, Wei Jiang, Yong-Jun Chen, Yan Xiao, Jin-Lei Shi, Yuan-Biao Qiao, Hua-Jing Zhang, Tao Li, Quan Wang. A novel chemiluminescent ELISA for detecting furaltadone metabolite, 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ) in fish, egg, honey and shrimp samples. Journal of immunological methods. 2013 Sep; 395(1-2):29-36. doi: 10.1016/j.jim.2013.06.006. [PMID: 23810835]
  • Zhen-Lin Xu, Yu-Dong Shen, Yuan-Ming Sun, Katrina Campbell, Yuan-Xin Tian, Shi-Wei Zhang, Hong-Tao Lei, Yue-Ming Jiang. Novel hapten synthesis for antibody production and development of an enzyme-linked immunosorbent assay for determination of furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ). Talanta. 2013 Jan; 103(?):306-13. doi: 10.1016/j.talanta.2012.10.059. [PMID: 23200392]
  • K M Cooper, P P J Mulder, J A van Rhijn, L Kovacsics, R J McCracken, P B Young, D G Kennedy. Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV. Food additives and contaminants. 2005 May; 22(5):406-14. doi: 10.1080/02652030512331385218. [PMID: 16019811]
  • F W Kari, R Weaver, M C Neville. Active transport of nitrofurantoin across the mammary epithelium in vivo. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):664-8. doi: . [PMID: 9023277]
  • A L Bartlet, S Harvey, H Klandorf. Contrasting effects of nitrofurans on plasma corticosterone in chickens following administration as a bolus or diet additive. Journal of veterinary pharmacology and therapeutics. 1990 Sep; 13(3):261-9. doi: 10.1111/j.1365-2885.1990.tb00775.x. [PMID: 2231866]
  • J F Nouws, J Laurensen. Postmortal degradation of furazolidone and furaltadone in edible tissues of calves. The veterinary quarterly. 1990 Jan; 12(1):56-9. doi: 10.1080/01652176.1990.9694243. [PMID: 2321352]
  • J F Nouws, T B Vree, M M Aerts, M Degen, F Driessens. Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves. The veterinary quarterly. 1987 Jul; 9(3):208-14. doi: 10.1080/01652176.1987.9694102. [PMID: 3672857]
  • L L Ng, R F Bevill, E G Perkins. In vivo and in vitro pharmacokinetics and fate of furaltadone in meat- and milk-producing animals. Journal of pharmaceutical sciences. 1984 Mar; 73(3):293-7. doi: 10.1002/jps.2600730303. [PMID: 6538904]
  • C G MCCARTHY, M FINLAND. Furaltadone. Antibacterial activity in vitro and in serum of patients during treatment. Archives of internal medicine. 1961 Jun; 107(?):863-71. doi: 10.1001/archinte.1961.03620060063008. [PMID: 13773763]