Classification Term: 231

Azaspirodecane derivatives (ontology term: CHEMONTID:0000130)

Organic compounds containing a spirodecane moiety with at least one nitrogen atom." []

found 26 associated metabolites at class metabolite taxonomy ontology rank level.

Ancestor: Organoheterocyclic compounds

Child Taxonomies: There is no child term of current ontology term.

Dioscorine

2,4-Dimethylspiro[2-azabicyclo[2.2.2]octane-5,2-[2H]pyran]-6(3H)-one, 9ci

C13H19NO2 (221.1415714)


Dioscorine is found in root vegetables. Dioscorine is an alkaloid from the tubers of wild yam Dioscorea hispid

   

Petasitenine

(1R,3R,4R,6R,7R,11Z)-7-hydroxy-3,6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadecane-4,2-oxiran]-11-ene-3,8,17-trione

C19H27NO7 (381.1787432)


Alkaloid from Petasites japonicus (sweet coltsfoot). Petasitenine is found in giant butterbur and green vegetables. Petasitenine is found in giant butterbur. Petasitenine is an alkaloid from Petasites japonicus (sweet coltsfoot

   

Brevianamide B

4,4-dimethyl-1,3-dihydro-9,14-diazaspiro[indole-2,5-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecane]-3,8,13-trione

C21H23N3O3 (365.1739328)


Brevianamide A is a mycotoxin from Penicillium brevi-compactum and some other Penicillium specie

   

(±)-Pandamarine

3-methyl-6-{4-[(2E)-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]butyl}-1,6-diazaspiro[4.5]dec-3-en-2-one

C18H25N3O2 (315.194667)


(±)-Pandamarine is a major alkaloid from leaves of Pandanus amaryllifolius. Major alkaloid from leaves of Pandanus amaryllifolius

   

Neopetasitenine

(1R,3r,4R,6R,7R,11Z)-3,6,7,14-Tetramethyl-3,8,17-trioxo-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadecane-4,2-oxiran]-11-en-7-yl acetic acid

C21H29NO8 (423.1893074)


Neopetasitenine is found in green vegetables. Neopetasitenine is an alkaloid from Petasites japonicus (sweet coltsfoot

   

Dihydrodioscorine

4,5-dimethyl-5-azaspiro[bicyclo[2.2.2]octane-2,2-oxane]-6-one

C13H21NO2 (223.15722060000002)


Dihydrodioscorine is found in root vegetables. Dihydrodioscorine is an alkaloid from the tubers of the famine food Dioscorea dumetoru

   

Azaspiracid 3

(4E)-5-(2-{hydroxy[2-hydroxy-5-methyl-6-(3-{3,5,10-trimethyl-3,7,12-trioxaspiro[piperidine-2,4-tricyclo[6.3.1.0²,⁶]dodecane]-8-yl}prop-1-en-2-yl)oxan-2-yl]methyl}-6-methyl-2,3,3,3a,6,6,7,7a-octahydrodispiro[furo[3,2-b]pyran-5,2-oxolane-5,2-pyran]-6-yl)pent-4-enoic acid

C46H69NO12 (827.4819514)


Azaspiracid 3 is found in mollusks. Azaspiracid 3 is an alkaloid from Mytilus edulis (blue mussel). Alkaloid from Mytilus edulis (blue mussel). Azaspiracid 3 is found in mollusks.

   

Azaspiracid

(4E)-5-(2-{hydroxy[2-hydroxy-3,5-dimethyl-6-(3-{3,5,10-trimethyl-3,7,12-trioxaspiro[piperidine-2,4-tricyclo[6.3.1.0²,⁶]dodecane]-8-yl}prop-1-en-2-yl)oxan-2-yl]methyl}-6-methyl-2,3,3,3a,6,6,7,7a-octahydrodispiro[furo[3,2-b]pyran-5,2-oxolane-5,2-pyran]-6-yl)pent-4-enoic acid

C47H71NO12 (841.4976005999999)


Azaspiracid is found in mollusks. Azaspiracid is an alkaloid from Mytilus edulis (blue mussel). Shellfish toxin. Alkaloid from Mytilus edulis (blue mussel). Shellfish toxin. Azaspiracid is found in mollusks.

   

Azaspiracid 4

(4E)-3-hydroxy-5-(2-{hydroxy[2-hydroxy-5-methyl-6-(3-{3,5,10-trimethyl-3,7,12-trioxaspiro[piperidine-2,4-tricyclo[6.3.1.0²,⁶]dodecane]-8-yl}prop-1-en-2-yl)oxan-2-yl]methyl}-6-methyl-2,3,3,3a,6,6,7,7a-octahydrodispiro[furo[3,2-b]pyran-5,2-oxolane-5,2-pyran]-6-yl)pent-4-enoic acid

C46H69NO13 (843.4768664)


Azaspiracid 4 is found in mollusks. Azaspiracid 4 is an alkaloid from Mytilus edulis (blue mussel). Alkaloid from Mytilus edulis (blue mussel). Azaspiracid 4 is found in mollusks.

   

Azaspiracid 5

(4E)-5-(2-{[2,4-dihydroxy-5-methyl-6-(3-{3,5,10-trimethyl-3,7,12-trioxaspiro[piperidine-2,4-tricyclo[6.3.1.0²,⁶]dodecane]-8-yl}prop-1-en-2-yl)oxan-2-yl](hydroxy)methyl}-6-methyl-2,3,3,3a,6,6,7,7a-octahydrodispiro[furo[3,2-b]pyran-5,2-oxolane-5,2-pyran]-6-yl)pent-4-enoic acid

C46H69NO13 (843.4768664)


Azaspiracid 5 is found in mollusks. Azaspiracid 5 is an alkaloid from Mytilus edulis (blue mussel). Alkaloid from Mytilus edulis (blue mussel). Azaspiracid 5 is found in mollusks.

   

Pandamarilactone 1

3-methyl-6-{4-[(2Z)-4-methyl-5-oxo-2,5-dihydrofuran-2-ylidene]butyl}-1-oxa-6-azaspiro[4.5]dec-3-en-2-one

C18H23NO4 (317.1626998)


Pandamarilactone 1 is an alkaloid from leaves of Pandanus amaryllifolius. Pandamarilactone 1 is a food flavouring. Alkaloid from leaves of Pandanus amaryllifolius. Food flavouring

   

Cevimeline

(2R)-5-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxathiolane]

C10H17NOS (199.1030792)


Cevimeline is only found in individuals that have used or taken this drug. It is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögrens syndrome. [Wikipedia] Muscarinic agonists such as cevimeline bind and activate the muscarinic M1 and M3 receptors. The M1 receptors are common in secretory glands (exocrine glands such as salivary and sweat glands), and their activation results in an increase in secretion from the secretory glands. The M3 receptors are found on smooth muscles and in many glands which help to stimulate secretion in salivary glands, and their activation generally results in smooth muscle contraction and increased glandular secretions. Therefore, as saliva excretion is increased, the symptoms of dry mouth are relieved. D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics

   

cevimeline trans-sulfoxide

(2R,5R)-5-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxathiolane]

C10H17NOS (199.1030792)


cevimeline trans-sulfoxide is a metabolite of cevimeline. Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors. It is used in the treatment of dry mouth associated with Sjögrens syndrome. (Wikipedia) D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics

   

cevimeline cis-sulfoxide

(2R,5S)-5-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxathiolane]

C10H17NOS (199.1030792)


cevimeline cis-sulfoxide is a metabolite of cevimeline. Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors. It is used in the treatment of dry mouth associated with Sjögrens syndrome. (Wikipedia)

   

4-Azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxazolidine]-5'-one

4-Azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxazolidine]-5-one

C9H14N2O2 (182.1055224)


   

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone

2-{[(benzyloxy)(hydroxy)methylidene]amino}-N-{1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)-C-hydroxycarbonimidoyl]ethyl}-3-methylbutanimidate

C22H30FN3O7 (467.2067682)


   

8-Azaspiro[4.5]decane-7,9-dione

9-hydroxy-8-azaspiro[4.5]dec-8-en-7-one

C9H13NO2 (167.09462380000002)


   

2-Azaspiro[4.5]decan-3-one

1-(Aminomethyl)cyclohexaneacetic acid lactam

C9H15NO (153.115358)


   

Alnespirone

8-{4-[(5-methoxy-3,4-dihydro-2H-1-benzopyran-3-yl)(propyl)amino]butyl}-8-azaspiro[4.5]decane-7,9-dione

C26H38N2O4 (442.2831428)


   

Atiprimod

N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine dihydrochloride

C22H44N2 (336.3504304)


C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor

   

(2S)-2-Methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]

(2S)-2-Methylspiro[1,3-oxathiolane-5,3-1-azabicyclo[2.2.2]octane]

C10H17NOS (199.1030792)


   

Fenspiride

8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]dec-2-en-2-ol

C15H20N2O2 (260.15247)


D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents R - Respiratory system > R03 - Drugs for obstructive airway diseases

   

1',3'-Dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one

1,5-dimethyl-17-oxa-7-azaspiro[1,5-diazinane-2,4-tetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadecane]-1(10),11,13,15-tetraen-6-one

C20H25N3O2 (339.194667)


D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

   

Solamargine

2-{[4-hydroxy-2-(hydroxymethyl)-6-{5,7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2-piperidin]-18-eneoxy}-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl]oxy}-6-methyloxane-3,4,5-triol

C45H73NO15 (867.4979947999999)


Solamargine, also known as beta-solamarine, is a member of the class of compounds known as steroidal saponins. Steroidal saponins are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative. Solamargine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Solamargine can be found in eggplant, which makes solamargine a potential biomarker for the consumption of this food product. Solamargine is a poisonous chemical compound that occurs in plants of the Solanaceae family, such as potatoes, tomatoes, and eggplants. It has been also isolated from Solanum nigrum fungal endophyte Aspergillus flavus. It is a glycoalkaloid derived from the steroidal alkaloid solasodine . Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2]. Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2].

   

Tedisamil

3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1-cyclopentane]

C19H32N2 (288.2565352)


C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents

   

Vatinoxan

N-(2-{2-hydroxy-3,5-dihydro-17-oxa-7-azaspiro[imidazole-4,4-tetracyclo[8.7.0.0,.0,]heptadecane]-1(10),11,13,15-tetraen-3-yl}ethyl)methanesulphonamide

C20H26N4O4S (418.16746760000007)