Etilefrine (BioDeep_00000178924)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H15NO2 (181.110273)
中文名称: 乙苯福林
谱图信息:
最多检出来源 Homo sapiens(blood) 33.33%
分子结构信息
SMILES: CCNCC(C1=CC(=CC=C1)O)O
InChI: InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D020011 - Protective Agents > D002316 - Cardiotonic Agents
同义名列表
40 个代谢物同义名
Boehringer ingelheim brand OF etilefrine hydrochloride; CT-Arzneimittel brand OF etilefrine hydrochloride; CT Arzneimittel brand OF etilefrine hydrochloride; Ratiopharm brand OF etilefrine hydrochloride; Südmedica brand OF etilefrine hydrochloride; Alpharma brand OF etilefrine hydrochloride; Apogepha brand OF etilefrine hydrochloride; Temmler brand OF etilefrine hydrochloride; 3-[2-(ethylamino)-1-hydroxyethyl]phenol; Aliud brand OF etilefrine hydrochloride; Fher brand OF etilefrine hydrochloride; NAM brand OF etilefrine hydrochloride; Hydrochloride, etilefrine pivalate; Pivalate hydrochloride, etilefrine; Etilefrine pivalate hydrochloride; Hydrochloride, etilefrine; Etilefrine hydrochloride; Ethylnorphenylephrine; Etilefrin-ratiopharm; Etilefrin ratiopharm; Ethylphenylephrine; Adrianol, ethyl; Ethyl adrianol; Ethyladrianol; Etilefrin al; Etil von CT; Etilefrine; Corcanfol; Eti-puren; Etilefrin; Eti puren; Bioflutin; Phetanol; Thomasin; Effortil; Circupon; Cardanat; Fetanol; Efortil; Adrenam
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:91518
- PubChem: 3306
- HMDB: HMDB0252100
- DrugBank: DB08985
- ChEMBL: CHEMBL86882
- Wikipedia: Etilefrine
- MeSH: Etilefrine
- CAS: 10128-36-6
- CAS: 709-55-7
- RefMet: Etilefrine
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiraku Onishi, Osamu Sakata. Preparation and evaluation of fast-dissolving films of etilefrine hydrochloride for practical buccal dosing.
Pharmaceutical development and technology.
2021 Jun; 26(5):610-616. doi:
10.1080/10837450.2021.1904260. [PMID: 33736577] - Osamu Sakata, Hiraku Onishi. Preparation of orally fast-dissolving tablets of etilefrine hydrochloride to achieve efficient absorption.
Pharmaceutical development and technology.
2020 Nov; 25(9):1162-1167. doi:
10.1080/10837450.2020.1794000. [PMID: 32644855] - Hiraku Onishi, Osamu Sakata. Absorption behavior of etilefrine after buccal administration in rats.
International journal of pharmaceutics.
2018 Oct; 550(1-2):14-23. doi:
10.1016/j.ijpharm.2018.08.009. [PMID: 30107221] - Noel Kong, Rong Yi, Sarah Zhao, Jasmeet Sandhu, Geoffrey Lam, Devan Loganathan, Barbara Morrissey. Development and validation of a hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine.
Journal of separation science.
2014 Nov; 37(21):3015-23. doi:
10.1002/jssc.201400662. [PMID: 25143252] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - P Ptácek, J Klíma, J Macek. Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of phenylephrine in human plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Oct; 858(1-2):263-8. doi:
10.1016/j.jchromb.2007.09.011. [PMID: 17900999] - K Järvelä, T Kööbi, P Kauppinen, S Kaukinen. Effects of hypertonic 75 mg/ml (7.5\%) saline on extracellular water volume when used for preloading before spinal anaesthesia.
Acta anaesthesiologica Scandinavica.
2001 Jul; 45(6):776-81. doi:
10.1034/j.1399-6576.2001.045006776.x. [PMID: 11421840] - F A Aly, S A Al-Tamimi, A A Alwarthan. Determination of phenolic sympathomimetic drugs in pharmaceutical samples and biological fluids by flow-injection chemiluminescence.
Journal of AOAC International.
2000 Nov; 83(6):1299-305. doi:
10.1093/jaoac/83.6.1299. [PMID: 11128130] - K Kojima, M Yamanaka, Y Nakanishi, S Arakawa. High-performance liquid chromatographic determination of etilefrine in human plasma using combined solid-phase and organic solvent extraction and electrochemical detection.
Journal of chromatography.
1990 Jan; 525(1):210-7. doi:
10.1016/s0378-4347(00)83395-2. [PMID: 1970985] - K O Haustein, G Hüller. [Bioavailability of etilefrine from Thomasin and Thomasin sustained-release tablets].
Die Pharmazie.
1985 Nov; 40(11):776-8. doi:
NULL. [PMID: 2869507] - E Koski, T Tuppurainen, M Mattila, A Gordin, H Salo. Hydroxyethyl starches, dextran and balanced salt solution in correction of hypotension during epidural anaesthesia.
Acta anaesthesiologica Scandinavica.
1984 Dec; 28(6):595-9. doi:
10.1111/j.1399-6576.1984.tb02127.x. [PMID: 6084389] - J H Hengstmann, R Hengstmann, S Schwonzen, H J Dengler. Dihydroergotamine increases the bioavailability of orally administered etilefrine.
European journal of clinical pharmacology.
1982; 22(5):463-7. doi:
10.1007/bf00542554. [PMID: 6126364] - K L Rominger, G Hitzenberger. Pharmacokinetic comparison of etilefrine to its prodrug, the stearic acid ester of etilefrine.
International journal of clinical pharmacology, therapy, and toxicology.
1980 Apr; 18(4):150-7. doi:
NULL. [PMID: 6103881] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435] - K A Meurer, H Geuchen, R Lang, W Kaufmann. [Hemodynamic and humoral changes during administration of a sympathomimetic and a sympatholytic drug with special notes on the regulation of renin release (author's transl)].
Klinische Wochenschrift.
1979 Apr; 57(7):331-9. doi:
10.1007/bf01476563. [PMID: 35650] - F Kaden, W Mäurer, A Schömig, U Spohr. [The effect of etilefrine and dihydroergotamine on sympathetic nervous system activity when standing up (author's transl)].
Deutsche medizinische Wochenschrift (1946).
1978 Sep; 103(39):1513-7. doi:
10.1055/s-0028-1129292. [PMID: 28936] - G Machata, G L Dadisch. [Current possibilities for analysis of etilefrin].
Beitrage zur gerichtlichen Medizin.
1978; 36(?):37-9. doi:
NULL. [PMID: 31157] - J H Hengstmann, U Weyand, H J Dengler. The physiological disposition of etilefrine in man.
European journal of clinical pharmacology.
1975 Dec; 9(2-3):179-87. doi:
10.1007/bf00614015. [PMID: 9300] - T Hiraoka. Determination of microquantity of ethylphenylephrine in plasma by radioisotope derivative method using p-toluenesulfonyl[35S] chloride.
Chemical & pharmaceutical bulletin.
1974 Nov; 22(11):2511-7. doi:
10.1248/cpb.22.2511. [PMID: 4157067] - F Ivanhoe. Pulmonary vasoconstriction and the pharmacology of respiratory distress (continued).
Pediatrics.
1966 Mar; 37(3):530-1. doi:
NULL. [PMID: 14640073] - E RENNER, H H EDEL, H J GURLAND. [COMPARATIVE STUDIES ON THE EFFECT OF ETHYLADRIANOL AND NORADRENALINE ON RENAL HEMODYNAMICS IN HEALTHY SUBJECTS].
Medizinische Klinik.
1965 Apr; 60(?):546-8. doi:
NULL. [PMID: 14273809] - J ESPLUGUES REQUENA, V LOPEZ MERINO. [Modifications of the action of digoxin by effortil and sympathol].
Medicina espanola.
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