Durabolin (BioDeep_00000176113)
human metabolite blood metabolite
代谢物信息卡片
15-methyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl 3-phenylpropanoate
化学式: C27H34O3 (406.25078140000005)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 92.86%
分子结构信息
SMILES: CC12CCC3C(C1CCC2OC(=O)CCC4=CC=CC=C4)CCC5=CC(=O)CCC35
InChI: InChI=1S/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
16 个代谢物同义名
15-methyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl 3-phenylpropanoate; 15-Methyl-5-oxotetracyclo[8.7.0.0,.0,]heptadec-6-en-14-yl 3-phenylpropanoic acid; 17 beta-Hydroxyestr-4-en-3-one hydrocinnamate; Nandrolone phenpropionate, (17alpha)-isomer; Nortestosterone phenylpropionate; Norandrolone phenylpropionate; Nandrolone phenpropionate; Protein, FSH-releasing; FSH Releasing protein; FSH-Releasing protein; Durabolin; Nerobolyl; Fenobolin; Nerobolil; Activins; Activin
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 4435
- HMDB: HMDB0248483
- ChEMBL: CHEMBL1357160
- Wikipedia: Nandrolone
- MeSH: Activins
- chemspider: 4282
- CAS: 104625-48-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jasmine A Richman, Leah R Davis, Michael P Phelps. Gene Function is a Driver of Activin Signaling Pathway Evolution Following Whole-Genome Duplication in Rainbow Trout (Oncorhynchus mykiss).
Genome biology and evolution.
2024 May; 16(5):. doi:
10.1093/gbe/evae096. [PMID: 38701021] - John D Griffin, Joanne M Buxton, Jeffrey A Culver, Robert Barnes, Emily A Jordan, Alexis R White, Stephen E Flaherty, Barbara Bernardo, Trenton Ross, Kendra K Bence, Morris J Birnbaum. Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids.
Molecular metabolism.
2023 Dec; 78(?):101830. doi:
10.1016/j.molmet.2023.101830. [PMID: 38787338] - Huan Liu, Armen Yerevanian, Maria Westerhoff, Margaret H Hastings, Justin Ralph Baldovino Guerra, Meng Zhao, Katrin J Svensson, Bishuang Cai, Alexander A Soukas, Anthony Rosenzweig. Roles of Activin A and Gpnmb in metabolic dysfunction-associated steatotic liver disease (MASLD).
Diabetes.
2023 Nov; ?(?):. doi:
10.2337/db23-0357. [PMID: 37934943] - Huan Liu, Margaret Hallauer Hastings, Robert Kitchen, Chunyang Xiao, Justin Ralph Baldovino Guerra, Alexandra Kuznetsov, Anthony Rosenzweig. Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2023 02; 43(2):330-349. doi:
10.1161/atvbaha.122.318138. [PMID: 36453275] - Jingjing Li, Letong Yin, Jingxiu Bi, David Stanley, Qili Feng, Qisheng Song. The TGF-β Receptor Gene Saxophone Influences Larval-Pupal-Adult Development in Tribolium castaneum.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27186017. [PMID: 36144752] - Excel R S Maylem, Leon J Spicer. Effects of transforming growth factor β1 on steroidogenesis of feline granulosa cells cultured in vitro.
Reproduction, fertility, and development.
2022 Jul; 34(11):789-797. doi:
10.1071/rd22034. [PMID: 35605602] - Stanislas Bataille, Laetitia Dou, Marc Bartoli, Marion Sallée, Julien Aniort, Borhane Ferkak, Rania Chermiti, Nathalie McKay, Nathalie Da Silva, Stéphane Burtey, Stéphane Poitevin. Mechanisms of myostatin and activin A accumulation in chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2022 06; 37(7):1249-1260. doi:
10.1093/ndt/gfac136. [PMID: 35333341] - Liqin Liu, Shijie Zhao, Zhenming Lü, Zan Pang, Bingjian Liu, Li Gong, Yinghui-Dong. Identification, expression and functional analysis of activin type I receptor in common Chinese Cuttlefish, Sepiella japonica.
Animal reproduction science.
2022 May; 240(?):106976. doi:
10.1016/j.anireprosci.2022.106976. [PMID: 35439681] - Jun-Li Du, Feng Chen, Jian-Jian Wu, Lin Jin, Guo-Qing Li. Smad on X is vital for larval-pupal transition in a herbivorous ladybird beetle.
Journal of insect physiology.
2022 May; 139(?):104387. doi:
10.1016/j.jinsphys.2022.104387. [PMID: 35367434] - Kelly L Walton, Monica P Goney, Zoe Peppas, Jessica M Stringer, Amy Winship, Karla Hutt, Georgia Goodchild, Shreya Maskey, Karen L Chan, Emilie Brûlé, Daniel J Bernard, William A Stocker, Craig A Harrison. Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss.
Endocrinology.
2022 04; 163(4):. doi:
10.1210/endocr/bqac025. [PMID: 35255139] - Joan C Krepinsky. Activin B, a new player in kidney fibrosis?†.
The Journal of pathology.
2022 04; 256(4):363-365. doi:
10.1002/path.5847. [PMID: 34882799] - Georgia P Wong, Faith Andres, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Emerson Keenan, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino. Circulating Activin A is elevated at 36 weeks' gestation preceding a diagnosis of preeclampsia.
Pregnancy hypertension.
2022 Mar; 27(?):23-26. doi:
10.1016/j.preghy.2021.11.006. [PMID: 34844073] - Szabina Szófia Szilágyi, Ayelet R Amsalem-Zafran, Keren E Shapira, Marcelo Ehrlich, Yoav I Henis. Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways.
BMC biology.
2022 02; 20(1):50. doi:
10.1186/s12915-022-01252-z. [PMID: 35177083] - Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter Ten Dijke, Andreas Teufel, Alexander Marx, Peter R Mertens, Hua Wang, Matthias P A Ebert, Heike Bantel, Enrico N De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong-Lei Weng. Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.
Hepatology (Baltimore, Md.).
2022 02; 75(2):322-337. doi:
10.1002/hep.32119. [PMID: 34435364] - Andrew S Terker, T Alp Ikizler. Untangling the fibers of sarcopenia: activin A in chronic kidney disease-associated muscle wasting.
Kidney international.
2022 02; 101(2):211-213. doi:
10.1016/j.kint.2021.08.034. [PMID: 34718004] - Elliot A Perens, Hal M Hoffman, Robert H Mak. Activin A Signaling Provides an Interorgan Link Between Kidney and Muscle in CKD-Associated Muscle Wasting.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2022 02; 79(2):302-304. doi:
10.1053/j.ajkd.2021.09.007. [PMID: 34653537] - Pauline C Xu, Mikyoung You, Seok-Yeong Yu, Yi Luan, Maya Eldani, Thomas C Caffrey, Paul M Grandgenett, Kelly A O'Connell, Surendra K Shukla, Chandramohan Kattamuri, Michael A Hollingsworth, Pankaj K Singh, Thomas B Thompson, Soonkyu Chung, So-Youn Kim. Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Scientific reports.
2022 01; 12(1):1659. doi:
10.1038/s41598-022-05660-7. [PMID: 35102236] - Megan McAleavy, Qian Zhang, Peter J Ehmann, Jianing Xu, Matthew F Wipperman, Dharani Ajithdoss, Li Pan, Matthew Wakai, Raphael Simonson, Abhilash Gadi, Adelekan Oyejide, Sara C Hamon, Anita Boyapati, Lori G Morton, Tea Shavlakadze, Christos A Kyratsous, David J Glass. The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.
Molecular and cellular biology.
2022 01; 42(1):e0046721. doi:
10.1128/mcb.00467-21. [PMID: 34723652] - Sahar E M El-Deek, Sary K H Abd-Elghaffar, Randa S Hna, Heba G Mohamed, Heba E M El-Deek. Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway.
Nutrition and cancer.
2022; 74(2):697-714. doi:
10.1080/01635581.2021.1907424. [PMID: 33818196] - Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C Crawford, Marina Pasca di Magliano, Kai Ge, Yali Dou, Jiaqi Shi. KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway.
Cellular and molecular gastroenterology and hepatology.
2022; 13(2):643-667. doi:
10.1016/j.jcmgh.2021.09.014. [PMID: 34583087] - Rukmali Wijayarathna, Rosemary Genovese, Andreas Meinhardt, Kate L Loveland, Nigel P Groome, Barry T Hinton, Mark P Hedger. Examination of testicular lumicrine regulation of activins and immunoregulatory genes in the epididymal caput.
Andrology.
2022 01; 10(1):190-201. doi:
10.1111/andr.13099. [PMID: 34415685] - Nandor Barany, Anita Rozsas, Zsolt Megyesfalvi, Michael Grusch, Balazs Hegedus, Christian Lang, Kristiina Boettiger, Anna Schwendenwein, Anna Tisza, Ferenc Renyi-Vamos, Karin Schelch, Konrad Hoetzenecker, Mir Alireza Hoda, Sandor Paku, Viktoria Laszlo, Balazs Dome. Clinical relevance of circulating activin A and follistatin in small cell lung cancer.
Lung cancer (Amsterdam, Netherlands).
2021 11; 161(?):128-135. doi:
10.1016/j.lungcan.2021.09.008. [PMID: 34583221] - Shih-Chen Chang, Chien-Yi Hsu, Li-Kuo Liu, Ya-Wen Lu, Yi-Lin Tsai, Ruey-Hsing Chou, Po-Hsun Huang, Liang-Kung Chen, Shing-Jong Lin. The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan.
Scientific reports.
2021 10; 11(1):20032. doi:
10.1038/s41598-021-99081-7. [PMID: 34625604] - Tian Xie, Lizhen Han, Yongxing Chen, Haihong Wu. Progranulin and Activin A Concentrations are Elevated in Serum from Patients with Acute Exacerbations of Idiopathic Pulmonary Fibrosis.
Lung.
2021 10; 199(5):467-473. doi:
10.1007/s00408-021-00470-6. [PMID: 34462814] - Maíra Casalechi, Bruna B Coimbra, Débora M Rocha, Fernanda R Carvalho, Alessandra D Clarizia, Wiviane A Assis, Regina Amelia Lopes Pessoa Aguiar, Fernando M Reis. Serum and urine levels of activin A in primigravidae and multigravidae: a prospective cross-sectional study.
Women & health.
2021 09; 61(8):745-750. doi:
10.1080/03630242.2021.1965693. [PMID: 34376125] - Pasquale Esposito, Daniela Verzola, Daniela Picciotto, Leda Cipriani, Francesca Viazzi, Giacomo Garibotto. Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification.
Cells.
2021 08; 10(8):. doi:
10.3390/cells10082070. [PMID: 34440838] - Marc Paul O'Sullivan, Niamh Denihan, Klaudia Sikora, Mikael Finder, Caroline Ahearne, Gerard Clarke, Boubou Hallberg, Geraldine B Boylan, Deirdre M Murray. Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy.
Neuropediatrics.
2021 08; 52(4):261-267. doi:
10.1055/s-0041-1725012. [PMID: 33706404] - Witold Kędzierski, Sylwester Kowalik, Wioleta Mojsym, Iwona Janczarek, Ewelina Tkaczyk. Plasma Activin A and Decorin in Exercised Purebred Arabian Horses - Preliminary Study.
Journal of equine veterinary science.
2021 07; 102(?):103638. doi:
10.1016/j.jevs.2021.103638. [PMID: 34119190] - Nikoleta Kostopoulou, Sofia Bellou, Eleni Bagli, Maria Markou, Eleftherios Kostaras, Marko Hyvönen, Yiannis Kalaidzidis, Angelos Papadopoulos, Varvara Chalmantzi, Athena Kyrkou, Ekaterini Panopoulou, Theodore Fotsis, Carol Murphy. Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated cells.
Journal of cell science.
2021 07; 134(13):. doi:
10.1242/jcs.246892. [PMID: 34313314] - Francesca Solagna, Caterina Tezze, Maja T Lindenmeyer, Shun Lu, Guochao Wu, Shuya Liu, Yu Zhao, Robert Mitchell, Charlotte Meyer, Saleh Omairi, Temel Kilic, Andrea Paolini, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Dominik Kylies, Julian Schulze Zur Wiesch, Jan-Eric Turner, Nicola Wanner, Viji Nair, Felix Eichinger, Rajasree Menon, Ina V Martin, Barbara M Klinkhammer, Elion Hoxha, Clemens D Cohen, Pierre-Louis Tharaux, Peter Boor, Tammo Ostendorf, Matthias Kretzler, Marco Sandri, Oliver Kretz, Victor G Puelles, Ketan Patel, Tobias B Huber. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.
The Journal of clinical investigation.
2021 06; 131(11):. doi:
10.1172/jci135821. [PMID: 34060483] - Giuseppe Cianciolo, Gaetano La Manna, Irene Capelli, Lorenzo Gasperoni, Andrea Galassi, Paola Ciceri, Mario Cozzolino. The role of activin: the other side of chronic kidney disease-mineral bone disorder?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 05; 36(6):966-974. doi:
10.1093/ndt/gfaa203. [PMID: 32940690] - Evgenia Synolaki, Vasileios Papadopoulos, Georgios Divolis, Olga Tsahouridou, Efstratios Gavriilidis, Georgia Loli, Ariana Gavriil, Christina Tsigalou, Nikolaos R Tziolos, Eleni Sertaridou, Bhanu Kalra, Ajay Kumar, Petros Rafailidis, Arja Pasternack, Dimitrios T Boumpas, Georgios Germanidis, Olli Ritvos, Simeon Metallidis, Panagiotis Skendros, Paschalis Sideras. The Activin/Follistatin Axis Is Severely Deregulated in COVID-19 and Independently Associated With In-Hospital Mortality.
The Journal of infectious diseases.
2021 05; 223(9):1544-1554. doi:
10.1093/infdis/jiab108. [PMID: 33625513] - Cheng Yuan, Lihua Ni, Xiaoyan Wu. Activin A activation drives renal fibrosis through the STAT3 signaling pathway.
The international journal of biochemistry & cell biology.
2021 05; 134(?):105950. doi:
10.1016/j.biocel.2021.105950. [PMID: 33609746] - Georgina Mancinelli, Carolina Torres, Nancy Krett, Jessica Bauer, Karla Castellanos, Ron McKinney, David Dawson, Grace Guzman, Rosa Hwang, Sam Grimaldo, Paul Grippo, Barbara Jung. Role of stromal activin A in human pancreatic cancer and metastasis in mice.
Scientific reports.
2021 04; 11(1):7986. doi:
10.1038/s41598-021-87213-y. [PMID: 33846512] - Cecilia Veraar, Jonathan Kliman, Alberto Benazzo, Felicitas Oberndorfer, Maria Laggner, Philipp Hacker, Thomas Raunegger, Stefan Janik, Peter Jaksch, Walter Klepetko, Hendrik J Ankersmit, Bernhard Moser. Potential novel biomarkers for chronic lung allograft dysfunction and azithromycin responsive allograft dysfunction.
Scientific reports.
2021 03; 11(1):6799. doi:
10.1038/s41598-021-85949-1. [PMID: 33762606] - Asfia Soomro, Jackie Trink, Kian O'Neil, Renzhong Li, Safaa Naiel, Bo Gao, Kjetil Ask, Joan C Krepinsky. Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062839. [PMID: 33799579] - V K Chin, T H Tie, R Abd Majid, H Hassan, N Nordin, R Abas, R Basir. Inhibition of Activin A suppressed tumor necrosis factor-α secretion and improved histopathological conditions in malarial mice.
Tropical biomedicine.
2021 Mar; 38(1):187-204. doi:
10.47665/tb.38.1.018. [PMID: 33797545] - Shenglin Xian, Ang Chen, Xiaodan Wu, Chuanghong Lu, Yunjiao Wu, Feng Huang, Zhiyu Zeng. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease.
Molecular medicine reports.
2021 01; 23(1):. doi:
10.3892/mmr.2020.11648. [PMID: 33179113] - Makoto Hashimoto, Gilbert Ho, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Hiromu Sugino, Satoshi Inoue, Eliezer Masliah. Possible Role of Activin in the Adiponectin Paradox-Induced Progress of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2021; 81(2):451-458. doi:
10.3233/jad-210206. [PMID: 33814453] - Carmen Picón, Amalia Tejeda-Velarde, José Ignacio Fernández-Velasco, Manuel Comabella, Roberto Álvarez-Lafuente, Ester Quintana, Susana Sainz de la Maza, Enric Monreal, Noelia Villarrubia, José Carlos Álvarez-Cermeño, María Inmaculada Domínguez-Mozo, Lluís Ramió-Torrentà, Eulalia Rodríguez-Martín, Ernesto Roldán, Yolanda Aladro, Silvia Medina, Mercedes Espiño, Jaime Masjuan, Clara Matute-Blanch, Marta Muñoz-San Martín, Carmen Espejo, Carmen Guaza, Alfonso Muriel, Lucienne Costa-Frossard, Luisa María Villar. Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis.
Frontiers in immunology.
2021; 12(?):685139. doi:
10.3389/fimmu.2021.685139. [PMID: 34322119] - Salah Aref, Lamiaa Ebrahim, Shaimaa El-Ashwah, Mohamed El Agdar, Mohamed Ayed. Relevance of plasma bone marrow Activin-A and CXCL-12 concentration levels as a biomarker in acute myeloid leukemia.
Cancer biomarkers : section A of Disease markers.
2021; 32(3):263-270. doi:
10.3233/cbm-203171. [PMID: 34092614] - Frédéric Vanhoutte, Su Liang, Marcella Ruddy, An Zhao, Tiera Drewery, Yuhuan Wang, Richard DelGizzi, Eduardo Forleo-Neto, Manoj Rajadhyaksha, Gary Herman, John D Davis. Pharmacokinetics and Pharmacodynamics of Garetosmab (Anti-Activin A): Results From a First-in-Human Phase 1 Study.
Journal of clinical pharmacology.
2020 11; 60(11):1424-1431. doi:
10.1002/jcph.1638. [PMID: 32557665] - Zhipeng Cao, Irvin Jose, Jason Glab, Hamsa Puthalakath, Laura D Osellame, Nick J Hoogenraad. Generation of reporter cell lines for factors inducing muscle wasting in cancer cachexia.
Analytical biochemistry.
2020 10; 606(?):113877. doi:
10.1016/j.ab.2020.113877. [PMID: 32738212] - Kai Chang, Ping Kang, Ying Liu, Kerui Huang, Ting Miao, Antonia P Sagona, Ioannis P Nezis, Rolf Bodmer, Karen Ocorr, Hua Bai. TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Autophagy.
2020 10; 16(10):1807-1822. doi:
10.1080/15548627.2019.1704117. [PMID: 31884871] - Penny A F Whiley, Liza O'Donnell, Sarah C Moody, David J Handelsman, Julia C Young, Elizabeth A Richards, Kristian Almstrup, Patrick S Western, Kate L Loveland. Activin A Determines Steroid Levels and Composition in the Fetal Testis.
Endocrinology.
2020 07; 161(7):. doi:
10.1210/endocr/bqaa058. [PMID: 32274496] - Rui Liang, Xiaoxiao Xiao, Lilin Luo, Tianxing Chen, Hui Yang, Wanpu Wang, Yinghong Zhang, Zhiqiang Wang. Efficient Definitive Endoderm Differentiation from Human Parthenogenetic Embryonic Stem Cells Induced by Activin A and Wnt3a.
Annals of clinical and laboratory science.
2020 Jul; 50(4):468-473. doi:
". [PMID: 32826243] - Nikolaos Perakakis, Alexander Kokkinos, Natia Peradze, Nikolaos Tentolouris, Wael Ghaly, Dimitrios Tsilingiris, Andreas Alexandrou, Christos S Mantzoros. Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery.
Diabetes/metabolism research and reviews.
2020 07; 36(5):e3297. doi:
10.1002/dmrr.3297. [PMID: 32026536] - Heba Naseem, John Dreixler, Ariel Mueller, Avery Tung, Rohin Dhir, Rachna Chibber, Abid Fazal, Joey P Granger, Bhavisha A Bakrania, Victoria deMartelly, Sarosh Rana, Sajid Shahul. Antepartum Aspirin Administration Reduces Activin A and Cardiac Global Longitudinal Strain in Preeclamptic Women.
Journal of the American Heart Association.
2020 06; 9(12):e015997. doi:
10.1161/jaha.119.015997. [PMID: 32495688] - Juuso Paajanen, Ilkka Ilonen, Helena Lauri, Tommi Järvinen, Eva Sutinen, Hely Ollila, Eeva Rouvinen, Karl Lemström, Jari Räsänen, Olli Ritvos, Katri Koli, Marjukka Myllärniemi. Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy.
Clinical lung cancer.
2020 05; 21(3):e142-e150. doi:
10.1016/j.cllc.2019.10.013. [PMID: 31734071] - Seong Son, Seung Hwan Yoon, Moon Hang Kim, Xiang Yun. Activin A and BMP chimera (AB204) induced bone fusion in osteoporotic spine using an ovariectomized rat model.
The spine journal : official journal of the North American Spine Society.
2020 05; 20(5):809-820. doi:
10.1016/j.spinee.2019.12.015. [PMID: 31899374] - Lykke Sylow, Birgitte F Vind, Rikke Kruse, Pauline M Møller, Jørgen F P Wojtaszewski, Erik A Richter, Kurt Højlund. Circulating Follistatin and Activin A and Their Regulation by Insulin in Obesity and Type 2 Diabetes.
The Journal of clinical endocrinology and metabolism.
2020 05; 105(5):. doi:
10.1210/clinem/dgaa090. [PMID: 32112102] - Alexandra L Thomas, Karla Castellanos, Georgina Mancinelli, Yinglin Xia, Jessica Bauer, Cemal Yazici, Giamila Fantuzzi, Rosa F Hwang, Nancy L Krett, Georgios I Papachristou, David C Whitcomb, Barbara Jung. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index.
Clinical and translational gastroenterology.
2020 05; 11(5):e00152. doi:
10.14309/ctg.0000000000000152. [PMID: 32358238] - Yi-Lin Tsai, Ruey-Hsing Chou, Ya-Wen Lu, Chung-Te Liu, Po-Hsun Huang, Shing-Jong Lin. Serum Activin A Levels and Renal Outcomes After Coronary Angiography.
Scientific reports.
2020 02; 10(1):3365. doi:
10.1038/s41598-020-60359-x. [PMID: 32099067] - Baojiang Wu, Lin Li, Bojiang Li, Junpeng Gao, Yanglin Chen, Mengyi Wei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li, Changshan Wang, M Azim Surani, Xihe Li, Fuchou Tang, Siqin Bao. Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media.
Stem cell reports.
2020 02; 14(2):241-255. doi:
10.1016/j.stemcr.2020.01.004. [PMID: 32032551] - R Talar-Wojnarowska, M Wozniak, A Borkowska, M Olakowski, E Malecka-Panas. Clinical significance of activin A and myostatin in patients with pancreatic adenocarcinoma and progressive weight loss.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Feb; 71(1):. doi:
10.26402/jpp.2020.1.10. [PMID: 32554845] - Bassem Refaat, Adil O Bahathiq. The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.
Clinica chimica acta; international journal of clinical chemistry.
2020 Jan; 500(?):69-74. doi:
10.1016/j.cca.2019.09.019. [PMID: 31647905] - Diane G Carnathan, Kirti Kaushik, Ali H Ellebedy, Chiamaka A Enemuo, Etse H Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Matthias G Pauthner, Gabriel Ozorowski, Rafi Ahmed, Dennis R Burton, Andrew B Ward, Guido Silvestri, Shane Crotty, Michela Locci. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers.
Frontiers in immunology.
2020; 11(?):1213. doi:
10.3389/fimmu.2020.01213. [PMID: 32612608] - Justin Komguep Nono, Manfred B Lutz, Klaus Brehm. Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis.
Frontiers in immunology.
2020; 11(?):798. doi:
10.3389/fimmu.2020.00798. [PMID: 32457746] - Teri N Hreha, Christina A Collins, Allyssa L Daugherty, Jessie M Griffith, Keith A Hruska, David A Hunstad. Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring.
Frontiers in immunology.
2020; 11(?):1641. doi:
10.3389/fimmu.2020.01641. [PMID: 32849562] - Neel Mehta, Joan C Krepinsky. The emerging role of activins in renal disease.
Current opinion in nephrology and hypertension.
2020 01; 29(1):136-144. doi:
10.1097/mnh.0000000000000560. [PMID: 31714286] - Rashid A Aldahhan, Peter G Stanton, Helen Ludlow, David M de Kretser, Mark P Hedger. Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis.
Molecular and cellular endocrinology.
2019 12; 498(?):110546. doi:
10.1016/j.mce.2019.110546. [PMID: 31422101] - Stefan Janik, Christine Bekos, Philipp Hacker, Thomas Raunegger, Ana-Iris Schiefer, Leonhard Müllauer, Cecilia Veraar, Balazs Dome, Walter Klepetko, Hendrik Jan Ankersmit, Bernhard Moser. Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors.
Scientific reports.
2019 11; 9(1):17359. doi:
10.1038/s41598-019-53671-8. [PMID: 31757999] - Yi Luo, Ya-Wei Cheng, Chang-Yin Yu, Ru-Ming Liu, Yu-Jie Zhao, Dai-Xiong Chen, Jian-Jiang Zhong, Jian-Hui Xiao. Effects of hyaluronic acid on differentiation of human amniotic epithelial cells and cell-replacement therapy in type 1 diabetic mice.
Experimental cell research.
2019 11; 384(2):111642. doi:
10.1016/j.yexcr.2019.111642. [PMID: 31562862] - Dan Zhang, Agata L Gava, Richard Van Krieken, Neel Mehta, Renzhong Li, Bo Gao, Eric M Desjardins, Gregory R Steinberg, Thomas Hawke, Joan C Krepinsky. The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Kidney international.
2019 11; 96(5):1134-1149. doi:
10.1016/j.kint.2019.05.032. [PMID: 31492508] - Kota Fujiki, Hisako Inamura, Takeshi Sugaya, Masato Matsuoka. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms.
Cell death and differentiation.
2019 Nov; 26(11):2371-2385. doi:
10.1038/s41418-019-0307-8. [PMID: 30804470] - Sanna Törnblom, Sara Nisula, Suvi T Vaara, Meri Poukkanen, Sture Andersson, Ville Pettilä, Eero Pesonen. Neutrophil activation in septic acute kidney injury: A post hoc analysis of the FINNAKI study.
Acta anaesthesiologica Scandinavica.
2019 11; 63(10):1390-1397. doi:
10.1111/aas.13451. [PMID: 31325317] - Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E Sandusky, Safi Shahda, Attila Nakeeb, C Max Schmidt, Michael G House, Eugene P Ceppa, Nicholas J Zyromski, Yunlong Liu, Guanglong Jiang, Marion E Couch, Leonidas G Koniaris, Teresa A Zimmers. The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.
Journal of cachexia, sarcopenia and muscle.
2019 10; 10(5):1083-1101. doi:
10.1002/jcsm.12461. [PMID: 31286691] - Tomonori Oka, Tomomitsu Miyagaki, Hiroaki Kamijo, Rina Nakajima, Naomi Shishido-Takahashi, Naoyuki Senda, Hiraku Suga, Makoto Sugaya, Shinichi Sato. Increased Serum Activin A Levels in Mycosis Fungoides and Sézary Syndrome.
Acta dermato-venereologica.
2019 Oct; 99(11):1039-1040. doi:
10.2340/00015555-3246. [PMID: 31240323] - Kelly L Walton, Justin L Chen, Quinn Arnold, Emily Kelly, Mylinh La, Louis Lu, George Lovrecz, Adam Hagg, Timothy D Colgan, Hongwei Qian, Paul Gregorevic, Craig A Harrison. Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice.
Endocrinology.
2019 10; 160(10):2417-2426. doi:
10.1210/en.2019-00257. [PMID: 31322699] - Neel Mehta, Agata L Gava, Dan Zhang, Bo Gao, Joan C Krepinsky. Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease.
Antioxidants & redox signaling.
2019 09; 31(8):551-571. doi:
10.1089/ars.2018.7684. [PMID: 31184201] - Daniela Egli-Spichtig, Carsten A Wagner. The rhythm of healthy kidneys.
Pflugers Archiv : European journal of physiology.
2019 09; 471(9):1159-1160. doi:
10.1007/s00424-019-02297-w. [PMID: 31300871] - Se Hyun Kim, Jin Won Kim, In Gyu Hwang, Joung Soon Jang, Soojung Hong, Tae-Yong Kim, Ji Yeon Baek, Seong Hoon Shin, Der Sheng Sun, Dae-Sik Hong, Hyo Jung Kim, Yong Sang Hong, In Sook Woo, Ju-Hyun Lee, Jee Hyun Kim. Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors.
Journal of geriatric oncology.
2019 09; 10(5):749-756. doi:
10.1016/j.jgo.2019.03.015. [PMID: 30952517] - Shunsuke Tanigawa, Hidekazu Naganuma, Yusuke Kaku, Takumi Era, Tetsushi Sakuma, Takashi Yamamoto, Atsuhiro Taguchi, Ryuichi Nishinakamura. Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors.
Stem cell reports.
2019 08; 13(2):322-337. doi:
10.1016/j.stemcr.2019.07.003. [PMID: 31378669] - Chang Liu, Hsun-Ming Chang, Yuyin Yi, Ying Fang, Feiyan Zhao, Peter C K Leung, Xiaokui Yang. ALK4-SMAD2/3-SMAD4 signaling mediates the activin A-induced suppression of PTX3 in human granulosa-lutein cells.
Molecular and cellular endocrinology.
2019 08; 493(?):110485. doi:
10.1016/j.mce.2019.110485. [PMID: 31185247] - Anders Nordholm, Søren Egstrand, Eva Gravesen, Maria L Mace, Marya Morevati, Klaus Olgaard, Ewa Lewin. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats.
Pflugers Archiv : European journal of physiology.
2019 08; 471(8):1079-1094. doi:
10.1007/s00424-019-02291-2. [PMID: 31236663] - Susan M Ott. Renal insufficiency and bone loss.
Current opinion in rheumatology.
2019 07; 31(4):394-399. doi:
10.1097/bor.0000000000000626. [PMID: 31135568] - Sachiyo Oikawa, Sachiyo Kobayashi, Shinichi Miyagawa, Taisen Iguchi, Tomomi Sato. Diethylstilbestrol Alters the Expression of Activins in the Neonatal Mouse Ovary In Vitro.
In vivo (Athens, Greece).
2019 Jul; 33(4):1095-1102. doi:
10.21873/invivo.11578. [PMID: 31280197] - Yi-Lin Tsai, Ruey-Hsing Chou, Chin-Sung Kuo, Chun-Chin Chang, Cheng-Hsueh Wu, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin. Circulating Activin A Is a Surrogate for the Incidence of Diastolic Dysfunction and Heart Failure in Patients With Preserved Ejection Fraction.
Circulation journal : official journal of the Japanese Circulation Society.
2019 06; 83(7):1514-1519. doi:
10.1253/circj.cj-18-0837. [PMID: 31092760] - Jee-Min Kim, Jung-Kyu Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee. Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.
BMC pulmonary medicine.
2019 Jun; 19(1):115. doi:
10.1186/s12890-019-0879-6. [PMID: 31238942] - Khalid Alyodawi, Wilbert P Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M C Brandt, Sander Barnhoorn, Nicole van Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins-Hooper, Tobias B Huber, Jan H J Hoeijmakers, Ketan Patel. Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.
Journal of cachexia, sarcopenia and muscle.
2019 06; 10(3):662-686. doi:
10.1002/jcsm.12404. [PMID: 30916493] - Hirono Iriuchishima, Akito Maeshima, Shunsuke Takahashi, Takuma Ishizaki, Akihiko Yokohama, Norifumi Tsukamoto, Takayuki Saitoh, Hirokazu Murakami, Hiroshi Handa. Activin A: a novel urinary biomarker of renal impairment in multiple myeloma.
Bioscience reports.
2019 05; 39(5):. doi:
10.1042/bsr20190206. [PMID: 31072919] - Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan, Xiaodong Han. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway.
Cell communication and signaling : CCS.
2019 05; 17(1):45. doi:
10.1186/s12964-019-0361-3. [PMID: 31101053] - Francesca Giampieri, Md Soriful Islam, Stefania Greco, Massimiliano Gasparrini, Tamara Y Forbes Hernandez, Giovanni Delli Carpini, Stefano Raffaele Giannubilo, Andrea Ciavattini, Bruno Mezzetti, Luca Mazzoni, Franco Capocasa, Mario Castellucci, Maurizio Battino, Pasquapina Ciarmela. Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells.
Journal of cellular physiology.
2019 05; 234(5):7622-7633. doi:
10.1002/jcp.27524. [PMID: 30317591] - Florence Lima, Hanna Mawad, Amr A El-Husseini, Daniel L Davenport, Hartmut H Malluche. Serum bone markers in ROD patients across the spectrum of decreases in GFR: Activin A increases before all other markers
.
Clinical nephrology.
2019 Apr; 91(4):222-230. doi:
10.5414/cn109650. [PMID: 30862350] - Daniela Verzola, Chiara Barisione, Daniela Picciotto, Giacomo Garibotto, Laetitia Koppe. Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.
Kidney international.
2019 03; 95(3):506-517. doi:
10.1016/j.kint.2018.10.010. [PMID: 30598193] - M Memtsa, D Jurkovic, Erm Jauniaux. Diagnostic Biomarkers for Predicting Adverse Early Pregnancy Outcomes: Scientific Impact Paper No. 58.
BJOG : an international journal of obstetrics and gynaecology.
2019 Feb; 126(3):e107-e113. doi:
10.1111/1471-0528.15468. [PMID: 30402915] - Grigorios Panagiotou, Eleni Papakonstantinou, Anastasios Vagionas, Stergios A Polyzos, Christos S Mantzoros. Serum Levels of Activins, Follistatins, and Growth Factors in Neoplasms of the Breast: A Case-Control Study.
The Journal of clinical endocrinology and metabolism.
2019 02; 104(2):349-358. doi:
10.1210/jc.2018-01581. [PMID: 30388235] - Yoshinori Takei, Shunsuke Takahashi, Masao Nakasatomi, Toru Sakairi, Hidekazu Ikeuchi, Yoriaki Kaneko, Keiju Hiromura, Yoshihisa Nojima, Akito Maeshima. Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis.
PloS one.
2019; 14(10):e0223703. doi:
10.1371/journal.pone.0223703. [PMID: 31613925] - Xiaohui Bian, Tomás P Griffin, Xiangyang Zhu, Md Nahidul Islam, Sabena M Conley, Alfonso Eirin, Hui Tang, Paula M O'Shea, Allyson K Palmer, Rozalina G McCoy, Sandra M Herrmann, Ramila A Mehta, John R Woollard, Andrew D Rule, James L Kirkland, Tamar Tchkonia, Stephen C Textor, Matthew D Griffin, Lilach O Lerman, LaTonya J Hickson. Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy.
BMJ open diabetes research & care.
2019; 7(1):e000720. doi:
10.1136/bmjdrc-2019-000720. [PMID: 31908790] - Julia Roider, J Zachary Porterfield, Paul Ogongo, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Lynn Morris, Penny L Moore, Thumbi Ndung'u, Henrik Kløverpris, Philip J R Goulder, Alasdair Leslie. Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children.
Frontiers in immunology.
2019; 10(?):1497. doi:
10.3389/fimmu.2019.01497. [PMID: 31333650] - Guanghui Zhou, Xianhua Gui, Ruhua Chen, Xingli Fu, Xiuhai Ji, Hui Ding. Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting.
Clinics (Sao Paulo, Brazil).
2019; 74(?):e981. doi:
10.6061/clinics/2019/e981. [PMID: 31271588] - Krithika Hariharan, Harald Stachelscheid, Bella Rossbach, Su-Jun Oh, Nancy Mah, Kai Schmidt-Ott, Andreas Kurtz, Petra Reinke. Parallel generation of easily selectable multiple nephronal cell types from human pluripotent stem cells.
Cellular and molecular life sciences : CMLS.
2019 Jan; 76(1):179-192. doi:
10.1007/s00018-018-2929-2. [PMID: 30310934] - Christian Reichel, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Updated protocols for the detection of Sotatercept and Luspatercept in human serum.
Drug testing and analysis.
2018 Nov; 10(11-12):1708-1713. doi:
10.1002/dta.2500. [PMID: 30203930] - Wei Song, Arpan C Ghosh, Daojun Cheng, Norbert Perrimon. Endocrine Regulation of Energy Balance by Drosophila TGF-β/Activins.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2018 11; 40(11):e1800044. doi:
10.1002/bies.201800044. [PMID: 30264417] - Katja Walpurgis, Andreas Thomas, Tobias Lange, Christian Reichel, Hans Geyer, Mario Thevis. Combined detection of the ActRII-Fc fusion proteins Sotatercept (ActRIIA-Fc) and Luspatercept (modified ActRIIB-Fc) in serum by means of immunoaffinity purification, tryptic digestion, and LC-MS/MS.
Drug testing and analysis.
2018 Nov; 10(11-12):1714-1721. doi:
10.1002/dta.2513. [PMID: 30285318] - Osamu Hashimoto, Masayuki Funaba, Kazunari Sekiyama, Satoru Doi, Daichi Shindo, Ryo Satoh, Hiroshi Itoi, Hiroaki Oiwa, Masahiro Morita, Chisato Suzuki, Makoto Sugiyama, Norio Yamakawa, Hitomi Takada, Shigenobu Matsumura, Kazuo Inoue, Seiichi Oyadomari, Hiromu Sugino, Akira Kurisaki. Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.
Cell reports.
2018 10; 25(5):1193-1203. doi:
10.1016/j.celrep.2018.10.008. [PMID: 30380411] - Li-Ning Peng, Ming-Yueh Chou, Chih-Kuang Liang, Wei-Ju Lee, Taro Kojima, Ming-Hsien Lin, Ching-Hui Loh, Liang-Kung Chen. Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease.
Experimental gerontology.
2018 10; 111(?):197-202. doi:
10.1016/j.exger.2018.07.020. [PMID: 30071284] - Wolfgang Jelkmann. Activin receptor ligand traps in chronic kidney disease.
Current opinion in nephrology and hypertension.
2018 09; 27(5):351-357. doi:
10.1097/mnh.0000000000000433. [PMID: 29847322] - Lady V Barrios-Silva, Mack Parnell, Zahida B Shinwari, Ghulam A Chaudhary, Thanasis Xenofontos, Angel van Bekhoven, Simon McArthur, Bradley T Elliott. Activin subfamily peptides predict chronological age in humans.
Physiological reports.
2018 09; 6(17):e13823. doi:
10.14814/phy2.13823. [PMID: 30178598]