cisapride (BioDeep_00000017059)
代谢物信息卡片
4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
化学式: C23H29ClFN3O4 (465.1831)
中文名称: 西沙必利
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1
InChI: InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m0/s1
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity[1][2][3][4].
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:93034
- ChEBI: CHEBI:3720
- KEGG: C76595
- PubChem: 5311047
- PubChem: 6917698
- DrugBank: DB00604
- ChEMBL: CHEMBL74656
- ChEMBL: CHEMBL560739
- MeSH: Cisapride
- CAS: 81098-60-4
- CAS: 86719-31-5
- CAS: 104860-66-4
- CAS: 86718-70-9
- MoNA: FiehnHILIC001836
- MoNA: FiehnHILIC000261
- RefMet: Cisapride
- medchemexpress: HY-14149
- KEGG: C06910
- PubChem: 9127
- KNApSAcK: 3720
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Journal of clinical endocrinology and metabolism.
2001 Nov; 86(11):5534-40. doi:
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Clinical therapeutics.
2001 Nov; 23(11):1855-66. doi:
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British journal of clinical pharmacology.
2001 Oct; 52(4):419-25. doi:
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British journal of clinical pharmacology.
2001 Oct; 52(4):399-407. doi:
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Journal of gastroenterology and hepatology.
2001 Sep; 16(9):1044-50. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2001 Aug; 31(8-9):633-50. doi:
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Journal of pediatric gastroenterology and nutrition.
2001 Aug; 33(2):178-81. doi:
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Pharmacology & toxicology.
2001 Aug; 89(2):96-103. doi:
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Journal of pediatric gastroenterology and nutrition.
2001 Jul; 33(1):41-6. doi:
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The Journal of pharmacy and pharmacology.
2001 Jul; 53(7):1041-5. doi:
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Clinical pharmacology and therapeutics.
2001 Jul; 70(1):17-23. doi:
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Journal of gastroenterology and hepatology.
2001 Jul; 16(7):816-20. doi:
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European journal of clinical pharmacology.
2001 Jun; 57(3):229-34. doi:
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Journal of cardiovascular pharmacology.
2001 May; 37(5):607-18. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Feb; 37(2):287-93. doi:
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Pharmacotherapy.
2001 Feb; 21(2):149-57. doi:
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Pharmacology.
2001 Jan; 62(1):23-28. doi:
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Journal of AOAC International.
2001 Jan; 84(1):9-12. doi:
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Endocrine research.
2000 Nov; 26(4):583-7. doi:
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Research communications in molecular pathology and pharmacology.
2000 Nov; 108(5-6):311-23. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2000 Nov; 15(11):1814-8. doi:
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The American journal of cardiology.
2000 Oct; 86(8):873-5. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2000 Oct; 28(10):1231-7. doi:
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European journal of clinical nutrition.
2000 Aug; 54(8):603-9. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
2000 Jul; 744(2):263-72. doi:
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Clinical pharmacokinetics.
2000 Jul; 39(1):49-75. doi:
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British journal of pharmacology.
2000 Apr; 129(8):1655-67. doi:
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Critical care medicine.
2000 Feb; 28(2):438-44. doi:
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Biology of the neonate.
2000 Feb; 77(2):92-5. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1999 Dec; 46(12):1181-4. doi:
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Clinical pharmacology and therapeutics.
1999 Nov; 66(5):448-53. doi:
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British journal of clinical pharmacology.
1999 Nov; 48(5):688-93. doi:
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British journal of clinical pharmacology.
1999 Nov; 48(5):728-32. doi:
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Arzneimittel-Forschung.
1999 Nov; 49(11):925-32. doi:
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The Journal of biological chemistry.
1999 Oct; 274(44):31123-6. doi:
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Journal of clinical pharmacology.
1999 Sep; 39(9):945-50. doi:
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Minerva pediatrica.
1999 Sep; 51(9-10):309-11. doi:
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