cisapride (BioDeep_00000017059)

   


代谢物信息卡片


4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide

化学式: C23H29ClFN3O4 (465.18305160000006)
中文名称: 西沙必利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1
InChI: InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m0/s1

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity[1][2][3][4].

同义名列表

4 个代谢物同义名

4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide; cisapride; R 51619; (±)-Cisaprid



数据库引用编号

17 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. European journal of medicinal chemistry. 2022 Feb; 229(?):114045. doi: 10.1016/j.ejmech.2021.114045. [PMID: 34922191]
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  • Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation. The Journal of toxicological sciences. 2005 Aug; 30(3):239-47. doi: 10.2131/jts.30.239. [PMID: 16141657]
  • Jeffrey Alderman. Coadministration of sertraline with cisapride or pimozide: an open-label, nonrandomized examination of pharmacokinetics and corrected QT intervals in healthy adult volunteers. Clinical therapeutics. 2005 Jul; 27(7):1050-63. doi: 10.1016/j.clinthera.2005.07.013. [PMID: 16154484]
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  • L G Hare, D S Mitchel, J S Millership, P S Collier, J C McElnay, M D Shields, D J Carson, R Fair. Liquid chromatographic determination including simultaneous "on-cartridge" separation of ranitidine cisapride drug combinations from paediatric plasma samples using an automated solid-phase extraction procedure. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jul; 806(2):263-9. doi: 10.1016/j.jchromb.2004.04.007. [PMID: 15171937]
  • Ender Tekes, Banu Bayar, Selda Emre-Aydingoz, Meral Tuncer. Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat. The Indian journal of medical research. 2004 Mar; 119(3):115-20. doi: . [PMID: 15115163]
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  • Massimo Mannelli, Pietro Ferruzzi, Paola Luciani, Clara Crescioli, Lisa Buci, Giovanni Corona, Mario Serio, Alessandro Peri. Cushing's syndrome in a patient with bilateral macronodular adrenal hyperplasia responding to cisapride: an in vivo and in vitro study. The Journal of clinical endocrinology and metabolism. 2003 Oct; 88(10):4616-22. doi: 10.1210/jc.2002-021949. [PMID: 14557431]
  • Gregory L Kearns, Patricia K Robinson, John T Wilson, Deanna Wilson-Costello, Gail R Knight, Robert M Ward, John N van den Anker. Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny. Clinical pharmacology and therapeutics. 2003 Oct; 74(4):312-25. doi: 10.1016/s0009-9236(03)00225-x. [PMID: 14534518]
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