3,5-Diiodo-L-tyrosine (BioDeep_00000001505)

 

Secondary id: BioDeep_00000055175, BioDeep_00001868065

human metabolite Endogenous blood metabolite natural product BioNovoGene_Lab2019


代谢物信息卡片


(2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid

化学式: C9H9I2NO3 (432.8671944)
中文名称: 3,5-二碘酪氨酸, 3,5-二碘-L-酪氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 10.87%

分子结构信息

SMILES: C1=C(C=C(C(=C1I)O)I)CC(C(=O)O)N
InChI: InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1

描述信息

3,5-Diiodo-L-tyrosine, also known as diiy or DIT, belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 3,5-Diiodo-L-tyrosine exists in all living organisms, ranging from bacteria to humans. In humans, 3,5-diiodo-L-tyrosine is involved in thyroid hormone synthesis. 3,5-Diiodo-L-tyrosine is a product from the iodination of monoiodotyrosine.
A product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (thyroxine and triiodothyronine). [HMDB]
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
KEIO_ID D056

同义名列表

19 个代谢物同义名

(2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoate; 4-Hydroxy-3,5-diiodophenylalanine; 3,5-Diiodo-L-tyrosine; 3,5-L-Diiodotyrosine; L-3,5-Diiodotyrosine; 3,5-Diiodo-tyrosine; 3,5-Iodo-L-tyrosine; 3,5-Diiodotyrosine; 3,5-Diiodotyrocine; Acid, iodogorgoic; L-Diiodotyrosine; Iodogorgoic acid; Diiodotyrosine; 66-02-4; DiIY; DIT; 3,5-Diiodo-tyrosine; 3,5-Diiodo-L-tyrosine



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(4)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jesús Nicolás Carcelén, Juan Manuel Marchante-Gayón, Pablo Rodríguez-González, Alfredo Ballesteros, José M González, José Ángel Cocho de Juan, José Ignacio García Alonso. Determination of 3-monoiodotyrosine and 3,5-diiodotyrosine in newborn urine and dried urine spots by isotope dilution tandem mass spectrometry. The Analyst. 2022 Mar; 147(7):1329-1340. doi: 10.1039/d1an02203b. [PMID: 35262098]
  • Naoya Fujita, Yosuke Ono, Azusa Sano, Motohiro Kimata, Seigo Oyama, Kenichi Hashimoto, Ikuya Sato, Masahiko Kudo, Yoshimichi Miyashiro, Akira Fujikata, Yuji Tanaka. Serum diiodotyrosine - a biomarker to differentiate destructive thyroiditis from Graves' disease. European journal of endocrinology. 2022 Jan; 186(2):245-253. doi: 10.1530/eje-21-0901. [PMID: 34874894]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Salvatore Benvenga, Fabrizio Guarneri. Thyroid hormone binding motifs and iodination pattern of thyroglobulin. Frontiers in bioscience (Landmark edition). 2019 01; 24(2):212-230. doi: 10.2741/4714. [PMID: 30468652]
  • Chayanon Ngambenjawong, Meilyn Sylvestre, Heather H Gustafson, Julio Marco B Pineda, Suzie H Pun. Reversibly Switchable, pH-Dependent Peptide Ligand Binding via 3,5-Diiodotyrosine Substitutions. ACS chemical biology. 2018 04; 13(4):995-1002. doi: 10.1021/acschembio.8b00171. [PMID: 29481044]
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