Nitrazepam (BioDeep_00000001501)

 

Secondary id: BioDeep_00000397494

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one

化学式: C15H11N3O3 (281.08003759999997)
中文名称: 硝西泮
谱图信息: 最多检出来源 Homo sapiens(blood) 1.2%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Nitrazepam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/nitrazepam (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000001501). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3
InChI: InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)

描述信息

Nitrazepam is only found in individuals that have used or taken this drug. It is a benzodiazepine derivative used as an anticonvulsant and hypnotic.Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3683

同义名列表

79 个代谢物同义名

1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-ON; CT-Arzneimittel brand OF nitrazepam; Rhoxalpharma brand OF nitrazepam; United drug brand OF nitrazepam; Wernigerode brand OF nitrazepam; Neuraxpharm brand OF nitrazepam; Alphapharma brand OF nitrazepam; Scheurich brand OF nitrazepam; Dermatech brand OF nitrazepam; Dormicum brand OF nitrazepam; Alpharma brand OF nitrazepam; Pfleger brand OF nitrazepam; Allphar brand OF nitrazepam; Norgine brand OF nitrazepam; Desitin brand OF nitrazepam; Taurus brand OF nitrazepam; Protea brand OF nitrazepam; Alter brand OF nitrazepam; Aliud brand OF nitrazepam; DDSA brand OF nitrazepam; ICN brand OF nitrazepam; CSP Brand OF nitrazepam; Nitrazepam neuraxpharm; Nitrazepam-neuraxpharm; N-Desmethylnimetazepam; Rhoxal-nitrazepam; Rhoxal nitrazepam; Nitrodiazepam; Nitrazepam al; Nitrazepamum; Dormo-puren; nitrazepam; Neuchlonic; Nitrazadon; Ro 4-5360; Unisomnia; Ro 5-3059; Dormicum; Benzalin; Nitrazep; Sonnolin; Nitrados; Somitran; Neozepam; Dormalon; Trazenin; Eunoctin; Radedorm; Serenade; Persopit; Imadorm; Somnite; Sonebon; Apodorm; Novanox; Paxisyn; Alodorm; Atempol; Ibrovek; Imesont; Calsmin; Mogadon; Gerson; Remnos; Relact; Imeson; Pelson; Nelmat; Nelbon; Hipsal; Hipnax; Surem; Eatan



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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