TRIAZIQUONE (BioDeep_00000012911)
Secondary id: BioDeep_00001868286
human metabolite blood metabolite
代谢物信息卡片
化学式: C12H13N3O2 (231.1008)
中文名称: 三亚胺醌
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C1CN1C2=CC(=O)C(=C(C2=O)N3CC3)N4CC4
InChI: InChI=1S/C12H13N3O2/c16-9-7-8(13-1-2-13)12(17)11(15-5-6-15)10(9)14-3-4-14/h7H,1-6H2
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AC - Ethylene imines
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents
同义名列表
28 个代谢物同义名
1,1,1-(3,6-Dioxo-1,4-cyclohexadiene-1,2,4-triyl)trisaziridine; 2,3,5-tris(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione; 2,3,5-Tris(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione; 2,5-Cyclohexadiene-1,4-dione,2,3,5-tri-1-aziridinyl-; 2,3,5-Tris(ethyleneimino)-1,4-benzoquinone; 2,3,5-Tris(ethylenimino)-1,4-benzoquinone; 2,3,5-Tris(ethylenimino)-p-benzoquinone; 2,3,5-Triethyleneimino-1,4-benzoquinone; 2,3,5-Tri-(1-aziridinyl)-p-benzoquinone; 2,3,5-Tris(1-aziridinyl)-p-benzoquinone; 2,3,5-Tris(1-aziridino)-p-benzoquinone; 2,3,5-Tris(aziridino)-1,4-benzoquinone; 2,3,5-Tri(1-aziridinyl)-p-benzoquinone; 2,3,5-Tris(ethyleneimine)benzoquinone; 2,3,5-Tris(ethylenimino)benzoquinone; 2,3,5-Ethylenimine-1,4-benzoquinone; 2,3,5-Trisethyleneiminobenzoquinone; Tris(aziridinyl)-para-benzoquinone; Tris(1-aziridinyl)-p-benzoquinone; Tris(ethyleneimino)benzoquinone; Tris(aziridinyl)-p-benzoquinone; Triethyleneaminobenzoquinone; Triaziquonum; Triazicuona; TRIAZIQUONE; Triazichon; Trenimon; Triaziquone
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:27090
- KEGG: C19542
- KEGGdrug: D07254
- PubChem: 6235
- HMDB: HMDB0259153
- Metlin: METLIN73219
- DrugBank: DB13304
- ChEMBL: CHEMBL313302
- Wikipedia: Triaziquone
- MeSH: Triaziquone
- chemspider: 5999
- CAS: 68-76-8
- PMhub: MS000027247
- PubChem: 124490214
- KNApSAcK: 27090
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- H Grunicke, K Grünewald, W Helliger, F Scheidl, E Wolff-Schreiner, B Puschendorf. Inhibition of tumor growth by an alkylation of the plasma membrane.
Advances in enzyme regulation.
1983; 21(?):21-30. doi:
10.1016/0065-2571(83)90006-7. [PMID: 6100583] - M Ihlenfeldt, G Gantner, M Harrer, B Puschendorf, H Putzer, H Grunicke. Interaction of the alkylating antitumor agent 2,3,5-tris(ethyleneimino)benzoquinone with the plasma membrane of Ehrlich ascites tumor cells.
Cancer research.
1981 Jan; 41(1):289-93. doi:
. [PMID: 6256062] - H W Asbach, W Bersch. The effect of in situ isolated perfusion of experimental renal tumors with cytotoxic agents in high concentration.
Urologia internationalis.
1980; 35(2):112-24. doi:
10.1159/000280311. [PMID: 7376296] - D Hecker, H Rose, A Powitz. [Electron microscopical and enzyme histochemical investigation of kidney and liver of the albino rat after cytostatic treatment (author's transl)].
Acta histochemica.
1979; 64(1):113-23. doi:
. [PMID: 112822] - A Basler. Timing of meiotic stages in oocytes of the Syrian hamster (Mesocricetus auratus) and analysis of induced chromosome aberrations.
Human genetics.
1978 May; 42(1):67-77. doi:
10.1007/bf00291627. [PMID: 649171] - J D Beatty, E Friesen, J H Linford, L G Israels. Effects of conjugated and nonconjugated antithymocyte globulin and trenimon on T lymphocytes and skin graft rejection.
Transplantation.
1978 Apr; 25(4):197-203. doi:
10.1097/00007890-197804000-00008. [PMID: 345547] - J H Linford, G Froese. Comparisons of the chemical and biologic properties of triaziquone and triaziquone-protein conjugates.
Journal of the National Cancer Institute.
1978 Feb; 60(2):307-16. doi:
10.1093/jnci/60.2.307. [PMID: 74416] - J D Beatty, E Friesen, J H Linford, L G Israels. Antithymocyte globulin (ATG) and trenimon (TR): effects on T cells and graft rejection.
Surgical forum.
1977; 28(?):327-9. doi:
NULL. [PMID: 364726] - M M Hossain, J W Huismans, J F Diehl. Mutagenicity studies on irradiated potatoes and chlorogenic acid; micronucleus test in rats.
Toxicology.
1976 Aug; 6(2):243-51. doi:
10.1016/0300-483x(76)90026-3. [PMID: 968919] - G Saul, S t Tanneberger. [Stability of clinically used cytostatics (author's transl)].
Archiv fur Geschwulstforschung.
1975; 45(3):259-67. doi:
. [PMID: 1180675] - M C Berenbaum, C E Sheard, J R Reittie, R V Bundick. The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
British journal of cancer.
1974 Jul; 30(1):13-32. doi:
10.1038/bjc.1974.109. [PMID: 4213444] - H Grunicke, K W Bock, H Becher, V Gäng, J Schnierda, B Puschendorf. Effect of alkylating antitumor agents on the binding of DNA to protein.
Cancer research.
1973 May; 33(5):1048-53. doi:
NULL. [PMID: 4349930] - K Norpoth, W Modlich, H Schumacher, H M Rauen. [Comparative studies using the urine metabolites of cyclophosphamide, bis-(2-chloroethyl)amine and triaziquone on Lactobacillus fermenti ATCC 9338].
Arzneimittel-Forschung.
1972 Oct; 22(10):1784-8. doi:
NULL. [PMID: 4677072] - A Ruiz-Torres. [Immunosuppression using antimitotics].
Verhandlungen der Deutschen Gesellschaft fur Rheumatologie.
1972; 2(?):Suppl 2:393-40. doi:
NULL. [PMID: 5051963] - D Tessmann, H Schill, J Voss, H Hamann, C Engelmann. [Renal changes following treatment with cytostatic drugs (Trenimon, cyclophosphamide, Imuran). Light and electron microscopic studies on the rat kidney].
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie.
1972; 115(5):522-31. doi:
NULL. [PMID: 4627720] - G Hartwich, W Butzler. [Secondary tumors in hemoblastoses during cytostatic treatment].
Medizinische Klinik.
1971 Oct; 66(43):1445-50. doi:
NULL. [PMID: 5001553] - L Jaenicke, K Scholz, M Donike. [Synthesis of dihydrofolate reductase by synchronized yeast cells. Relationship between DNA replication and the graded time course of enzyme synthesis].
European journal of biochemistry.
1970 Mar; 13(1):137-41. doi:
10.1111/j.1432-1033.1970.tb00909.x. [PMID: 5439076] - G Rathgen. [Amount of glutathione of some organs in rats under the influence of cytostatic substances].
Strahlentherapie.
1969 Dec; 138(6):754-9. doi:
NULL. [PMID: 5381731] - J Patkowski. [Effect of immunosuppressive agents on transplantation immunity. II. The effect of proteolytic activity in plasma].
Postepy higieny i medycyny doswiadczalnej.
1969; 23(3):371-83. doi:
NULL. [PMID: 4896417] - H Siering, K Abendroth. [Experimental studies on the effect of aristolochic acid in immunosuppressive therapy].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1969 Jan; 24(1):Suppl:155-6. doi:
NULL. [PMID: 5402574] - H W Asbach. [On the electrolyte changes in serum and ascites during cytostatic therapy of transplanted tumors].
Arzneimittel-Forschung.
1968 Sep; 18(9):1180-2. doi:
NULL. [PMID: 5755934] - R J Wieme, W Z Van Hove, M E Van der Straeten. The influence of cytostatic treatment on serum LDH patterns of patients with bronchial carcinoma and its relation to tumor regression.
Annals of the New York Academy of Sciences.
1968 Jun; 151(1):213-21. doi:
10.1111/j.1749-6632.1968.tb11891.x. [PMID: 5251868] - E Păuşescu, A Dincă, R Chirvasie. [On the effects of immunosuppressive and cytostatic substances on the oxidative metabolism of leukocytes during the rejection of kidney homotransplants].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1968 Jan; 23(2):33-7. doi:
NULL. [PMID: 4879774] - P Dittrich, K Goldberg. [Partial function of the kidney in acute test during administration of cytostatic agents].
Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete.
1968; 49(9):347-50. doi:
NULL. [PMID: 5737659] - G Dietrich, E Egger, T Erdmann. [Leucine-p-nitranilide splitting enzymes in the urine after kidney transplantation].
Acta biologica et medica Germanica.
1968; 20(4):518-20. doi:
NULL. [PMID: 4880098] - B von Broen, T Erdmann. [About the immunosuppressive action of triaziquonum in homologous transplantation of skin and kidney in dogs].
Acta biologica et medica Germanica.
1968; 20(1):113-6. doi:
NULL. [PMID: 4881478] - H Bartelheimer, H Frenzel. [Desired and undesirable effects of cytostatic therapy].
Medizinische Klinik.
1967 Oct; 62(43):1653-9. doi:
". [PMID: 5594047] - Z Daccić. [Serum enzyme studies during intra-arterial Trenimon therapy of genital carcinoma].
Die Medizinische Welt.
1967 May; 18(?):1148-51. doi:
NULL. [PMID: 5634311] - H Langhammer, J Klemm, H W Pabst. [Cytostatic chemotherapy in the treatment of malignant tumors].
Arztliche Forschung.
1966 Aug; 20(8):393-403. doi:
NULL. [PMID: 6014703] - M Glowiński, M Limanski, M Skorczyński, S Polak. [Dynamic determination of polarographically active groups in blood serum in the case of pregnancy complicated by cancer of the uterine cervix].
Zentralblatt fur Gynakologie.
1966 Jul; 88(27):883-6. doi:
NULL. [PMID: 5989061] - L Simonelli, C Rizzoli. [Survival of normal and neoplastic strains after brief exposure to ethyleniminoquinones].
Bollettino della Societa italiana di biologia sperimentale.
1964 Feb; 40(3):125-8. doi:
NULL. [PMID: 5896202] - H SIERING, M REINHARDT. [CLINICAL TRIALS OF TRIETHYLENEIMINOBENZOQUINONE (TRENIMON)].
Neoplasma.
1964; 11(?):469-90. doi:
NULL. [PMID: 14220337]
