3-Succinoylpyridine (BioDeep_00000001243)
Secondary id: BioDeep_00001868797
human metabolite Endogenous
代谢物信息卡片
化学式: C9H9NO3 (179.0582)
中文名称: 4-氧代-4-（吡啶-3-基）丁酸
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 21.33%
分子结构信息
SMILES: C1=CC(=CN=C1)C(=O)CCC(=O)O
InChI: InChI=1S/C9H9NO3/c11-8(3-4-9(12)13)7-2-1-5-10-6-7/h1-2,5-6H,3-4H2,(H,12,13)
描述信息
3-succinoylpyridine is the byproduct of tobacco-specific N-nitrosamines generated by the enzyme cytochrome P 450 which catalyzes methylnitrosaminopyridylbutanone hydroxylation. (PMID: 11368333). This nicotine metabolite is commonly found in the urine of smokers. (PMID: 14581070).
3-succinoylpyridine is the byproduct of tobacco-specific N-nitrosamines generated by the enzyme cytochrome P 450 which catalyzes methylnitrosaminopyridylbutanone hydroxylation. (PMID: 11368333)
同义名列表
26 个代谢物同义名
4-OXO-4-(PYRIDIN-3-YL)BUTANOIC ACID; 4-oxo-4-(Pyridin-3-yl)butyric acid; 4-oxo-4-(3-Pyridyl)-butanoic acid; gamma-oxo-3-Pyridinebutanoic acid; 4-oxo-4-(3-Pyridyl)butanoic acid; 4-oxo-4-(3-Pyridyl)-butyric acid; gamma-oxo-3-Pyridinebutyric acid; 4-oxo-4-(Pyridin-3-yl)butanoate; 4-oxo-4-(3-Pyridyl)butyric acid; 4-oxo-4-(Pyridin-3-yl)butyrate; gamma-oxo-3-Pyridinebutanoate; 4-oxo-4-(3-Pyridyl)-butanoate; g-oxo-3-Pyridinebutanoic acid; Γ-oxo-3-pyridinebutanoic acid; g-oxo-3-Pyridinebutyric acid; gamma-oxo-3-Pyridinebutyrate; Γ-oxo-3-pyridinebutyric acid; 4-oxo-4-(3-Pyridyl)-butyrate; g-oxo-3-Pyridinebutanoate; Γ-oxo-3-pyridinebutanoate; g-oxo-3-Pyridinebutyrate; Γ-oxo-3-pyridinebutyrate; 3-succinoylpyridine; 4-OPC4a; 3-Succinoylpyridine; 4-Oxo-4-(pyridin-3-yl)butanoic acid
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:66951
- KEGG: C19569
- PubChem: 437
- HMDB: HMDB0000992
- Metlin: METLIN5924
- ChEMBL: CHEMBL3544790
- MetaCyc: CPD-14094
- foodb: FDB022355
- chemspider: 424
- PMhub: MS000000196
- PubChem: 124490241
- CAS: 4192-31-8
- RefMet: 3-Succinoylpyridine
- KNApSAcK: 66951
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Irina Stepanov, Pramod Upadhyaya, Steven G Carmella, Rachel Feuer, Joni Jensen, Dorothy K Hatsukami, Stephen S Hecht. Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008 Jul; 17(7):1764-73. doi:
10.1158/1055-9965.epi-07-2844. [PMID: 18628430] - Stefan Tyroller, Wolfgang Zwickenpflug, Charlotte Thalheim, Elmar Richter. Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats.
Toxicology.
2005 Nov; 215(3):245-53. doi:
10.1016/j.tox.2005.07.011. [PMID: 16118032] - Wolfgang Zwickenpflug, Stefan Tyroller, Elmar Richter. Metabolism of myosmine in Wistar rats.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Nov; 33(11):1648-56. doi:
10.1124/dmd.104.003087. [PMID: 16079272] - B G Brown, E Richter, A R Tricker, P H Ayres, D J Doolittle. The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Chemico-biological interactions.
2001 Nov; 138(2):125-35. doi:
10.1016/s0009-2797(01)00265-4. [PMID: 11672696] - H Isaacs, J J Heffron, M Badenhorst. 'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1975 Nov; 49(46):1923-6. doi:
NULL. [PMID: 795] - . .
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. doi:
. [PMID: 10027795]
