4-Methylhistamine (BioDeep_00000011968)
Secondary id: BioDeep_00001869155
human metabolite blood metabolite
代谢物信息卡片
2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine
化学式: C6H11N3 (125.0953)
中文名称: 5-(2-氨基乙基)-4-甲基咪唑, 4-甲基组胺
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CC1=C(CCN)N=CN1
InChI: InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:74760
- KEGG: C17929
- PubChem: 37463
- HMDB: HMDB0246510
- Metlin: METLIN71951
- ChEMBL: CHEMBL275443
- Wikipedia: 4-Methylhistamine
- chemspider: 34368
- CAS: 36507-31-0
- PMhub: MS000026216
- PubChem: 96024150
- NIKKAJI: J86.802G
- KNApSAcK: 74760
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sheikh Fayaz Ahmad, Khairy M A Zoheir, Mushtaq Ahmad Ansari, Ahmed Nadeem, Saleh A Bakheet, Ali R Al-Hoshani, Othman A Al-Shabanah, Mohammed M Al-Harbi, Sabry M Attia. Histamine 4 receptor promotes expression of costimulatory B7.1/B7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses.
Journal of neuroimmunology.
2015 Dec; 289(?):30-42. doi:
10.1016/j.jneuroim.2015.10.008. [PMID: 26616869] - Adel R A Abd-Allah, Sheikh Fayaz Ahmad, Ibrahim Alrashidi, Hala E Abdel-Hamied, Khairy M A Zoheir, Abdelkader E Ashour, Saleh A Bakheet, Sabry M Attia. Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis.
International immunology.
2014 Jun; 26(6):325-40. doi:
10.1093/intimm/dxt075. [PMID: 24402309] - Herman D Lim, Chris de Graaf, Wen Jiang, Payman Sadek, Patricia M McGovern, Enade P Istyastono, Remko A Bakker, Iwan J P de Esch, Robin L Thurmond, Rob Leurs. Molecular determinants of ligand binding to H4R species variants.
Molecular pharmacology.
2010 May; 77(5):734-43. doi:
10.1124/mol.109.063040. [PMID: 20103609] - Yuji Sugata, Mitsuhiro Okano, Tazuko Fujiwara, Rie Matsumoto, Hisashi Hattori, Miki Yamamoto, Masahiro Nishibori, Kazunori Nishizaki. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.
Immunology.
2007 Jun; 121(2):266-75. doi:
10.1111/j.1365-2567.2007.02574.x. [PMID: 17346280] - Florence Gbahou, Ludwig Vincent, Marie Humbert-Claude, Joel Tardivel-Lacombe, Claude Chabret, Jean-Michel Arrang. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
British journal of pharmacology.
2006 Apr; 147(7):744-54. doi:
10.1038/sj.bjp.0706666. [PMID: 16432504] - Hideo Kohka Takahashi, Toshihiko Morichika, Hiromi Iwagaki, Ryuji Tamura, Shinichiro Kubo, Tadashi Yoshino, Shuji Mori, Tadaatsu Akagi, Noriaki Tanaka, Masahiro Nishibori. Histamine downregulates CD14 expression via H2 receptors on human monocytes.
Clinical immunology (Orlando, Fla.).
2003 Sep; 108(3):274-81. doi:
10.1016/s1521-6616(03)00140-2. [PMID: 14499251] - Hideyuki Itoh, Hideo K Takahashi, Hiromi Iwagaki, Tadashi Yoshino, Yoshinori Morimoto, Shinnya Saito, Takahito Yagi, Tadaatsu Akagi, Masahiro Nishibori, Noriaki Tanaka. Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18.
Transplantation.
2002 Sep; 74(6):864-70. doi:
10.1097/00007890-200209270-00021. [PMID: 12364868] - G Kanny, D A Moneret-Vautrin, H Schohn, L Feldman, J P Mallie, J L Gueant. Abnormalities in histamine pharmacodynamics in chronic urticaria.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1993 Dec; 23(12):1015-20. doi:
10.1111/j.1365-2222.1993.tb00293.x. [PMID: 10779295] - S Tsujimoto, C Kamei, T Yoshida, K Tasaka. Changes in plasma adrenocorticotropic hormone and cortisol levels induced by intracerebroventricular injection of histamine and its related compounds in dogs.
Pharmacology.
1993 Aug; 47(2):73-83. doi:
10.1159/000139081. [PMID: 8102804] - A Kjaer, U Knigge, P M Plotsky, F W Bach, J Warberg. Histamine H1 and H2 receptor activation stimulates ACTH and beta-endorphin secretion by increasing corticotropin-releasing hormone in the hypophyseal portal blood.
Neuroendocrinology.
1992 Dec; 56(6):851-5. doi:
10.1159/000126316. [PMID: 1369594] - Y Akiyama, T Mukai, C Kamei, K Tasaka. Histamine lipolysis I: changes in the free fatty acid levels of dog plasma after intravenous infusion of histamine.
Methods and findings in experimental and clinical pharmacology.
1990 Jun; 12(5):315-24. doi:
NULL. [PMID: 1977972] - A Gadek-Michalska, J Bugajski. Antagonistic action of naloxone on central histamine receptors-stimulated corticosterone secretion in rats under stress.
Agents and actions.
1989 Nov; 28(3-4):159-63. doi:
10.1007/bf01967395. [PMID: 2531971] - Z C Tang, Y H Xu. Comparison of the effects of 4-methylhistamine on the cell-cycle response between CFU-s and its subpopulation.
International journal of cell cloning.
1987 Nov; 5(6):511-7. doi:
10.1002/stem.5530050609. [PMID: 3429935] - G Schmidt, P Kannisto, C Owman, N O Sjöberg. Alteration by histamine of the sympathetic nerve-mediated contractions in the bovine ovarian follicle wall in vitro.
European journal of pharmacology.
1987 Mar; 135(1):11-22. doi:
10.1016/0014-2999(87)90752-7. [PMID: 3569422] - K Muirhead, P Bender, N Hanna, G Poste. Binding of histamine and histamine analogs to lymphocyte subsets analyzed by flow cytometry.
Journal of immunology (Baltimore, Md. : 1950).
1985 Dec; 135(6):4120-8. doi:
NULL. [PMID: 2415600] - J Bugajski, A Gadek. Effect of intracerebroventricular impromidine on pituitary-adrenocortical response to stress in rats.
Agents and actions.
1984 Jun; 14(5-6):569-73. doi:
10.1007/bf01978888. [PMID: 6236678] - E O Alvarez. Induction of prolactin release by H1- or H2-histamine agonists in maturing male and female rats.
Journal of neural transmission.
1984; 59(3):241-50. doi:
10.1007/bf01250011. [PMID: 6736949] - A O Donoso, M B Zárate, A Seltzer. Histamine-induced prolactin release: pharmacological characterization of receptors in male rats.
Neuroendocrinology.
1983 Jun; 36(6):436-42. doi:
10.1159/000123495. [PMID: 6308490] - J Bugajski, A Gadek. Central H1- and H2-histaminergic stimulation of pituitary-adrenocortical response under stress in rats.
Neuroendocrinology.
1983 Jun; 36(6):424-30. doi:
10.1159/000123493. [PMID: 6224096] - A O Donoso, M B Zárate. Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized, steroid-treated rats under ether anesthesia.
Experimental brain research.
1983; 52(2):277-80. doi:
10.1007/bf00236637. [PMID: 6139293] - A P Baker, L W Chakrin, D A Holden, W J Smith, C P Sung. Effect of histamine agonists and antagonists on the production of murine reaginic antibodies.
International journal of immunopharmacology.
1981; 3(4):349-56. doi:
10.1016/0192-0561(81)90030-8. [PMID: 6460705] - M C Arakelian, C Libertun. H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats.
Endocrinology.
1977 Mar; 100(3):890-5. doi:
10.1210/endo-100-3-890. [PMID: 401035] - H BLASCHKO. Oxidation of 1, 4-methylhistamine by mammalian plasma.
The Journal of physiology.
1959 Oct; 148(?):570-3. doi:
10.1113/jphysiol.1959.sp006307. [PMID: 13801350]
