Astromicin (BioDeep_00000011843)
natural product
代谢物信息卡片
化学式: C17H35N5O6 (405.2587)
中文名称: 阿司米星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1CCC(C(O1)OC2C(C(C(C(C2O)N(C)C(=O)CN)OC)O)N)N)N
InChI: InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
描述信息
An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
5 个代谢物同义名
FORTIMICIN; Astromicin; Fortimicin A; 55779-06-1; Fortimicin A
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:37923
- KEGG: C17708
- KEGGdrug: D07470
- PubChem: 5284517
- Metlin: METLIN71870
- ChEMBL: CHEMBL3084803
- KNApSAcK: C00018137
- CAS: 55779-06-1
- PMhub: MS000026022
- MetaboLights: MTBLC37923
- PubChem: 96024038
- NIKKAJI: J34.182G
- RefMet: Astromicin
- KNApSAcK: 37923
- LOTUS: LTS0089018
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0089018
- 1873 - Micromonospora: 10.7164/ANTIBIOTICS.30.552
- 1873 - Micromonospora: LTS0089018
- 1880 - Micromonospora olivasterospora: 10.7164/ANTIBIOTICS.37.1670
- 1880 - Micromonospora olivasterospora: LTS0089018
- 28056 - Micromonosporaceae: LTS0089018
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- T Uematsu. Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug.
International journal of clinical pharmacology, therapy, and toxicology.
1993 Dec; 31(12):606-10. doi:
. [PMID: 8314363] - T Yoshino, K Sato. [Combination effect of KW-2228 and aminoglycoside antibiotics on systemic infection in cyclophosphamide-treated tumor-bearing mice].
The Japanese journal of antibiotics.
1992 Jan; 45(1):98-105. doi:
. [PMID: 1379653] - K Sato, H Yoneyama, T Yoshino. [Combination effects between KW-2228 and antibiotics against systemic infections in normal and neutropenic mice].
The Japanese journal of antibiotics.
1992 Jan; 45(1):91-7. doi:
. [PMID: 1379652] - K Kikuchi. [Studies of dosing regimens and combination effects of aminoglycosides and beta-lactam in an experimental Pseudomonas aeruginosa infection in mice].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
1991 Feb; 65(2):216-25. doi:
10.11150/kansenshogakuzasshi1970.65.216. [PMID: 2066605] - N Satomi, A Sakurai, F Iimura, R Haranaka, K Haranaka. Preventive effect of several drugs against Pseudomonas aeruginosa infection and the toxicity of combined tumor necrosis factor with lipopolysaccharide: relationship between lethality and the arachidonic cascade.
Biotherapy (Dordrecht, Netherlands).
1990; 2(3):227-34. doi:
10.1007/bf02173524. [PMID: 2169830] - S Inouye, T Niizato, T Shomura, I Kitasato. Nephrotoxicity of dactimicin, a novel pseudo-disaccharide aminoglycoside possessing the N-formimidoyl group, compared with that of astromicin, amikacin and other aminoglycoside antibiotics in animals.
Drugs under experimental and clinical research.
1989; 15(5):189-209. doi:
. [PMID: 2791871] - M Imaizumi, T Niimi, Y Uchida, M Asaoka, T Ozika, Y Amano, T Uchida, K Hirai, M Kazita, T Abe. [A clinical trial of astromicin, a new aminoglycoside antibiotic, in thoracotomized patients and astromicin concentrations in the lung tissue].
The Japanese journal of antibiotics.
1988 Nov; 41(11):1635-49. doi:
. [PMID: 3210298] - M Morita, A Hasuda. [Astromicin sulfate concentration in human prostatic tissue after an intramuscular injection].
Hinyokika kiyo. Acta urologica Japonica.
1988 Oct; 34(10):1865-8. doi:
NULL. [PMID: 2469325] - T Uematsu, R Sato, A Mizuno, M Nishimoto, S Nagashima, M Nakashima. A fluorescence polarization immunoassay evaluated for quantifying astromicin, a new aminoglycoside antibiotic.
Clinical chemistry.
1988 Sep; 34(9):1880-2. doi:
10.1093/clinchem/34.9.1878. [PMID: 3416438] - T Kurimoto, H Yoneyama, K Sato, R Okachi. [Combined effects of astromicin and human gamma-globulin prepared for intravenous use].
The Japanese journal of antibiotics.
1987 Feb; 40(2):303-10. doi:
. [PMID: 2439721] - S Omoto, T Yoshida, M Kurebe, S Inouye. Dactimicin, a new, less toxic aminoglycoside antibiotic active against resistant bacteria.
Drugs under experimental and clinical research.
1987; 13(12):719-25. doi:
. [PMID: 3447874] - K Fujita, T Murayama, M Kawamura, K Narita. Comparison of the effect of aminoglycosides on excretion of N-acetyl-beta-glucosaminidase.
International journal of clinical pharmacology research.
1987; 7(6):477-80. doi:
. [PMID: 3440638] - H Yoneyama, R Okachi. [Effects of astromicin on a host defence mechanism].
The Japanese journal of antibiotics.
1986 Jun; 39(6):1494-503. doi:
. [PMID: 3761562] - F Yamasaku, S Kobayashi, A Inoue. [Pharmacokinetic studies of astromicin using a constant-rate continuous intravenous infusion method].
The Japanese journal of antibiotics.
1986 Jun; 39(6):1473-9. doi:
. [PMID: 3761560] - S Kobayashi, A Inoue, T Deguchi. [The pharmacokinetic studies on astromicin in dogs. Intramuscular, intravenous or drip intravenous administration].
The Japanese journal of antibiotics.
1986 Jun; 39(6):1443-52. doi:
NULL. [PMID: 3761558] - M Nakashima, Y Takiguchi, A Inoue, S Kobayashi. [A phase I study on intravenous drip infusion of astromicin].
The Japanese journal of antibiotics.
1986 Jun; 39(6):1453-72. doi:
NULL. [PMID: 3761559] - R Moriguchi, T Yamagoshi, S Nemoto, Y Naide, K Suzuki, A Inoue, S Kobayashi. [Pharmacokinetics of astromicin intravenous drip infusion in patients with renal disorders].
The Japanese journal of antibiotics.
1986 Jun; 39(6):1480-6. doi:
NULL. [PMID: 3761561] - T Kurimoto, H Kobayashi, A Inoue, R Okachi. [The pharmacokinetic studies on astromicin in rats. Intramuscular, intravenous or drip intravenous administration].
The Japanese journal of antibiotics.
1984 Jul; 37(7):1263-71. doi:
NULL. [PMID: 6492390] - T Kawamoto, I Mashimo, S Yamauchi, M Watanabe. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography.
Journal of chromatography.
1984 Feb; 305(2):373-9. doi:
10.1016/s0378-4347(00)83351-4. [PMID: 6707164] - L T Sennello, B I Berman, J F Vance, R C Sonders. Simultaneous analysis of the serum and urinary pharmacokinetics of fortimicin A after intravenous administration to healthy subjects.
International journal of clinical pharmacology, therapy, and toxicology.
1982 Sep; 20(9):393-8. doi:
NULL. [PMID: 7141758] - E T Kimura, S Tekeli, J P Lewkowski, K R Majors, J W Kesterson. Acute and subacute toxicity studies with fortimicin A sulfate (Abbott-44747), a new aminoglycoside antibiotic.
Toxicology and applied pharmacology.
1980 May; 53(3):399-409. doi:
10.1016/0041-008x(80)90353-1. [PMID: 7385242] - R N Jones, A L Barry, P C Fuchs, T L Gavan, H M Sommers, E H Gerlach. Fortimicin A: collaborative in vitro susceptibility. Comparison with amikacin and gentamicin against 11,840 clinical bacterial isolates.
Antimicrobial agents and chemotherapy.
1979 Dec; 16(6):823-8. doi:
10.1128/aac.16.6.823. [PMID: 533262]
