7-Aminomethyl-7-carbaguanine (BioDeep_00000011345)

 

Secondary id: BioDeep_00001871558

human metabolite Endogenous natural product


代谢物信息卡片


2-amino-5-(aminomethyl)-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one

化学式: C7H9N5O (179.0807)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 18.63%

分子结构信息

SMILES: C(c1c[nH]c2c1c(=O)[nH]c(N)n2)N
InChI: InChI=1S/C7H9N5O/c8-1-3-2-10-5-4(3)6(13)12-7(9)11-5/h2H,1,8H2,(H4,9,10,11,12,13)

描述信息

7-Aminomethyl-7-carbaguanine is one of the precursors of nucleoside Q (queuosine) biosynthesis. It is a substrate for preQ1 synthase (EC 1.7.1.13) which catalyzes the NADPH-dependent reduction of 7-cyano-7-carbaguanine (preQ0) to 7-aminomethyl-7-carbaguanine (preQ1). More specifically, this enzyme catalyzes the chemical reaction. 7-aminomethyl-7-carbaguanine + 2 NADP+ <-> 7-cyano-7-carbaguanine + 2 NADPH + 2 H+.
7-Aminomethyl-7-carbaguanine is one of the precursors of nucleoside Q (queuosine) biosynthesis. It is a substrate for preQ1 synthase (EC 1.7.1.13) which catalyzes the NADPH-dependent reduction of 7-cyano-7-carbaguanine (preQ0) to 7-aminomethyl-7-carbaguanine (preQ1). More specifically, this enzyme catalyzes the chemical reaction

同义名列表

5 个代谢物同义名

2-amino-5-(aminomethyl)-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one; 7-DEAZA-7-aminomethyl-guanine; 7-aminomethyl-7-deazaguanine; 7-Aminomethyl-7-carbaguanine; PreQ1



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

  • PreQ0 Metabolism: S-Adenosylmethionine ⟶ Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine
  • PreQ0 Metabolism: S-Adenosylmethionine ⟶ Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 GCH1, HPGDS, LDHA, METTL3, QTRT1, QTRT2, TXN
Peripheral membrane protein 4 GBA1, HSD17B6, QTRT1, QTRT2
Nucleus 6 GCH1, LDHA, METTL14, METTL3, QTRT1, TXN
cytosol 5 GCH1, HPGDS, LDHA, METTL3, TXN
nuclear body 1 METTL3
trans-Golgi network 1 GBA1
nucleoplasm 5 GCH1, HPGDS, METTL14, METTL3, TXN
Cytoplasmic side 2 QTRT1, QTRT2
Early endosome membrane 1 HSD17B6
Golgi apparatus 3 ATRN, GBA1, METTL3
lysosomal membrane 1 GBA1
Lysosome 1 GBA1
plasma membrane 1 ATRN
Membrane 1 LDHA
extracellular exosome 4 ATRN, GBA1, LDHA, TXN
Lysosome membrane 1 GBA1
Lumenal side 2 GBA1, HSD17B6
endoplasmic reticulum 2 GBA1, HSD17B6
extracellular space 1 ATRN
lysosomal lumen 1 GBA1
mitochondrion 4 GCH1, LDHA, QTRT1, QTRT2
protein-containing complex 1 GCH1
intracellular membrane-bounded organelle 2 HPGDS, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 ATRN
Secreted 1 TXN
extracellular region 1 TXN
Mitochondrion outer membrane 2 QTRT1, QTRT2
mitochondrial outer membrane 2 QTRT1, QTRT2
[Isoform 2]: Secreted 1 ATRN
nuclear membrane 1 GCH1
cytoplasmic vesicle 1 GCH1
nuclear speck 1 METTL3
[Isoform 3]: Secreted 1 ATRN
Nucleus speckle 1 METTL3
[Isoform 1]: Cell membrane 1 ATRN
transferase complex 2 QTRT1, QTRT2
oxidoreductase complex 2 LDHA, METTL3
neuron projection terminus 1 GCH1
cytoplasmic side of mitochondrial outer membrane 1 QTRT1
RNA N6-methyladenosine methyltransferase complex 2 METTL14, METTL3
tRNA-guanine transglycosylase complex 2 QTRT1, QTRT2


文献列表

  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Sep; 71(6):609-29. doi: NULL. [PMID: 281]