1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one (BioDeep_00000018283)

human metabolite

代谢物信息卡片

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

化学式: C16H14O4 (270.0892044)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COc1cc(O)cc(O)c1C(=O)C=Cc1ccccc1
InChI:

描述信息

同义名列表

1 个代谢物同义名

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

数据库引用编号

3 个数据库交叉引用编号

PubChem: 154102
HMDB: HMDB0132913
PMhub: MS000004903

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

105668 - Alpinia blepharocalyx:
105671 - Alpinia conchigera: 10.1124/JPET.105.092486
125259 - Alpinia hainanensis:
299931 - Alpinia mutica:
125262 - Alpinia pinnanensis:
299937 - Alpinia pricei: 10.1021/JF900517D
1335102 - Alpinia roxburghii:
97723 - Alpinia zerumbet:
1008370 - Amomum subulatum:
97729 - Boesenbergia rotunda:
864332 - Cedrelopsis grevei: 10.1016/S0031-9422(02)00675-1
1202408 - Desmos cochinchinensis: 10.1016/J.PHYTOCHEM.2011.07.002
188493 - Etlingera elatior: 10.1016/0031-9422(81)83082-8
630302 - Helichrysum forskahlii: 10.1016/J.PHYTOCHEM.2008.03.025
9606 - Homo sapiens: -
487993 - Persicaria ferruginea:
488000 - Persicaria limbata: 10.1055/S-0031-1298431
130377 - Piper aduncum: 10.1055/S-0028-1100006
405323 - Piper dilatatum: 10.1016/S0031-9422(98)00197-6
130401 - Piper hispidum:
548845 - Vitex tripinnata: 10.1016/S0031-9422(98)00411-7
1498956 - Woodsia scopulina: 10.1016/S0031-9422(98)00214-3

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mee-Young Lee, Chang-Seob Seo, Jin-Ah Lee, In-Sik Shin, Su-Jeong Kim, HeyKyung Ha, Hyeun-Kyoo Shin. Alpinia katsumadai H(AYATA) seed extract inhibit LPS-induced inflammation by induction of heme oxygenase-1 in RAW264.7 cells. Inflammation. 2012 Apr; 35(2):746-57. doi: 10.1007/s10753-011-9370-0. [PMID: 21830094]
Vivek R Yadav, Sahdeo Prasad, Bharat B Aggarwal. Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. British journal of pharmacology. 2012 Feb; 165(3):741-53. doi: 10.1111/j.1476-5381.2011.01603.x. [PMID: 21797841]
S N López, R L E Furlan, S A Zacchino. Detection of antifungal compounds in Polygonum ferrugineum Wedd. extracts by bioassay-guided fractionation. Some evidences of their mode of action. Journal of ethnopharmacology. 2011 Nov; 138(2):633-6. doi: 10.1016/j.jep.2011.09.038. [PMID: 22001591]
Norio Yamamoto, Kyuichi Kawabata, Keisuke Sawada, Manabu Ueda, Itsuko Fukuda, Kengo Kawasaki, Akira Murakami, Hitoshi Ashida. Cardamonin stimulates glucose uptake through translocation of glucose transporter-4 in L6 myotubes. Phytotherapy research : PTR. 2011 Aug; 25(8):1218-24. doi: 10.1002/ptr.3416. [PMID: 21305634]
Supriya Agnihotri, S Wakode. Antimicrobial activity of essential oil and various extracts of fruits of greater cardamom. Indian journal of pharmaceutical sciences. 2010 Sep; 72(5):657-9. doi: 10.4103/0250-474x.78542. [PMID: 21695005]
Jun Tang, Ning Li, Haofu Dai, Kaijin Wang. [Chemical constituents from seeds of Alpinia katsumadai, inhibition on NF-kappaB activation and anti-tumor effect]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jul; 35(13):1710-4. doi: 10.4268/cjcmm20101313. [PMID: 20862963]
Yu-Qi He, Li Yang, Yong Liu, Jiang-Wei Zhang, Jun Tang, Juan Su, Yuan-Yuan Li, Yan-Liu Lu, Chang-Hong Wang, Ling Yang, Zheng-Tao Wang. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry. Acta pharmacologica Sinica. 2009 Oct; 30(10):1462-70. doi: 10.1038/aps.2009.127. [PMID: 19767764]
Takashi Ohtsuki, Hiroyuki Kikuchi, Takashi Koyano, Thaworn Kowithayakorn, Toshiyuki Sakai, Masami Ishibashi. Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis. Bioorganic & medicinal chemistry. 2009 Sep; 17(18):6748-54. doi: 10.1016/j.bmc.2009.07.041. [PMID: 19682913]
Congmei Cao, Lijia Xu, Kui Chen, Yong Peng, Peigen Xiao. [Chemical study on petroleum ether portion of Sarcandra hainanensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Apr; 34(8):1009-10. doi: ". [PMID: 19639789]
Xiu-Qin Wang, Xiao-Jiang Yang, Jiao-She Li. [Studies on chemical constituents of alpinia katsumadai]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2008 Jun; 31(6):853-5. doi: ". [PMID: 18998568]
I Jantan, S M Raweh, H M Sirat, S Jamil, Y H Mohd Yasin, J Jalil, J A Jamal. Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Apr; 15(4):306-9. doi: 10.1016/j.phymed.2007.08.002. [PMID: 17913483]
D A Israf, T A Khaizurin, A Syahida, N H Lajis, S Khozirah. Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells. Molecular immunology. 2007 Feb; 44(5):673-9. doi: 10.1016/j.molimm.2006.04.025. [PMID: 16777230]
Kazutoshi Shindo, Miki Kato, Asuka Kinoshita, Asami Kobayashi, Yukiko Koike. Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. Rhizome. Bioscience, biotechnology, and biochemistry. 2006 Sep; 70(9):2281-4. doi: 10.1271/bbb.60086. [PMID: 16960369]
S Hatziieremia, A I Gray, V A Ferro, A Paul, R Plevin. The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFkappaB signalling pathways in monocytes/macrophages. British journal of pharmacology. 2006 Sep; 149(2):188-98. doi: 10.1038/sj.bjp.0706856. [PMID: 16894344]
Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorganic & medicinal chemistry letters. 2006 Jun; 16(12):3337-40. doi: 10.1016/j.bmcl.2005.12.075. [PMID: 16621533]
Jeong-Hyung Lee, Haeng Sun Jung, Phan Minh Giang, Xuejun Jin, Sangku Lee, Phan Tong Son, Dongho Lee, Young-Soo Hong, Kyeong Lee, Jung Joon Lee. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. The Journal of pharmacology and experimental therapeutics. 2006 Jan; 316(1):271-8. doi: 10.1124/jpet.105.092486. [PMID: 16183703]
Wenying He, Ying Li, Jiaqin Liu, Zhide Hu, Xingguo Chen. Specific interaction of chalcone-protein: cardamonin binding site II on the human serum albumin molecule. Biopolymers. 2005 Sep; 79(1):48-57. doi: 10.1002/bip.20328. [PMID: 15942949]
G Trakoontivakorn, K Nakahara, H Shinmoto, M Takenaka, M Onishi-Kameyama, H Ono, M Yoshida, T Nagata, T Tsushida. Structural analysis of a novel antimutagenic compound, 4-Hydroxypanduratin A, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult.) against mutagenic heterocyclic amines. Journal of agricultural and food chemistry. 2001 Jun; 49(6):3046-50. doi: 10.1021/jf010016o. [PMID: 11410007]