Cardamomin (BioDeep_00000229865)
Secondary id: BioDeep_00000267341, BioDeep_00000269606, BioDeep_00000859482
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
InChI=1/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7
化学式: C16H14O4 (270.0892044)
中文名称: 小豆蔻明, 豆寇明, 豆蔻明, 豆蔻素, 小豆蔻明, 1-(2,4-二羟基-6-甲氧苯基)-3-苯基丙-2-烯-1-酮, 小豆蔻素
谱图信息:
最多检出来源 Macaca mulatta(otcml) 70.59%
分子结构信息
SMILES: C1(O)=CC(OC)=C(C(=O)/C=C/C2C=CC=CC=2)C(O)=C1
InChI: InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
描述信息
Cardamonin is a member of chalcones.
Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. Cardamonins name comes from the fact that it can be found in cardamom spice.
Cardamonin is a natural product found in Amomum subulatum, Alpinia blepharocalyx, and other organisms with data available.
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].
同义名列表
33 个代谢物同义名
InChI=1/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7; 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-; (E)-1-(2,4-dihydroxy-6-methoxy-phenyl)-3-phenyl-prop-2-en-1-one; (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-; (E)-1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-phenyl-propenone; 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one; 1-(2\,4\-Dihydroxy-6\-methoxy-phenyl)-3-phenyl-propenone; (E)-Cardamomin; (E)-Alpinetin chalcone; 24-Dihydroxy-6-methoxy-chalcone; 2,4-dihydroxy-6-methoxychalcone; DIHYDROXYMETHOXYCHALCONE [INCI]; Cardamomin; Alpinetin chalcone; Cardamomin;Alpinetin chalcone; Cardamonin, >=98\\% (HPLC); Dihydroxymethoxychalcone; Alpinetin chalcone; UNII-H8KP1OJ8JX; Cardamonin ,(S); (E)-Cardamonin; (E)-Cardamoni; MEGxp0_000534; ACon1_000221; cardamomin; PHYTO-DKK1; H8KP1OJ8JX; Cardamonin; Cardamoni; (E)-Cardamomin; (E)-Alpinetin chalcone
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:125601
- ChEBI: CHEBI:186253
- PubChem: 641785
- DrugBank: DB14122
- ChEMBL: CHEMBL378104
- Wikipedia: Cardamomin
- LipidMAPS: LMPK12120245
- MeSH: cardamonin
- ChemIDplus: 0019309149
- chemspider: 557026
- CAS: 18956-16-6
- CAS: 19309-14-9
- medchemexpress: HY-N0279
- medchemexpress: HY-N1378
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shaocong Li, Qi He, Baihao Chen, Jiaxu Zeng, Xiangyun Dou, Zhaofeng Pan, Jiacong Xiao, Miao Li, Fanchen Wang, Chuyi Chen, Yuewei Lin, Xintian Wang, Haibin Wang, Jianfa Chen. Cardamonin protects against iron overload induced arthritis by attenuating ROS production and NLRP3 inflammasome activation via the SIRT1/p38MAPK signaling pathway.
Scientific reports.
2023 08; 13(1):13744. doi:
10.1038/s41598-023-40930-y. [PMID: 37612419] - Xiaofei Shen, Hongqing Chen, Tian Wen, Lu Liu, Qiongying Hu, Fan Xie, Lun Wang. A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases.
European journal of pharmacology.
2023 Jun; ?(?):175840. doi:
10.1016/j.ejphar.2023.175840. [PMID: 37302524] - Yang Lu, Juan Liu, Jiaqi Tong, Chenxiao Zhang, Yi Duan, Xiaoli Song, Yongling Lu, Lishuang Lv. Dual effects of cardamonin/alpinetin and their acrolein adducts on scavenging acrolein and the anti-bacterial activity from Alpinia katsumadai Hayata as a spice in roasted meat.
Food & function.
2022 Jul; 13(13):7088-7097. doi:
10.1039/d2fo00100d. [PMID: 35697027] - Chan Gao, Xiao Fei, Ming Wang, Qi Chen, Ning Zhao. Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats.
International immunopharmacology.
2022 Jun; 107(?):108610. doi:
10.1016/j.intimp.2022.108610. [PMID: 35219163] - Rhubaniya Mahendran, Soo Kun Lim, Kien Chai Ong, Kek Heng Chua, Hwa Chia Chai. Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment.
Clinical and experimental nephrology.
2021 Nov; 25(11):1163-1172. doi:
10.1007/s10157-021-02111-x. [PMID: 34254206] - Lara Soares Aleixo de Carvalho, Lívia Mara Silva, Vinícius Carius de Souza, Marcos Paulo Nascimento da Silva, Priscila V S Z Capriles, Priscila de Faria Pinto, Josué de Moraes, Ademar Alves Da Silva Filho. Cardamonin Presents in Vivo Activity against Schistosoma mansoni and Inhibits Potato Apyrase.
Chemistry & biodiversity.
2021 Nov; 18(11):e2100604. doi:
10.1002/cbdv.202100604. [PMID: 34608744] - Yang Lu, Juan Liu, Anqi Tong, Yongling Lu, Lishuang Lv. Interconversion and Acrolein-Trapping Capacity of Cardamonin/Alpinetin and Their Metabolites In Vitro and In Vivo.
Journal of agricultural and food chemistry.
2021 Oct; 69(40):11926-11936. doi:
10.1021/acs.jafc.1c04373. [PMID: 34587738] - Jianqing Jiang, Mingsong Cai. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte.
Journal of microbiology and biotechnology.
2021 Jun; 31(6):794-802. doi:
10.4014/jmb.2103.03057. [PMID: 34024891] - Ying Tan, Hong-Hong Wan, Ming-Ming Sun, Wen-Jing Zhang, Maolong Dong, Wei Ge, Jun Ren, Hu Peng. Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism.
Acta pharmacologica Sinica.
2021 Mar; 42(3):404-413. doi:
10.1038/s41401-020-0397-3. [PMID: 32317756] - Jinzhao He, Hong Zhou, Jia Meng, Shun Zhang, Xiaowei Li, Shuyuan Wang, Guangying Shao, William Jin, Xiaoqiang Geng, Shuai Zhu, Baoxue Yang. Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis.
Pharmacological research.
2020 05; 155(?):104751. doi:
10.1016/j.phrs.2020.104751. [PMID: 32151678] - Wang Qi, Wang Boliang, Tian Xiaoxi, Fu Guoqiang, Xiao Jianbo, Wang Gang. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Feb; 122(?):109547. doi:
10.1016/j.biopha.2019.109547. [PMID: 31918264] - Young-Jin Seo, Heegu Jin, Kippeum Lee, Ji-Hyeon Song, Sungwoo Chei, Hyun-Ji Oh, Jae-Hoon Oh, Boo-Yong Lee. Cardamonin suppresses lipogenesis by activating protein kinase A-mediated browning of 3T3-L1 cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Dec; 65(?):153064. doi:
10.1016/j.phymed.2019.153064. [PMID: 31645009] - Jinmei Jin, Shuiping Qiu, Ping Wang, Xiaohui Liang, Fei Huang, Hui Wu, Beibei Zhang, Weidong Zhang, Xinhui Tian, Ren Xu, Hailian Shi, Xiaojun Wu. Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming.
Journal of experimental & clinical cancer research : CR.
2019 Aug; 38(1):377. doi:
10.1186/s13046-019-1351-4. [PMID: 31455352] - Kumju Youn, Mira Jun. Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda.
Nutrients.
2019 Mar; 11(3):. doi:
10.3390/nu11030662. [PMID: 30893825] - Yoshiharu Okuno, Shinsuke Marumoto, Mitsuo Miyazawa. Antimutagenic activity of flavonoids from Sozuku.
Natural product research.
2019 Mar; 33(6):862-865. doi:
10.1080/14786419.2017.1408104. [PMID: 29183163] - Lee Kee Chua, Chooi Ling Lim, Anna Pick Kiong Ling, Soi Moi Chye, Rhun Yian Koh. Anticancer Potential of Syzygium Species: a Review.
Plant foods for human nutrition (Dordrecht, Netherlands).
2019 Mar; 74(1):18-27. doi:
10.1007/s11130-018-0704-z. [PMID: 30535971] - Lena Berning, Lisa Scharf, Elif Aplak, David Stucki, Claudia von Montfort, Andreas S Reichert, Wilhelm Stahl, Peter Brenneisen. In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis.
PloS one.
2019; 14(9):e0222267. doi:
10.1371/journal.pone.0222267. [PMID: 31553748] - Nien-Chieh Liao, Yung-Luen Shih, Jiann-Shang Chou, Kuo-Wei Chen, Yung-Liang Chen, Mei-Hui Lee, Shu-Fen Peng, Sy-Jye Leu, Jing-Gung Chung. Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells.
The American journal of Chinese medicine.
2019; 47(3):635-656. doi:
10.1142/s0192415x19500332. [PMID: 31023073] - Chung Pui Ping, Tengku Azam Shah Tengku Mohamad, Muhammad Nadeem Akhtar, Enoch Kumar Perimal, Ahmad Akira, Daud Ahmad Israf Ali, Mohd Roslan Sulaiman. Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV₁, Glutamate, and Opioid Receptors.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
10.3390/molecules23092237. [PMID: 30177603] - Svetlana S Efimova, Anastasiia A Zakharova, Roman Ya Medvedev, Olga S Ostroumova. Ion Channels Induced by Antimicrobial Agents in Model Lipid Membranes are Modulated by Plant Polyphenols Through Surrounding Lipid Media.
The Journal of membrane biology.
2018 08; 251(4):551-562. doi:
10.1007/s00232-018-0031-1. [PMID: 29549386] - Hong Xiao, Ranga Rao Ravu, Babu L Tekwani, Wei Li, Wen-Bin Liu, Melissa R Jacob, Shabana I Khan, Xiong Cai, Cai-Yun Peng, Ikhlas A Khan, Xing-Cong Li, Wei Wang. Biological evaluation of phytoconstituents from Polygonum hydropiper.
Natural product research.
2017 Sep; 31(17):2053-2057. doi:
10.1080/14786419.2016.1269094. [PMID: 28000515] - Swati Jaiswal, Mahendra Shukla, Abhisheak Sharma, Nagarjun Rangaraj, Kalpesh Vaghasiya, Mohd Yaseen Malik, Jawahar Lal. Preclinical pharmacokinetics and ADME characterization of a novel anticancer chalcone, cardamonin.
Drug testing and analysis.
2017 Aug; 9(8):1124-1136. doi:
10.1002/dta.2128. [PMID: 27794181] - Azza Abdelfattah Ali, Ekram Nemr Abd Al Haleem, Sahar Abdel-Hafeez Khaleel, Amany Said Sallam. Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats.
Pharmacological reports : PR.
2017 Apr; 69(2):268-275. doi:
10.1016/j.pharep.2016.11.002. [PMID: 28129600] - Shoujiao Peng, Yanan Hou, Juan Yao, Jianguo Fang. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage.
Food & function.
2017 Mar; 8(3):997-1007. doi:
10.1039/c7fo00054e. [PMID: 28271112] - Fui-Ling Voon, Mohd Roslan Sulaiman, Muhammad Nadeem Akhtar, Mohamad Fauzi Idris, Ahmad Akira, Enoch Kumar Perimal, Daud Ahmad Israf, Lee Ming-Tatt. Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats.
European journal of pharmacology.
2017 Jan; 794(?):127-134. doi:
10.1016/j.ejphar.2016.11.009. [PMID: 27845065] - Silke De Spirt, Anna Eckers, Carina Wehrend, Mustafa Micoogullari, Helmut Sies, Wilhelm Stahl, Holger Steinbrenner. Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells.
Free radical biology & medicine.
2016 Feb; 91(?):164-71. doi:
10.1016/j.freeradbiomed.2015.12.011. [PMID: 26698667] - Gaiyan Ren, Aning Sun, Chao Deng, Jingjing Zhang, Xiaojun Wu, Xiaohui Wei, Sridhar Mani, Wei Dou, Zhengtao Wang. The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology.
2015 Oct; 309(7):G517-27. doi:
10.1152/ajpgi.00133.2015. [PMID: 26251468] - Young-Joo Kim, Ki Sung Kang, Kyung-Chul Choi, Hyeonseok Ko. Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells.
Bioorganic & medicinal chemistry letters.
2015 Jun; 25(12):2559-64. doi:
10.1016/j.bmcl.2015.04.054. [PMID: 25959811] - Jue Wang, Rubiao Qiu, Lianjing Yuan, Fei Meng, Qian Tang. Analysis on the Alpinia katsumadai components of Zingiberaceae plants and their functions on myeloma resistance.
Pakistan journal of pharmaceutical sciences.
2015 May; 28(3 Suppl):1065-8. doi:
". [PMID: 26051719] - Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Jawahar Lal. Gender-related pharmacokinetics and bioavailability of a novel anticancer chalcone, cardamonin, in rats determined by liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Apr; 986-987(?):23-30. doi:
10.1016/j.jchromb.2015.01.041. [PMID: 25703949] - Yuan-Yuan Li, Shyh-Shyun Huang, Min-Min Lee, Jeng-Shyan Deng, Guan-Jhong Huang. Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema.
International immunopharmacology.
2015 Apr; 25(2):332-9. doi:
10.1016/j.intimp.2015.02.002. [PMID: 25681284] - Victor Kuete, Antoine H L Nkuete, Armelle T Mbaveng, Benjamin Wiench, Hippolyte K Wabo, Pierre Tane, Thomas Efferth. Cytotoxicity and modes of action of 4'-hydroxy-2',6'-dimethoxychalcone and other flavonoids toward drug-sensitive and multidrug-resistant cancer cell lines.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Oct; 21(12):1651-7. doi:
10.1016/j.phymed.2014.08.001. [PMID: 25442273] - Tianshun Zhang, Norio Yamamoto, Yoko Yamashita, Hitoshi Ashida. The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK.
Archives of biochemistry and biophysics.
2014 Jul; 554(?):44-54. doi:
10.1016/j.abb.2014.05.008. [PMID: 24845100] - Luís Moreira Gonçalves, Inês Maria Valente, José António Rodrigues. An overview on cardamonin.
Journal of medicinal food.
2014 Jun; 17(6):633-40. doi:
10.1089/jmf.2013.0061. [PMID: 24433078] - Tianshun Zhang, Norio Yamamoto, Hitoshi Ashida. Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells.
Food & function.
2014 Jun; 5(6):1134-41. doi:
10.1039/c3fo60694e. [PMID: 24722377] - Aislan Cristina Rheder Fagundes Pascoal, Carlos Augusto Ehrenfried, Begoña Gimenez-Cassina Lopez, Thiago Matos de Araujo, Vinicius D'ávila Bitencourt Pascoal, Rovilson Gilioli, Gabriel Forato Anhê, Ana Lúcia Tasca Goes Ruiz, João Ernesto de Carvalho, Maria Elida Alves Stefanello, Marcos José Salvador. Antiproliferative activity and induction of apoptosis in PC-3 cells by the chalcone cardamonin from Campomanesia adamantium (Myrtaceae) in a bioactivity-guided study.
Molecules (Basel, Switzerland).
2014 Feb; 19(2):1843-55. doi:
10.3390/molecules19021843. [PMID: 24514747] - Sha-Sha Tian, Fu-Sheng Jiang, Kun Zhang, Xue-Xin Zhu, Bo Jin, Jin-Jian Lu, Zhi-Shan Ding. Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis.
Fitoterapia.
2014 Jan; 92(?):34-40. doi:
10.1016/j.fitote.2013.09.016. [PMID: 24096161] - Reem N El-Naga. Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: impact on NOX-1, inflammation and apoptosis.
Toxicology and applied pharmacology.
2014 Jan; 274(1):87-95. doi:
10.1016/j.taap.2013.10.031. [PMID: 24211271] - David R Katerere, Alexander I Gray, Robert J Nash, Roger D Waigh. Phytochemical and antimicrobial investigations of stilbenoids and flavonoids isolated from three species of Combretaceae.
Fitoterapia.
2012 Jul; 83(5):932-40. doi:
10.1016/j.fitote.2012.04.011. [PMID: 22546149] - Mee-Young Lee, Chang-Seob Seo, Jin-Ah Lee, In-Sik Shin, Su-Jeong Kim, HeyKyung Ha, Hyeun-Kyoo Shin. Alpinia katsumadai H(AYATA) seed extract inhibit LPS-induced inflammation by induction of heme oxygenase-1 in RAW264.7 cells.
Inflammation.
2012 Apr; 35(2):746-57. doi:
10.1007/s10753-011-9370-0. [PMID: 21830094] - Vivek R Yadav, Sahdeo Prasad, Bharat B Aggarwal. Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.
British journal of pharmacology.
2012 Feb; 165(3):741-53. doi:
10.1111/j.1476-5381.2011.01603.x. [PMID: 21797841] - Xu-Dong Cao, Zhi-Shan Ding, Fu-Sheng Jiang, Xing-Hong Ding, Jian-Zhen Chen, Su-Hong Chen, Gui-Yuan Lv. Antitumor constituents from the leaves of Carya cathayensis.
Natural product research.
2012; 26(22):2089-94. doi:
10.1080/14786419.2011.628174. [PMID: 22007794] - Norio Yamamoto, Kyuichi Kawabata, Keisuke Sawada, Manabu Ueda, Itsuko Fukuda, Kengo Kawasaki, Akira Murakami, Hitoshi Ashida. Cardamonin stimulates glucose uptake through translocation of glucose transporter-4 in L6 myotubes.
Phytotherapy research : PTR.
2011 Aug; 25(8):1218-24. doi:
10.1002/ptr.3416. [PMID: 21305634] - Yu-Qi He, Li Yang, Yong Liu, Jiang-Wei Zhang, Jun Tang, Juan Su, Yuan-Yuan Li, Yan-Liu Lu, Chang-Hong Wang, Ling Yang, Zheng-Tao Wang. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry.
Acta pharmacologica Sinica.
2009 Oct; 30(10):1462-70. doi:
10.1038/aps.2009.127. [PMID: 19767764] - Takashi Ohtsuki, Hiroyuki Kikuchi, Takashi Koyano, Thaworn Kowithayakorn, Toshiyuki Sakai, Masami Ishibashi. Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis.
Bioorganic & medicinal chemistry.
2009 Sep; 17(18):6748-54. doi:
10.1016/j.bmc.2009.07.041. [PMID: 19682913] - Congmei Cao, Lijia Xu, Kui Chen, Yong Peng, Peigen Xiao. [Chemical study on petroleum ether portion of Sarcandra hainanensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Apr; 34(8):1009-10. doi:
". [PMID: 19639789] - Xiu-Qin Wang, Xiao-Jiang Yang, Jiao-She Li. [Studies on chemical constituents of alpinia katsumadai].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2008 Jun; 31(6):853-5. doi:
". [PMID: 18998568] - I Jantan, S M Raweh, H M Sirat, S Jamil, Y H Mohd Yasin, J Jalil, J A Jamal. Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2008 Apr; 15(4):306-9. doi:
10.1016/j.phymed.2007.08.002. [PMID: 17913483] - D A Israf, T A Khaizurin, A Syahida, N H Lajis, S Khozirah. Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells.
Molecular immunology.
2007 Feb; 44(5):673-9. doi:
10.1016/j.molimm.2006.04.025. [PMID: 16777230] - S Hatziieremia, A I Gray, V A Ferro, A Paul, R Plevin. The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFkappaB signalling pathways in monocytes/macrophages.
British journal of pharmacology.
2006 Sep; 149(2):188-98. doi:
10.1038/sj.bjp.0706856. [PMID: 16894344] - Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
Bioorganic & medicinal chemistry letters.
2006 Jun; 16(12):3337-40. doi:
10.1016/j.bmcl.2005.12.075. [PMID: 16621533] - Sarot Cheenpracha, Chatchanok Karalai, Chanita Ponglimanont, Sanan Subhadhirasakul, Supinya Tewtrakul. Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata.
Bioorganic & medicinal chemistry.
2006 Mar; 14(6):1710-4. doi:
10.1016/j.bmc.2005.10.019. [PMID: 16263298] - Jeong-Hyung Lee, Haeng Sun Jung, Phan Minh Giang, Xuejun Jin, Sangku Lee, Phan Tong Son, Dongho Lee, Young-Soo Hong, Kyeong Lee, Jung Joon Lee. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.
The Journal of pharmacology and experimental therapeutics.
2006 Jan; 316(1):271-8. doi:
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