D-mannose 6-phosphate (BioDeep_00000229003)

Main id: BioDeep_00000014397

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


{[(2R,3S,4S,5S)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid

  化学式: C6H13O9P (260.0297)
中文名称:
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: C(C1C(C(C(C(O1)O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1


描述信息

D-mannose 6-phosphate, also known as mannose-6-phosphate disodium salt, is a member of the class of compounds known as hexose phosphates. Hexose phosphates are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. D-mannose 6-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). D-mannose 6-phosphate can be found in a number of food items such as bog bilberry, wild celery, common pea, and breadnut tree seed, which makes D-mannose 6-phosphate a potential biomarker for the consumption of these food products. D-mannose 6-phosphate may be a unique S.cerevisiae (yeast) metabolite. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate. The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor. Upon release, the enzymes are ferried to their final destination in the lysosomes. The MPRs are packed into vesicles that bud off the late endosome and return to the "trans"-Golgi network. In this way, the MPRs can be recycled .
D-mannose 6-phosphate, also known as mannose-6-phosphate disodium salt, is a member of the class of compounds known as hexose phosphates. Hexose phosphates are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. D-mannose 6-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). D-mannose 6-phosphate can be found in a number of food items such as bog bilberry, wild celery, common pea, and breadnut tree seed, which makes D-mannose 6-phosphate a potential biomarker for the consumption of these food products. D-mannose 6-phosphate may be a unique S.cerevisiae (yeast) metabolite. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate. The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor. Upon release, the enzymes are ferried to their final destination in the lysosomes. The MPRs are packed into vesicles that bud off the late endosome and return to the "trans"-Golgi network. In this way, the MPRs can be recycled.

同义名列表

24 个代谢物同义名

{[(2R,3S,4S,5S)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid; Mannose-6-phosphate sodium salt, (D)-isomer; Mannose-6-phosphate dilithium salt; Mannose-6-phosphate disodium salt; D-Mannose 6-phosphoric acid; D-Mannose 6-phosphate; Mannose-6-phosphate; Mannose 6-phosphate; [(2R,3S,4S,5S)-3,4,5,6-tetrahydroxytetrahydropyran-2-yl]methyl dihydrogen phosphate; [(2R,3S,4S,5S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl dihydrogen phosphate; 6-O-phosphono-D-mannopyranose; alpha-D-mannose-6-P; alpha-D-mannose-6-phosphate; D-mannopyranose 6-(dihydrogen phosphate); D-mannopyranose 6-phosphate; D-mannopyranose, 6-(dihydrogen phosphate); D-mannopyranose,6-(dihydrogenphosphate); D-mannose-6-phosphate; D-Mannose, 6-(dihydrogen phosphate) (9CI); D-Mannose, 6-phosphate (6CI); Man-6-p; Mannose 6-phosphate (7CI); Mannose, 6-(dihydrogen phosphate), D- (8CI); Phosphoric acid, mono-(3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethyl) ester



数据库引用编号

19 个数据库交叉引用编号

分类词条

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Nan Zhao, Gang Deng, Pei-Xin Yuan, Ya-Fen Zhang, Lu-Yi Jiang, Xiaolu Zhao, Bao-Liang Song. TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport. Journal of lipid research. 2023 Oct; ?(?):100465. doi: 10.1016/j.jlr.2023.100465. [PMID: 37890669]
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  • Abigail Cline, Ningguo Gao, Heather Flanagan-Steet, Vandana Sharma, Sabrina Rosa, Roberto Sonon, Parastoo Azadi, Kirsten C Sadler, Hudson H Freeze, Mark A Lehrman, Richard Steet. A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency. Molecular biology of the cell. 2012 Nov; 23(21):4175-87. doi: 10.1091/mbc.e12-05-0411. [PMID: 22956764]
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  • Alberto Ramírez-Mata, Colette Michalak, Guillermo Mendoza-Hernández, Alfonso León-Del-Río, Alfonso González-Noriega. Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine β-glucuronidase. Experimental cell research. 2011 Oct; 317(16):2364-73. doi: 10.1016/j.yexcr.2011.05.025. [PMID: 21672540]
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