myo-Inositol 1-phosphate (BioDeep_00000004604)

Secondary id: BioDeep_00000027851, BioDeep_00001868776

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid

化学式: C6H13O9P (260.0297178)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 1%

分子结构信息

SMILES: C1(C(C(C(C(C1O)O)OP(=O)(O)O)O)O)O
InChI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)

描述信息

myo-Inositol 1-phosphate, also known as I1P or ins(1)p, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. myo-Inositol 1-phosphate is a metabolite of inositol phosphate metabolism and the phosphatidylinositol signalling system. Inositol phosphatases (EC:3.1.3.25) play a crucial role in the phosphatidylinositol signalling pathway. Expression is substantially higher in the subcortical regions of the brain, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder (OMIM: 605922).
Myo-inositol 1-phosphate is a metabolite of the Inositol phosphate metabolism and the Phosphatidylinositol signaling system. Inositol phosphatases [EC:3.1.3.25] play a crucial role in the phosphatidylinositol signaling pathway; in brain, the expression is substantially higher in the subcortical regions, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder. (OMIM 605922) [HMDB]

同义名列表

30 个代谢物同义名

{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid; (2,3,4,5,6-Pentahydroxycyclohexyl) dihydrogen phosphate; 1D-Myo-inositol 1-monophosphoric acid; 1-(Dihydrogen phosphate) myo-inositol; D-myo-inositol-1-hydrogen phosphate; DL-Myoinositol-1-phosphate 2 CHA; 1D-Myo-inositol 1-phosphoric acid; D-Myo-inositol 1-phosphoric acid; 1D-Myo-inositol 1-monophosphate; D-myo-Inositol-1-monophosphate; Myo-inositol 1-phosphoric acid; Myoinositol 1-phosphoric acid; myo-Inositol 1-monophosphate; 1D-myo-Inositol 1-phosphate; D-myo-Inositol-1-phosphate; D-Myo-inositol 1-phosphate; Inositol 1-phosphoric acid; myo-Inositol-1-phosphate; myo-Inositol 1-phosphate; Myoinositol 1-phosphate; Inositophosphoric acid; Inositol monophosphate; Inositol 1-phosphate; Inositol phosphate; Ins(1)P1; Ins(1)p; Ins1p; 1-IP1; IPhC; I1P

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:18297
KEGG: C01177
PubChem: 107737
PubChem: 9
HMDB: HMDB0000213
Metlin: METLIN5223
Metlin: METLIN359
ChEMBL: CHEMBL3959608
ChEMBL: CHEMBL281435
Wikipedia: Inositol_phosphate
MetaCyc: D-MYO-INOSITOL-1-MONOPHOSPHATE
MetaCyc: 1-L-MYO-INOSITOL-1-P
KNApSAcK: C00007483
foodb: FDB021907
chemspider: 10375592
CAS: 13004-72-3
CAS: 15421-51-9
CAS: 2831-74-5
CAS: 573-35-3
PMhub: MS000017138
PubChem: 4404
PDB-CCD: IPD
3DMET: B01403
NIKKAJI: J6.548J
RefMet: Inositol phosphate

分类词条

Inositol phosphates

代谢反应

52 个相关的代谢反应过程信息。

Reactome(51)

Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
Inositol phosphate metabolism: ATP + I(3,4,5,6)P4 ⟶ ADP + I(1,3,4,5,6)P5
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Mycobacterium tuberculosis biological processes: CYSTA + H2O ⟶ 2OBUTA + L-Cys + ammonia
Mycothiol metabolism: GlcNAc-Ins + H2O ⟶ CH3COO- + GlcNI
Mycothiol biosynthesis: GlcNAc-Ins + H2O ⟶ CH3COO- + GlcNI
Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
Inositol phosphate metabolism: ATP + I(1,3,4)P3 ⟶ ADP + I(1,3,4,5)P4
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
Inositol phosphate metabolism: H2O + I(1,4,5)P3 ⟶ I(1,4)P2 + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I(1,4,5)P3 ⟶ I(1,4)P2 + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi
Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
Inositol phosphate metabolism: H2O + I4P ⟶ Ins + Pi
Synthesis of IP2, IP, and Ins in the cytosol: H2O + I4P ⟶ Ins + Pi

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

Inositol phosphate metabolism ( Inositol phosphate metabolism ): O2 + myo-Inositol ⟶ D-Glucuronic acid + H2O

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

3821 Cajanus cajan: 10.1016/S0021-9673(98)00542-1
3823 Canavalia ensiformis: 10.1016/S0021-9673(98)00542-1
92480 Sphenostylis stenocarpa: 10.1016/S0021-9673(98)00542-1
3884 Phaseolus lunatus: 10.1016/S0021-9673(98)00542-1
1890 Streptomyces antibioticus: 10.1021/JA908285H
3821 Cajanus cajan: 10.1016/S0021-9673(98)00542-1
3823 Canavalia ensiformis: 10.1016/S0021-9673(98)00542-1
92480 Sphenostylis stenocarpa: 10.1016/S0021-9673(98)00542-1
3884 Phaseolus lunatus: 10.1016/S0021-9673(98)00542-1
1890 Streptomyces antibioticus: 10.1021/JA908285H
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Maythem Al-Amery, Ashley Fowler, Jason M Unrine, Paul Armstrong, Elizabeth Maghirang, Kai Su, Julia de Melo, Feng-Jie Yuan, Qing-Yao Shu, David Hildebrand. Generation and Characterization of a Soybean Line with a Vernonia galamensis Diacylglycerol Acyltransferase-1 Gene and a myo-Inositol 1-Phosphate Synthase Knockout Mutation. Lipids. 2020 09; 55(5):469-477. doi: 10.1002/lipd.12253. [PMID: 32542681]
Anatoly Tiulpakov, Carl W White, Rekhati S Abhayawardana, Heng B See, Audrey S Chan, Ruth M Seeber, Julian I Heng, Ivan Dedov, Nathan J Pavlos, Kevin D G Pfleger. Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking. Molecular endocrinology (Baltimore, Md.). 2016 Aug; 30(8):889-904. doi: 10.1210/me.2016-1002. [PMID: 27355191]
Carla D Jorge, Nuno Borges, Helena Santos. A novel pathway for the synthesis of inositol phospholipids uses cytidine diphosphate (CDP)-inositol as donor of the polar head group. Environmental microbiology. 2015 Jul; 17(7):2492-504. doi: 10.1111/1462-2920.12734. [PMID: 25472423]
A E Cook, S N Mistry, K J Gregory, S G B Furness, P M Sexton, P J Scammells, A D Conigrave, A Christopoulos, K Leach. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British journal of pharmacology. 2015 Jan; 172(1):185-200. doi: 10.1111/bph.12937. [PMID: 25220431]
Hiroyuki Morii, Midori Ogawa, Kazumasa Fukuda, Hatsumi Taniguchi. Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in Bacteria and Archaea, which contain inositol phospholipid. Biochemical and biophysical research communications. 2014 Jan; 443(1):86-90. doi: 10.1016/j.bbrc.2013.11.054. [PMID: 24269814]
Saurabh C Saxena, Prafull Salvi, Harmeet Kaur, Pooja Verma, Bhanu Prakash Petla, Venkateswara Rao, Nitin Kamble, Manoj Majee. Differentially expressed myo-inositol monophosphatase gene (CaIMP) in chickpea (Cicer arietinum L.) encodes a lithium-sensitive phosphatase enzyme with broad substrate specificity and improves seed germination and seedling growth under abiotic stresses. Journal of experimental botany. 2013 Dec; 64(18):5623-39. doi: 10.1093/jxb/ert336. [PMID: 24123252]
Ying Wang, Hsien-yu Wang. Dvl3 translocates IPMK to the cell membrane in response to Wnt. Cellular signalling. 2012 Dec; 24(12):2389-95. doi: 10.1016/j.cellsig.2012.08.009. [PMID: 22940627]
O N Donkor, L Stojanovska, P Ginn, J Ashton, T Vasiljevic. Germinated grains--sources of bioactive compounds. Food chemistry. 2012 Dec; 135(3):950-9. doi: 10.1016/j.foodchem.2012.05.058. [PMID: 22953810]
Daniel Bosch, Adolfo Saiardi. Arginine transcriptional response does not require inositol phosphate synthesis. The Journal of biological chemistry. 2012 Nov; 287(45):38347-55. doi: 10.1074/jbc.m112.384255. [PMID: 22992733]
Nisha Singh, Amy C Halliday, Matthew Knight, Nathan A Lack, Edward Lowe, Grant C Churchill. Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. Acta crystallographica. Section F, Structural biology and crystallization communications. 2012 Oct; 68(Pt 10):1149-52. doi: 10.1107/s1744309112035191. [PMID: 23027737]
Young-Bin Oh, Jong Hun Kim, Byung Mun Park, Byung Hyun Park, Suhn Hee Kim. Captopril intake decreases body weight gain via angiotensin-(1-7). Peptides. 2012 Sep; 37(1):79-85. doi: 10.1016/j.peptides.2012.06.005. [PMID: 22743141]
Robert Taylor, Po-Hao Chen, Chia-Ching Chou, Jasmin Patel, Shengkan V Jin. KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation. Autophagy. 2012 Sep; 8(9):1300-11. doi: 10.4161/auto.20681. [PMID: 22889849]
Dmitry M Mebel, Jovi C Y Wong, Yifei J Dong, Stephanie L Borgland. Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake. The European journal of neuroscience. 2012 Aug; 36(3):2336-46. doi: 10.1111/j.1460-9568.2012.08168.x. [PMID: 22712725]
Alisa Boutin, Michael D Allen, Susanne Neumann, Marvin C Gershengorn. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Aug; 26(8):3473-82. doi: 10.1096/fj.12-207860. [PMID: 22593547]
David E Hanke, Paroo N Parmar, Samuel E K Caddick, Porntip Green, Charles A Brearley. Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover. The Biochemical journal. 2012 Jun; 444(3):601-9. doi: 10.1042/bj20111811. [PMID: 22429240]
Fanbo Song, Jing Zhang, Yuefang Zhao, Wenbin Chen, Luyuan Li, Zhen Xi. Synthesis and antitumor activity of inositol phosphotriester analogues. Organic & biomolecular chemistry. 2012 May; 10(18):3642-54. doi: 10.1039/c2ob00031h. [PMID: 22469854]
Margaret R Cunningham, Kathryn A McIntosh, John D Pediani, Joris Robben, Alexandra E Cooke, Mary Nilsson, Gwyn W Gould, Stuart Mundell, Graeme Milligan, Robin Plevin. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). The Journal of biological chemistry. 2012 May; 287(20):16656-69. doi: 10.1074/jbc.m111.315911. [PMID: 22411985]
Svenja Wagner, Franziska Arnold, Zeguang Wu, Axel Schubert, Claudia Walliser, Kenjiro Tadagaki, Ralf Jockers, Thomas Mertens, Detlef Michel. The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments. Archives of virology. 2012 May; 157(5):935-49. doi: 10.1007/s00705-012-1246-6. [PMID: 22327422]
Megan J Dailey, Seyun Kim. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochemical and biophysical research communications. 2012 Apr; 421(1):1-3. doi: 10.1016/j.bbrc.2012.04.010. [PMID: 22503973]
Constance Chollet, Ralf Bergmann, Jens Pietzsch, Annette G Beck-Sickinger. Design, evaluation, and comparison of ghrelin receptor agonists and inverse agonists as suitable radiotracers for PET imaging. Bioconjugate chemistry. 2012 Apr; 23(4):771-84. doi: 10.1021/bc2005889. [PMID: 22372770]
Shurong Zhong, FoSheng Hsu, Christopher J Stefan, Xiaochun Wu, Anamika Patel, Michael S Cosgrove, Yuxin Mao. Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids. Biochemistry. 2012 Apr; 51(15):3170-7. doi: 10.1021/bi300086c. [PMID: 22452743]
Sanam Mustafa, Heng B See, Ruth M Seeber, Stephen P Armstrong, Carl W White, Sabatino Ventura, Mohammed Akli Ayoub, Kevin D G Pfleger. Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer. The Journal of biological chemistry. 2012 Apr; 287(16):12952-65. doi: 10.1074/jbc.m111.322834. [PMID: 22371491]
Yan Gu, Cheng Lu, Qinglin Zha, Hongwei Kong, Xin Lu, Aiping Lu, Guowang Xu. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry. Molecular bioSystems. 2012 Apr; 8(5):1535-43. doi: 10.1039/c2mb25022e. [PMID: 22419152]
Hoang-Yen Phi Tran, Eun-Joo Shin, Kuniaki Saito, Xuan-Khanh Thi Nguyen, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Dae Hun Park, Kiyofumi Yamada, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim. Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo. Free radical biology & medicine. 2012 Apr; 52(7):1159-74. doi: 10.1016/j.freeradbiomed.2011.12.008. [PMID: 22245015]
Paco Romero, María J Rodrigo, Fernando Alférez, Ana-Rosa Ballester, Luis González-Candelas, Lorenzo Zacarías, María T Lafuente. Unravelling molecular responses to moderate dehydration in harvested fruit of sweet orange (Citrus sinensis L. Osbeck) using a fruit-specific ABA-deficient mutant. Journal of experimental botany. 2012 Apr; 63(7):2753-67. doi: 10.1093/jxb/err461. [PMID: 22315241]
Robert Zorec, Alfonso Araque, Giorgio Carmignoto, Philip G Haydon, Alexei Verkhratsky, Vladimir Parpura. Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN neuro. 2012 Mar; 4(2):. doi: 10.1042/an20110061. [PMID: 22313347]
Lucy M Elphick, Nadine Pawolleck, Irina A Guschina, Leila Chaieb, Daniel Eikel, Heinz Nau, John L Harwood, Nick J Plant, Robin S B Williams. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease models & mechanisms. 2012 Mar; 5(2):231-40. doi: 10.1242/dmm.008391. [PMID: 22003123]
Marcus M Nalaskowski, Anja Metzner, Maria A Brehm, Sena Labiadh, Helena Brauer, Nicole Grabinski, Georg W Mayr, Manfred Jücker. The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei. Cellular signalling. 2012 Mar; 24(3):621-8. doi: 10.1016/j.cellsig.2011.07.012. [PMID: 21864674]
Dustin E Bosch, Francis S Willard, Ravikrishna Ramanujam, Adam J Kimple, Melinda D Willard, Naweed I Naqvi, David P Siderovski. A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS pathogens. 2012 Feb; 8(2):e1002553. doi: 10.1371/journal.ppat.1002553. [PMID: 22383884]
Dariusz Jan Smoliński, Agnieszka Kołowerzo. mRNA accumulation in the Cajal bodies of the diplotene larch microsporocyte. Chromosoma. 2012 Feb; 121(1):37-48. doi: 10.1007/s00412-011-0339-4. [PMID: 21909692]
Marco Scioscia, Pierre-Yves Robillard, David R Hall, Laurens H Rademacher, Philip J Williams, Thomas W Rademacher. Inositol phosphoglycan P-type in infants of preeclamptic mothers. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2012 Feb; 25(2):193-5. doi: 10.3109/14767058.2011.557789. [PMID: 21401313]
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Kanchan Anand, Kenji Maeda, Anne-Claude Gavin. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. PloS one. 2012; 7(5):e36526. doi: 10.1371/journal.pone.0036526. [PMID: 22574179]
Shingo Sakamoto, Yukichi Fujikawa, Nobukazu Tanaka, Muneharu Esaka. Molecular cloning and characterization of L-galactose-1-phosphate phosphatase from tobacco (Nicotiana tabacum). Bioscience, biotechnology, and biochemistry. 2012; 76(6):1155-62. doi: 10.1271/bbb.110995. [PMID: 22790939]
Emmanuel Ugochukwu Okoro, Yanfeng Zhao, ZhongMao Guo, Lichun Zhou, Xinghua Lin, Hong Yang. Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PloS one. 2012; 7(9):e44430. doi: 10.1371/journal.pone.0044430. [PMID: 22984509]
Adam R Cole. GSK3 as a Sensor Determining Cell Fate in the Brain. Frontiers in molecular neuroscience. 2012; 5(?):4. doi: 10.3389/fnmol.2012.00004. [PMID: 22363258]
Hong Xu, Yi Gao, Jianbo Wang. Transcriptomic analysis of rice (Oryza sativa) developing embryos using the RNA-Seq technique. PloS one. 2012; 7(2):e30646. doi: 10.1371/journal.pone.0030646. [PMID: 22347394]
Liang Guo, Xuemin Wang. Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling. Frontiers in plant science. 2012; 3(?):51. doi: 10.3389/fpls.2012.00051. [PMID: 22639650]
Tong Zhang, Zhuangjie Li, Huong Dang, Ruoping Chen, Chen Liaw, Thuy-Anh Tran, P Douglas Boatman, Daniel T Connolly, John W Adams. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. American journal of physiology. Heart and circulatory physiology. 2012 Jan; 302(1):H299-311. doi: 10.1152/ajpheart.00723.2011. [PMID: 22003054]
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Ana Carolina Ariza, Peter Meinardus T Deen, Joris Hubertus Robben. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Frontiers in endocrinology. 2012; 3(?):22. doi: 10.3389/fendo.2012.00022. [PMID: 22649411]
Mary K McCarthy, Jason B Weinberg. Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets. Mediators of inflammation. 2012; 2012(?):236345. doi: 10.1155/2012/236345. [PMID: 22665949]
Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Auemduan Prawan, Upa Kukongviriyapan, Arunporn Itharat. Mulberry leaf extract stimulates glucose uptake and GLUT4 translocation in rat adipocytes. The American journal of Chinese medicine. 2012; 40(1):163-75. doi: 10.1142/s0192415x12500139. [PMID: 22298456]
Robert C Jackson. Pharmacodynamic modelling of biomarker data in oncology. ISRN pharmacology. 2012; 2012(?):590626. doi: 10.5402/2012/590626. [PMID: 22523699]
Mayanka Awasthi, Jyoti Batra, Suneel Kateriya. Disulphide bridges of phospholipase C of Chlamydomonas reinhardtii modulates lipid interaction and dimer stability. PloS one. 2012; 7(6):e39258. doi: 10.1371/journal.pone.0039258. [PMID: 22737232]
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Mohammad Alimohammadi, Kanishka de Silva, Clarisse Ballu, Nawab Ali, Mariya V Khodakovskaya. Reduction of inositol (1,4,5)-trisphosphate affects the overall phosphoinositol pathway and leads to modifications in light signalling and secondary metabolism in tomato plants. Journal of experimental botany. 2012 Jan; 63(2):825-35. doi: 10.1093/jxb/err306. [PMID: 21994174]
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Saydul Alam, Hongling Li, Andriana Margariti, Daniel Martin, Anna Zampetaki, Ouassila Habi, Gillian Cockerill, Yanhua Hu, Qingbo Xu, Lingfang Zeng. Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3. The Journal of biological chemistry. 2011 Dec; 286(51):44211-44217. doi: 10.1074/jbc.m111.242289. [PMID: 22027828]
John J H Shin, Christopher J R Loewen. Putting the pH into phosphatidic acid signaling. BMC biology. 2011 Dec; 9(?):85. doi: 10.1186/1741-7007-9-85. [PMID: 22136116]
Ali Moumeni, Kouji Satoh, Hiroaki Kondoh, Takayuki Asano, Aeni Hosaka, Ramiah Venuprasad, Rachid Serraj, Arvind Kumar, Hei Leung, Shoshi Kikuchi. Comparative analysis of root transcriptome profiles of two pairs of drought-tolerant and susceptible rice near-isogenic lines under different drought stress. BMC plant biology. 2011 Dec; 11(?):174. doi: 10.1186/1471-2229-11-174. [PMID: 22136218]
Joo-Hark Yi, Hyun-Jong Shin, Ho-Jung Kim. V2 receptor antagonist; tolvaptan. Electrolyte & blood pressure : E & BP. 2011 Dec; 9(2):50-4. doi: 10.5049/ebp.2011.9.2.50. [PMID: 22438856]
Emi Yamamoto, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate. Immunohistochemical Expressions of Main PGE(2) Biosynthesis-related Enzymes and PGE(2) Receptor in Rat Nephrogenesis. Journal of toxicologic pathology. 2011 Dec; 24(4):257-61. doi: 10.1293/tox.24.257. [PMID: 22319240]
Harel Weinstein, Suzanne Scarlata. The correlation between multidomain enzymes and multiple activation mechanisms--the case of phospholipase Cβ and its membrane interactions. Biochimica et biophysica acta. 2011 Dec; 1808(12):2940-7. doi: 10.1016/j.bbamem.2011.08.028. [PMID: 21906583]
Wei Cao, Yan-Hua Xie, Xiao-Qiang Li, Xiao-Kai Zhang, Yue-Tao Chen, Rong Kang, Xi Chen, Shan Miao, Si-Wang Wang. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic research in cardiology. 2011 Nov; 106(6):1207-20. doi: 10.1007/s00395-011-0199-3. [PMID: 21706383]
Melissa J Morine, Audrey C Tierney, Ben van Ommen, Hannelore Daniel, Sinead Toomey, Ingrid M F Gjelstad, Isobel C Gormley, Pablo Pérez-Martinez, Christian A Drevon, Jose López-Miranda, Helen M Roche. Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health. PLoS computational biology. 2011 Nov; 7(11):e1002223. doi: 10.1371/journal.pcbi.1002223. [PMID: 22072950]
Arun K Mishra, Nicole N Driessen, Ben J Appelmelk, Gurdyal S Besra. Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction. FEMS microbiology reviews. 2011 Nov; 35(6):1126-57. doi: 10.1111/j.1574-6976.2011.00276.x. [PMID: 21521247]
Gonzalo M Estavillo, Peter A Crisp, Wannarat Pornsiriwong, Markus Wirtz, Derek Collinge, Chris Carrie, Estelle Giraud, James Whelan, Pascale David, Hélène Javot, Charles Brearley, Rüdiger Hell, Elena Marin, Barry J Pogson. Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis. The Plant cell. 2011 Nov; 23(11):3992-4012. doi: 10.1105/tpc.111.091033. [PMID: 22128124]
Bruce J Shenker, Hydar Ali, Kathleen Boesze-Battaglia. PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Current pharmaceutical design. 2011 Nov; 17(34):3815-22. doi: 10.2174/138161211798357926. [PMID: 22103853]
Toni Segovia-Silvestre, Caroline Bonnefond, Bodil C Sondergaard, Tjorbjoern Christensen, Morten A Karsdal, Anne C Bay-Jensen. Identification of the calcitonin receptor in osteoarthritic chondrocytes. BMC research notes. 2011 Oct; 4(?):407. doi: 10.1186/1756-0500-4-407. [PMID: 21996094]
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Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki, Ayako Harada, Nobuyuki Negoro, Tsuneo Yasuma, Yu Momose, Koji Takeuchi. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. The Journal of pharmacology and experimental therapeutics. 2011 Oct; 339(1):228-37. doi: 10.1124/jpet.111.183772. [PMID: 21752941]
S B Bansal, V Saxena, S Pokhariyal, P Gupta, V Kher, R Ahlawat, M Singhal, S Gulati. Comparison of azathioprine with mycophenolate mofetil in a living donor kidney transplant programme. Indian journal of nephrology. 2011 Oct; 21(4):258-63. doi: 10.4103/0971-4065.85483. [PMID: 22022086]
Sherry-Ann Brown, Ion I Moraru, James C Schaff, Leslie M Loew. Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling. Journal of computational neuroscience. 2011 Oct; 31(2):385-400. doi: 10.1007/s10827-011-0317-0. [PMID: 21340454]
Michael D Allen, Susanne Neumann, Marvin C Gershengorn. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Oct; 25(10):3687-94. doi: 10.1096/fj.11-188961. [PMID: 21705666]
John S Lyssand, Kyung-Soon Lee, Mia DeFino, Marvin E Adams, Chris Hague. Syntrophin isoforms play specific functional roles in the α1D-adrenergic receptor/DAPC signalosome. Biochemical and biophysical research communications. 2011 Sep; 412(4):596-601. doi: 10.1016/j.bbrc.2011.08.004. [PMID: 21846462]
Craig N Lumb, Ju He, Yi Xue, Phillip J Stansfeld, Robert V Stahelin, Tatiana G Kutateladze, Mark S P Sansom. Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain. Structure (London, England : 1993). 2011 Sep; 19(9):1338-46. doi: 10.1016/j.str.2011.04.010. [PMID: 21893292]
Karin Nuernberg, Bernhard H Breier, Shakeela N Jayasinghe, Hannes Bergmann, Nichola Thompson, Gerd Nuernberg, Dirk Dannenberger, Falk Schneider, Ulla Renne, Martina Langhammer, Korinna Huber. Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes. Nutrition & metabolism. 2011 Aug; 8(1):56. doi: 10.1186/1743-7075-8-56. [PMID: 21835020]
Alisa Boutin, Michael D Allen, Elizabeth Geras-Raaka, Wenwei Huang, Susanne Neumann, Marvin C Gershengorn. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Molecular pharmacology. 2011 Aug; 80(2):240-6. doi: 10.1124/mol.111.072157. [PMID: 21525174]
Sang-Ic Kim, Thomas H Tai. Identification of genes necessary for wild-type levels of seed phytic acid in Arabidopsis thaliana using a reverse genetics approach. Molecular genetics and genomics : MGG. 2011 Aug; 286(2):119-33. doi: 10.1007/s00438-011-0631-2. [PMID: 21698461]
Giuseppe Dionisio, Claus K Madsen, Preben B Holm, Karen G Welinder, Malene Jørgensen, Eva Stoger, Elsa Arcalis, Henrik Brinch-Pedersen. Cloning and characterization of purple acid phosphatase phytases from wheat, barley, maize, and rice. Plant physiology. 2011 Jul; 156(3):1087-100. doi: 10.1104/pp.110.164756. [PMID: 21220762]
Charlotte U Andersen, Ole Hilberg, Søren Mellemkjær, Jens E Nielsen-Kudsk, U Simonsen. Apelin and pulmonary hypertension. Pulmonary circulation. 2011 Jul; 1(3):334-46. doi: 10.4103/2045-8932.87299. [PMID: 22140623]
Daniela Kocourková, Zuzana Krcková, Premysl Pejchar, Stepánka Veselková, Olga Valentová, Rinukshi Wimalasekera, Günther F E Scherer, Jan Martinec. The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress. Journal of experimental botany. 2011 Jul; 62(11):3753-63. doi: 10.1093/jxb/err039. [PMID: 21525137]
Marjana Regvar, Diane Eichert, Burkhard Kaulich, Alessandra Gianoncelli, Paula Pongrac, Katarina Vogel-Mikus, Ivan Kreft. New insights into globoids of protein storage vacuoles in wheat aleurone using synchrotron soft X-ray microscopy. Journal of experimental botany. 2011 Jul; 62(11):3929-39. doi: 10.1093/jxb/err090. [PMID: 21447756]
Lingyun Cheng, Bruna Bucciarelli, Junqi Liu, Kelly Zinn, Susan Miller, Jana Patton-Vogt, Deborah Allan, Jianbo Shen, Carroll P Vance. White lupin cluster root acclimation to phosphorus deficiency and root hair development involve unique glycerophosphodiester phosphodiesterases. Plant physiology. 2011 Jul; 156(3):1131-48. doi: 10.1104/pp.111.173724. [PMID: 21464471]
Amit Prasad, Yonghui Jia, Anutosh Chakraborty, Yitang Li, Supriya K Jain, Jia Zhong, Saurabh Ghosh Roy, Fabien Loison, Subhanjan Mondal, Jiro Sakai, Catlyn Blanchard, Solomon H Snyder, Hongbo R Luo. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nature immunology. 2011 Jun; 12(8):752-60. doi: 10.1038/ni.2052. [PMID: 21685907]
Yuka Kumagai, Yuji Kamioka, Shunsuke Yagi, Michiyuki Matsuda, Etsuko Kiyokawa. A genetically encoded Förster resonance energy transfer biosensor for two-photon excitation microscopy. Analytical biochemistry. 2011 Jun; 413(2):192-9. doi: 10.1016/j.ab.2011.02.021. [PMID: 21352796]
Gillian L Fell, Amanda M Munson, Merriah A Croston, Anne G Rosenwald. Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda, Md.). 2011 Jun; 1(1):43-56. doi: 10.1534/g3.111.000166. [PMID: 22384317]
Ola El-Zein, Sawsan Ibrahim Kreydiyyeh. Pine bark extract inhibits glucose transport in enterocytes via mitogen-activated kinase and phosphoinositol 3-kinase. Nutrition (Burbank, Los Angeles County, Calif.). 2011 Jun; 27(6):707-12. doi: 10.1016/j.nut.2010.07.001. [PMID: 20869203]
Fabio Fassetti, Ofelia Leone, Luigi Palopoli, Simona E Rombo, Adolfo Saiardi. IP6K gene identification in plant genomes by tag searching. BMC proceedings. 2011 May; 5 Suppl 2(?):S1. doi: 10.1186/1753-6561-5-s2-s1. [PMID: 21554757]
Marco Scioscia, Philip J Williams, Khalid Gumaa, Nicola Fratelli, Carlotta Zorzi, Thomas W Rademacher. Inositol phosphoglycans and preeclampsia: from bench to bedside. Journal of reproductive immunology. 2011 May; 89(2):173-7. doi: 10.1016/j.jri.2011.03.001. [PMID: 21549431]
Evgeny A Zemskov, Irina Mikhailenko, Ru-Ching Hsia, Liubov Zaritskaya, Alexey M Belkin. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PloS one. 2011 Apr; 6(4):e19414. doi: 10.1371/journal.pone.0019414. [PMID: 21556374]
Fei Dai, Long Qiu, Lingzhen Ye, Dezhi Wu, Meixue Zhou, Guoping Zhang. Identification of a phytase gene in barley (Hordeum vulgare L.). PloS one. 2011 Apr; 6(4):e18829. doi: 10.1371/journal.pone.0018829. [PMID: 21533044]
Santeri Kiviluoto, Jean-Paul Decuypere, Humbert De Smedt, Ludwig Missiaen, Jan B Parys, Geert Bultynck. STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function. Skeletal muscle. 2011 Apr; 1(1):16. doi: 10.1186/2044-5040-1-16. [PMID: 21798093]
Philipp Ternes, Tobias Wobbe, Marnie Schwarz, Sandra Albrecht, Kirstin Feussner, Isabelle Riezman, James M Cregg, Ernst Heinz, Howard Riezman, Ivo Feussner, Dirk Warnecke. Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris. The Journal of biological chemistry. 2011 Apr; 286(13):11401-14. doi: 10.1074/jbc.m110.193094. [PMID: 21303904]
Yu Luo, Genji Qin, Jun Zhang, Yuan Liang, Yingqi Song, Meiping Zhao, Tomohiko Tsuge, Takashi Aoyama, Jingjing Liu, Hongya Gu, Li-Jia Qu. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. The Plant cell. 2011 Apr; 23(4):1352-72. doi: 10.1105/tpc.111.083337. [PMID: 21505066]
Irina U Agoulnik, Myles C Hodgson, Wayne A Bowden, Michael M Ittmann. INPP4B: the new kid on the PI3K block. Oncotarget. 2011 Apr; 2(4):321-8. doi: 10.18632/oncotarget.260. [PMID: 21487159]
Benjamin Misselwitz, Sabrina Dilling, Pascale Vonaesch, Raphael Sacher, Berend Snijder, Markus Schlumberger, Samuel Rout, Manuel Stark, Christian von Mering, Lucas Pelkmans, Wolf-Dietrich Hardt. RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Molecular systems biology. 2011 Mar; 7(?):474. doi: 10.1038/msb.2011.7. [PMID: 21407211]
Elise Hamard-Peron, Delphine Muriaux. Retroviral matrix and lipids, the intimate interaction. Retrovirology. 2011 Mar; 8(?):15. doi: 10.1186/1742-4690-8-15. [PMID: 21385335]
J Carl Pallais, E Helen Kemp, Clemens Bergwitz, Lakshmi Kantham, David M Slovik, Anthony P Weetman, Edward M Brown. Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor. The Journal of clinical endocrinology and metabolism. 2011 Mar; 96(3):672-80. doi: 10.1210/jc.2010-1739. [PMID: 21159843]
Steven C Elbein, Philip A Kern, Neda Rasouli, Aiwei Yao-Borengasser, Neeraj K Sharma, Swapan K Das. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes. 2011 Mar; 60(3):1019-29. doi: 10.2337/db10-1270. [PMID: 21266331]
Scott Bidlingmaier, Yong Wang, Yue Liu, Niu Zhang, Bin Liu. Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Molecular & cellular proteomics : MCP. 2011 Mar; 10(3):M110.005116. doi: 10.1074/mcp.m110.005116. [PMID: 21127146]
Cheng-Ying Shi, Hua Yang, Chao-Ling Wei, Oliver Yu, Zheng-Zhu Zhang, Chang-Jun Jiang, Jun Sun, Ye-Yun Li, Qi Chen, Tao Xia, Xiao-Chun Wan. Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds. BMC genomics. 2011 Feb; 12(?):131. doi: 10.1186/1471-2164-12-131. [PMID: 21356090]
Miyako Kusano, Henning Redestig, Tadayoshi Hirai, Akira Oikawa, Fumio Matsuda, Atsushi Fukushima, Masanori Arita, Shin Watanabe, Megumu Yano, Kyoko Hiwasa-Tanase, Hiroshi Ezura, Kazuki Saito. Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment. PloS one. 2011 Feb; 6(2):e16989. doi: 10.1371/journal.pone.0016989. [PMID: 21359231]
Sean G Jackson, Sarra Al-Saigh, Carsten Schultz, Murray S Junop. Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions. BMC structural biology. 2011 Feb; 11(?):11. doi: 10.1186/1472-6807-11-11. [PMID: 21310079]
Michael A Kennedy, Nazir Kabbani, Jean-Philippe Lambert, Leigh Anne Swayne, Fida Ahmed, Daniel Figeys, Steffany A L Bennett, Jennnifer Bryan, Kristin Baetz. Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. PLoS genetics. 2011 Feb; 7(2):e1001299. doi: 10.1371/journal.pgen.1001299. [PMID: 21347278]
Seyun Kim, Sangwon F Kim, David Maag, Micah J Maxwell, Adam C Resnick, Krishna R Juluri, Anutosh Chakraborty, Michael A Koldobskiy, Seung Hun Cha, Roxanne Barrow, Adele M Snowman, Solomon H Snyder. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell metabolism. 2011 Feb; 13(2):215-21. doi: 10.1016/j.cmet.2011.01.007. [PMID: 21284988]
José M López-Novoa, Ana B Rodríguez-Peña, Alberto Ortiz, Carlos Martínez-Salgado, Francisco J López Hernández. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. Journal of translational medicine. 2011 Jan; 9(?):13. doi: 10.1186/1479-5876-9-13. [PMID: 21251296]