Exact Mass: 374.0573
Exact Mass Matches: 374.0573
Found 449 metabolites which its exact mass value is equals to given mass value 374.0573,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Chrysosplenetin
Chrysosplenetin, also known as quercetagetin 3,6,7,3-tetramethyl ether or 3,6,7,3-tetra-methylquercetagetin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, chrysosplenetin is considered to be a flavonoid lipid molecule. Chrysosplenetin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Chrysosplenetin can be found in german camomile, which makes chrysosplenetin a potential biomarker for the consumption of this food product. Chrysosplenetin is an O-methylated flavonol. It can be found in the root of Berneuxia thibetica and in Chamomilla recutita . Chrysosplenetin is a tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Chrysosplenetin is a natural product found in Haplophyllum myrtifolium, Cleome amblyocarpa, and other organisms with data available. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Skullcapflavone II
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
Isodiospyrin
Isodiospyrin is a member of biphenyls. Isodiospyrin is a natural product found in Diospyros morrisiana, Diospyros verrucosa, and other organisms with data available. Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].
Chlorophacinone
D006401 - Hematologic Agents > D000925 - Anticoagulants D010575 - Pesticides > D012378 - Rodenticides D009676 - Noxae > D009153 - Mutagens D016573 - Agrochemicals
Casticin
Casticin is a tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4 have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. It has a role as an apoptosis inducer and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Casticin is a natural product found in Psiadia viscosa, Psiadia dentata, and other organisms with data available. See also: Chaste tree fruit (part of). A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4 have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. Casticin is found in fruits. Casticin is a constituent of Vitex agnus-castus (agnus castus) seeds Casticin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=479-91-4 (retrieved 2024-07-01) (CAS RN: 479-91-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
Methylrosmarinic acid
Methyl rosmarinate is a hydroxycinnamic acid. Methyl rosmarinate is a natural product found in Dimetia scandens, Bourreria pulchra, and other organisms with data available. Methylrosmarinic acid is found in herbs and spices. Methylrosmarinic acid is isolated from Salvia (sage) species. Isolated from Salvia (sage) subspecies Methyl rosmarinate is found in herbs and spices. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1]. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1].
Neobaicalein
Scullcapflavone II is a tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. It has a role as a plant metabolite and an anti-asthmatic drug. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone. Skullcapflavone II is a natural product found in Lagochilus leiacanthus, Scutellaria guatemalensis, and other organisms with data available. A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
5,8-Dihydroxy-3,3',4',7-tetramethoxyflavone
5,8-Dihydroxy-3,3,4,7-tetramethoxyflavone is found in citrus. 5,8-Dihydroxy-3,3,4,7-tetramethoxyflavone is isolated from sweet orange oi
3-O-Methylrosmarinic acid
3-O-Methylrosmarinic acid is a polyphenol metabolite detected in biological fluids (PMID: 20428313). A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Comosin
Comosin is found in herbs and spices. Comosin is a constituent of Muscari comosum (tassel hyacinth). Constituent of Muscari comosum (tassel hyacinth). Comosin is found in herbs and spices.
3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}propanoic acid
Neodiospyrin
Neodiospyrin is found in fruits. Neodiospyrin is isolated from roots of Diospyros kaki (Japanese persimmon
Pebrellin
Constituent of Mentha piperita and Thymus piperella. Pebrellin is found in many foods, some of which are spearmint, peppermint, pot marjoram, and herbs and spices. Pebrellin is found in herbs and spices. Pebrellin is a constituent of Mentha piperita and Thymus piperella
Hymenoxin
Isolated from Mentha piperita (peppermint). Hymenoxin is found in sunflower, peppermint, and herbs and spices. Hymenoxin is found in herbs and spices. Hymenoxin is isolated from Mentha piperita (peppermint).
6-Hydroxymethyletoricoxib
6-Hydroxymethyletoricoxib is only found in individuals that have used or taken Etoricoxib. 6-Hydroxymethyletoricoxib is a metabolite of Etoricoxib. 6-hydroxymethyletoricoxib belongs to the family of Bipyridines. These are organic compounds containing two pyridine rings linked to each other.
4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone
4,5-Dihydroxy-3,5,7,8-tetramethoxyflavone is isolated from Lepidium sativum (garden cress). Isolated from Lepidium sativum (garden cress).
Menadiol disuccinate
Prothrombogenic vitamin. Prothrombogenic vitamin
N-Desmethylzopiclone
N-Desmethylzopiclone is a metabolite of Eszopiclone. Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones. (Wikipedia)
Etoricoxib 1'-N'-oxide
Etoricoxib 1-N-oxide is a metabolite of etoricoxib. Etoricoxib (brand name NUSHIN MASCOT HEALTH SERIES Arcoxia worldwide; also Algix and Tauxib in Italy, Nucoxia in India) is a COX-2 selective inhibitor (approx. 106.0 times more selective for COX-2 inhibition over COX-1) from Merck & Co. Currently it is approved in more than 70 countries worldwide but not in the US, where the Food and Drug Administration (FDA) requires additional safety and efficacy data for etoricoxib before it will issue approval. (Wikipedia)
Ethyl gallate 3-glucuronide
Ethyl gallate 3-glucuronide belongs to the class of organic compounds known as hydrolyzable tannins. These are tannins with a structure characterized by either (1) galloyl units (in some cases, shikimic acid units) that are linked to diverse polyol carbohydrate-, catechin-, or triterpenoid units, or (2) at least two galloyl units C-C coupled to each other and without a glycosidically linked catechin unit. Ethyl gallate 3-glucuronide is an extremely weak basic (essentially neutral) compound (based on its pKa).
Ethyl gallate 4-glucuronide
Ethyl gallate 4-glucuronide belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans and flavonoids. Ethyl gallate 4-glucuronide is an extremely weak basic (essentially neutral) compound (based on its pKa).
Syringic acid glucuronide
3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide
(4-Methoxyphenyl)-morpholin-4-yl-morpholin-4-ylsulfanyl-sulfidophosphanium
Iguratimod
C308 - Immunotherapeutic Agent
(6'-Hydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate
Valeant
Parmelin
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2].
[2,2-Binaphthalene]-1,1,4,4-tetrone, 5,5-dihydroxy-7,7-dimethyl-
5,8-Dihydroxy-7,6-dimethyl-2,2-binaphthalene-1,1,4,4-tetraone
Paeciloquinone D
(2R,3R)-5,2-Dihydroxy-7,8-dimethoxy-3-O-acetylflavanone
5,4-Dihidroxy-6,7,3,5-tetramethoxyflavone
5,3-Dihydroxy-6,7,4,5-tetramethoxyflavone
Quercetagetin 6,7,34-tetramethyl ether
Gossypetin 3,7,8,4-tetramethyl ether
Myricetin 3,3,4,5-tetramethyl ether
8-C-Methylquercetagetin 3,6,7-trimethyl ether
8-C-Methylquercetagetin 3,6,3-trimethyl ether
5,4-Dihydroxy-7,2,3,5-tetramethoxyflavone
5,7-Dihydroxy-2,3,4,5-tetramethoxyflavone
3,5-Dihydroxy-6,7,8,4-tetramethoxyflavone
3,5-Dihydroxy-7,3,4,5-tetramethoxyflavone
Arteanoflavone
Arteanoflavone is a natural product found in Artemisia lucentica with data available.
Polycladin
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Casticin
[Raw Data] CB178_Casticin_pos_50eV_CB000067.txt [Raw Data] CB178_Casticin_pos_40eV_CB000067.txt [Raw Data] CB178_Casticin_pos_30eV_CB000067.txt [Raw Data] CB178_Casticin_pos_20eV_CB000067.txt [Raw Data] CB178_Casticin_pos_10eV_CB000067.txt Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
Neobaicalein
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
3,5-dihydroxy-3,4,5,7-tetramethoxyflavone
A tetramethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 7, 4 and 5 have been replaced by methoxy groups. It has been isolated from Combretum quadrangulare.
4-Hydroxybenzophenone glucuronide|O1-(4-benzoyl-phenyl)-beta-D-glucopyranuronic acid|O1-(4-Benzoyl-phenyl)-beta-D-glucopyranuronsaeure
5-hydroxy-2-(4-hydroxy-2,3,5-trimethoxyphenyl)-7-methoxychromen-4-one
Neodiospyrin
(5E,11E,15E,19E)-20-bromoeicosa-5,11,15,19-tetraen-9,17-diynoic acid|(all-E)-form-20-Bromo-5, 11, 15, 19-eicosatetraene-9, 17-diynoic aicd
1-(2,5-Dihydroxy-4-bromophenyl)-3,7-dihydroxy-3,7-dimethyl-1-octanone
Diospyrin, 1.1.4.4-Tetraoxo-7.7-dimethyl-5.5-dihydroxy-1.1.4.4-tetrahydro-binaphthyl-(2.6 oder 3.6)|Euclein
4,4-Dihydroxy-7,7-dimethyl-2,2-binaphthalene-5,5,8,8-tetraone
Diplotrin A
A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 2 and 5 and methoxy groups at positions 3, 7, 8 and 4. It has been isolated from the aerial parts of Mimosa diplotricha.
5-hydroxy-2-(2-hydroxy-3,4,5-trimethoxy-phenyl)-7-methoxy-chromen-4-one
7-Hydroxy-2-(3-methoxy-4-hydroxyphenyl)-3,5,8-trimethoxy-4H-1-benzopyran-4-one
1-Hydroxy-2,3,7,8-tetramethoxy-chromeno[5,4,3-cde]chromen-5,10-dion|1-hydroxy-2,3,7,8-tetramethoxy-chromeno[5,4,3-cde]chromene-5,10-dione|3,3,4,4-tetra-O-methylflavellagic acid
Me glycoside,4,6-O-benzylidene,2-mesyl-3-O-Methylgalactose
3,7-diacetoxy epicatechin|3,7-diacetyl (-) epicatechin|3,7-O-diacetyl-(-)-epicatechin
Atranorin
Atranorin is a carbonyl compound. Atranorin is a natural product found in Candelaria concolor, Loxospora elatina, and other organisms with data available. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2].
6-(Hydroxymethyl)-1,2,3,5-tetramethoxy-8-hydroxy-9,10-anthraquinone
impatienol
A hydroxy-1,4-naphthoquinone that is ethane in which one of the carbons is substituted by two 3-hydroxy-1,4-naphthoquinon-2-yl groups.
2,3,5,7-Tetra-Me ether-2,3,5,5,6,7-Hexahydroxyflavone|6,5-dihydroxy-3,5,7,2-tetramethoxyflavone
3,4,5,6tetrahydroxy-2-(3,4,5-trihydroxyphenoxy)biphenyl
2-(5-Hydroxy-2,3-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
3,4,7-Tri-Me ether-3,3,4,5,5,7-Hexahydroxy-8-methylflavone
7-Hydroxy-2-phenoxy-3-(2-carboxybenzyl)chromone
5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxychromen-4-one
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one
CHLOROPHACINONE
D006401 - Hematologic Agents > D000925 - Anticoagulants D010575 - Pesticides > D012378 - Rodenticides D009676 - Noxae > D009153 - Mutagens D016573 - Agrochemicals
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one [IIN-based: Match]
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one [IIN-based on: CCMSLIB00000848808]
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-chromen-4-one
6-Hydroxymethyletoricoxib
4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone
Methyl rosmarinate
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1]. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1].
3-O-Methylrosmarinic acid
4-amino-n-[2-[(2-sulfoxy)ethyl]-sulfonyl]ethyl benzamide,sodium
1,1,1,7,7,7-hexafluoro-2,6-bis(trifluoromethyl)hept-3-ene-2,6-diol
Bis(1-ethyl-3-methylcyclopentadienyl)zirconium dichloride
Bis(1-ethyl-2-methylcyclopentadienyl)zirconium dichloride
acetic acid,4-bromo-6-(2-phenyl-1H-pyrazol-3-ylidene)cyclohexa-2,4-dien-1-one
(1S,2S)-1,2-Bis(4-nitrophenyl)-1,2-ethanediamine dihydrochloride
(11ar)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1,7-fg][1,3,2]dioxaphosphocin-5-phenoxy
3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone
(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
Magnesium Ascorbate
D020011 - Protective Agents > D000975 - Antioxidants D018977 - Micronutrients > D014815 - Vitamins
4-chloro-1-tosyl-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
ethyl (2S)-3-(4-aminophenyl)-2-(1,3-dioxoisoindol-2-yl)propanoate,hydrochloride
2-[2-[(3-Aminobenzoyl)amino]ethylsulfonyl]ethyl hydrogen sulfate
2,2:5,2'-Terthiophene-5-boronic acid pinacol ester
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
3-O-(4-TOLUENESULFONYL)-2-O-ACETYL-L-METHYLFUCOSIDE
3-(4-(2-chlorophenoxy)piperidine-1-carboxamido)benzoic acid
1-(2,6-Dichlorobenzyl)-3-(1-Pyrrolidinylmethyl)-1H-Indazol-6-Amine
ethyl 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptanoate
ethene,3,3,4,4,5,5,6,6,6-nonafluorohex-1-ene,1,1,2,2-tetrafluoroethene
(2S,TRANS)-4-NITROBENZYL 2-(HYDROXYMETHYL)-4-((METHYLSULFONYL)OXY)PYRROLIDINE-1-CARBOXYLATE
4-Amino-5-cyano-6-ethoxy-N-[4-(methylsulfonyl)benzyl]-2-pyridinec arboxamide
6-deoxy-1,2-O-isopropylidene-6-(4-methylbenzene)sulfonyloxy-D-glucofuranose
N-(benzo[d][1,3]dioxol-5-yl)-2-(thiophen-2-yl)quinoline-4-carboxamide
4-Methylumbelliferyla-L-idopyranosiduronicacidsodiumsalt
6,8-difluoro-4-methyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
(1R,2R)-1,2-BIS(4-NITROPHENYL)ETHANE-1,2-DIAMINE DIHYDROCHLORIDE
3-iodo-4-(4-propan-2-ylpiperazin-1-yl)benzoic acid
4-[(4-ethylpiperazin-1-yl)methyl]-3-iodobenzoic acid
methyl 3-iodo-4-[(3-methylpiperazin-1-yl)methyl]benzoate
N-(4-Chlorobenzyl)-N-Methylbenzene-1,4-Disulfonamide
Ethyl 3-(benzylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
Gavestinel
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent D018377 - Neurotransmitter Agents > D018684 - Glycine Agents
n-Hydroxy-4-[(4-methoxylphenyl)sulfonyl]-2,2-dimethyl-hexahydro-1,4-thiazepine-3(s)-carboxamide
4-(1,3-Benzodioxol-5-Yloxy)-2-[4-(1h-Imidazol-1-Yl)phenoxy]pyrimidine
(2s)-({(5z)-5-[(5-Ethyl-2-Furyl)methylene]-4-Oxo-4,5-Dihydro-1,3-Thiazol-2-Yl}amino)(4-Fluorophenyl)acetic Acid
NCI60_040650
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
603-56-5
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
N-[2-[[3-chloro-5-(triluoromethyl)pyridin-2-yl]methylsulanyl]ethyl]benzamide
4H-1-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxy-
[(2R,3S,4R,5S)-3,4-dihydroxy-5-(5-methoxy-6-methylbenzimidazol-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
2-[[(5E)-5-[(5-ethylfuran-2-yl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]-2-(4-fluorophenyl)acetic acid
ethyl (2Z)-5-phenyl-2-(1,1,1-trifluoro-3-methoxy-3-oxopropan-2-ylidene)-1,3-oxathiole-4-carboxylate
4-Fluorobenzoic acid 4-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)thio]but-2-ynyl ester
N-[(5-bromo-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide
3-Tert-butyl-7-[[2-(4-methylphenyl)-2-oxoethyl]thio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
3-(3-bromophenyl)-2-(4-fluorophenyl)-5,6,7,7a-tetrahydro-3H-pyrrolo[1,2-c]imidazol-1-one
2-[[5-(2-Furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]-1-(4-morpholinyl)ethanone
3-Hydroxy-2-[5-[4-(trifluoromethyl)phenyl]-2-furanyl]-1,2-dihydroquinazolin-4-one
2-(4-chlorophenyl)-N-[(Z)-pyrrol-2-ylidenemethyl]cinchoninohydrazide
1-butyl-3-thiophen-2-ylsulfonyl-2H-imidazo[4,5-b]quinoxaline
1-[[2-(1,3-Benzothiazol-2-ylthio)-1-oxoethyl]amino]-3-phenylthiourea
2-(4-Chlorophenyl)-6-(phenacylthio)-2,3-dihydrothiopyran-4-one
N-[3-chloro-2-(4-morpholinyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide
2-(8,9-Dimethyl-thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-ylsulfanyl)-N-(5-methyl-isoxazol-3-yl)-acetamide
6-[(1H-benzimidazol-2-ylthio)methyl]-1-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate
5-[(3-Formyl-2-hydroxy-4-methoxy-6-methylphenyl)-oxomethoxy]-2-hydroxy-3,6-dimethylbenzoic acid
1-S-[(1Z)-N-(sulfonatooxy)pentanimidoyl]-1-thio-beta-D-glucopyranose
2-(7-hydroxy-4-oxo-3-phenoxy-4H-chromen-2-yl)benzoic acid
Chrysosplenetin
Chrysosplenetin is a tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Chrysosplenetin is a natural product found in Haplophyllum myrtifolium, Cleome amblyocarpa, and other organisms with data available. A tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
glucocochlearin(1-)
An alkylglucosinolate that is the conjugate base of glucocochlearin.
isobutylglucosinolate
An alkylglucosinolate that is the conjugate base of isobutylglucosinolic acid.
butylglucosinolate
An alkylglucosinolate that is the conjugate base of butylglucosinolic acid.
3,3,4,5-tetramethylmyricetin
A tetramethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 3, 4 and 5 are replaced by methoxy groups. It is isolated from Bridelia ferruginea, a subtropical medicinal plant widely used in traditional African medicine.
BMS-984923
BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling[1][2].
Fatostatin (hydrobromide)
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].
Gavestinel
Gavestinel (GV 150526) is a selective and potent the glycine site of the NMDA receptor antagonist. Gavestinel has neuroprotectant effects[1].
3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate
(3r)-1-(4-bromo-2,5-dihydroxyphenyl)-3,7-dihydroxy-3,7-dimethyloctan-1-one
3,5-dihydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7,8-trimethoxychromen-4-one
(5r,5's,9s)-5'-(furan-3-yl)-2',3,6-trioxo-4,7,8,9-tetrahydro-1h-spiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate
10-hydroxy-5-methoxy-2-(1,2,3-trihydroxypropan-2-yl)-1h,2h-furo[2,3-c]xanthen-6-one
5-hydroxy-2-(3-hydroxy-2,4,5-trimethoxyphenyl)-7-methoxychromen-4-one
6'-(2,4,6-trihydroxyphenoxy)-[1,1'-biphenyl]-2,2',4,4',6-pentol
4,13,17-trihydroxy-5-methoxy-7,12-dimethyl-2,10,16-trioxatetracyclo[9.7.0.0³,⁸.0¹⁴,¹⁸]octadeca-1(11),3,5,7,12,14(18)-hexaene-9,15-dione
(5r)-5-[(2r)-2-hydroxy-2-[(2s)-9-oxo-2h,3h-[1,4]dioxino[2,3-h]chromen-2-yl]propyl]-3-(hydroxymethyl)-5h-furan-2-one
3-(acetyloxy)-2-(3,4-dihydroxyphenyl)-5-hydroxy-3,4-dihydro-2h-1-benzopyran-7-yl acetate
(2r,3s,6s)-2-bromo-8-chloro-1,1,9-trimethyl-5-methylidenespiro[5.5]undec-8-en-3-yl acetate
2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7,8-dimethoxychromen-4-one
5-hydroxy-3-(3-hydroxy-2-methoxyphenyl)-6,7,8-trimethoxychromen-4-one
5-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one
5-[2-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy]benzene-1,2,3-triol
(1s)-1-(3,4-dihydroxyphenyl)-3-methoxy-3-oxopropyl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate
6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one
methyl 5-hydroxy-4-methoxy-2-[4-methoxy-2-(methoxycarbonyl)benzoyl]benzoate
2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3,8-dimethoxychromen-4-one
(1r,2s,3s,4as,9ar,10s)-9a-chloro-1,2,3,4a,8,10-hexahydroxy-6-methoxy-3-methyl-1,2,4,10-tetrahydroanthracen-9-one
4-hydroxy-2-(1,3,6,8-tetrahydroxy-9,10-dioxoanthracen-2-yl)butanoic acid
3,8'-biplumbagin
{"Ingredient_id": "HBIN007821","Ingredient_name": "3,8'-biplumbagin","Alias": "NA","Ingredient_formula": "C22H14O6","Ingredient_Smile": "CC1=CC(=O)C2=C(C=CC(=C2C1=O)C3=C(C(=O)C4=C(C3=O)C(=CC=C4)O)C)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "2403","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
5,3'-dihydroxy-3,7,4',5'-tetramethoxyflavone
{"Ingredient_id": "HBIN011018","Ingredient_name": "5,3'-dihydroxy-3,7,4',5'-tetramethoxyflavone","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "COC1=CC(=C2C(=C1)OC(=C(C2=O)OC)C3=CC(=C(C=C3OC)OC)O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "6146","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
6-methoxyboeravinone c
{"Ingredient_id": "HBIN012518","Ingredient_name": "6-methoxyboeravinone c","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "CC1=C(C=C2C(=C1O)C(=O)C3(C(O2)C(OC4=C3C=CC=C4O)OC)O)OC","Ingredient_weight": "374.3 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "13853","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "487169","DrugBank_id": "NA"}
ariseminone
{"Ingredient_id": "HBIN016751","Ingredient_name": "ariseminone","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "NA","Ingredient_weight": "374.34","OB_score": "NA","CAS_id": "149575-60-0","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "6679","PubChem_id": "NA","DrugBank_id": "NA"}
