N-Desmethylzopiclone (BioDeep_00000054129)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


6-(5-Chloro-2-pyridyl)-7-((1-piperazinyl)carbonyloxy)-6,7-dihydro(5H)pyrrolo(3,4-b)pyrazin-5-one

化学式: C16H15ClN6O3 (374.08941100000004)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 95.12%

分子结构信息

SMILES: C1CN(CCN1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl
InChI: InChI=1S/C16H15ClN6O3/c17-10-1-2-11(21-9-10)23-14(24)12-13(20-4-3-19-12)15(23)26-16(25)22-7-5-18-6-8-22/h1-4,9,15,18H,5-8H2

描述信息

N-Desmethylzopiclone is a metabolite of Eszopiclone. Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones. (Wikipedia)

同义名列表

4 个代谢物同义名

6-(5-Chloro-2-pyridyl)-7-((1-piperazinyl)carbonyloxy)-6,7-dihydro(5H)pyrrolo(3,4-b)pyrazin-5-one; 6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate; 6-(5-chloropyridin-2-yl)-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate; N-Desmethylzopiclone



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gunnel H Nilsson, Fredrik C Kugelberg, Johan Ahlner, Robert Kronstrand. Quantitative analysis of zopiclone, N-desmethylzopiclone, zopiclone N-oxide and 2-amino-5-chloropyridine in urine using LC-MS-MS. Journal of analytical toxicology. 2014 Jul; 38(6):327-34. doi: 10.1093/jat/bku042. [PMID: 24790062]
  • Hiren N Mistri, Arvind G Jangid, Ashutosh Pudage, Pranav Shrivastav. HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Mar; 864(1-2):137-48. doi: 10.1016/j.jchromb.2008.02.004. [PMID: 18313371]
  • Mark W Fleck. Molecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone. The Journal of pharmacology and experimental therapeutics. 2002 Aug; 302(2):612-8. doi: 10.1124/jpet.102.033886. [PMID: 12130723]
  • Li-jun Yang, Gertrud Rochholz. [Determination of zopiclone in serum by reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2002 May; 20(3):256-8. doi: NULL. [PMID: 12541950]
  • E Mannaert, J Tytgat, P Daenens. Development of a stereospecific radioimmunoassay for the analysis of zopiclone and metabolites in urine. Clinica chimica acta; international journal of clinical chemistry. 1996 Sep; 253(1-2):103-15. doi: 10.1016/0009-8981(96)06350-4. [PMID: 8879842]
  • E Mannaert, P Daenens. Development of a fluorescence polarization immunoassay for the routine detection of N-desmethylzopiclone in urine samples. The Analyst. 1996 Jun; 121(6):857-61. doi: 10.1039/an9962100857. [PMID: 8763209]
  • E Mannaert, P Daenens. Development of a radioimmunoassay for the determination of N-desmethylzopiclone in urine. The Analyst. 1994 Oct; 119(10):2221-6. doi: 10.1039/an9941902221. [PMID: 7992879]
  • C Fernandez, V Maradeix, F Gimenez, A Thuillier, R Farinotti. Pharmacokinetics of zopiclone and its enantiomers in Caucasian young healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals. 1993 Nov; 21(6):1125-8. doi: NULL. [PMID: 7905394]
  • C Fernandez, F Gimenez, B Baune, V Maradeix, A Thuillier, R Farinotti. Determination of the enantiomers of zopiclone and its two chiral metabolites in urine using an automated coupled achiral-chiral chromatographic system. Journal of chromatography. 1993 Aug; 617(2):271-8. doi: 10.1016/0378-4347(93)80498-s. [PMID: 8408393]
  • A Le Liboux, A Frydman, J Gaillot. Simultaneous determination of zopiclone and its two major metabolites (N-oxide and N-desmethyl) in human biological fluids by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1987 Jun; 417(1):151-8. doi: 10.1016/0378-4347(87)80101-9. [PMID: 3624392]