Gavestinel (BioDeep_00000855631)

   


代谢物信息卡片


Gavestinel

化学式: C18H12Cl2N2O3 (374.0224942)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)NC(=O)C=CC2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O
InChI: InChI=1S/C18H12Cl2N2O3/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11/h1-9,22H,(H,21,23)(H,24,25)/b7-6+

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
D018377 - Neurotransmitter Agents > D018684 - Glycine Agents

同义名列表

1 个代谢物同义名

Gavestinel



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • M Kajbaf, R J Barnaby, M Bottacini, L Bertolotti, I M Ismail, T J Cholerton, M Pellegatti. Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Apr; 33(4):415-28. doi: 10.1080/0049825031000072469. [PMID: 12745876]
  • R A Gilissen, L Ferrari, R J Barnaby, M Kajbaf. Human hepatic metabolism of a novel 2-carboxyindole glycine antagonist for stroke: in vitro-in vivo correlations. Xenobiotica; the fate of foreign compounds in biological systems. 2000 Sep; 30(9):843-56. doi: 10.1080/004982500433273. [PMID: 11055263]
  • J F Hoke, A G Dyker, R J Barnaby, K R Lees. Pharmacokinetics of a glycine site antagonist (gavestinel) following multiple dosing in patients with acute stroke. European journal of clinical pharmacology. 2000 Feb; 55(11-12):867-72. doi: 10.1007/s002280050709. [PMID: 10805066]
  • R A Gilissen, R J Barnaby, M Kajbaf. Identification of UDP-glucuronosyltransferases involved in the human hepatic metabolism of GV150526, a novel glycine antagonist. Drug metabolism and drug interactions. 2000; 16(3):173-89. doi: 10.1515/dmdi.2000.16.3.173. [PMID: 11116752]
  • L Iavarone, J F Hoke, M Bottacini, R Barnaby, G C Preston. First time in human for GV196771: interspecies scaling applied on dose selection. Journal of clinical pharmacology. 1999 Jun; 39(6):560-6. doi: 10.1177/00912709922008164. [PMID: 10354959]
  • M Mugnaini, M Antolini, M Corsi, F T van Amsterdam. [3H]5,7-dichlorokynurenic acid recognizes two binding sites in rat cerebral cortex membranes. Journal of receptor and signal transduction research. 1998 Mar; 18(2-3):91-112. doi: 10.3109/10799899809047739. [PMID: 9651880]
  • M Rowley, J J Kulagowski, A P Watt, D Rathbone, G I Stevenson, R W Carling, R Baker, G R Marshall, J A Kemp, A C Foster, S Grimwood, R Hargreaves, C Hurley, K L Saywell, M D Tricklebank, P D Leeson. Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists. Journal of medicinal chemistry. 1997 Dec; 40(25):4053-68. doi: 10.1021/jm970417o. [PMID: 9406596]