Chlorophacinone (BioDeep_00000012307)

 

Secondary id: BioDeep_00000408977

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-[2-(4-chlorophenyl)-2-phenylacetyl]-2,3-dihydro-1H-indene-1,3-dione

化学式: C23H15ClO3 (374.070967)
中文名称: 氯鼠酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)C(=O)C3C(=O)C4=CC=CC=C4C3=O
InChI: InChI=1S/C23H15ClO3/c24-16-12-10-15(11-13-16)19(14-6-2-1-3-7-14)23(27)20-21(25)17-8-4-5-9-18(17)22(20)26/h1-13,19-20H

描述信息

D006401 - Hematologic Agents > D000925 - Anticoagulants
D010575 - Pesticides > D012378 - Rodenticides
D009676 - Noxae > D009153 - Mutagens
D016573 - Agrochemicals

同义名列表

4 个代谢物同义名

2-[2-(4-chlorophenyl)-2-phenylacetyl]-2,3-dihydro-1H-indene-1,3-dione; CHLOROPHACINONE; Redentin; Chlorophacinone



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Meg-Anne Moriceau, Sébastien Lefebvre, Isabelle Fourel, Etienne Benoit, Barnett A Rattner, Virginie Lattard. Accidental chlorophacinone exposure of lactating ewes: Clinical follow-up and human health dietary implications. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Sep; 143(?):111518. doi: 10.1016/j.fct.2020.111518. [PMID: 32645465]
  • Barnett A Rattner, Steven F Volker, Julia S Lankton, Thomas G Bean, Rebecca S Lazarus, Katherine E Horak. Brodifacoum Toxicity in American Kestrels (Falco sparverius) with Evidence of Increased Hazard on Subsequent Anticoagulant Rodenticide Exposure. Environmental toxicology and chemistry. 2020 02; 39(2):468-481. doi: 10.1002/etc.4629. [PMID: 31707739]
  • Gary W Witmer, Nathan P Snow, Rachael S Moulton. Retention time of chlorophacinone in black-tailed prairie dogs informs secondary hazards from a prairie dog rodenticide bait. Pest management science. 2016 Apr; 72(4):725-30. doi: 10.1002/ps.4045. [PMID: 25997570]
  • Micong Jin, Meiqiang Cai, Xiaohong Chen. An Yttrium-sensitized luminescence system and its application for the determination of trace chlorophacinone in serum. Analytical biochemistry. 2011 Jun; 413(2):142-7. doi: 10.1016/j.ab.2011.02.020. [PMID: 21342655]
  • Isabelle Fourel, Christophe Hugnet, Isabelle Goy-Thollot, Philippe Berny. Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products. Journal of analytical toxicology. 2010 Mar; 34(2):95-102. doi: 10.1093/jat/34.2.95. [PMID: 20223102]
  • Micong Jin, Xiaohong Chen. [Simultaneous determination of trace diphacinone and chlorophacinone in biological samples by high performance liquid chromatography coupled with ion trap mass spectrometry]. Se pu = Chinese journal of chromatography. 2010 Feb; 28(2):197-203. doi: 10.3724/sp.j.1123.2012.00197. [PMID: 20556961]
  • Mi-cong Jin, Mei-qiang Cai, Xiao-hong Chen. Simultaneous measurement of indandione-type rodenticides in human serum by liquid chromatography-electrospray ionization- tandem mass spectrometry. Journal of analytical toxicology. 2009 Jul; 33(6):294-300. doi: 10.1093/jat/33.6.294. [PMID: 19653932]
  • Xiao-kun Ouyang, Xiao-hong Chen, Yong-qing Yan, Mi-cong Jin. Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry. Biomedical chromatography : BMC. 2009 May; 23(5):524-30. doi: 10.1002/bmc.1148. [PMID: 19016234]
  • V Vandenbroucke, A Bousquet-Melou, P De Backer, S Croubels. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. Journal of veterinary pharmacology and therapeutics. 2008 Oct; 31(5):437-45. doi: 10.1111/j.1365-2885.2008.00979.x. [PMID: 19000263]
  • Virginie Vandenbroucke, Noël Desmet, Patrick De Backer, Siska Croubels. Multi-residue analysis of eight anticoagulant rodenticides in animal plasma and liver using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 869(1-2):101-10. doi: 10.1016/j.jchromb.2008.05.011. [PMID: 18502701]
  • Simon Binks, Phil Davies. Case of the month: 'Oh! Drat!--A case of transcutaneous superwarfarin poisoning and its recurrent presentation'. Emergency medicine journal : EMJ. 2007 Apr; 24(4):307-8. doi: 10.1136/emj.2006.044925. [PMID: 17384395]
  • Philippe J Berny, Laurent Alves de Oliveira, Bernadette Videmann, Stéphanie Rossi. Assessment of ruminal degradation, oral bioavailability, and toxic effects of anticoagulant rodenticides in sheep. American journal of veterinary research. 2006 Feb; 67(2):363-71. doi: 10.2460/ajvr.67.2.363. [PMID: 16454646]
  • Barbara E Watt, Alex T Proudfoot, Sally M Bradberry, J Allister Vale. Anticoagulant rodenticides. Toxicological reviews. 2005; 24(4):259-69. doi: 10.2165/00139709-200524040-00005. [PMID: 16499407]
  • H A Mesban, E H Tayeb, A K Mourad, L K Younis, M A el Zaher, M T M Aly. Toxicology and histopathology of some rodenticides and palatable food items combinations on the common mice Mus musculus var. albus in Egypt. Communications in agricultural and applied biological sciences. 2003; 68(4 Pt B):771-87. doi: . [PMID: 15151313]
  • F Lagrange, A G Corniot, K Titier, R Bedry, F Pehourcq. Toxicological management of chlorophacinone poisoning. Acta clinica Belgica. 1999; 53 Suppl 1(?):13-6. doi: NULL. [PMID: 10216974]
  • E A Kuijpers, J den Hartigh, T J Savelkoul, F A de Wolff. A method for the simultaneous identification and quantitation of five superwarfarin rodenticides in human serum. Journal of analytical toxicology. 1995 Nov; 19(7):557-62. doi: 10.1093/jat/19.7.557. [PMID: 8577178]
  • P J Berny, T Buronfosse, G Lorgue. Anticoagulant poisoning in animals: a simple new high-performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of eight anticoagulant rodenticides in liver samples. Journal of analytical toxicology. 1995 Nov; 19(7):576-80. doi: 10.1093/jat/19.7.576. [PMID: 8577181]
  • P Mura, A Piriou, Y Papet, D Lochon, D Reiss. Rapid high-performance liquid chromatographic assay of chlorophacinone in human serum. Journal of analytical toxicology. 1992 May; 16(3):179-81. doi: 10.1093/jat/16.3.179. [PMID: 1522713]
  • C Burucoa, P Mura, R Robert, C Boinot, S Bouquet, A Piriou. Chlorophacinone intoxication. A biological and toxicological study. Journal of toxicology. Clinical toxicology. 1989; 27(1-2):79-89. doi: 10.3109/15563658909038571. [PMID: 2769823]
  • J J Vogel, P de Moerloose, C A Bouvier, J Gaspoz, P Riant. [Prolonged anticoagulation following chlorophacinone poisoning]. Schweizerische medizinische Wochenschrift. 1988 Dec; 118(50):1915-7. doi: NULL. [PMID: 3222685]
  • A Shlosberg, M N Egyed. Stability of prothrombin times in sheep dosed with natural and synthetic anticoagulants. Research in veterinary science. 1986 Mar; 40(2):141-3. doi: 10.1016/s0034-5288(18)30502-2. [PMID: 3704331]
  • L J Blus, C J Henny, R A Grove. Effects of pelletized anticoagulant rodenticides on California quail. Journal of wildlife diseases. 1985 Oct; 21(4):391-5. doi: 10.7589/0090-3558-21.4.391. [PMID: 4078974]
  • K Hunter. Reversed-phase ion-pair liquid chromatographic determination of chlorophacinone residues in animal tissues. Journal of chromatography. 1984 Sep; 299(2):405-14. doi: 10.1016/s0021-9673(01)97856-2. [PMID: 6501477]
  • R W Bullard, G Holguin, J E Peterson. Determination of chlorophacinone and diphenadione residues in biological materials. Journal of agricultural and food chemistry. 1975 Jan; 23(1):72-4. doi: 10.1021/jf60197a011. [PMID: 1173369]