Exact Mass: 263.1341

Exact Mass Matches: 263.1341

Found 500 metabolites which its exact mass value is equals to given mass value 263.1341, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Nortriptyline

methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine

C19H21N (263.1674)

Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as a drug metabolite, an antidepressant, an adrenergic uptake inhibitor, an analgesic, an antineoplastic agent and an apoptosis inducer. It is an organic tricyclic compound and a secondary amine. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene. Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions. Nortriptyline is a Tricyclic Antidepressant. Nortriptyline is a tricyclic antidepressant that is also used in smoking cessation. Nortriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute and chronic cholestatic liver injury. Nortriptyline is a natural product found in Senegalia berlandieri with data available. Nortriptyline is a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors. Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use). A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. See also: Nortriptyline Hydrochloride (active moiety of). Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use). An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents D049990 - Membrane Transport Modulators CONFIDENCE standard compound; EAWAG_UCHEM_ID 3692 Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N

Protriptyline

methyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine

C19H21N (263.1674)

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents D049990 - Membrane Transport Modulators

2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline

5-ethyl-2-methyl-4,4-diphenyl-3,4-dihydro-2H-pyrrole

C19H21N (263.1674)

2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline is a metabolite of methadone. Methadone (also known as Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon, Phy and many other names) is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive for use in patients with opioid dependency. It was developed in Germany in 1937. Although chemically unlike morphine or heroin, methadone acts on the same opioid receptors as these drugs, and thus has many of the same effects. (Wikipedia)

Dimepiperate

S-1-Methyl-1-phenylethyl piperidine 1-carbothioate

C15H21NOS (263.1344)

7-Mercaptoheptanoylthreonine

C11H21NO4S (263.1191)

Axisothiocyanate 3

C16H25NS (263.1708)

4-O-(beta-L-Araf)-cis-L-Hyp

4-O-(beta-L-Arabinofuranosyl)-(2S,4S)-4-hydroxyproline

C10H17NO7 (263.1005)

An O(4)-glycosyl-L-hydroxyproline that is cis-L-hydroxylproline glycosylated by a beta-L-Araf moiety.

Girinimbine

5,5,8-trimethyl-6-oxa-17-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1,3,7,9,11,13,15-heptaene

C18H17NO (263.131)

Girinimbine is a member of carbazoles. It has a role as a metabolite. Girinimbine is a natural product found in Clausena vestita, Murraya euchrestifolia, and other organisms with data available. Girinimbine is found in herbs and spices. Girinimbine is an alkaloid from the roots of Murraya koenigii (curry leaf tree A natural product found in Clausena harmandiana.

(E,E)-Lansamide I

(2E)-N-methyl-3-phenyl-N-[(Z)-2-phenylethenyl]prop-2-enamide

C18H17NO (263.131)

(E,E)-Lansamide I is found in fruits. (E,E)-Lansamide I is an alkaloid from the leaves and seeds of Clausena lansium (wampee

N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide

N-(Heptan-4-yl)-2H-1,3-benzodioxole-5-carboximidate

C15H21NO3 (263.1521)

N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")

Lansiumamide B

(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide

C18H17NO (263.131)

Lansiumamide B is found in fruits. Lansiumamide B is isolated from seeds of Clausena lansium (wampee). Isolated from seeds of Clausena lansium (wampee). Lansiumamide B is found in fruits.

demethylmaprotiline

3-{tetracyclo[6.6.2.0²,⁷.0⁹,¹⁴]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propan-1-amine

C19H21N (263.1674)

demethylmaprotiline is a metabolite of maprotiline. Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotilines fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. (Wikipedia)

desethylzaleplon

7-[3-(ethylamino)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile

C15H13N5 (263.1171)

desethylzaleplon is a metabolite of zaleplon. Zaleplon (marketed under the brand names Sonata and Starnoc) is a sedative/hypnotic, mainly used for insomnia. It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. In terms of adverse effects zaleplon appears to offer little improvement compared to both benzodiazepines and other non-benzodiazepine Z-drugs. Sonata (US) is manufactured by King Pharm. of Bristol, TN; Starnoc has been discontinued in Canada. (Wikipedia)

Creatine riboside

N-(N-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)carbamimidoyl)-N-methylglycine

C9H17N3O6 (263.1117)

Creatine riboside is a conjugate between creatine and ribose. It is a novel diagnostic marker for lung cancer that is elevated in the urine of non-small cell lung cancer subjects (PMID: 24736543). Creatine riboside may be a product of both high creatine levels within tumor cells and the characteristic high phosphate flux of cancer cells. Increased mutagenicity of creatine and ribose pyrolysis products in cooked foods has been reported, suggesting a functional role of creatine riboside in tumorigenesis (PMID: 24736543). Creatine riboside is likely not an enzyme-synthesized product as it can be formed spontaneously by mixing creatine with ribose. It can be synthesized in modestly high yields by reacting ribose and creatine in the presence of ammonium bicarbonate and heating the two compounds at 80°C for 10 minutes.

Didesethyl Chloroquine

N4-(7-chloroquinolin-4-yl)pentane-1,4-diamine

C14H18ClN3 (263.1189)

Boc-D-FMK

methyl 3-{[(tert-butoxy)carbonyl]amino}-5-fluoro-4-oxopentanoate

C11H18FNO5 (263.1169)

Gacyclidine

1-[2-methyl-1-(thiophen-2-yl)cyclohexyl]piperidine

C16H25NS (263.1708)

Melperone

1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one

C16H22FNO (263.1685)

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

Neplanocin A

5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

C11H13N5O3 (263.1018)

N(6)-L-Homocysteinyl-L-lysine

2-Amino-6-[(2-amino-4-sulfanylbutanoyl)amino]hexanoic acid

C10H21N3O3S (263.1304)

5-Amino-2-[(2-amino-3-carboxypropanoyl)oxyamino]pentanoic acid

5-amino-2-{[(2-amino-3-carboxypropanoyl)oxy]amino}pentanoic acid

C9H17N3O6 (263.1117)

2-cis-abscisate

5-(1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methylpenta-2,4-dienoic acid

C15H19O4 (263.1283)

2-cis-abscisate is practically insoluble (in water) and a weakly acidic compound (based on its pKa). 2-cis-abscisate can be found in a number of food items such as common wheat, lemon thyme, black raspberry, and acorn, which makes 2-cis-abscisate a potential biomarker for the consumption of these food products.

10alpha-Isothiocyanatoalloaromadendrane

C16H25NS (263.1708)

Axisothiocyanate 1

(1R,3aR,7aR)-Octahydro-1-[(1S)-1-isothiocyanato-2-methylpropyl]-3a-methyl-7-methylene-1H-indene

C16H25NS (263.1708)

Epipolasin A

(1aR,3aS,7S,7aS,7bR)-Decahydro-7-isothiocyanato-1,1,3a,7-tetramethyl-1H-cyclopropa[a]naphthalene

C16H25NS (263.1708)

1-Isothiocyanato-4-muurolene

C16H25NS (263.1708)

Axinythiocyanate A

C16H25NS (263.1708)

1-Isothiocyanatoaromadendrane

C16H25NS (263.1708)

7-isothiocyanato-7,8-dihydro-alpha-bisabolene