MELPERONE (BioDeep_00000275489)
代谢物信息卡片
MELPERONE
化学式: C16H22FNO (263.1685334)
中文名称: 美哌隆
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F
InChI: InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:93626
- KEGGdrug: D07309
- PubChem: 15387
- Metlin: METLIN96326
- DrugBank: DB09224
- ChEMBL: CHEMBL1531134
- CAS: 3575-80-2
- MoNA: FiehnHILIC002080
- MoNA: FiehnHILIC000508
- PMhub: MS000007856
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - M Kowar, A H Jacobs. [Altered orientation and aggressiveness in an 89-year-old woman].
Der Internist.
2018 01; 59(1):97-101. doi:
10.1007/s00108-017-0270-8. [PMID: 28653147] - William V Bobo, Karuna Jayathilake, Myung A Lee, Herbert Y Meltzer. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.
Human psychopharmacology.
2009 Jul; 24(5):415-22. doi:
10.1002/hup.1036. [PMID: 19551763] - Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
BMC psychiatry.
2008 Dec; 8(?):95. doi:
10.1186/1471-244x-8-95. [PMID: 19102734] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Morris B Goldman, Gordon Wood, Megan B Goldman, Michelle Gavin, Stacey Paul, Suhaila Zaheer, Ghazala Fayyaz, Ramani S Pilla. Diminished glucocorticoid negative feedback in polydipsic hyponatremic schizophrenic patients.
The Journal of clinical endocrinology and metabolism.
2007 Feb; 92(2):698-704. doi:
10.1210/jc.2006-1131. [PMID: 17118992] - Stéphane Bastianetto, Marc Danik, Françoise Mennicken, Sylvain Williams, Rémi Quirion. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
BMC neuroscience.
2006 Mar; 7(?):28. doi:
10.1186/1471-2202-7-28. [PMID: 16573831] - Manfred Uhr, Christian Namendorf, Markus T Grauer, Markus Rosenhagen, Martin Ebinger. P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.
Journal of psychopharmacology (Oxford, England).
2004 Dec; 18(4):509-15. doi:
10.1177/0269881104047278. [PMID: 15582917] - Tomiki Sumiyoshi, Karu Jayathilake, Herbert Y Meltzer. A comparison of two doses of melperone, an atypical antipsychotic drug, in the treatment of schizophrenia.
Schizophrenia research.
2003 Jul; 62(1-2):65-72. doi:
10.1016/s0920-9964(02)00351-1. [PMID: 12765745] - Carsten Kratzsch, Frank T Peters, Thomas Kraemer, Armin A Weber, Hans H Maurer. Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
Journal of mass spectrometry : JMS.
2003 Mar; 38(3):283-95. doi:
10.1002/jms.440. [PMID: 12644990] - M Grözinger, A Dragicevic, C Hiemke, M Shams, M J Müller, S Härtter. Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.
Pharmacopsychiatry.
2003 Jan; 36(1):3-6. doi:
10.1055/s-2003-38084. [PMID: 12649767] - H Y Meltzer, T Sumiyoshi, K Jayathilake. Melperone in the treatment of neuroleptic-resistant schizophrenia.
Psychiatry research.
2001 Dec; 105(3):201-9. doi:
10.1016/s0165-1781(01)00346-8. [PMID: 11814539] - L Rauser, J E Savage, H Y Meltzer, B L Roth. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.
The Journal of pharmacology and experimental therapeutics.
2001 Oct; 299(1):83-9. doi:
. [PMID: 11561066] - T Wobrock, B Schwaab, M Böhm, H J Schäfers, K Wanke, T Supprian. [Pharmacotherapeutical approaches to insomnia patients with cardiac diseases and after heart transplantation].
Zeitschrift fur Kardiologie.
2001 Oct; 90(10):717-28. doi:
10.1007/s003920170091. [PMID: 11757467] - S Stein, A Schmoldt, M Schulz. Fatal intoxication with melperone.
Forensic science international.
2000 Sep; 113(1-3):409-13. doi:
10.1016/s0379-0738(00)00201-2. [PMID: 10978656] - H Soygür, O Palaoğlu, N Altinörs, D Corapçioğlu, G Erdoğan, I H Ayhan. Melperone treatment in an organic delusional syndrome induced by hyperprolactinemia: a case report.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
1997 May; 7(2):161-3. doi:
10.1016/s0924-977x(96)00387-2. [PMID: 9169304] - U Klages, H Hippius, F Müller-Spahn. [Atypical neuroleptics, pharmacology and clinical importance].
Fortschritte der Neurologie-Psychiatrie.
1993 Nov; 61(11):390-8. doi:
10.1055/s-2007-999110. [PMID: 7903656] - L Bjerkenstedt. Melperone in the treatment of schizophrenia.
Acta psychiatrica Scandinavica. Supplementum.
1989; 352(?):35-9. doi:
10.1111/j.1600-0447.1989.tb06434.x. [PMID: 2479227] - H Y Meltzer, J I Koenig, J F Nash, G A Gudelsky. Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs.
Acta psychiatrica Scandinavica. Supplementum.
1989; 352(?):24-9. doi:
10.1111/j.1600-0447.1989.tb06432.x. [PMID: 2573238] - C Köppel, J Tenczer, K Ibe. Gas chromatographic-mass spectrometric study of urinary metabolism of melperone.
Journal of chromatography.
1988 May; 427(1):144-50. doi:
10.1016/0378-4347(88)80113-0. [PMID: 3410895] - S Aanderud, J Sundsfjord, J Aarbakke. Amiodarone inhibits the conversion of thyroxine to triiodothyronine in isolated rat hepatocytes.
Endocrinology.
1984 Oct; 115(4):1605-8. doi:
10.1210/endo-115-4-1605. [PMID: 6479103] - K Y Chan, R A Okerholm. Quantitative analysis of melperone in human plasma by gas chromatography--mass spectrometry--selected ion monitoring.
Journal of chromatography.
1983 May; 274(?):121-7. doi:
10.1016/s0378-4347(00)84415-1. [PMID: 6135699] - L Molander, L Borgström. Relationship between plasma concentration and arousal in normal subjects after single oral and parenteral doses of melperone, a butyrophenone neuroleptic.
Psychopharmacology.
1983; 79(2-3):111-4. doi:
10.1007/bf00427795. [PMID: 6133299] - L Molander, L Borgström. Sedative effects and prolactin response to single oral doses of melperone.
Psychopharmacology.
1983; 79(2-3):142-7. doi:
10.1007/bf00427801. [PMID: 6133301] - E S Platou, H Refsum, J P Amlie, K Landmark. Plasma levels and cardiac electrophysiological effects of melperone in the dog.
European journal of pharmacology.
1982 Aug; 82(1-2):1-7. doi:
10.1016/0014-2999(82)90545-3. [PMID: 7128676] - H Bergman, S Borg, B Högman, H Larsson, B Tengroth. The effect of melperon on ocular readaptation time, as assessed by a new recording technique.
Acta ophthalmologica.
1980 Aug; 58(4):632-8. doi:
10.1111/j.1755-3768.1980.tb08305.x. [PMID: 7211253] - L Bjerkenstedt, P Eneroth, C Härnryd, G Sedvall. Effects of melperone and thiothixene on prolactin levels in cerebrospinal fluid and plasma of psychotic women.
Archiv fur Psychiatrie und Nervenkrankheiten.
1977 Dec; 224(4):281-93. doi:
10.1007/bf00341611. [PMID: 343747]