Desmethylmaprotiline (BioDeep_00000408920)

   


代谢物信息卡片


Desmethylmaprotiline

化学式: C19H21N (263.16739060000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2(C3=CC=CC=C3C1C4=CC=CC=C42)CCCN
InChI: InChI=1S/C19H21N/c20-13-5-11-19-12-10-14(15-6-1-3-8-17(15)19)16-7-2-4-9-18(16)19/h1-4,6-9,14H,5,10-13,20H2

描述信息

同义名列表

1 个代谢物同义名

Desmethylmaprotiline



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • R Waschgler, M R Hubmann, A Conca, W Moll, P König. Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis. International journal of clinical pharmacology and therapeutics. 2002 Dec; 40(12):554-9. doi: 10.5414/cpp40554. [PMID: 12503813]
  • H J Kuss, S Sirch, D Y Zhao. Assay for maprotiline in human serum with improved sensitivity and selectivity. Journal of chromatography. B, Biomedical applications. 1994 Jun; 656(1):245-9. doi: 10.1016/0378-4347(94)00071-9. [PMID: 7952036]
  • K Miyake, H Fukuchi, T Kitaura, M Kimura, Y Kimura. Pharmacokinetic analysis of maprotiline and its demethylated metabolite in serum and brain of rats after acute and chronic oral administration of maprotiline. Journal of pharmaceutical sciences. 1992 Oct; 81(10):1032-7. doi: 10.1002/jps.2600811016. [PMID: 1432616]
  • K Miyake, H Fukuchi, T Kitaura, M Kimura, Y Kimura, T Nakahara. Pharmacokinetics of maprotiline and its demethylated metabolite in serum and specific brain regions of rats after acute and chronic administration of maprotiline. Journal of pharmaceutical sciences. 1991 Dec; 80(12):1114-8. doi: 10.1002/jps.2600801205. [PMID: 1815068]
  • R Drebit, G B Baker, W G Dewhurst. Determination of maprotiline and desmethylmaprotiline in plasma and urine by gas chromatography with nitrogen-phosphorus detection. Journal of chromatography. 1988 Nov; 432(?):334-9. doi: 10.1016/s0378-4347(00)80662-3. [PMID: 3220903]
  • P Baumann, P Bosshart, G Gabris, M Gastpar, L Koeb, B Woggon. Acetylation of maprotiline and desmethylmaprotiline in depressive patients phenotyped with sulfamidine, debrisoquine, and mephenytoin. Arzneimittel-Forschung. 1988 Feb; 38(2):292-6. doi: . [PMID: 3370079]
  • K Kurata, H Kido, M Hasegawa, M Inoue, N Yamaguchi. Serum levels of maprotiline and its adverse effects on depressed patients. The Japanese journal of psychiatry and neurology. 1987 Jun; 41(2):247-54. doi: 10.1111/j.1440-1819.1987.tb00408.x. [PMID: 3437612]
  • K Kurata, H Kido, M Hasegawa, M Inoue, N Yamaguchi. A comparison of maprotiline and its desmethylated metabolite serum concentrations in outpatients and inpatients. The Japanese journal of psychiatry and neurology. 1987 Jun; 41(2):255-60. doi: 10.1111/j.1440-1819.1987.tb00409.x. [PMID: 3437613]
  • P D Hrdina, Y D Lapierre. Plasma levels of maprotiline and zimelidine and their relationship to clinical response in depressed patients. Therapeutic drug monitoring. 1986; 8(4):400-6. doi: 10.1097/00007691-198612000-00003. [PMID: 2950616]
  • N Yufu, M Itoh, A Notomi, H Nakao. Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography. Folia psychiatrica et neurologica japonica. 1984; 38(1):57-64. doi: 10.1111/j.1440-1819.1984.tb00355.x. [PMID: 6537393]
  • S P Jindal, T Lutz, P Vestergaard. GLC-mass spectrometric determination of maprotiline and its major metabolite using stable isotope-labeled analog as internal standard. Journal of pharmaceutical sciences. 1980 Jun; 69(6):684-7. doi: 10.1002/jps.2600690619. [PMID: 7205583]