Girinimbine (BioDeep_00000017664)

 

Secondary id: BioDeep_00000616177

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


5,5,8-trimethyl-6-oxa-17-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1,3,7,9,11,13,15-heptaene

化学式: C18H17NO (263.1310072)
中文名称: 吉九里香碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.65%

分子结构信息

SMILES: CC1=C2OC(C)(C)C=CC2=C2NC3=CC=CC=C3C2=C1
InChI: InChI=1S/C18H17NO/c1-11-10-14-12-6-4-5-7-15(12)19-16(14)13-8-9-18(2,3)20-17(11)13/h4-10,19H,1-3H3

描述信息

Girinimbine is a member of carbazoles. It has a role as a metabolite.
Girinimbine is a natural product found in Clausena vestita, Murraya euchrestifolia, and other organisms with data available.
Girinimbine is found in herbs and spices. Girinimbine is an alkaloid from the roots of Murraya koenigii (curry leaf tree
A natural product found in Clausena harmandiana.

同义名列表

16 个代谢物同义名

5,5,8-trimethyl-6-oxa-17-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1,3,7,9,11,13,15-heptaene; 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole, 9CI; Pyrano(3,2-a)carbazole, 3,11-dihydro-3,3,5-trimethyl-; Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl-; 3,11-Dihydro-3,3,5-trimethyl-Pyrano(3,2-a)carbazole; 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole; 3,3,5-trimethyl-3,11-dihydropyrano[3,2-a]carbazole; 3,3,5-trimethyl-3H,11H-pyrano[3,2-a]carbazole; 3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole; GAEQWKVGMHUUKO-UHFFFAOYSA-N; MEGxp0_000255; ACon1_001999; Girinimbine; girinimbin; NSC 94932; C18H17NO



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Syam Mohan, Yahya Hasan Hobani, Emad Shaheen, Alaa Sayed Abou-Elhamd, Aymen Abdelhaleem, Hassan A Alhazmi, Siddig Ibrahim Abdelwahab. Girinimbine from curry leaves promotes gastro protection against ethanol induced peptic ulcers and improves healing via regulation of anti-inflammatory and antioxidant mechanisms. Food & function. 2020 Apr; 11(4):3493-3505. doi: 10.1039/d0fo00053a. [PMID: 32248216]
  • Jules Lobe Songue, Kouam, Etienne Dongo, Theophile Ngando Mpondo, Robert L White. Chemical constituents from stem bark and roots of Clausena anisata. Molecules (Basel, Switzerland). 2012 Nov; 17(11):13673-86. doi: 10.3390/molecules171113673. [PMID: 23169265]
  • Wisanu Maneerat, Thunwadee Ritthiwigrom, Sarot Cheenpracha, Trinop Promgool, Kulsiri Yossathera, Suwanna Deachathai, Wong Phakhodee, Surat Laphookhieo. Bioactive carbazole alkaloids from Clausena wallichii roots. Journal of natural products. 2012 Apr; 75(4):741-6. doi: 10.1021/np3000365. [PMID: 22482432]
  • Yih Yih Kok, Lim Yang Mooi, Kartini Ahmad, Mohd Aspollah Sukari, Nashriyah Mat, Mawardi Rahmani, Abdul Manaf Ali. Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S. Molecules (Basel, Switzerland). 2012 Apr; 17(4):4651-60. doi: 10.3390/molecules17044651. [PMID: 22522395]
  • Kooi-Mow Sim, Hui-Ming Teh. A new carbazole alkaloid from the leaves of Malayan Murraya koenigii. Journal of Asian natural products research. 2011 Oct; 13(10):972-5. doi: 10.1080/10286020.2011.602970. [PMID: 21972815]
  • Suvitha Syam, Ahmad Bustamam Abdul, Mohd Aspollah Sukari, Syam Mohan, Siddig Ibrahim Abdelwahab, Tang Sook Wah. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules (Basel, Switzerland). 2011 Aug; 16(8):7155-70. doi: 10.3390/molecules16087155. [PMID: 21862957]
  • Uraiwan Songsiang, Tula Thongthoom, Chantana Boonyarat, Chavi Yenjai. Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. Journal of natural products. 2011 Feb; 74(2):208-12. doi: 10.1021/np100654m. [PMID: 21302964]
  • L Zou, C Yang, H Zhang. [Study on carbazole alkaloids of Murraya microphylla]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 1999 Sep; 22(9):458-60. doi: ". [PMID: 12571921]
  • F N Ko, Y S Lee, T S Wu, C M Teng. Inhibition of cyclooxygenase activity and increase in platelet cyclic AMP by girinimbine, isolated from Murraya euchrestifolia. Biochemical pharmacology. 1994 Jul; 48(2):353-60. doi: 10.1016/0006-2952(94)90107-4. [PMID: 8053931]