Testosterone (BioDeep_00000001450)

 

Secondary id: BioDeep_00000398239, BioDeep_00000860372

human metabolite Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

化学式: C19H28O2 (288.2089188)
中文名称: 睾酮
谱图信息: 最多检出来源 Viridiplantae(plant) 0.43%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Testosterone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/testosterone (retrieved 2024-11-23) (BioDeep RN: BioDeep_00000001450). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2CCC2(C)C(O)CCC12
InChI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

描述信息

Testosterone is the primary male sex hormone and anabolic steroid from the androstane class of steroids. It is the most important androgen in potency and quantity for vertebrates. In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. In addition, testosterone is involved in health and well-being, and the prevention of osteoporosis. Testosterone exerts its action through binding to and activation of the androgen receptor. In mammals, testosterone is metabolized mainly in the liver. Approximately 50\\% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases. An additional 40\\% of testosterone is metabolized in equal proportions into the 17-ketosteroids androsterone and etiocholanolone via the combined actions of 5alpha- and 5beta-reductases, 3alpha-hydroxysteroid dehydrogenase, and 17beta-HSD. Like other steroid hormones, testosterone is derived from cholesterol. The first step in the biosynthesis of testosterone involves the oxidative cleavage of the side-chain of cholesterol by the cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) to give pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17alpha-hydroxylase/17,20-lyase) enzyme to yield a variety of C19 steroids. In addition, the 3beta-hydroxyl group is oxidized by 3beta-hydroxysteroid dehydrogenase to produce androstenedione. In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17beta-hydroxysteroid hydrogenase to yield testosterone. Testosterone is synthesized and released by the Leydig cells in the testes that lie between the tubules and comprise less than 5\\% of the total testicular volume. Testosterone diffuses into the seminiferous tubules where it is essential for maintaining spermatogenesis. Some testosterone binds to an androgen-binding protein (ABP) that is produced by the Sertoli cells and is homologous to the sex-hormone binding globulin that transports testosterone in the general circulation. The ABP carries testosterone in the testicular fluid where it maintains the activity of the accessory sex glands and may also help to retain testosterone within the tubule and bind excess free hormone. Some testosterone is converted to estradiol by Sertoli cell-derived aromatase enzyme. Leydig cell steroidogenesis is controlled primarily by luteinizing hormone with negative feedback of testosterone on the hypothalamic-pituitary axis. The requirement of spermatogenesis for high local concentrations of testosterone means that loss of androgen production is likely to be accompanied by loss of spermatogenesis. Indeed, if testicular androgen production is inhibited by the administration of exogenous androgens then spermatogenesis ceases. This is the basis of using exogenous testosterone as a male contraceptive. The largest amounts of testosterone (>95\\%) are produced by the testes in men, while the adrenal glands account for most of the remainder. Testosterone is also synthesized in far smaller total quantities in women by the adrenal glands, thecal cells of the ovaries, and, during pregnancy, by the placenta. Testosterone levels fall by about 1\\% each year in men. Therefore, with increasing longevity and the aging of the population, the number of older men with testosterone deficiency will increase substantially over the next several decades. Serum testosterone levels decrease progressively in aging men, but the rate and magnitude of decrease vary considerably. Approximately 1\\% of healthy young men have total serum testosterone levels below normal; in contrast, approximately 20\\% of healthy men over age 60 years have serum testosterone levels below normal. (PMID: 17904450, 17875487).
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03B - Androgens > G03BA - 3-oxoandrosten (4) derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D000728 - Androgens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

131 个代谢物同义名

17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one; (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; Auxilium pharmaceuticals inc. brand OF testosterone; rac-17b-Hydroxy-(9b,10a)androst-4-en-3-one; 17-beta-Hydroxy-8 alpha-4-androsten-3-one; 17 beta Hydroxy 8 alpha 4 androsten 3 one; SmithKline beecham brand OF testosterone; 17b-Hydroxy-(8a,10a)-androst-4-en-3-one; rac-17b-Hydroxy-(8a)-androst-4-en-3-one; rac-17b-Hydroxy-(13a)androst-4-en-3-one; 17b-Hydroxy-(9b,10a)-androst-4-en-3-one; GlaxoSmithKline brand OF testosterone; 17b-Hydroxy-(13a)-androst-4-en-3-one; 17b-Hydroxy-(10a)-androst-4-en-3-one; 17a-Hydroxy-(13a)-androst-4-en-3-one; 17b-Hydroxy-(8a)-androst-4-en-3-one; (17b)-17-Hydroxy-androst-4-en-3-one; 17b-Hydroxy-(9b)-androst-4-en-3-one; 17a-Hydroxy-14b-androst-4-en-3-one; 17b-Hydroxy-13a-androst-4-en-3-one; 17β-hydroxyandrost-4-en-3-one; rac-17b-Hydroxy-androst-4-en-3-one; 17a-Hydroxy-13a-androst-4-en-3-one; 17b-Hydroxy-8a-androst-4-en-3-one; 17 beta Hydroxy 4 androsten 3 one; AstraZeneca brand OF testosterone; 17-beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-4-androsten-3-one; Schering brand OF testosterone; Faulding brand OF testosterone; 17b-Hydroxy-androst-4-en-3-one; 17b-Hydroxy-D4-androsten-3-one; 17a-Hydroxy-androst-4-en-3-one; 17b-Hydroxyandrost-4-ene-3-one; Pasadena brand OF testosterone; Dr. kade brand OF testosterone; 17-Hydroxy-androst-4-en-3-one; 17b-Hydroxy-androst-4-en-3-ON; Paladin brand OF testosterone; Ferring brand OF testosterone; 17b-Hydroxy-4-androsten-3-one; 17b-Hydroxyandrost-4-en-3-one; 17-Hydroxy-D4-androsten-3-one; 17Β-hydroxy-4-androsten-3-one; Unimed brand OF testosterone; Bartor brand OF testosterone; Solvay brand OF testosterone; Watson brand OF testosterone; 4-Androsten-17beta-ol-3-one; Ortho brand OF testosterone; Hauck brand OF testosterone; Ulmer brand OF testosterone; CEPA brand OF testosterone; Androst-4-ene-17b-ol-3-one; Androst-4-en-17b-ol-3-one; Percutacrine androgenique; D4-Androsten-17b-ol-3-one; 4-Androsten-17b-ol-3-one; 4-Androsten-17β-ol-3-one; 4-Androsten-3-one-17b-ol; (+-)-8-Iso-testosterone; (+-)-Retrotestosterone; Testosterone sulfate; 9b,10a-Testosterone; Testoviron schering; 13-Iso-testosterone; Geno-cristaux gremy; 8-Iso-testosterone; 8 Isotestosterone; Retrotestosterone; 8-Isotestosterone; (+-)-Testosterone; 17b-Testosterone; Testiculosterone; (+)-Testosterone; 9b-Testosterone; Lumitestosteron; Epitestosteron; Testosteronum; Sustason 250; Cristerona T; Testosterona; Testosteroid; Testoviron T; Testosterone; Testopropon; Homosterone; Testosteron; Virosterone; Primoteston; Testandrone; Synandrol F; Orquisteron; Andropatch; Mertestate; Homosteron; Androderm; Neotestis; Sustanone; Testobase; Histerone; Tostrelle; Testoderm; Testolent; Perandren; Primotest; Virormone; Sterotate; Testro aq; Oreton F; Sustanon; Testopel; Testrone; Testolin; Andrusol; Testogel; Andronaq; Androlin; Androtop; Androgel; Tostrex; Relibra; Viatrel; Testryl; Striant; Axiron; Teslen; Oreton; Testim; Testosterone; Testosterone



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(10)

BioCyc(3)

PlantCyc(0)

代谢反应

195 个相关的代谢反应过程信息。

Reactome(163)

BioCyc(9)

WikiPathways(5)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(18)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • V V Sathibabu Uddandrao, Seshathri Eraniappan, Asokan Balakrishnan Ramajayam, Sengottuvelu Singaravel, Anitha Roy, Brahma Naidu Parim, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar. Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation. Systems biology in reproductive medicine. 2024 Dec; 70(1):20-37. doi: 10.1080/19396368.2024.2306403. [PMID: 38323592]
  • Shedrach C Kanu, Fidelis E Ejezie, Chioma S Ejezie, Chinedum O Eleazu. Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats. Journal of ethnopharmacology. 2024 Sep; 331(?):118301. doi: 10.1016/j.jep.2024.118301. [PMID: 38735419]
  • Ahmed M E Shipa, Khaled A Kahilo, Samir A Elshazly, Ehab S Taher, Nasr E Nasr, Badriyah S Alotaibi, Essam A Almadaly, Mona Assas, Walied Abdo, Tarek K Abouzed, Abdulati Elsanusi Salem, Damla Kirci, Hesham R El-Seedi, Mohamed S Refaey, Nermin I Rizk, Mustafa Shukry, Doaa A Dorghamm. Protective effect of Petroselinum crispum methanolic extract against acrylamide-induced reproductive toxicity in male rats through NF-ĸB, kinesin, steroidogenesis pathways. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108586. doi: 10.1016/j.reprotox.2024.108586. [PMID: 38614435]
  • Waseem Ali, Uzma Khatyan, Jian Sun, Abdulrahman Alasmari, Mohammad Y Alshahrani, Izhar Hyder Qazi, Tao Wang, Zongping Liu, Hui Zou. Mitigating effect of pomegranate peel extract against the furan induced testicular injury by apoptosis, steroidogenic enzymes and oxidative stress. Chemosphere. 2024 Jun; 358(?):142086. doi: 10.1016/j.chemosphere.2024.142086. [PMID: 38670510]
  • Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li. Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells. Ecotoxicology and environmental safety. 2024 Jun; 277(?):116394. doi: 10.1016/j.ecoenv.2024.116394. [PMID: 38663197]
  • Mengyu Zhang, Jiankang Zhang, Yunzhi Cui, Zengshu Xing. Predictive power of lipid-related indicators for testosterone deficiency: a comparative analysis, NHANES 2011-2016. International urology and nephrology. 2024 Jun; 56(6):1825-1833. doi: 10.1007/s11255-023-03935-0. [PMID: 38280934]
  • Ogechukwu E Ezim, Joy Nyeche, Chisom E Nebeolisa, Chuka D Belonwu, Sunny O Abarikwu. Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats. Toxicology and industrial health. 2024 Jun; 40(6):323-336. doi: 10.1177/07482337241245154. [PMID: 38597120]
  • Thomas M Campbell, Erin K Campbell, Eva Culakova, Lisa M Blanchard, Nellie Wixom, Joseph J Guido, James Fetten, Alissa Huston, Michelle Shayne, Michelle C Janelsins, Karen M Mustian, Richard G Moore, Luke J Peppone. A whole-food, plant-based randomized controlled trial in metastatic breast cancer: weight, cardiometabolic, and hormonal outcomes. Breast cancer research and treatment. 2024 Jun; 205(2):257-266. doi: 10.1007/s10549-024-07266-1. [PMID: 38446316]
  • Young-Jin Choi, Nishala Erandi Wedamulla, Seok-Hee Kim, Mirae Oh, Kang Sik Seo, Jeong Su Han, Eun Joo Lee, Young Ho Park, Young Jin Park, Eun-Kyung Kim. Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/HO-1 Activation. Journal of microbiology and biotechnology. 2024 May; 34(5):1059-1072. doi: 10.4014/jmb.2308.08053. [PMID: 37994101]
  • Ivana Regina da Costa, Débora Hipólito Quadreli, Lucas Marcelo Meira da Silva, Fábio Goulart de Andrade, Glaura Scantamburlo Alves Fernandes. Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period. Toxicology. 2024 May; 504(?):153789. doi: 10.1016/j.tox.2024.153789. [PMID: 38522820]
  • Wijden Niama, Samia Ben Saïd, Mohamed Aroua, Sihem Amiri, Hnia Chograni, Christelle Ramé, Kahena Bouzid, Ahlem Bartakiz, Pascal Froment, Joelle Dupont, Mokhtar Mahouachi. Oral supplementation with Scabiosa artropurperea L. aqueous extract improves the in vivo sexual behaviour, sperm quality and androgen level in rams. Reproduction in domestic animals = Zuchthygiene. 2024 May; 59(5):e14569. doi: 10.1111/rda.14569. [PMID: 38715435]
  • Seong Min Lee, Sang Mok Lee, Jungbin Song. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081189. [PMID: 38674879]
  • Hang Ge, Hui Chang, Yu Wang, Jing Cong, Yang Liu, Bei Zhang, Xiaoke Wu. Establishment and validation of a nomogram model for predicting ovulation in the PCOS women. Medicine. 2024 Apr; 103(14):e37733. doi: 10.1097/md.0000000000037733. [PMID: 38579058]
  • Mohamed H Elashal, Aida A Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A M Khalifa, Badr Aldahmash, Hesham R El-Seedi, Bishoy El-Aarag. Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression. Reproductive toxicology (Elmsford, N.Y.). 2024 Apr; 125(?):108570. doi: 10.1016/j.reprotox.2024.108570. [PMID: 38484946]
  • Yahya S Alqahtani, Vijay R Chidrawar, Shruti Shiromwar, Sudarshan Singh, Rahul Maheshwari, Havagiray Chitme, Naresh Babu Chilamakuru, Popat Mohite, Ahmed M Aljameeli, Masood Medleri Khateeb. A multi-modal approach to investigate Desmodium gangeticum's influence on stress-induced male infertility: In vivo, in vitro, and in silico assessments. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116358. doi: 10.1016/j.biopha.2024.116358. [PMID: 38430634]
  • Jan Gebauer, Nikola Hodkovicova, Kristina Tosnerova, Kristyna Skoupa, Andrej Batik, Iva Bartejsova, Michaela Charvatova, Lenka Leva, Rea Jarosova, Zbysek Sladek, Martin Faldyna, Kamil Stastny. Anabolic steroids induced changes at the level of protein expression: Effects of prolonged administration of testosterone and nandrolone to pigs. Environmental toxicology and pharmacology. 2024 Apr; 107(?):104422. doi: 10.1016/j.etap.2024.104422. [PMID: 38521435]
  • Samet Tekin, Emin Sengul, Serkan Yildirim, Emrah Hicazi Aksu, İsmail Bolat, Burak Çınar, Azizeh Shadidizaji, Fikret Çelebi, Mohamad Warda. Molecular insights into the antioxidative and anti-inflammatory effects of P-coumaric acid against bisphenol A-induced testicular injury: In vivo and in silico studies. Reproductive toxicology (Elmsford, N.Y.). 2024 Apr; 125(?):108579. doi: 10.1016/j.reprotox.2024.108579. [PMID: 38513920]
  • Yisheng Zhang, Liu Yang, Shan Xue, Yichang Zhang, Zihan Li, Min Zhang, Guoyin Kai, Juan Li. Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells. Journal of cellular and molecular medicine. 2024 Apr; 28(8):e18303. doi: 10.1111/jcmm.18303. [PMID: 38613362]
  • Ségolène Delaitre, Marcel E Visser, Kees van Oers, Samuel P Caro. Odours of caterpillar-infested trees increase testosterone concentrations in male great tits. Hormones and behavior. 2024 Apr; 160(?):105491. doi: 10.1016/j.yhbeh.2024.105491. [PMID: 38340412]
  • Feilan Xuan, Yuefang Ren, Jiali Lu, Weimei Zhou, Ruiying Jin, Aixue Chen, Yongju Ye. CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome. Molecular reproduction and development. 2024 Apr; 91(4):e23741. doi: 10.1002/mrd.23741. [PMID: 38616716]
  • Qian Xu, Hong Shen, Yifan Zhu, Junlei Zhang, Zhongmei Shen, Jianming Jiang, Jie Zhou. Causal effects of genetically predicted testosterone on Alzheimer's disease: a two-sample mendelian randomization study. Acta neurologica Belgica. 2024 Apr; 124(2):591-601. doi: 10.1007/s13760-023-02426-4. [PMID: 38007406]
  • Jing-Yi Jia, Guang-Hui Chen, Ting-Ting Shu, Qi-Yong Lou, Xia Jin, Jiang-Yan He, Wu-Han Xiao, Gang Zhai, Zhan Yin. Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Zoological research. 2024 Mar; 45(2):355-366. doi: 10.24272/j.issn.2095-8137.2023.324. [PMID: 38485505]
  • Nadia Saadat, Brooke Pallas, Joseph Ciarelli, Arpita Kalla Vyas, Vasantha Padmanabhan. Gestational testosterone excess early to mid-pregnancy disrupts maternal lipid homeostasis and activates biosynthesis of phosphoinositides and phosphatidylethanolamines in sheep. Scientific reports. 2024 03; 14(1):6230. doi: 10.1038/s41598-024-56886-6. [PMID: 38486090]
  • Cheng-Qi Zhang, Shuang-Shuang Li, Bo Hu, Li-Wen Xu, Jia-Jia Liu, Ya-Jie Sun, Xue Bai. Effect of GnRH Active Immunisation on Reproductive Performance of Male Sprague Dawley Rats. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063193. [PMID: 38542167]
  • Lu Lu, Cai-Yu Lian, Yan-Ting Lv, Shu-Hui Zhang, Long Wang, Lin Wang. Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells. The Science of the total environment. 2024 Mar; 914(?):169927. doi: 10.1016/j.scitotenv.2024.169927. [PMID: 38199345]
  • Mai Takehara, Mitsuki Kyakuno, Kazuko Okamoto, Ichiro Tazawa, Nobuaki Furuno, Megumi Furumitsu, Kazuyoshi Ukena, Takuya Imamura, Takashi Takeuchi, Toshinori Hayashi. Amphibian newts as experimental models for studying weight gain after castration. Endocrine journal. 2024 Feb; 71(2):181-191. doi: 10.1507/endocrj.ej23-0207. [PMID: 38220202]
  • Kaiyue Zhang, Chunnan Li, Xueqin Feng, Nanxi Zhang, Xiaochen Gao, Guangfu Lv, Jiaming Shen, Peitong Wu, Jingwei Lv, Jiaming Sun. Integrated cell metabolomics and network pharmacology approach deciphers the anti-testosterone deficiency mechanisms of Bushen Zhuanggu Tang. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115919. doi: 10.1016/j.jpba.2023.115919. [PMID: 38134707]
  • Nanhui Chen, Zengjun Wang, Ming Chen, Qi Ma, Yi He, Yujie Wang, Xin Li, Mingxing Qiu, Lei Shi, Shaoxing Zhu, Qun Xie, Xiuheng Liu, Benkang Shi, Guowen Lin, Weizhong Yang, Yongbin Liao, Haibin Zhang, Shusheng Wang, Jiexian Li, Shaogang Wang, Lijun Dong, Hui Chen, Jiaju Lu, Yongyi Cheng, Xiaoping Zhang, Lulin Ma, Liqun Zhou, He Wang, Shen Li, Dingwei Ye. Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer. Cancer biology & medicine. 2024 02; 20(12):. doi: 10.20892/j.issn.2095-3941.2023.0335. [PMID: 38318809]
  • Zihan Li, Chengshan Zhu, Cong Yin, Heyu Li, Yimei Liu, Juan Li. Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on leydig cells. Journal of ethnopharmacology. 2024 Feb; ?(?):117817. doi: 10.1016/j.jep.2024.117817. [PMID: 38316217]
  • Xianglin Chen, Shangyue Yang, Biran Zhu, Mengyuan Zhang, Na Zheng, Jianghuan Hua, Ruiwen Li, Jian Han, Lihua Yang, Bingsheng Zhou. Effects of environmentally relevant concentrations of niclosamide on lipid metabolism and steroid hormone synthesis in adult female zebrafish. The Science of the total environment. 2024 Feb; 910(?):168737. doi: 10.1016/j.scitotenv.2023.168737. [PMID: 37992841]
  • Özge Besci, Yağmur Damla Akçura, Kübra Yüksek Acinikli, Gözde Akın Kağızmanlı, Korcan Demir, Ece Böber, Mustafa Kır, Ayhan Abacı. Aromatase Inhibitors May Increase the Risk of Cardiometabolic Complications in Adolescent Boys. Pediatric cardiology. 2024 Feb; 45(2):228-239. doi: 10.1007/s00246-023-03260-4. [PMID: 37544952]
  • Supakorn Authaida, Vibuntita Chankitisakul, Ruthaiporn Ratchamak, Jutarat Pimpa, Thirawat Koedkanmark, Wuttigrai Boonkum, Jaruwan Khonmee, Sarunya Tuntiyasawasdikul. The effect of Thai ginger (Kaempferia parviflora) extract orally administration on sperm production, semen preservation, and fertility in Thai native chickens under heat stress. Poultry science. 2024 Feb; 103(2):103372. doi: 10.1016/j.psj.2023.103372. [PMID: 38160614]
  • Amina Essawy, Shreen Matar, Nema Mohamed, Wessam Abdel-Wahab, Heba Abdou. Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Environmental science and pollution research international. 2024 Feb; 31(10):15065-15077. doi: 10.1007/s11356-024-32047-0. [PMID: 38286926]
  • Ali Akbar, Muhammad Umar Ijaz. Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics-instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment. Environmental science and pollution research international. 2024 Feb; 31(6):9031-9044. doi: 10.1007/s11356-023-31662-7. [PMID: 38182957]
  • Rui-Rong Zheng, Qian-Xi Ouyang, Zi-Yao Liu, Lin-Nan Li, Li Yang, Zheng-Tao Wang. [Natural 5α-reductase inhibitors in treatment of benign prostatic hyperplasia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):858-867. doi: 10.19540/j.cnki.cjcmm.20231113.601. [PMID: 38621893]
  • Shashank Tripathi, Shweta Maurya, Ajit Singh. Adropin, a novel hepatokine: localization and expression during postnatal development and its impact on testicular functions of pre-pubertal mice. Cell and tissue research. 2024 Feb; 395(2):171-187. doi: 10.1007/s00441-023-03852-9. [PMID: 38087073]
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  • Xinguang Sun, Yingfei Li, Juan Li, Haizhen Liang, Jie Zhang, Xiaojuan Chen, Qi Li, Xu Pang, Qianzhi Ding, Juan Song, Baolin Guo, Baiping Ma. Bioactive metabolites reveal the therapeutic consistency of epimedii folium from multi-plant sources for the treatment of kidney-yang deficiency. Journal of ethnopharmacology. 2024 Jan; 319(Pt 2):117215. doi: 10.1016/j.jep.2023.117215. [PMID: 37774896]
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