Normorphine (BioDeep_00001873787)

Main id: BioDeep_00000002572

 

natural product


代谢物信息卡片


Normorphine

化学式: C16H17NO3 (271.1208)
中文名称: 去甲吗啡
谱图信息: 最多检出来源 Homo sapiens(urine) 73.68%

分子结构信息

SMILES: C1CNC2CC3=C4C15C2C=CC(C5OC4=C(C=C3)O)O
InChI: InChI=1S/C16H17NO3/c18-11-3-1-8-7-10-9-2-4-12(19)15-16(9,5-6-17-10)13(8)14(11)20-15/h1-4,9-10,12,15,17-19H,5-7H2/t9-,10+,12-,15-,16-/m0/s1

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist

同义名列表

3 个代谢物同义名

Normorphine; Normorphine; Normorphine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, CA1, CNR1, CYP2C8, CYP2D6, CYP3A4, MME, PGP, POMC, SLC6A3, TRIM13
Endoplasmic reticulum membrane 5 CYP19A1, CYP2C8, CYP2D6, CYP3A4, TRIM13
cytosol 2 CA1, PRF1
dendrite 3 MME, OPRM1, PDYN
trans-Golgi network 1 MME
Cell membrane 7 ABCB1, CNR1, MME, OPRD1, OPRM1, PRF1, SLC6A3
Cell projection, axon 3 CNR1, OPRM1, SLC6A3
Multi-pass membrane protein 7 ABCB1, CNR1, CYP19A1, OPRD1, OPRM1, PRF1, SLC6A3
Synapse 4 MME, OPRM1, PDYN, TAC1
cell surface 4 ABCB1, MME, SLC6A3, TNR
glutamatergic synapse 2 CNR1, TNR
Golgi apparatus 1 OPRM1
growth cone 1 CNR1
neuronal cell body 4 MME, PDYN, SLC6A3, TAC1
presynaptic membrane 3 CNR1, OPRD1, SLC6A3
synaptic vesicle 1 MME
Presynapse 2 CNR1, MME
endosome 1 OPRM1
plasma membrane 9 ABCB1, CNR1, CYP2C8, MME, OPRD1, OPRM1, PDYN, PRF1, SLC6A3
synaptic vesicle membrane 1 OPRD1
Membrane 9 ABCB1, CYP19A1, CYP2D6, CYP3A4, MME, OPRD1, OPRM1, PRF1, SLC6A3
apical plasma membrane 1 ABCB1
axon 5 CNR1, MME, OPRM1, SLC6A3, TAC1
brush border 1 MME
extracellular exosome 3 ABCB1, CA1, MME
endoplasmic reticulum 3 CYP19A1, CYP2D6, OPRM1
extracellular space 4 IL4, POMC, TAC1, TNR
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 1 CYP2D6
intracellular membrane-bounded organelle 3 CYP2C8, CYP2D6, CYP3A4
Microsome membrane 3 CYP19A1, CYP2D6, CYP3A4
Secreted 4 IL4, PDYN, POMC, PRF1
extracellular region 6 IL4, PDYN, POMC, PRF1, TAC1, TNR
Mitochondrion outer membrane 1 CNR1
Single-pass membrane protein 2 CYP2D6, TRIM13
mitochondrial outer membrane 1 CNR1
hippocampal mossy fiber to CA3 synapse 1 PDYN
neuronal cell body membrane 1 SLC6A3
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 CNR1
perikaryon 1 OPRM1
cytoplasmic vesicle 1 MME
Early endosome 1 MME
Single-pass type II membrane protein 1 MME
postsynaptic membrane 1 SLC6A3
Apical cell membrane 1 ABCB1
Membrane raft 4 CNR1, MME, SLC6A3, TNR
focal adhesion 1 MME
GABA-ergic synapse 1 CNR1
flotillin complex 1 SLC6A3
collagen-containing extracellular matrix 1 TNR
secretory granule 1 POMC
Cell projection, neuron projection 1 SLC6A3
neuron projection 3 OPRD1, OPRM1, SLC6A3
endosome lumen 1 PRF1
Cell projection, dendrite 1 OPRM1
secretory granule lumen 1 POMC
endoplasmic reticulum quality control compartment 1 TRIM13
secretory granule membrane 1 MME
axon terminus 3 OPRD1, PDYN, SLC6A3
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRF1
perineuronal net 1 TNR
neuronal dense core vesicle 2 OPRD1, PDYN
perinuclear endoplasmic reticulum 1 TRIM13
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 1 SLC6A3
dendrite membrane 1 OPRD1
neuron projection terminus 1 MME
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
tenascin complex 1 TNR
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1


文献列表

  • David Sartori, Tamorah Lewis, Autumn Breaud, William Clarke. The development of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of morphine, morphine-3-β-glucuronide, morphine-6-β-glucuronide, hydromorphone, and normorphine in serum. Clinical biochemistry. 2015 Dec; 48(18):1283-90. doi: 10.1016/j.clinbiochem.2015.05.023. [PMID: 26118474]
  • Nerea Ferreirós, Sebastian Dresen, Maren Hermanns-Clausen, Volker Auwaerter, Annette Thierauf, Christoph Müller, Roland Hentschel, Rainer Trittler, Gisela Skopp, Wolfgang Weinmann. Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations. International journal of legal medicine. 2009 Sep; 123(5):387-94. doi: 10.1007/s00414-009-0340-0. [PMID: 19350261]
  • Yi-Hui Lin, Jui-Feng Chiang, Maw-Rong Lee, Ren-Jye Lee, Wei-Kung Ko, Shou-Mei Wu. Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for analysis of morphine and its four metabolites in human urine. Electrophoresis. 2008 Jun; 29(11):2340-7. doi: 10.1002/elps.200700825. [PMID: 18435499]
  • O Dale, J Thoner, T Nilsen, T Tveita, P C Borchgrevink, P Klepstad. Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery. European journal of clinical pharmacology. 2007 Sep; 63(9):837-42. doi: 10.1007/s00228-007-0329-x. [PMID: 17619868]
  • Ahmed Alnajjar, Jared A Butcher, Bruce McCord. Determination of multiple drugs of abuse in human urine using capillary electrophoresis with fluorescence detection. Electrophoresis. 2004 Jun; 25(10-11):1592-600. doi: 10.1002/elps.200305847. [PMID: 15188246]
  • C Meadway, S George, R Braithwaite. A rapid GC-MS method for the determination of dihydrocodeine, codeine, norcodeine, morphine, normorphine and 6-MAM in urine. Forensic science international. 2002 Jun; 127(1-2):136-41. doi: 10.1016/s0379-0738(01)00644-2. [PMID: 12098538]
  • C Meadway, S George, R Braithwaite. Opiate concentrations following the ingestion of poppy seed products--evidence for 'the poppy seed defence'. Forensic science international. 1998 Aug; 96(1):29-38. doi: 10.1016/s0379-0738(98)00107-8. [PMID: 9800363]
  • M Zheng, K M McErlane, M C Ong. High-performance liquid chromatography-mass spectrometry-mass spectrometry analysis of morphine and morphine metabolites and its application to a pharmacokinetic study in male Sprague-Dawley rats. Journal of pharmaceutical and biomedical analysis. 1998 Feb; 16(6):971-80. doi: 10.1016/s0731-7085(97)00094-0. [PMID: 9547700]
  • D Bourquin, T Lehmann, R Hämmig, M Bührer, R Brenneisen. High-performance liquid chromatographic monitoring of intravenously administered diacetylmorphine and morphine and their metabolites in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 694(1):233-8. doi: 10.1016/s0378-4347(97)00149-7. [PMID: 9234868]
  • D G Watson, Q Su, J M Midgley, E Doyle, N S Morton. Analysis of unconjugated morphine, codeine, normorphine and morphine as glucuronides in small volumes of plasma from children. Journal of pharmaceutical and biomedical analysis. 1995 Jan; 13(1):27-32. doi: 10.1016/0731-7085(94)00121-h. [PMID: 7718630]
  • D Wielbo, R Bhat, G Chari, D Vidyasagar, I R Tebbett, A Gulati. High-performance liquid chromatographic determination of morphine and its metabolites in plasma using diode-array detection. Journal of chromatography. 1993 May; 615(1):164-8. doi: 10.1016/0378-4347(93)80304-m. [PMID: 8340456]
  • M Pawula, D A Barrett, P N Shaw. An improved extraction method for the HPLC determination of morphine and its metabolites in plasma. Journal of pharmaceutical and biomedical analysis. 1993 Apr; 11(4-5):401-6. doi: 10.1016/0731-7085(93)80036-z. [PMID: 8357878]
  • J Hasselström, J Säwe. Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clinical pharmacokinetics. 1993 Apr; 24(4):344-54. doi: 10.2165/00003088-199324040-00007. [PMID: 8491060]
  • C P Verwey-van Wissen, P M Koopman-Kimenai, T B Vree. Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1991 Oct; 570(2):309-20. doi: 10.1016/0378-4347(91)80534-j. [PMID: 1797846]
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