alpha-Cedrene (BioDeep_00000395670)

Main id: BioDeep_00000007506

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(-)-alpha-cedrene;(1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.0(1,5)]undec-8-ene;[3R-(3alpha,3abeta,7beta,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene

化学式: C15H24 (204.1878)
中文名称: α-柏木烯, 8-烯, （5S，7S，8R）-6,6,8-三甲基-2-亚甲基三环[5.3.1.01,5]十一烷, 雪松烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2C13CC=C(C(C3)C2(C)C)C
InChI: InChI=1S/C15H24/c1-10-7-8-15-9-12(10)14(3,4)13(15)6-5-11(15)2/h7,11-13H,5-6,8-9H2,1-4H3/t11-,12+,13+,15+/m1/s1

描述信息

Alpha-cedrene, also known as (-)-α-cedrene or beta-cedrene, is a member of the class of compounds known as cedrane and isocedrane sesquiterpenoids. Cedrane and isocedrane sesquiterpenoids are sesquiternoids with a structure based on the cedrane or the isocedrane skeleton. Cedrane is a tricyclic molecules a 3,6,8,8-tetramethyl-1H-3a,7-methano-azulene moiety. Isocedrane is a rearranged cedrane arising from the migration of methyl group moved from the 6-position to the 4-position. Thus, alpha-cedrene is considered to be an isoprenoid lipid molecule. Alpha-cedrene is a sweet, cedar, and fresh tasting compound and can be found in a number of food items such as tarragon, peppermint, wild celery, and common sage, which makes alpha-cedrene a potential biomarker for the consumption of these food products. Alpha-cedrene can be found primarily in urine.
Cedr-8-ene is a sesquiterpene that is cedrane which has a double bond between positions 8 and 9. It has a role as a human urinary metabolite and a volatile oil component. It is a sesquiterpene, a bridged compound, a polycyclic olefin and a carbotricyclic compound. It derives from a hydride of a cedrane.
alpha-Cedrene is a natural product found in Aloysia gratissima, Widdringtonia whytei, and other organisms with data available.
alpha-Cedrene alpha-Cedrene is one of the two isomers of cedrene. Cedrene is a sesquiterpene found in the essential oil of cedar. There are two isomers of cedrene, (-)-alpha-cedrene and (+)-beta-cedrene, which differ in the position of a double bond (Wikipedia)
A sesquiterpene that is cedrane which has a double bond between positions 8 and 9.
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities[1].
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities[1].
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities[1].
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities[1].

同义名列表

44 个代谢物同义名

(-)-alpha-cedrene;(1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.0(1,5)]undec-8-ene;[3R-(3alpha,3abeta,7beta,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene; 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3.alpha.,3a.beta.,7.beta.,8a.alpha.)]-; (3R-(3.ALPHA.,3A.BETA.,7.BETA.,8A.ALPHA.))-2,3,4,7,8,8A-HEXAHYDRO-3,6,8,8-TETRAMETHYL-1H-3A,7-METHANOAZULENE; [3R-(3alpha,3abeta,7beta,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene; (3R-(3alpha,3Abeta,7beta,8aalpha))-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene; [3R-(3Α,3abeta,7β,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene; [3R-(3a,3Abeta,7b,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene; 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, (3R,3aS,7S,8aS)-; 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-,(3R,3aS,7S,8aS)-; (3R,3aS,7S,8aS)-3,6,8,8-Tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene; (3R,3AS,7S,8AS)-2,3,4,7,8,8A-HEXAHYDRO-3,6,8,8-TETRAMETHYL-1H-3A,7-METHANOAZULENE; (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.0^{1,5}]undec-8-ene; (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.0(1,5)]undec-8-ene; (1S,2R,5S)-2,6,6,8-Tetramethyltricyclo[5.3.1.01.5]undec-8-ene; (1S,2R,5S)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undec-8-ene; (-)-alpha-Cedrene, >=95.0\\% (sum of enantiomers, GC); 3-05-00-01095 (Beilstein Handbook Reference); IRAQOCYXUMOFCW-OSFYFWSMSA-N; LEVO-.ALPHA.-CEDRENE; (-)- alpha -Cedrene; (-)-.alpha.-Cedrene; Laevo-alpha-cedrene; Levo-alpha-cedrene; (-)-alpha-cedrene; .alpha.-Cedrene; UNII-50D4A81G8T; (-)-Α-cedrene; alpha-Cedrene; (-)-a-Cedrene; Tox21_302305; beta-cedrene; (-)--Cedrene; (-)-Cedrene; 50D4A81G8T; Cedr-8-ene; a-Cedrene; Α-cedrene; cedrone; cedrene; J5.927G; (5S,7S,8R)-6,6,8-Trimethyl-2-methylidenetricyclo[5.3.1.01,5]undecane; alpha-Cedrene; Cedr-8-ene; alpha-Cedrene



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

55 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ADCY3, ADIG, PMP2, PRKAA2
Nucleus 4 ADIG, NOTO, PMP2, PRKAA2
autophagosome 1 MAP1LC3A
cytosol 3 MAP1LC3A, PMP2, PRKAA2
dendrite 1 PRKAA2
nucleoplasm 1 PRKAA2
Cell membrane 2 ADCY3, OR10J5
Lipid-anchor 1 MAP1LC3A
Multi-pass membrane protein 3 ADCY3, OR10J5, UCP1
glutamatergic synapse 1 MAP1LC3A
Golgi apparatus 3 ADCY3, ATRN, PRKAA2
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 UCP1
neuronal cell body 1 PRKAA2
Lysosome 1 GAA
plasma membrane 4 ADCY3, ATRN, GAA, OR10J5
Membrane 5 ADCY3, ADIG, GAA, OR10J5, PRKAA2
axon 1 PRKAA2
extracellular exosome 3 ATRN, GAA, PMP2
Lysosome membrane 1 GAA
extracellular space 2 ATRN, INS
lysosomal lumen 1 GAA
mitochondrion 1 UCP1
intracellular membrane-bounded organelle 2 GAA, MAP1LC3A
Single-pass type I membrane protein 1 ATRN
Secreted 3 ADIG, GAA, INS
extracellular region 3 ADIG, GAA, INS
Single-pass membrane protein 1 ADIG
[Isoform 2]: Secreted 1 ATRN
Cell projection, cilium 1 ADCY3
ciliary membrane 1 ADCY3
cytoplasmic vesicle 1 ARL14
Mitochondrion inner membrane 1 UCP1
Cytoplasm, cytoskeleton 1 MAP1LC3A
microtubule 1 MAP1LC3A
nuclear speck 1 PRKAA2
Late endosome 1 MAP1LC3A
cilium 1 ADCY3
chromatin 1 NOTO
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
autophagosome membrane 1 MAP1LC3A
organelle membrane 1 MAP1LC3A
[Isoform 3]: Secreted 1 ATRN
Endomembrane system 1 MAP1LC3A
endosome lumen 1 INS
Lipid droplet 1 ADIG
tertiary granule membrane 1 GAA
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 PMP2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 GAA
[Isoform 1]: Cell membrane 1 ATRN
nucleotide-activated protein kinase complex 1 PRKAA2
Autolysosome 1 MAP1LC3A
autolysosome lumen 1 GAA


文献列表

  • Yucong Li, Jiahui Shao, Yansong Fu, Yu Chen, Hongzhe Wang, Zhihui Xu, Haichao Feng, Weibing Xun, Yunpeng Liu, Nan Zhang, Qirong Shen, Wei Xuan, Ruifu Zhang. The volatile cedrene from Trichoderma guizhouense modulates Arabidopsis root development through auxin transport and signalling. Plant, cell & environment. 2022 03; 45(3):969-984. doi: 10.1111/pce.14230. [PMID: 34800291]
  • Anhye Kim, Stephen R Dueker, Jun Gi Hwang, Jangsoo Yoon, Sang-Won Lee, Hye Suk Lee, Byung-Yong Yu, Kyung-Sang Yu, Howard Lee. An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans. Clinical and translational science. 2021 01; 14(1):231-238. doi: 10.1111/cts.12848. [PMID: 33460293]
  • Li Bai, Mei-Ling Jiao, Hong-Yuan Zang, Shan-Shan Guo, Yang Wang, Yu-Li Sang, Shu-Shan Du. Chemical composition of essential oils from four Rhododendron species and their repellent activity against three stored-product insects. Environmental science and pollution research international. 2019 Aug; 26(22):23198-23205. doi: 10.1007/s11356-019-05577-1. [PMID: 31201707]
  • Yuan Yuan, Ye Sun, Yanchun Zhao, Chungui Liu, Xiulan Chen, Fengtong Li, Jianzhong Bao. Identification of Floral Scent Profiles in Bearded Irises. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091773. [PMID: 31067789]
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  • Tao Tong, Sang Eun Ryu, Yeojin Min, Claire A de March, Caroline Bushdid, Jérôme Golebiowski, Cheil Moon, Taesun Park. Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP-PKA pathway. Scientific reports. 2017 08; 7(1):9471. doi: 10.1038/s41598-017-10379-x. [PMID: 28842679]
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