Penicilloic acid (BioDeep_00000011342)

 

Secondary id: BioDeep_00000409517

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-{carboxy[(1-hydroxy-2-phenylethylidene)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

化学式: C16H20N2O5S (352.10928700000005)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.16%

分子结构信息

SMILES: CC1(C(NC(S1)C(C(=O)O)NC(=O)CC2=CC=CC=C2)C(=O)O)C
InChI: InChI=1S/C16H20N2O5S/c1-16(2)12(15(22)23)18-13(24-16)11(14(20)21)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-13,18H,8H2,1-2H3,(H,17,19)(H,20,21)(H,22,23)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
Penicilloic acid is a metabolite of penicillin v; penicillin g.

同义名列表

10 个代谢物同义名

2-{carboxy[(1-hydroxy-2-phenylethylidene)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylate; 2-[carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid; Benzylpenicilloic acid, disodium salt, (2R-(2alpha(r*),4beta))-isomer; Benzylpenicilloic acid, sodium salt, (2R-(2alpha(r*),4beta))-isomer; Benzylpenicilloic acid, monosodium salt; Penicilloic acid, disodium salt; Benzylpenicilloic acid; Penicilloic G acid; Penicilloic acid; Penicilloate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexandra Maier-Salamon, Salwa Ahmed Elgendy, Brigitte Meyer, Matthias Vossen, Theresia Thalhammer, Florian Thalhammer, Walter Jäger. Pharmacokinetics of flucloxacillin and its metabolites in patients with renal failure: Impact on liver toxicity
. International journal of clinical pharmacology and therapeutics. 2017 Sep; 55(9):701-711. doi: 10.5414/cp202796. [PMID: 28737131]
  • Meihui Qi, Xiaoyan Huang, Yujie Zhou, Liying Zhang, Yang Jin, Yan Peng, Huijun Jiang, Shuhu Du. Label-free surface-enhanced Raman scattering strategy for rapid detection of penicilloic acid in milk products. Food chemistry. 2016 Apr; 197(Pt A):723-9. doi: 10.1016/j.foodchem.2015.11.014. [PMID: 26617009]
  • Hsin-Pin Ho, Ren-Jye Lee, Chung-Yu Chen, Soo-Ray Wang, Zu-Guang Li, Maw-Rong Lee. Identification of new minor metabolites of penicillin G in human serum by multiple-stage tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2011 Jan; 25(1):25-32. doi: 10.1002/rcm.4823. [PMID: 21154651]
  • W J Krauwinkel, N J Volkers-Kamermans. Determination of penicillin-V in human plasma by high-performance liquid chromatography and solid-phase extraction. Journal of chromatography. B, Biomedical applications. 1996 Apr; 679(1-2):129-35. doi: 10.1016/0378-4347(95)00560-9. [PMID: 8998551]
  • J Knöller, K D Bremm, W Schönfeld, W König. Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures. Antimicrobial agents and chemotherapy. 1986 Mar; 29(3):527-9. doi: 10.1128/aac.29.3.527. [PMID: 3013089]
  • W Schönfeld, J Knöller, K D Bremm, W König. Degradation of azlocillin in human serum. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 1985 Oct; 260(2):254-9. doi: 10.1016/s0176-6724(85)80122-x. [PMID: 3002076]
  • K Miyazaki, K Iseki, T Ishizawa, T Arita, S Sakai, Y Kumamoto. Effect of clavulanic acid on inactivated amoxicillin excretion in urinary tract infection. Clinical pharmacology and therapeutics. 1985 May; 37(5):508-11. doi: 10.1038/clpt.1985.80. [PMID: 2985324]
  • P D Gorevic, B B Levine. Desensitization of anaphylactic hypersensitivity specific for the penicilloate minor determinant of penicillin and carbenicillin. The Journal of allergy and clinical immunology. 1981 Oct; 68(4):267-72. doi: 10.1016/0091-6749(81)90150-0. [PMID: 6169752]
  • M E MacCara, W A Parker. In vitro effect of penicillins and aminoglycosides on commonly used tests for glycosuria. American journal of hospital pharmacy. 1981 Sep; 38(9):1340-5. doi: . [PMID: 6269424]
  • C W Filer, M J Humphrey, D J Jeffery, K H Jones, P F Langley. The metabolism of carfecillin in rat, dog and man. Xenobiotica; the fate of foreign compounds in biological systems. 1980 Oct; 10(10):761-9. doi: 10.3109/00498258009033804. [PMID: 6256982]
  • A Tsuji, E Miyamoto, T Yamana. A new fluorometric method for simultaneous determination of penicillins and penicilloic acids. The Journal of pharmacy and pharmacology. 1978 Dec; 30(12):811-3. doi: 10.1111/j.2042-7158.1978.tb13404.x. [PMID: 32256]
  • A Ingold. Conversion of benzylpenicillin to penicilloic acid in patients with chronic bronchial infections. Chemotherapy. 1976; 22(2):88-96. doi: 10.1159/000221917. [PMID: 1253635]
  • M Cole, M D Kenig, V A Hewitt. Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption. Antimicrobial agents and chemotherapy. 1973 Apr; 3(4):463-8. doi: 10.1128/aac.3.4.463. [PMID: 4364176]
  • A S JOSEPHSON. The development of antibodies to penicilin in rabbits. The Journal of experimental medicine. 1960 May; 111(?):611-20. doi: 10.1084/jem.111.5.611. [PMID: 13790762]