Oxmetidine (BioDeep_00000008884)
Secondary id: BioDeep_00001875890
human metabolite
代谢物信息卡片
化学式: C19H21N5O3S (399.1365)
中文名称: 奥美替丁
谱图信息:
最多检出来源 Mentha canadensis(plant) 50%
分子结构信息
SMILES: CC1=C(CSCCNC2=NC(=O)C(CC3=CC=C4OCOC4=C3)=CN2)N=CN1
InChI: InChI=1S/C19H21N5O3S/c1-12-15(23-10-22-12)9-28-5-4-20-19-21-8-14(18(25)24-19)6-13-2-3-16-17(7-13)27-11-26-16/h2-3,7-8,10H,4-6,9,11H2,1H3,(H,22,23)(H2,20,21,24,25)
描述信息
Oxmetidine belongs to the family of Benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole.
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
10 个代谢物同义名
5-[(2H-1,3-benzodioxol-5-yl)methyl]-2-[(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)amino]-1,4-dihydropyrimidin-4-one; 5-(1,3-Benzodioxol-5-ylmethyl)-2-[(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)amino]pyrimidin-4(1H)-one; Oxmetidine dihydrochloride; Oxmetidine hydrochloride; SK And F 92994; SK And F-92994; Oxmetidinum; OXMETIDINE; Oxmetidina; Oxmetidine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:7847
- KEGG: C11803
- PubChem: 51710
- HMDB: HMDB0041970
- Metlin: METLIN69232
- ChEMBL: CHEMBL2110657
- Wikipedia: Oxmetidine
- chemspider: 46799
- CAS: 72830-39-8
- PMhub: MS000022588
- PubChem: 13967
- NIKKAJI: J11.244E
- RefMet: Oxmetidine
- KNApSAcK: 7847
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R A Willson, T Hall, J Hart. Oxmetidine (H2 receptor antagonist) induced cytotoxicity in isolated rat hepatocytes.
Journal of applied toxicology : JAT.
1988 Jun; 8(3):223-5. doi:
10.1002/jat.2550080311. [PMID: 2902116] - G F Rush, D Alberts, S Lupo, L A Yodis, T H Brown, G J Durant. Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships.
The Journal of pharmacology and experimental therapeutics.
1988 Jan; 244(1):113-7. doi:
. [PMID: 2891842] - U R Fölsch, G C Wichmann, A Torossian. Effect of 6-hourly intermittent intravenous boluses of oxmetidine and ranitidine on gastric acidity and serum prolactin.
European journal of clinical pharmacology.
1987; 33(3):267-71. doi:
10.1007/bf00637560. [PMID: 2891536] - G F Rush, M Ripple, R Chenery. Mechanism of oxmetidine (SK&F 92994) cytotoxicity in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics.
1985 Jun; 233(3):741-6. doi:
. [PMID: 2861279] - F Miglio, M Baraldini, S Serra, A Facchini, G F Stefanini, R Meliconi, G Gasbarrini, G Labo'. Oxmetidine (SK&F 92994): pharmacokinetic study in patients with in patients with liver cirrhosis.
International journal of clinical pharmacology research.
1985; 5(6):399-404. doi:
. [PMID: 2869000] - G C Wichmann, R Körber, U R Fölsch. [Intragastric acidity, serum gastrin and serum levels of the H2 receptor oxmetidine administered by continuous infusion].
Arzneimittel-Forschung.
1985; 35(8):1307-10. doi:
. [PMID: 2866776] - R D McDowall, G S Murkitt, J A Walford. High-performance liquid chromatographic determination of oxmetidine in human plasma: comparison of liquid-liquid and liquid-solid extraction techniques.
Journal of chromatography.
1984 Dec; 317(?):475-81. doi:
10.1016/s0021-9673(01)91687-5. [PMID: 6152271] - P J Cox, W M Heijbroek, D C Taylor, P J Wood, P R Cresswell, E S Pepper, P J Moore, R C Mitchell, T J Blake, J S Dawborne. The metabolism in animals and man of oxmetidine--a new histamine H2-receptor antagonist.
Xenobiotica; the fate of foreign compounds in biological systems.
1984 Jul; 14(7):509-14. doi:
10.3109/00498258409151439. [PMID: 6150580] - T B Leonard, J G Dent. Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals.
Research communications in chemical pathology and pharmacology.
1984 Jun; 44(3):375-88. doi:
. [PMID: 6147001] - G C Wichmann, U R Fölsch, E von Kleist, F M Hasse, M Dillon, B Clowdus, W Creutzfeldt. Effect of three single doses of oxmetidine administered intravenously on the volume and acidity of gastric secretion, serum prolactin and gastrin concentration in healthy volunteers.
Zeitschrift fur Gastroenterologie.
1984 Jun; 22(6):285-93. doi:
. [PMID: 6147051] - R D McDowall, G S Murkitt, R M Lee. Improved assay procedure for oxmetidine and its metabolites in plasma, urine and bile samples.
Journal of chromatography.
1984 Jan; 305(1):214-21. doi:
10.1016/s0378-4347(00)83333-2. [PMID: 6707147] - G Soldani, M Del Tacca, A Polloni, C Bernardini, E Martinotti. Comparative study with oxmetidine and ranitidine on acid secretion and gastrin release in the dog.
International journal of tissue reactions.
1984; 6(2):181-4. doi:
. [PMID: 6145677] - R Arnold, I Garbe, H Koop, H Mönnikes, H Schwarting. Effect of antacid and H2-receptor blocker treatment on gastric endocrine cells.
Scandinavian journal of gastroenterology. Supplement.
1984; 101(?):31-7. doi:
. [PMID: 6152750] - G O Barbezat, D Brown, M Schlup, B P Maclaurin. A comparison of oxmetidine and cimetidine in the treatment of duodenal ulcer.
The New Zealand medical journal.
1983 Apr; 96(729):250-2. doi:
. [PMID: 6340009] - R M Lee, R D McDowall. Comparison of two high-performance liquid chromatographic methods for the determination of oxmetidine and its metabolites in plasma, bile and urine samples.
Journal of chromatography.
1983 Apr; 273(2):335-45. doi:
10.1016/s0378-4347(00)80954-8. [PMID: 6863448] - K A Jönsson, G Bodemar, R Gotthard, B Norlander, A Walan. Pharmacokinetics of oxmetidine, a new histamine H2-receptor antagonist, after single oral and intravenous doses.
European journal of clinical pharmacology.
1983; 24(3):353-6. doi:
10.1007/bf00610054. [PMID: 6134622] - K A Jönsson, S E Eriksson, I Kagevi, B Norlander, G Bodemar, A Walan. Cimetidine, but not oxmetidine, penetrates into the cerebrospinal fluid after a single intravenous dose.
British journal of clinical pharmacology.
1982 Dec; 14(6):815-9. doi:
10.1111/j.1365-2125.1982.tb02042.x. [PMID: 7150460] - R Gugler, H G Rohner, A A Somogyi. Gastric acid inhibition and oxmetidine kinetics in duodenal ulcer.
Clinical pharmacology and therapeutics.
1982 Apr; 31(4):501-8. doi:
10.1038/clpt.1982.67. [PMID: 6120776] - P C Sharpe, M A Melvin, J G Mills, W L Burland, G V Groom. Prolactin responses to histamine H2 receptor antagonists.
Acta endocrinologica.
1980 Nov; 95(3):308-13. doi:
10.1530/acta.0.0950308. [PMID: 6108034]
