Estriol-3-glucuronide (BioDeep_00000008578)
Secondary id: BioDeep_00001883344
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C24H32O9 (464.2046)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(not specific) 24.71%
分子结构信息
SMILES: CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)OC5C(C(C(C(O5)C(=O)O)O)O)O
InChI: InChI=1S/C24H32O9/c1-24-7-6-13-12-5-3-11(32-23-19(28)17(26)18(27)20(33-23)22(30)31)8-10(12)2-4-14(13)15(24)9-16(25)21(24)29/h3,5,8,13-21,23,25-29H,2,4,6-7,9H2,1H3,(H,30,31)/t13-,14-,15+,16-,17+,18+,19-,20+,21+,23-,24+/m1/s1
描述信息
Estriol-3-glucuronide is a natural human metabolite of estriol generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Estriol-3-glucuronide is a natural human metabolite of estriol generated in the liver by UDP glucuonyltransferase.
同义名列表
26 个代谢物同义名
(2S,3S,4S,5R,6S)-6-[[(13S,16R,17R)-16,17-Dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-{[(13R,14R,15S)-13,14-dihydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-5-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid; 16alpha,17beta-Dihydroxyestra-1,3,5(10)-trien-3-yl-beta-delta-glucosiduronic acid; 16alpha,17beta-Dihydroxyestra-1,3,5(10)-trien-3-yl-beta-D-glucosiduronic acid; 16alpha,17beta-Dihydroxyestra-1,3,5(10)-trien-3-yl-glucopyranosiduronic acid; 16a,17b-Dihydroxyestra-1,3,5(10)-trien-3-yl-beta-delta-glucosiduronic acid; 16a,17b-Dihydroxyestra-1,3,5(10)-trien-3-yl-beta-D-glucosiduronic acid; 16a,17b-Dihydroxyestra-1,3,5(10)-trien-3-yl-glucopyranosiduronic acid; estra-1,3,5(10)-triene-3,16alpha,17beta-triol 3-D-glucuronide; Estriol 3-glucuronide, monosodium salt, 2,4,17-(2)H-labeled; 16α,17β-Estriol 3-(β-D-glucuronide); Estriol 3-glucuronide, (16alpha,17alpha)-isomer; 16alpha,17beta-Estriol 3-(beta-D-glucuronide); Estriol 3-glucuronide, (16beta,17beta)-isomer; Estriol 3-glucuronide, monosodium salt; Estriol 3-(beta-delta-glucuronide); Estriol 3-(beta-D-glucuronide); Estriol 3-glucopyranuronoside; Estriol 3-beta-glucuronide; Estriol 3-glucosiduronate; Estriol 3-monoglucuronide; Estriol 3-glucuronoside; Estriol-3-glucuronide; Estriol 3-glucuronide; Estriol glucuronide; ST 18:3;O3;GlcA
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:45869
- KEGG: C11288
- PubChem: 3465724
- PubChem: 443103
- PubChem: 160638
- HMDB: HMDB0010335
- Metlin: METLIN43178
- LipidMAPS: LMST05010017
- foodb: FDB027487
- chemspider: 141153
- CAS: 2479-91-6
- PMhub: MS000022209
- PubChem: 13463
- PDB-CCD: STG
- 3DMET: B04217
- NIKKAJI: J901.482I
- RefMet: Estriol-3-glucuronide
- RefMet: Estriol glucuronide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Keiko Mouri, Keiko Shimizu. Stability of chimpanzee (Pan troglodytes) urinary reproductive hormones during long-term preservation on filter paper.
Primates; journal of primatology.
2021 Mar; 62(2):289-296. doi:
10.1007/s10329-020-00864-9. [PMID: 32955646] - Kathleen A O'Connor, Eleanor Brindle, Darryl J Holman, Nancy A Klein, Michael R Soules, Kenneth L Campbell, Fortüne Kohen, Coralie J Munro, Jane B Shofer, Bill L Lasley, James W Wood. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research.
Clinical chemistry.
2003 Jul; 49(7):1139-48. doi:
10.1373/49.7.1139. [PMID: 12816911] - Yoon Jung Yang, Jeongae Lee, Man Ho Choi, Bong Chul Chung. Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry.
Biomedical chromatography : BMC.
2003 Jun; 17(4):219-25. doi:
10.1002/bmc.215. [PMID: 12833386] - Zhe-Sheng Chen, Elizabeth Hopper-Borge, Martin G Belinsky, Irina Shchaveleva, Elena Kotova, Gary D Kruh. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Molecular pharmacology.
2003 Feb; 63(2):351-8. doi:
10.1124/mol.63.2.351. [PMID: 12527806] - T Iwata, T Hirose, M Yamaguchi. Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 695(2):201-7. doi:
10.1016/s0378-4347(97)00194-1. [PMID: 9300855] - C H Trinh, S D Hemmington, M E Verhoeyen, S E Phillips. Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity.
Structure (London, England : 1993).
1997 Jul; 5(7):937-48. doi:
10.1016/s0969-2126(97)00247-5. [PMID: 9261086] - F Caccamo, G Carfagnini, A Di Corcia, R Samperi. Measurement of urinary estriol glucuronides during the menstrual cycle by high-performance liquid chromatography.
Journal of chromatography.
1988 Dec; 434(1):61-70. doi:
10.1016/0378-4347(88)80062-8. [PMID: 2854136] - F Andreolini, C Borra, F Caccamo, A Di Corcia, I Nicoletti, R Samperi, F Improta. Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection.
Clinical chemistry.
1985 Oct; 31(10):1698-702. doi:
. [PMID: 2994907] - T Nambara, T Ohkubo, T Yamaki, K Shimada. Preparation of specific antisera to estrone-3-glucuronide and estriol-3-glucuronide.
Journal of steroid biochemistry.
1984 Feb; 20(2):621-6. doi:
10.1016/0022-4731(84)90133-x. [PMID: 6323874] - T Nambara, T Ohkubo, K Shimada. Antigenic properties of estriol 3-glucuronide-[C-6]-bovine serum albumin conjugates having oxime bridges.
Journal of pharmacobio-dynamics.
1983 Sep; 6(9):692-7. doi:
10.1248/bpb1978.6.692. [PMID: 6655549] - R V Haning, C W Austin, D L Kuzma, S S Shapiro, W J Zweibel. Ultrasound evaluation of estrogen monitoring for induction of ovulation with menotropins.
Fertility and sterility.
1982 May; 37(5):627-32. doi:
10.1016/s0015-0282(16)46273-4. [PMID: 6804275] - I Schiff, D Tulchinsky, K J Ryan, S Kadner, M Levitz. Plasma estriol and its conjugates following oral and vaginal administration of estriol to postmenopausal women: correlations with gonadotropin levels.
American journal of obstetrics and gynecology.
1980 Dec; 138(8):1137-41. doi:
10.1016/s0002-9378(16)32780-6. [PMID: 6778214] - F Z Stanczyk, I Miyakawa, U Goebelsmann. Direct radioimmunoassay of urinary estrogen and pregnanediol glucuronides during the menstrual cycle.
American journal of obstetrics and gynecology.
1980 Jun; 137(4):443-50. doi:
10.1016/0002-9378(80)91125-4. [PMID: 7386528] - T Miyazaki, H Mizukoshi, Y Araki, N Shimizu. The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.
Endocrinologia japonica.
1980 Apr; 27(2):175-82. doi:
10.1507/endocrj1954.27.175. [PMID: 6250804] - T S Baker, K Jennison, A E Kellie. A possible method for the detection of ovulation and the determination of the duration of the fertile period.
Journal of steroid biochemistry.
1980 Jan; 12(?):411-5. doi:
10.1016/0022-4731(80)90300-3. [PMID: 7421226]
